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Discovery of Gut-Restricted PRMT5 Inhibitors to Intercept Colorectal Cancer in Patients with Genetic Loss of Tumor Suppressor Adenomatous Polyposis Coli Hulpia, F.; Schepens, W.; Lepri, S.; Nicolai, J.; Jiang, Z.; Boj, S.F.; Bush, T.L.; Carvalho, M.A.; Chen, F.; Chu, G.; 等. 发现肠道特异性的PRMT5抑制剂，以阻断具有腺瘤性息肉病 coli基因缺失的肿瘤抑制基因患者的结直肠癌。J. Med. Chem. 2025. [Google Scholar] [CrossRef] [PubMed] Hulpia, Fabian; Schepens, Wim; Lepri, Susan; Nicolai, Johan; Jiang, Zhengyu; Boj, Sylvia F.; Bush, Tammy L.; Carvalho, Mary-ambre; Chen, Falian; Chu, Gerald; Clancy, Kathleen W.; Etwebi, Zienab; Everaerts, Melissa; Fan, Yi; Fernandez Candelaria, Froylan Omar; Francis, Albi; Hixon, Mark S.; Jardi, Ferran; Jin, Shuai; Larin, Egor M.; Last, Stefaan; Leenaerts, Joseph E.; Li, Siyu; Liddane, Alexandra G.; Lutter, Ferdinand H.; Lv, Dan; Mattson, Bethany; Milligan, Cynthia M.; Patrick, Aaron N.; Patwardhan, Gauri Anand; Perez-Benito, Laura; Pieters, Serge; Renders, Evelien; Retzbach, Ed; Smith-Monroy, Constance; Silva, Jose; Silva, Mariana; Sterckx, Hans; ten Hag, Gerben; Thate, Claudia; Van Brandt, Sven; Verissimo, Carla S.; Verniest, Guido; Vesely, Eileen; Vetrano, Irene; Vinken, Petra; Wang, Yufei; Wong, Victoria; Yao, Xuemei; Yang, Jie; Zijlmans, Remco; Bachman, Kurtis E.; Pocalyko, David; Jimenez, Juan-Miguel; Gaffney, Dana; Thuring, Jan Willem 分享 收藏
Centralized intestinal organoid generation is a feasible and safe approach for personalized medicine as demonstrated in the HIT-CF Europe Organoid Study Bierlaagh, Marlou C.; van Mourik, Peter; Vonk, Annelotte M.; Pott, Johanna; Muilwijk, Danya; Berkers, Gitte; Aalbers, Bente L.; Vleggaar, Frank P.; Michel, Sabine; Boj, Sylvia F.; Vries, Robert G. J.; Beekman, Jeffrey M.; van der Ent, Cornelis K. 分享 收藏
Repeatability and reproducibility of the Forskolin-induced swelling (FIS) assay on intestinal organoids from people with Cystic Fibrosis Bierlaagh, Marlou C.; Ramalho, Anabela S.; Silva, Iris A. L.; Vonk, Annelotte M.; van den Bor, Rutger M.; van Mourik, Peter; Pott, Johanna; Suen, Sylvia W. F.; Boj, Sylvia F.; Vries, Robert G. J.; Lammertyn, Elise; Vermeulen, Francois; Amaral, Margarida D.; de Boeck, Kris; van der Ent, Cornelis K.; Beekman, Jeffrey M. 分享 收藏
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Organoids to predict treatment response in metastatic colorectal cancer (OPTIC) Smabers, Lidwien P.; Wensink, Emerens; Verissimo, Carla S.; Doorn, Mayke; Yang, Tao; Voskuilen, Timo; Abouleila, Yasmine; Huismans, Maarten A.; Valkenburg-van Iersel, Liselot; Cirkel, Geert A.; Gootjes, Elske C.; Jeurissen, Frank J.; Bol, Guus M.; Nienhuis, Hilde H.; Braat, Manon M.; de Vries, Bas Penning; Elias, Sjoerd G.; Cuppen, Edwin; Vries, Robert G.; Kranenburg, Onno; Koopman, Miriam; Boj, Sylvia F.; Roodhart, Jeanine M. 分享 收藏
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Miniaturizing patient-derived organoid screening assays for predictive drug testing Abouleila, Yasmine; Verkerk, Roel; Doorn, Mayke; Voskuilen, Timo; Harada, Gakuro; Watanabe, Masahiko; Smabers, Lidwien; Kyan, Hideaki; Kumagai, Takahiko; Hikichi, Yuichi; Overmeer, Rene; Roodhart, Jeanine; Matsuno, Kiyotaka; Verissimo, Carla; Boj, Sylvia 分享 收藏
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Organoids as a biomarker for personalized treatment in metastatic colorectal cancer: drug screen optimization and correlation with patient response 类器官作为转移性结直肠癌个性化治疗的生物标志物: 药物筛选优化及其与患者反应的相关性 Smabers, Lidwien P.; Wensink, Emerens; Verissimo, Carla S.; Koedoot, Esmee; Pitsa, Katerina-Chara; Huismans, Maarten A.; Baron, Celia Higuera; Doorn, Mayke; Valkenburg-van Iersel, Liselot B.; Cirkel, Geert A.; Brousali, Anneta; Overmeer, Rene; Koopman, Miriam; Braat, Manon N.; de Vries, Bas Penning; Elias, Sjoerd G.; Vries, Robert G.; Kranenburg, Onno; Boj, Sylvia F.; Roodhart, Jeanine M. 分享 收藏
Organoids as a biomarker for personalized treatment in metastatic colorectal cancer: Drug screen optimization and correlation with patient response Smabers, L. P.; Wensink, E.; Verissimo, C. S.; Koedoot, E.; Doorn, M.; Pitsa, K-C.; Huismans, M.; Baron, C. Higuera; Valkenburg-van Iersel, L.; Brousali, A.; Overmeer, R.; Braat, M.; Elias, S.; Vries, R.; Kranenburg, O.; Koopman, M.; Boj, S.; Roodhart, J. M. L. 分享 收藏
Intestinal organoids as an in vitro platform to characterize disposition, metabolism, and safety profile of small molecules Kourula, Stephanie; Derksen, Merel; Jardi, Ferran; Jonkers, Sophie; van Heerden, Marjolein; Verboven, Peter; Theuns, Veronique; Van Asten, Stijn; Huybrechts, Tinne; Kunze, Annett; Frazer-Mendelewska, Ewa; Lai, Ka Wai; Overmeer, Rene; Roos, Jamie Lee; Vries, Robert G. J.; Boj, Sylvia F.; Monshouwer, Mario; Pourfarzad, Farzin; Snoeys, Jan 分享 收藏
Development of a medium-to-high throughput organoid-bacteria co-culture platform for the assessment of host pathogen interaction Valle-Encinas, Eider; Nair, Roshni; Pisa, Katerina; Doorn, Mayke; Pourfarzad, Farzin; Mateo, Lani San; Desch, Nicole; Gokare, Prashanth; Pocalyko, David; Boj, Sylvia F.; Verissimo, Carla 分享 收藏
Patient in the lab: Down-scaling patient-derived organoid screening for diagnostic purposes Koedoot, Esmee; van Weersch, Inez; Harada, Gakuro; Watanabe, Masahiko; Warda, Hamdy; Kyan, Hideaki; Abouleila, Yasmine; Kumagai, Takahiko; Hikichi, Yuichi; Overmeer, Rene; Roodhart, Jeanine; Matsuno, Kiyotaka; Verissimo, Carla; Boj, Sylvia F. 分享 收藏
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