Douglas A. Melton - Publications, H-index & Citations

Douglas A. Melton

Harvard University

122H指数

280论文数

7.3W被引数

收录论文 90

发表时间

Improving cellular fitness of human stem cell-derived islets under hypoxia 改善缺氧条件下人干细胞来源胰岛的细胞活力

NATURE COMMUNICATIONS

IF15.7

2025-05-23

OAAI

Wang, Xi; Brielle, Shlomi; Kenty-Ryu, Jennifer; Korover, Nataly; Bavli, Danny; Pop, Ramona; Melton, Douglas A.

Repurposing the Antihypertensive Agent Hydralazine As an Inhibitor of the Base Excision Repair Enzyme APE1

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2024-12-24

PREAI

Islam, Tanhaul; Nunna, Venkatrao; Liyanarachchi, Don Pivithuru; Melton, Douglas; Lewis, Calvin D.; Gates, Kent S.

Ultrafast Reaction of the Drug Hydralazine with Apurinic/Apyrimidinic Sites in DNA Gives Rise to a Stable Triazolo[3,4-a]phthalazine Adduct 药物肼苯哒嗪与DNA中的嘌呤/嘧啶位点的超快反应产生稳定的三唑并 [3，4-a] 酞嗪加合物

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2024-05-14

PREAI

Islam, Tanhaul; Shim, Garam; Melton, Douglas; Lewis, Calvin D.; Lei, Zhentian; Gates, Kent S.

Glucose-Dependent Insulin Production and Insulin-Independence in Type 1 Diabetes from Stem Cell-Derived, Fully Differentiated Islet Cells-Updated Data from the VX-880 Clinical Trial

DIABETES

IF7.5

2023-06-23

PREAI

Reichman, Trevor W.; Ricordi, Camillo; Naji, Ali; Markmann, James F.; Perkins, Bruce A.; Wijkstrom, Martin; Paraskevas, Steven; Bruinsma, Bote; Marigowda, Gautham; Shih, Judy L.; Wang, Chenkun; Melton, Douglas; Pagliuca, Felicia; Sanna, Bastiano; Kean, Leslie S.; Peters, Anne L.; Witkowski, Piotr; Rickels, Michael R.

Matters arising: Insufficient evidence that pancreatic b cells are derived from adult ductal Neurog3-expressing progenitors

CELL STEM CELL

IF20.4

2023-04-01

OAAI

Magenheim, Judith; Maestro, Miguel Angel; Sharon, Nadav; Herrera, Pedro L.; Murtaugh, L. Charles; Kopp, Janel; Sander, Maike; Gu, Guoqiang; Melton, Douglas A.; Ferrer, Jorge; Dor, Yuval

Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance

CELL REPORTS MEDICINE

IF10.6

2023-01-01

OAAI

Gerace, Dario; Zhou, Qua; Kenty, Jennifer Hyoje-Ryu; Veres, Adrian; Sintov, Elad; Wang, Xi; Boulanger, Kyle R.; Li, Hongfei; Melton, Douglas A.

Whole-genome CRISPR screening identifies genetic manipulations to reduce immune rejection of stem cell-derived islets

STEM CELL REPORTS

IF5.1

2022-09-01

OAAI

Sintov, Elad; Nikolskiy, Igor; Barrera, Victor; Kenty, Jennifer Hyoje-Ryu; Atkin, Alexander S.; Gerace, Dario; Sui, Shannan J. Ho; Boulanger, Kyle; Melton, Douglas A.

Genetic manipulation of stress pathways can protect stem-cell-derived islets from apoptosis in vitro

STEM CELL REPORTS

IF5.1

2022-04-01

OAAI

Leite, Nayara C.; Pelayo, Gabriela C.; Melton, Douglas A.

A therapeutic convection-enhanced macroencapsulation device for enhancing β cell viability and insulin secretion 用于增强 β 细胞活力和胰岛素分泌的治疗性对流增强巨囊装置

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2021-09-09

OAAI

Yang, Kisuk; O'Cearbhaill, Eoin D.; Liu, Sophie S.; Zhou, Angela; Chitnis, Girish D.; Hamilos, Allison E.; Xu, Jun; Verma, Mohan K. S.; Giraldo, Jaime A.; Kudo, Yoshimasa; Lee, Eunjee A.; Lee, Yuhan; Pop, Ramona; Langer, Robert; Melton, Douglas A.; Greiner, Dale L.; Karp, Jeffrey M.

The promise of stem cell-derived islet replacement therapy

DIABETOLOGIA

IF10.2

2021-01-16

OAAI

Melton, Douglas

Building Biomimetic Potency Tests for Islet Transplantation 建立胰岛移植的仿生效能测试

DIABETES

IF7.5

2021-01-14

OAAI

Glieberman, Aaron L.; Pope, Benjamin D.; Melton, Douglas A.; Parker, Kevin Kit

A 3D culture platform enables development of zinc-binding prodrugs for targeted proliferation of β cells

SCIENCE ADVANCES

IF12.5

2020-11-20

OAAI

Yang, Kisuk; Lee, Miseon; Jones, Peter Anthony; Liu, Sophie S.; Zhou, Angela; Xu, Jun; Sreekanth, Vedagopuram; Wu, Jamie L. Y.; Vo, Lillian; Lee, Eunjee A.; Pop, Ramona; Lee, Yuhan; Wagner, Bridget K.; Melton, Douglas A.; Choudhary, Amit; Karp, Jeffrey M.

Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells

CELL REPORTS

IF6.9

2020-07-01

OAAI

Leite, Nayara C.; Sintov, Elad; Meissner, Torsten B.; Brehm, Michael A.; Greiner, Dale L.; Harlan, David M.; Melton, Douglas A.

A method for the generation of human stem cell-derived alpha cells

NATURE COMMUNICATIONS

IF15.7

2020-05-07

OAAI

Peterson, Quinn P.; Veres, Adrian; Chen, Lihua; Slama, Michael Q.; Kenty, Jennifer H. R.; Hassoun, Shaimaa; Brown, Matthew R.; Dou, Haiqiang; Duffy, Caden D.; Zhou, Quan; Matveyenko, Aleksey V.; Tyrberg, Bjoern; Soerhede-Winzell, Maria; Rorsman, Patrik; Melton, Douglas A.

A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion

CELL METABOLISM

IF30.9

2020-05-01

OAAI

Helman, Aharon; Cangelosi, Andrew L.; Davis, Jeffrey C.; Quan Pham; Rothman, Arielle; Faust, Aubrey L.; Straubhaar, Juerg R.; Sabatini, David M.; Melton, Douglas A.

Glucose Response by Stem Cell-Derived β Cells In Vitro Is Inhibited by a Bottleneck in Glycolysis

CELL REPORTS

IF6.9

2020-05-01

OAAI

Davis, Jeffrey C.; Alves, Tiago C.; Helman, Aharon; Chen, Jonathan C.; Kenty, Jennifer H.; Cardone, Rebecca L.; Liu, David R.; Kibbey, Richard G.; Melton, Douglas A.

Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice 外源性GDF11而非GDF8可降低小鼠体重并改善葡萄糖稳态

SCIENTIFIC REPORTS

IF3.9

2020-03-12

OAAI

Walker, Ryan G.; Barrandon, Ornella; Poggioli, Tommaso; Dagdeviren, Sezin; Carroll, Shannon H.; Mills, Melanie J.; Mendello, Kourtney R.; Gomez, Yanet; Loffredo, Francesco S.; Pancoast, James R.; Macias-Trevino, Claudio; Marts, Colin; LeClair, Katherine B.; Noh, Hye-Lim; Kim, Taekyoon; Banks, Alexander S.; Kim, Jason K.; Cohen, David E.; Wagers, Amy J.; Melton, Douglas A.; Lee, Richard T.

Identification of a LIF-Responsive, Replication-Competent Subpopulation of Human β Cells

CELL METABOLISM

IF30.9

2020-02-01

OAAI

Rosado-Olivieri, Edwin A.; Aigha, Idil I.; Kenty, Jennifer H.; Melton, Douglas A.

Inhibition of mTOR Signaling Enhances Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells via p53-Induced Quiescence 抑制mTOR信号通过p53-Induced静止促进人诱导多能干细胞来源的心肌细胞成熟

CIRCULATION

IF38.6

2020-01-28

OAAI

Garbern, Jessica C.; Helman, Aharon; Sereda, Rebecca; Sarikhani, Mohsen; Ahmed, Aishah; Escalante, Gabriela O.; Ogurlu, Roza; Kim, Sean L.; Zimmerman, John F.; Cho, Alexander; MacQueen, Luke; Bezzerides, Vassilios J.; Parker, Kevin Kit; Melton, Douglas A.; Lee, Richard T.

Midkine is a dual regulator of wound epidermis development and inflammation during the initiation of limb regeneration Midkine是肢体再生过程中伤口表皮发育和炎症的双重调节剂

ELIFE

IF0

2020-01-14

OAAI

Tsai, Stephanie L.; Baselga-Garriga, Clara; Melton, Douglas A.

研究方向