未登录Synergistic antitumor effect of FRa TOP1i antibody drug conjugate, AZD5335, in combination with the PARP1 inhibitor, saruparib (AZD5305), in preclinical models of ovarian cancer
Gymnopoulos, Marco; Tammali, Ravinder; De Almeida, Ana; Wang, Jixin; Myers, Claire; Albertella, Mark; Fraenkel, Paula G.; Sapra, Puja .png)
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收藏FPI-2068: A novel anti-EGFR/cMET, alpha-particle emitting, radioimmunoconjugate for cancer therapyAghevlian, Sadaf; Collens, Sean; Metcalf, Julie; Grinshtein, Natalie; Forbes, John; Comer, Frank; Dalal, Darshan; Sapra, Puja; Burak, Eric 分享 收藏 AZD9592: An EGFR-cMET bispecific antibody-drug conjugate (ADC) targeting key oncogenic drivers in non-small-cell lung cancer (NSCLC) and beyondComer, Frank; Mazor, Yariv; Hurt, Elaine; Yang, Chunning; Fleming, Ryan; Shandilya, Harini; Vijayakrishnan, Balakumar; Sterba, Meghan; Chen, Ruoyan; Rosfjord, Edward; Floch, Nicolas; Rosenbaum, Anton I.; Huang, Yue; Yuan, Jiaqi; Beaumont, Kevin; Godfrey, Lisa; McGrath, Lara; Arnaldez, Fernanda; Sapra, Puja 分享 收藏 Preclinical evaluation of a novel B7-H4 targeted antibody-drug conjugate AZD8205 as a single agent and in combination with novel PARP inhibitor and checkpoint blockadeCazes, Alex; Kinneer, Krista; Omar, Bilal; Chesebrough, Jon; Anderton, Judith; Wang, Jixin; Staniszewska, Anna D.; Arbitman, Steven; Daita, Kalyani; Desai, Himanshi; Johnson, Yoshimi; Rothstein, Raymond; Gymnopoulos, Marco; Fabbri, Giulia; Cooper, Zachary A.; Albertella, Mark; Hammond, Scott A.; Cosulich, Sabina; Luheshi, Nadia; Sapra, Puja 分享 收藏 分享 收藏 AZD4820 ONCOLYTIC VACCINIA VIRUS ENCODING IL-12 MEDIATES ANTI-TUMOR ACTIVITY THROUGH ONCOLYSIS AND TUMOR-SPECIFIC IMMUNITYKurokawa, Cheyne; Agrawal, Sonia; Mitra, Abhisek; Galvani, Elena; Burke, Shannon; Varshine, Ankita; Rothstein, Raymond; Foloppe, Johann; Silvestre, Nathalie; Quemeneur, Eric; Sapra, Puja; Barrett, Carl; Hammond, Scott; Laliberte, Jason; Durham, Nicholas; Oberst, Michael; Broggi, Maria 分享 收藏 Anti-Extra Domain B Splice Variant of Fibronectin Antibody-Drug Conjugate Eliminates Tumors with Enhanced Efficacy When Combined with Checkpoint Blockade纤连蛋白抗体-药物偶联物的抗外域B剪接变体与检查点阻断相结合可消除肿瘤，并提高疗效Hooper, Andrea T.; Marquette, Kimberly; Chang, Chao -Pei Betty; Golas, Jonathon; Jain, Sadhana; Lam, My-Hanh; Guffroy, Magali; Leal, Mauricio; Falahatpisheh, Hadi; Mathur, Divya; Chen, Ting; Kelleher, Kerry; Khandke, Kiran; Muszynska, Elwira; Loganzo, Frank; Rosfjord, Edward; Lucas, Judy; Kan, Zhengyan; Subramanyam, Chakrapani; O'Donnell, Christopher; Neri, Dario; Gerber, Hans-Peter; May, Chad; Sapra, Puja 分享 收藏 Targeting and pharmacology of an anti-IL13Rα2 antibody and antibody-drug conjugate in a melanoma xenograft modelGupta, Parul; Jiang, Ziyue Karen; Yang, Bing; Manzuk, Lisa; Rosfjord, Edward; Yao, Johnny; Lemon, Luanna; Noorbehesht, Kavon; David, John; Puthenveetil, Sujiet; Casavant, Jeffrey M.; Muszynska, Elwira; Li, Fengping; Leal, Mauricio; Sapra, Puja; Giddabasappa, Anand 分享 收藏 Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumorsRoot, Adam R.; Guntas, Gurkan; Katragadda, Madan; Apgar, James R.; Narula, Jatin; Chang, Chew Shun; Hanscom, Sara; McKenna, Matthew; Wade, Jason; Meade, Caryl; Ma, Weijun; Guo, Yongjing; Liu, Yan; Duan, Weili; Hendershot, Claire; King, Amy C.; Zhang, Yan; Sousa, Eric; Tam, Amy; Benard, Susan; Yang, Han; Kelleher, Kerry; Jin, Fang; Piche-Nicholas, Nicole; Keating, Sinead E.; Narciandi, Fernando; Lawrence-Henderson, Rosemary; Arai, Maya; Stochaj, Wayne R.; Svenson, Kristine; Mosyak, Lidia; Lam, Khetemcnee; Francis, Christopher; Marquette, Kimberly; Wroblewska, Liliana; Zhu, H. Lily; Sheehan, Alfredo Darmanin; LaVallie, Edward R.; D'Antona, Aaron M.; Betts, Alison; King, Lindsay; Rosfjord, Edward; Cunningham, Orla; Lin, Laura; Sapra, Puja; Tchistiakova, Lioudmila; Mathur, Divya; Bloom, Laird 分享 收藏 PF-06804103, A Site-specific Anti-HER2 Antibody-Drug Conjugate for the Treatment of HER2-expressing Breast, Gastric, and Lung CancersGraziani, Edmund, I; Sung, Matthew; Ma, Dangshe; Narayanan, Bitha; Marquette, Kimberly; Puthenveetil, Sujiet; Tumey, L. Nathan; Bikker, Jack; Casavant, Jeffrey; Bennett, Eric M.; Charati, Manoj B.; Golas, Jonathon; Hosselet, Christine; Rohde, Cynthia M.; Hu, George; Guffroy, Magali; Falahatpisheh, Hadi; Finkelstein, Martin; Clark, Tracey; Barletta, Frank; Tchistiakova, Lioudmila; Lucas, Judy; Rosfjord, Edward; Loganzo, Frank; O'Donnell, Christopher J.; Gerber, Hans-Peter; Sapra, Puja 分享 收藏 A novel GUCY2C-CD3 bispecific engages T cells to induce cytotoxicity in gastrointestinal tumorsMathur, Divya; Root, Adam; Bugaj-Gaweda, Bozena; Tan, Xingzhi; Fang, Wei; Bisulco, Stephanie; Golas, Jonathan; Fernandez, Diane; Kearney, Jessica; Upeslacis, Eric; Yao, Johnny; Rosfjord, Edward; Stevens, Chad; Kobylarz, Keith; King, Lindsay; Narula, Jatin; Kelleher, Kerry; Schaer, David; Kamperschroer, Cris; Buetow, Bernard; Rohde, Cynthia; Moreau, Allison; Wong, Gilbert; Sapra, Puja 分享 收藏 分享 收藏 分享 收藏 分享 收藏 NG-HER2 ADC (PF-06804103) is superior to trastuzumab emtansine in a mouse 'avatar' head-to-head clinical trialSung, Matthew S.; Hopf, Christine; Upeslacis, Erik; Golas, Jonathon; Kaplan, Mark; Khandke, Kiran; Charati, Manoj; Kotch, Frank; Loganzo, Frank; Geles, Ken; Lucas, Judy; Gerber, Hans-Peter; Sapra, Puja; Rosfjord, Edward 分享 收藏 Gemtuzumab Ozogamicin (GO) Inclusion to Induction Chemotherapy Eliminates Leukemic Initiating Cells and Significantly Improves Survival in Mouse Models of Acute Myeloid LeukemiaZhang, Cathy C.; Yan, Zhengming; Pascual, Bernadette; Jackson-Fisher, Amy; Huang, Donghui Stephen; Zong, Qing; Elliott, Mark; Fan, Conglin; Huser, Nanni; Lee, Joseph; Sung, Matthew; Sapra, Puja 分享 收藏 The development of CPI as a novel, next-generation DNA-targeting payload for ADCsKahler, Jennifer; Dougher, Maureen; Xu, Jane; Doroski, Matthew; Maderna, Andreas; Dushin, Russell; Thibault, Stephane; Leal, Mauricio; Katragadda, Madan; O'Donnell, Christopher J.; Sung, Matthew; Sapra, Puja 分享 收藏 分享 收藏 A PTK7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressionsDamelin, Marc; Bankovich, Alexander; Bernstein, Jeffrey; Lucas, Justin; Chen, Liang; Williams, Samuel; Park, Albert; Aguilar, Jorge; Ernstoff, Elana; Charati, Manoj; Dushin, Russell; Aujay, Monette; Lee, Christina; Ramoth, Hanna; Milton, Milly; Hampl, Johannes; Lazetic, Sasha; Pulito, Virginia; Rosfjord, Edward; Sun, Yongliang; King, Lindsay; Barletta, Frank; Betts, Alison; Guffroy, Magali; Falahatpisheh, Hadi; O'Donnell, Christopher J.; Stull, Robert; Pysz, Marybeth; Escarpe, Paul; Liu, David; Foord, Orit; Gerber, Hans Peter; Sapra, Puja; Dylla, Scott J. 分享 收藏 Biodistribution and Targeting of Anti-5T4 Antibody-Drug Conjugate Using Fluorescence Molecular TomographyGiddabasappa, Anand; Gupta, Vijay R.; Norberg, Rand; Gupta, Parul; Spilker, Mary E.; Wentland, Joann; Rago, Brian; Eswaraka, Jeetendra; Leal, Mauricio; Sapra, Puja 分享 收藏 
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