未登录 分享 收藏
分享 收藏
Acalabrutinib-obinutuzumab improves survival vs chemoimmunotherapy in treatment-naive CLL in the 6-year follow-up of ELEVATE-TN Sharman, J.P.; Egyed, M.; Jurczak, W.; Skarbnik, A.; Patel, K.; Flinn, I.W.; Kamdar, M.; Munir, T.; Walewska, R.; Hughes, M.; et al. Acalabrutinib-obinutuzumab在ELEVATE-TN的6年随访中，与化疗免疫疗法相比，提高了初治CLL患者的生存率。Blood 2025, 146, 1276–1285. [Google Scholar] [CrossRef] Jeff P. Sharman; Miklos Egyed; Wojciech Jurczak; Alan Skarbnik; Krish Patel; Ian W. Flinn; Manali Kamdar; Talha Munir; Renata Walewska; Marie Hughes; Laura Maria Fogliatto; Yair Herishanu; Versha Banerji; George Follows; Patricia Walker; Paolo Ghia; Ann Janssens; John C. Byrd; Emmanuelle Ferrant; Alessandra Ferrajoli; William G. Wierda; Catherine Wangui Wachira; Batul T. Suterwala; Paulo Miranda; Veerendra Munugalavadla; Chuan-Chuan Wun; Jennifer A. Woyach 分享 收藏
DHODH inhibition alters T cell metabolism limiting acute graft-versus-host disease while retaining graft-versus-leukemia response DHODH抑制改变了T细胞代谢，限制了急性移植物抗宿主病，同时保留了移植物抗白血病反应。 Kumar, Rathan; Braunreiter, Kara M.; Neidemire-Colley, Lotus; Sell, Natalie; Gao, Yandi; Steere, Camryn; Weber, Margot; Vanakeri, Dhruva; Choi, Eunice; Choe, Hannah K.; Vibhute, Sandip; Bennett, Chad; Byersdorfer, Craig A.; Elgamal, Ola A.; Goodwin, Thomas E.; Hertlein, Erin K.; Byrd, John C.; Ranganathan, Parvathi 分享 收藏
Efficacy and safety in a 4-year follow-up of the ELEVATE-TN study comparing acalabrutinib with or without obinutuzumab versus obinutuzumab plus chlorambucil in treatment-naive chronic lymphocytic leukemia (Dec, 10.1038/s41375-024-02487-1, 2024) Sharman, Jeff P.; Egyed, Miklos; Jurczak, Wojciech; Skarbnik, Alan; Pagel, John M.; Flinn, Ian W.; Kamdar, Manali; Munir, Talha; Walewska, Renata; Corbett, Gillian; Fogliatto, Laura Maria; Herishanu, Yair; Banerji, Versha; Coutre, Steven; Follows, George; Walker, Patricia; Karlsson, Karin; Ghia, Paolo; Janssens, Ann; Cymbalista, Florence; Woyach, Jennifer A.; Ferrant, Emmanuelle; Wierda, William G.; Munugalavadla, Veerendra; Yu, Ting; Wang, Min Hui; Byrd, John C. 分享 收藏
LP-168 (Rocbrutinib), a Novel Covalent and Non-Covalent Next-Generation Inhibitor of Bruton's Tyrosine Kinase: Updates on the Phase 1 Trial and Initial Results of the CLL Gatekeeper Mutation Cohort LP-168 (Rocbrutinib)，一种新型共价和非共价布鲁顿酪氨酸激酶下一代抑制剂：1期临床试验更新及CLL门控突变队列的初步结果 Woyach, Jennifer A.; Brander, Danielle M.; Hu, Boyu; Rogers, Kerry A.; Omer, Zulfa; Stephens, Deborah M.; Sitlinger, Andrea; Tan, Fenlai; Chen, Yi; Anthony, Stephen P.; Chen, Yu; Shang, Kewei; Byrd, John C. 分享 收藏
Outcomes and Survival in Newly Diagnosed, Older, Acute Myeloid Leukemia Patients from the Beat AML Master Trial in the Venetoclax/Azacitidine Age 新诊断、老年急性髓系白血病患者在Venetoclax/阿扎胞苷时代的Beat AML主试验中的结局与生存情况 Borate, Uma; Huang, Ying; Li Welkie, Rina; Swords, Ronan T.; Traer, Elie; Stein, Eytan M.; Lin, Tara L.; Madanat, Yazan F.; Patel, Prapti A.; Collins, Robert H.; Baer, Maria R.; Duong, Vu H.; Blum, William; Arellano, Martha L.; Stock, Wendy; Odenike, Olatoyosi; Redner, Robert L.; Kovacsovics, Tibor J.; Deininger, Michael W.; Zeidner, Joshua F.; Olin, Rebecca; Smith, Catherine C.; Foran, James M.; Schiller, Gary J.; Curran, Emily K.; Koenig, Kristin L.; Heerema, Nyla A.; Chen, Timothy; Martycz, Molly; Stefanos, Mona; Marcus, Sonja Gullen; Druker, Brian J.; Levine, Ross L.; Burd, Amy; Rossenber, Leohard; Yocum, Ashley Owen; Mims, Alice; Byrd, John C. 分享 收藏
Feasibility of Discontinuation of Bruton's Tyrosine Kinase Inhibitors in Patients with Chronic Lymphocytic Leukemia: A Patient Survey 慢性淋巴细胞白血病患者停用布托替尼酪氨酸激酶抑制剂的可行性：一项患者调查 Stephens, Deborah M.; Stewart, Chris; Avruch, Liza; Coombs, Catherine C.; Danilov, Alexey; Hill, Brian T.; Shadman, Mazyar; Gerrie, Alina S.; Jensen, Christopher E.; Hoffmann, Marc; Winter, Allison M.; Ermann, Daniel A.; Barr, Paul M.; O'Brien, Susan M.; Koffman, Brian; Byrd, John C. 分享 收藏
A Multicenter, Open-Label, Phase 1 Clinical Trial of AJ1-11095 Administered As Oral Monotherapy in Patients with Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed By a Type I JAK2 Inhibitor (JAK2i) 一项多中心、开放标签、I期临床试验，评估AJ1-11095以口服单药疗法给药在曾接受过I型JAK2抑制剂（JAK2i）治疗失败的原发性骨髓纤维化（PMF）、真性红细胞增多症后骨髓纤维化（PPV-MF）或原发性血小板增多症后骨髓纤维化（PET-MF）患者中的疗效。 Mascarenhas, John O.; Borate, Uma; Bose, Prithviraj; Byrd, John C.; Garcia, Jacqueline S.; Grunwald, Michael R.; Hobbs, Gabriela S.; Hoffman, Ronald; Kuykendall, Andrew T.; Mesa, Ruben A.; Oh, Stephen; Rampal, Raajit; Yacoub, Abdulraheem; Steensma, David P. 分享 收藏
Improving risk stratification for 2022 European LeukemiaNet favorable- risk patients with acute myeloid leukemia Archer, Kellie J.; Fu, Han; Mrozek, Krzysztof; Nicolet, Deedra; Mims, Alice S.; Uy, Geoffrey L.; Stock, Wendy; Byrd, John C.; Hiddemann, Wolfgang; Metzeler, Klaus H.; Rausch, Christian; Krug, Utz; Sauerland, Cristina; Goerlich, Dennis; Berdel, Wolfgang E.; Woermann, Bernhard J.; Braess, Jan; Spiekermann, Karsten; Herold, Tobias; Eisfeld, Ann-Kathrin 分享 收藏
Beat-AML 2024 ELN-refined risk stratification for older adults with newly diagnosed AML given lower-intensity therapy Beat-aml 2024 ELN-对新诊断AML的老年人进行低强度治疗的风险分层 Hoff, Fieke W.; Blum, William G.; Huang, Ying; Li Welkie, Rina; Swords, Ronan T.; Traer, Elie; Stein, Eytan M.; Lin, Tara L.; Archer, Kellie J.; Patel, Prapti A.; Collins, Robert H.; Baer, Maria R.; Duong, Vu H.; Arellano, Martha L.; Stock, Wendy; Odenike, Olatoyosi; Redner, Robert L.; Kovacsovics, Tibor; Deininger, Michael W.; Zeidner, Joshua F.; Olin, Rebecca L.; Smith, Catherine C.; Foran, James M.; Schiller, Gary J.; Curran, Emily K.; Koenig, Kristin L.; Heerema, Nyla A.; Chen, Timothy; Martycz, Molly; Stefanos, Mona; Marcus, Sonja G.; Rosenberg, Leonard; Druker, Brian J.; Levine, Ross L.; Burd, Amy; Yocum, Ashley O.; Borate, Uma M.; Mims, Alice S.; Byrd, John C.; Madanat, Yazan F. 分享 收藏
LP-118 is a novel B-cell lymphoma 2 / extra-large inhibitor that demonstrates efficacy in models of venetoclax-resistant chronic lymphocytic leukemia Ravikrishnan, Janani; Diaz-Rohena, Daisy Y.; Muhowski, Elizabeth; Mo, Xiaokui; Lai, Tzung-Huei; Misra, Shrilekha; Williams, Charmelle D.; Sanchez II, John R.; Mitchell, Andrew; Satpati, Suresh; Perry, Elizabeth; Kaufman, Tierney; Liu, Chaomei; Lozanski, Arletta; Lozanski, Gerard; Rogers, Kerry A.; Kittai, Adam S.; Bhat, Seema A.; Collins, Mary C.; Davids, Matthew S.; Jain, Nitin; Wierda, William G.; Lapalombella, Rosa; Byrd, John C.; Tan, Fenlai; Chen, Yi; Chen, Yu; Shen, Yue; Anthony, Stephen P.; Woyach, Jennifer A.; Sampath, Deepa 分享 收藏
分享 收藏
A Bayesian framework to study tumor subclone-specific expression by combining bulk DNA and single-cell RNA sequencing data Qiao, Yi; Huang, Xiaomeng; Moos, Philip J.; Ahmann, Jonathan M.; Pomicter, Anthony D.; Deininger, Michael W.; Byrd, John C.; Woyach, Jennifer A.; Stephens, Deborah M.; Marth, Gabor T. 分享 收藏
Samples from patients with AML show high concordance in detection of mutations by NGS at local institutions vs central laboratories 来自AML患者的样本在地方机构与中央实验室的NGS检测突变方面显示出高度一致性 Borate, Uma; Yang, Fei; Press, Richard; Ruppert, Amy S.; Jones, Dan; Caruthers, Sean; Zhao, Weiqiang; Vergilio, Jo-Anne; Pavlick, Dean C.; Juckett, Luke; Norris, Brianna; Bucy, Taylor; Burd, Amy; Stein, Eytan M.; Patel, Prapti; Baer, Maria R.; Stock, Wendy; Schiller, Gary; Blum, William; Kovacsovics, Tibor; Litzow, Mark; Foran, James; Heerema, Nyla A.; Rosenberg, Leonard; Marcus, Sonja; Yocum, Ashley; Stefanos, Mona; Druker, Brian; Byrd, John C.; Levine, Ross L.; Mims, Alice 分享 收藏
Framework of clonal mutations concurrent with WT1 mutations in adults with acute myeloid leukemia: Alliance for Clinical Trials in Oncology study Bhatnagar, Bhavana; Kohlschmidt, Jessica; Orwick, Shelley J.; Buelow, Daelynn R.; Fobare, Sydney; Oakes, Christopher C.; Kolitz, Jonathan E.; Uy, Geoff; Stock, Wendy; Powell, Bayard L.; Nicolet, Deedra; Hertlein, Erin K.; Mrozek, Krzysztof; Blachly, James S.; Eisfeld, Ann-Kathrin; Baker, Sharyn D.; Byrd, John C. 分享 收藏
Association of social deprivation with survival in younger adult patients with AML: an Alliance study Rebechi, Melanie; Kohlschmidt, Jessica; Mrozek, Krzysztof; Nicolet, Deedra; Mims, Alice S.; Blachly, James S.; Orwick, Shelley; Larkin, Karilyn T.; Oakes, Christopher C.; Hantel, Andrew; Carroll, Andrew J.; Blum, William G.; Powell, Bayard L.; Uy, Geoffrey L.; Stone, Richard M.; Larson, Richard A.; Byrd, John C.; Paskett, Electra D.; Plascak, Jesse J.; Eisfeld, Ann-Kathrin 分享 收藏
Evaluation of bleeding events in patients receiving acalabrutinib therapy (Mar, 10.1038/s41375-023-01869-1, 2023) Kumar, Pooja S.; Wiczer, Tracy; Rosen, Lindsay; Pollauf, Arthur J.; Zheng, Amy; Palettas, Marilly; Azali, Leylah; Bhat, Seema A.; Byrd, John C.; Grever, Michael R.; Rogers, Kerry A.; Woyach, Jennifer A.; Kittai, Adam S. 分享 收藏
Entospletinib with decitabine in acute myeloid leukemia with mutant TP53 or complex karyotype: A phase 2 substudy of the Beat AML Master Trial Entospletinib联合地西他滨治疗TP53突变或复杂核型的急性髓系白血病: Beat AML Master试验的2期子研究 Duong, Vu H.; Ruppert, Amy S.; Mims, Alice S.; Borate, Uma; Stein, Eytan M.; Baer, Maria R.; Stock, Wendy; Kovacsovics, Tibor; Blum, William; Arellano, Martha L.; Schiller, Gary J.; Olin, Rebecca L.; Foran, James M.; Litzow, Mark R.; Lin, Tara L.; Patel, Prapti A.; Foster, Matthew C.; Redner, Robert L.; Al-Mansour, Zeina; Cogle, Christopher R.; Swords, Ronan T.; Collins, Robert H.; Vergilio, Jo-Anne; Heerema, Nyla A.; Rosenberg, Leonard; Yocum, Ashley O.; Marcus, Sonja; Chen, Timothy; Druggan, Franchesca; Stefanos, Mona; Gana, Theophilus J.; Shoben, Abigail B.; Druker, Brian J.; Burd, Amy; Byrd, John C.; Levine, Ross L.; Boyiadzis, Michael M. 分享 收藏
Evaluation of bleeding events in patients receiving acalabrutinib therapy Kumar, Pooja S.; Wiczer, Tracy; Rosen, Lindsay; Pollauf, Arthur J.; Zheng, Amy; Palettas, Marilly; Azali, Leylah; Bhat, Seema A.; Byrd, John C.; Grever, Michael R.; Rogers, Kerry A.; Woyach, Jennifer A.; Kittai, Adam S. 分享 收藏
.png){kind=icon}
.png){kind=icon}
.png)
Leukemia.png)
OAAI
.png){kind=icon}
分享.png){kind=icon}
收藏