Nei‐Li Chan - Publications, H-index & Citations

Nei‐Li Chan

National Taiwan University Hospital

46H指数

196论文数

7.2K被引数

收录论文 36

发表时间

The Src family kinase YES regulates DNAJB6b chaperone activity to modulate tau aggregation in Alzheimer's disease Src家族激酶YES通过调控DNAJB6b分子伴侣活性来调节阿尔茨海默病中的tau蛋白聚集

Journal of Biological Chemistry

IF3.9

2026-08-01

PREAI

Lin, Meng-Chieh; Chen, Huan-Yun; Lin, Te-Sheng; Lin, Sue-Jane; Lin, Pei-Jie; Liao, Chia-Yu; Chan, Nei-Li; Lin, Chin-Hsien; Teng, Shu-Chun

Core elements play distinct roles in promoter birth and transcriptional regulation 核心元件在启动子产生和转录调控中发挥不同作用

Nature Communications

IF15.7

2026-07-17

OAAI

Syue-Ting Antony Kuo; Wei-Yi Shen; Sheng-Wen Lai; Joshua Kevin Chang; Cheng-Wei Ni; Chih-Chiang Chang; Zoltan Palmai; Lee-Wei Yang; Nei-Li Chan; I-Ren Lee; Hsin-Hung David Chou

Structural insights into the assembly of type IIA topoisomerase DNA cleavage-religation center

NUCLEIC ACIDS RESEARCH

IF13.1

2024-07-30

OAAI

Liu, Ko-Ting; Chen, Shin-Fu; Chan, Nei-Li

Biochemical characterization of the meiosis-essential yet evolutionarily divergent topoisomerase VIB-like protein MTOPVIB from Arabidopsis thaliana

NUCLEIC ACIDS RESEARCH

IF13.1

2024-03-18

OAAI

Chen, Hsin-Wen; Yeh, Hsin-Yi; Chang, Chih-Chiang; Kuo, Wei-Chen; Lin, Sheng-Wei; Vrielynck, Nathalie; Grelon, Mathilde; Chan, Nei-Li; Chi, Peter

Sequential Phosphorylation of Hepatitis C Virus NS5A Protein Requires the ATP-Binding Domain of NS3 Helicase

JOURNAL OF VIROLOGY

IF3.8

2022-04-13

OAAI

Yu, Chun-Chiao; Lin, Pei-Chen; Chiang, Cho-Han; Jen, Shu-Tang; Lai, Yen-Ling; Hsu, Shih-Chin; Lo, Lee-Chiang; Lin, Jing-Jer; Chan, Nei-Li; Yu, Ming-Jiun

Mechanistic analysis of carbon-carbon bond formation by deoxypodophyllotoxin synthase

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2021-12-28

OAAI

Tang, Haoyu; Wu, Min-Hao; Lin, Hsiao-Yu; Han, Meng-Ru; Tu, Yueh-Hua; Yang, Zhi-Jie; Chien, Tun-Cheng; Chan, Nei-Li; Chang, Wei-chen

Harnessing the Substrate Promiscuity of Dioxygenase AsqJ and Developing Efficient Chemoenzymatic Synthesis for Quinolones

ACS CATALYSIS

IF13.1

2021-06-06

OAAI

Tang, Haoyu; Tang, Yijie; Kurnikov, Igor, V; Liao, Hsuan-Jen; Chan, Nei-Li; Kurnikova, Maria G.; Guo, Yisong; Chang, Wei-chen

Structure of Human Phosphodiesterase 5A1 Complexed with Avanafil Reveals Molecular Basis of Isoform Selectivity and Guidelines for Targeting α-Helix Backbone Oxygen by Halogen Bonding

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2020-07-14

PREAI

Hsieh, Chao-Ming; Chen, Chun-Yi; Chern, Ji-Wang; Chan, Nei-Li

Epoxidation Catalyzed by the Nonheme Iron(II)- and 2-Oxoglutarate-Dependent Oxygenase, AsqJ: Mechanistic Elucidation of Oxygen Atom Transfer by a Ferryl Intermediate

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2020-03-04

OAAI

Li, Jikun; Liao, Hsuan-Jen; Tang, Yijie; Huang, Jhih-Liang; Cha, Lide; Lin, Te-Sheng; Lee, Justin L.; Kurnikov, Igor, V; Kurnikova, Maria G.; Chang, Wei-Chen; Chan, Nei-Li; Guo, Yisong

Hypoxia-induced Slug SUMOylation enhances lung cancer metastasis

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

IF12.8

2019-01-06

OAAI

Hung, Pei-Fang; Hong, Tse-Ming; Chang, Che-Chang; Hung, Chung-Lieh; Hsu, Yuan-Ling; Chang, Yih-Leong; Wu, Chen-Tu; Chang, Gee-Chen; Chan, Nei-Li; Yu, Sung-Liang; Yang, Pan-Chyr; Pan, Szu-Hua

Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate

NATURE COMMUNICATIONS

IF15.7

2018-08-06

OAAI

Chen, Shin-Fu; Huang, Nan-Lan; Lin, Jung-Hsin; Wu, Chyuan-Chuan; Wang, Ying-Ren; Yu, Yu-Jen; Gilson, Michael K.; Chan, Nei-Li

Topoisomerases as anticancer targets

BIOCHEMICAL JOURNAL

IF4.3

2018-01-23

357

OAAI

Delgado, Justine L.; Hsieh, Chao-Ming; Chan, Nei-Li; Hiasa, Hiroshi

Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry (vol 45, pg 10861, 2017)

NUCLEIC ACIDS RESEARCH

IF13.1

2017-09-04

OAAI

Wang, Ying-Ren; Chen, Shin-Fu; Wu, Chyuan-Chuan; Liao, Yi-Wen; Lin, Te-Sheng; Liu, Ko-Ting; Chen, Yi-Song; Li, Tsai-Kun; Chien, Tun-Cheng; Chan, Nei-Li

Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry

NUCLEIC ACIDS RESEARCH

IF13.1

2017-08-24

OAAI

Wang, Ying-Ren; Chen, Shin-Fu; Wu, Chyuan-Chuan; Liao, Yi-Wen; Lin, Te-Sheng; Liu, Ko-Ting; Chen, Yi-Song; Li, Tsai-Kun; Chien, Tun-Cheng; Chan, Nei-Li

Functional characterization of the meiosis-specific DNA double-strand break inducing factor SPO-11 from C-elegans

SCIENTIFIC REPORTS

IF3.9

2017-05-24

OAAI

Yeh, Hsin-Yi; Lin, Sheng-Wei; Wu, Yi-Chun; Chan, Nei-Li; Chi, Peter

Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity

SCIENTIFIC REPORTS

IF3.9

2016-12-09

OAAI

Lee, Yi-Ru; Lin, Te-Sheng; Lai, Shu-Jung; Liu, Mu-Sen; Lai, Mei-Chin; Chan, Nei-Li

Chemical Inhibition of Human Thymidylate Kinase and Structural Insights into the Phosphate Binding Loop and Ligand-Induced Degradation 对人胸苷酸激酶的化学抑制作用以及对磷酸结合环和配体诱导降解的结构见解

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2016-10-28

PREAI

Chen, Yi-Hsuan; Hsu, Hua-Yi; Yeh, Ming-Tyng; Chen, Chen-Cheng; Huang, Chang-Yu; Chung, Ying-Hsuan; Chang, Zee-Fen; Kuo, Wei-Chen; Chan, Nei-Li; Weng, Jui-Hsia; Chung, Bon-chu; Chen, Yu-Ju; Jian, Cheng-Bang; Shen, Ching-Chieh; Tai, Hwan-Ching; Sheu, Sheh-Yi; Fang, Jim-Min

SMYD3-Mediated H2AZ1 Methylation Promotes Cell Cycle and Cancer Proliferation

CANCER RESEARCH

IF16.6

2016-10-13

OAAI

Tsai, Cheng-Hui; Chen, Yun-Ju; Yu, Chia-Jung; Tzeng, Shiou-Ru; Wu, I-Chen; Kuo, Wen-Hung; Lin, Ming-Chieh; Chan, Nei-Li; Wu, Kou-Juey; Teng, Shu-Chun

Structural basis of antizyme-mediated regulation of polyamine homeostasis

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2015-08-24

OAAI

Wu, Hsiang-Yi; Chen, Shin-Fu; Hsieh, Ju-Yi; Chou, Fang; Wang, Yu-Hsuan; Lin, Wan-Ting; Lee, Pei-Ying; Yu, Yu-Jen; Lin, Li-Ying; Lin, Te-Sheng; Lin, Chieh-Liang; Liu, Guang-Yaw; Tzeng, Shiou-Ru; Hung, Hui-Chih; Chan, Nei-Li

Structural basis of the mercury(II)-mediated conformational switching of the dual-function transcriptional regulator MerR

NUCLEIC ACIDS RESEARCH

IF13.1

2015-07-06

OAAI

Chang, Chih-Chiang; Lin, Li-Ying; Zou, Xiao-Wei; Huang, Chieh-Chen; Chan, Nei-Li

研究方向