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Combination of Orai1 inhibitor CM5480 with specific therapy mitigates pulmonary hypertension and its cardiac dysfunction Orai1抑制剂CM5480与特异性疗法的联合应用减轻了肺动脉高压及其心脏功能障碍 Willer, Anais Saint-Martin; Ruffenach, Gregoire; Masson, Bastien; El jekmek, Kristelle; Boet, Angele; Adao, Rui; Gourmelon, Mathieu; Beauvais, Antoine; Sabourin, Jessica; Dutheil, Mary; Ghigna, Maria-Rosa; Tesson, Laurent; Menoret, Severine; Anegon, Ignacio; Bauer, Fabrice; de Montpreville, Vincent; Hebbar, Sudarshan; Bras-Silva, Carmen; Stauderman, Kenneth; Humbert, Marc; Mercier, Olaf; Montani, David; Capuano, Veronique; Antigny, Fabrice 分享 收藏
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Generation of a compound heterozygous ABCA4 rat model with pathological features of STGD1 生成具有STGD1病理特征的复合杂合子ABCA4大鼠模型 Morival, Clement; Croyal, Mikael; Remy, Severine; Mortier, Elodie; Libeau, Lyse; Veziers, Joelle; Provost, Nathalie; Demilly, Joanna; Mendes-Madeira, Alexandra; Isiegas, Carolina; Tesson, Laurent; Anegon, Ignacio; Adjali, Oumeya; Cronin, Therese 分享 收藏
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New soluble CSF-1R-dimeric mutein with enhanced trapping of both CSF-1 and IL-34 reduces suppressive tumor-associated macrophages in pleural mesothelioma 新型可溶性CSF-1R-二聚体突变蛋白,能够增强对CSF-1和IL-34的捕获,可减少胸膜间皮瘤中的肿瘤相关巨噬细胞。 Joalland, Noemie; Quemener, Agnes; Deshayes, Sophie; Humeau, Romain; Maillasson, Mike; Lebihan, Heloise; Salama, Apolline; Fresquet, Judith; Remy, Severine; Mortier, Erwan; Blanquart, Christophe; Guillonneau, Carole; Anegon, Ignacio 分享 收藏
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New Insights in Non-syndromic Mitral Valve Dystrophy: Role of Inflammation and Macrophages 非综合征性二尖瓣病变的新见解:炎症和巨噬细胞的作用 Le Vely, Benjamin; Delwarde, Constance; Toquet, Claire; Aumond, Pascal; Charon, Emilie; Remy, Severine; Anegon, Ignacio; Le Scouarnec, Solena; Schott, Jean-Jacques; Le Tourneau, Thierry; Mass, Elvira; Merot, Jean; Capoulade, Romain 分享 收藏
Advancing CD8+Treg cell therapy to the clinic for the treatment of kidney transplanted patients. Bezie, Severine; Salle, Sonia; Lucazeau, Mariane; Saiagh, Soraya; Leveque, Marie-Christine; Braudeau, Cecile; Benjelloun Zahar, Mina; Vrignaud, Florence; Guillot-Gueguen, Cecile; Papuchon, Emmanuelle; Clemenceau, Beatrice; Ningre, Maelle; Josien, Regis; Blancho, Gilles; Cantarovich, Diego; Anegon, Ignacio; Guillonneau, Carole 分享 收藏
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Changes in social behavior with MAPK2 and KCTD13/CUL3 pathways alterations in two new outbred rat models for the 16p11.2 syndromes with autism spectrum disorders 在两个新的16 p11.2自闭症谱系障碍综合征的近交大鼠模型中,MAPK2和KCTD13/CUL3途径的社会行为变化 Martin Lorenzo, Sandra; Muniz Moreno, Maria del Mar; Atas, Helin; Pellen, Marion; Nalesso, Valerie; Raffelsberger, Wolfgang; Prevost, Geraldine; Lindner, Loic; Birling, Marie-Christine; Menoret, Severine; Tesson, Laurent; Negroni, Luc; Concordet, Jean-Paul; Anegon, Ignacio; Herault, Yann 分享 收藏
Interleukin 27 is a novel cytokine with anti-inflammatory effects against spondyloarthritis through the suppression of Th17 responses 白细胞介素27是一种新型细胞因子,通过抑制Th17反应对脊柱关节炎具有抗炎作用 Jouhault, Quentin; Cherqaoui, Bilade; Jobart-Malfait, Aude; Glatigny, Simon; Lauraine, Marc; Hulot, Audrey; Morelle, Guillaume; Hagege, Benjamin; Ermoza, Ketia; El Marjou, Ahmed; Izac, Brigitte; Saintpierre, Benjamin; Letourneur, Franck; Remy, Severine; Anegon, Ignacio; Boissier, Marie-Christophe; Chiocchia, Gilles; Breban, Maxime; Araujo, Luiza M. 分享 收藏
CRISPR/Cas9-mediated inactivation of the phosphatase activity of soluble epoxide hydrolase prevents obesity and cardiac ischemic injury Leuillier, Matthieu; Duflot, Thomas; Menoret, Severine; Messaoudi, Hind; Djerada, Zoubir; Groussard, Deborah; Denis, Raphael G. P.; Chevalier, Laurence; Karoui, Ahmed; Panthu, Baptiste; Thiebaut, Pierre-Alain; Schmitz-Afonso, Isabelle; Nobis, Severine; Campart, Cynthia; Henry, Tiphaine; Sautreuil, Camille; Luquet, Serge H.; Beseme, Olivia; Feliu, Catherine; Peyret, Helene; Nicol, Lionel; Henry, Jean-Paul; Renet, Sylvanie; Mulder, Paul; Wan, Debin; Tesson, Laurent; Heslan, Jean-Marie; Duche, Angeline; Jacques, Sebastien; Ziegler, Frederic; Brunel, Valery; Rautureau, Gilles J. P.; Monteil, Christelle; do Rego, Jean-Luc; do Rego, Jean-Claude; Afonso, Carlos; Hammock, Bruce; Madec, Anne-Marie; Pinet, Florence; Richard, Vincent; Anegon, Ignacio; Guignabert, Christophe; Morisseau, Christophe; Bellien, Jeremy 分享 收藏
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Patients With Severe Multiple Sclerosis Exhibit Functionally Altered CD8+ Regulatory T Cells Benallegue, Nail; Nicol, Bryan; Lasselin, Juliette; Bezie, Severine; Flippe, Lea; Regue, Hadrien; Vimond, Nadege; Remy, Severine; Garcia, Alexandra; Le Frere, Fabienne; Anegon, Ignacio; Laplaud, David; Guillonneau, Carole 分享 收藏