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BRD9 degraders as chemosensitizers in acute leukemia and multiple myeloma BRD9降解剂作为急性白血病和多发性骨髓瘤的化学增敏剂 Weisberg, Ellen; Chowdhury, Basudev; Meng, Chengcheng; Case, Abigail E.; Ni, Wei; Garg, Swati; Sattler, Martin; Azab, Abdel Kareem; Sun, Jennifer; Muz, Barbara; Sanchez, Dana; Toure, Anthia; Stone, Richard M.; Galinsky, Ilene; Winer, Eric; Gleim, Scott; Gkountela, Sofia; Kedves, Alexia; Harrington, Edmund; Abrams, Tinya; Zoller, Thomas; Vaupel, Andrea; Manley, Paul; Faller, Michael; Chung, BoYee; Chen, Xin; Busenhart, Philipp; Stephan, Christine; Calkins, Keith; Bonenfant, Debora; Thoma, Claudio R.; Forrester, William; Griffin, James D. 分享 收藏
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BET bromodomain inhibitors regulate keratinocyte plasticity Schutzius, Gabi; Kolter, Christian; Bergling, Sebastian; Tortelli, Federico; Fuchs, Florian; Renner, Steffen; Guagnano, Vito; Cotesta, Simona; Rueeger, Heinrich; Faller, Michael; Bouchez, Laure; Salathe, Adrian; Nigsch, Florian; Richards, Shola M.; Louis, Malvina; Gruber, Viktoria; Aebi, Alexandra; Turner, Jonathan; Grandjean, Frederic; Li, Jun; Dimitri, Chris; Thomas, Jason R.; Schirle, Markus; Blank, Jutta; Drueckes, Peter; Vaupel, Andrea; Tiedt, Ralph; Manley, Paul W.; Klopp, Julia; Hemmig, Rene; Zink, Florence; Leroy, Nelly; Carbone, Walter; Roma, Guglielmo; Keller, Caroline Gubser; Dales, Natalie; Beyerbach, Armin; Zimmerlin, Alfred; Bonenfant, Debora; Terranova, Remi; Berwick, Amy; Sahambi, Sukhdeep; Reynolds, Aimee; Jennings, Lori L.; Ruffner, Heinz; Tarsa, Peter; Bouwmeester, Tewis; Driver, Vickie; Frederiksen, Mathias; Lohmann, Felix; Kirkland, Susan 分享 收藏
Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing Soldermann, Carole Pissot; Simic, Oliver; Renatus, Martin; Erbel, Paulus; Melkko, Samu; Wartmann, Markus; Bigaud, Marc; Weiss, Andreas; McSheehy, Paul; Endres, Ralf; Santos, Paulo; Blank, Jutta; Schuffenhauer, Ansgar; Bold, Guido; Buschmann, Nicole; Zoller, Thomas; Altmann, Eva; Manley, Paul W.; Dix, Ina; Buchdunger, Elisabeth; Scesa, Julien; Quancard, Jean; Schlapbach, Achim; Bornancin, Frederic; Radimerski, Thomas; Regnier, Catherine H. 分享 收藏
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Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1 Schoepfer, Joseph; Jahnke, Wolfgang; Berellini, Giuliano; Buonamici, Silvia; Cotesta, Simona; Cowan-Jacob, Sandra W.; Dodd, Stephanie; Drueckes, Peter; Fabbro, Doriano; Gabriel, Tobias; Groell, Jean-Marc; Grotzfeld, Robert M.; Hassan, A. Quamrul; Henry, Chrystele; Iyer, Varsha; Jones, Darryl; Lombardo, Franco; Loo, Alice; Manley, Paul W.; Pelle, Xavier; Rummel, Gabriele; Salem, Bahaa; Warmuth, Markus; Wylie, Andrew A.; Zoller, Thomas; Marzinzik, Andreas L.; Furet, Pascal 分享 收藏
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Midostaurin: a magic bullet that blocks mast cell expansion and activation Valent, P.; Akin, C.; Hartmann, K.; George, T. I.; Sotlar, K.; Peter, B.; Gleixner, K. V.; Blatt, K.; Sperr, W. R.; Manley, P. W.; Hermine, O.; Kluin-Nelemans, H. C.; Arock, M.; Horny, H. -P.; Reiter, A.; Gotlib, J. 分享 收藏
Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia Irvine, David A.; Zhang, Bin; Kinstrie, Ross; Tarafdar, Anuradha; Morrison, Heather; Campbell, Victoria L.; Moka, Hothri A.; Ho, Yinwei; Nixon, Colin; Manley, Paul W.; Wheadon, Helen; Goodlad, John R.; Holyoake, Tessa L.; Bhatia, Ravi; Copland, Mhairi 分享 收藏
A Novel Potent Oral Series of VEGFR2 Inhibitors Abrogate Tumor Growth by Inhibiting Angiogenesis Bold, Guido; Schnell, Christian; Furet, Pascal; McSheehy, Paul; Brueggen, Josef; Mestan, Juergen; Manley, Paul W.; Drueckes, Peter; Burglin, Marion; Duerler, Ursula; Loretan, Jacqueline; Reuter, Robert; Wartmann, Markus; Theuer, Andreas; Bauer-Probst, Beatrice; Martiny-Baron, Georg; Allegrini, Peter; Goepfert, Arnaud; Wood, Jeanette; Littlewood-Evans, Amanda 分享 收藏
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Target interaction profiling of midostaurin and its metabolites in neoplastic mast cells predicts distinct effects on activation and growth Peter, B.; Winter, G. E.; Blatt, K.; Bennett, K. L.; Stefanzl, G.; Rix, U.; Eisenwort, G.; Hadzijusufovic, E.; Gridling, M.; Dutreix, C.; Hoermann, G.; Schwaab, J.; Radia, D.; Roesel, J.; Manley, P. W.; Reiter, A.; Superti-Furga, G.; Valent, P. 分享 收藏
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KIT Signaling Governs Differential Sensitivity of Mature and Primitive CML Progenitors to Tyrosine Kinase Inhibitors Corbin, Amie S.; O'Hare, Thomas; Gu, Zhimin; Kraft, Ira L.; Eiring, Anna M.; Khorashad, Jamshid S.; Pomicter, Anthony D.; Zhang, Tian Y.; Eide, Christopher A.; Manley, Paul W.; Cortes, Jorge E.; Druker, Brian J.; Deininger, Michael W. 分享 收藏
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Modulation of Activation-Loop Phosphorylation by JAK Inhibitors Is Binding Mode Dependent JAK抑制剂对激活环磷酸化的调节是结合模式依赖性的 Andraos, Rita; Qian, Zhiyan; Bonenfant, Debora; Rubert, Joelle; Vangrevelinghe, Eric; Scheufler, Clemens; Marque, Fanny; Regnier, Catherine H.; De Pover, Alain; Ryckelynck, Hugues; Bhagwat, Neha; Koppikar, Priya; Goel, Aviva; Wyder, Lorenza; Tavares, Gisele; Baffert, Fabienne; Pissot-Soldermann, Carole; Manley, Paul W.; Gaul, Christoph; Voshol, Hans; Levine, Ross L.; Sellers, William R.; Hofmann, Francesco; Radimerski, Thomas 分享 收藏
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