Sarra Merzouk - Publications, H-index & Citations

Sarra Merzouk

Broad Institute of MIT and Harvard

8H指数

19论文数

446被引数

收录论文 12

发表时间

Optimized parameters for CRISPR-Cas9 interference library design CRISPR-Cas9干扰文库设计的优化参数

Cell Genomics

IF9

2026-08-28

OAAI

Smriti Srikanth; Fengyi Zheng; Laura M. Drepanos; Spencer T. Shah; Eleanor G. Kaplan; Daytan Gibson; Grace O. Lynch; Allison T. Uebele; Ganna Reint; Sarra Merzouk; John G. Doench

Balancing off-target and on-target considerations for optimized CRISPR-Cas9 knockout library design 平衡脱靶和击中靶点考量以优化CRISPR-Cas9敲除文库设计

Cell Genomics

IF9

2026-03-25

OAAI

Laura M. Drepanos; Smriti Srikanth; Eleanor G. Kaplan; Spencer T. Shah; Berta Escude Velasco; Sarra Merzouk; John G. Doench

X-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels X-染色体上调在RNA和蛋白质水平上以基因特异性方式发挥作用。

Nature Communications

IF15.7

2025-09-30

OAAI

Ryan N. Allsop; Jeffrey Boeren; Beatrice F. Tan; Sarra Merzouk; Suresh Poovanthingal; Wilfred F. J. van IJcken; Jeroen A. A. Demmers; Hegias Mira Bontenbal; Cristina Gontan; Joost Gribnau; Vincent Pasque

Efficient generation of ETX embryoids that recapitulate the entire window of murine egg cylinder development

SCIENCE ADVANCES

IF12.5

2023-01-20

OAAI

Dupont, Catherine; Schaffers, Olivier J. M.; Tan, Beatrice F.; Merzouk, Sarra; Bindels, Eric M.; Zwijsen, An; Huylebroeck, Danny; Gribnau, Joost

Different responses to DNA damage determine ageing differences between organs

AGING CELL

IF7.1

2022-03-04

OAAI

Vougioukalaki, Maria; Demmers, Joris; Vermeij, Wilbert P.; Baar, Marjolein; Bruens, Serena; Magaraki, Aristea; Kuijk, Ewart; Jager, Myrthe; Merzouk, Sarra; Brandt, Renata M. C.; Kouwenberg, Janneke; van Boxtel, Ruben; Cuppen, Edwin; Pothof, Joris; Hoeijmakers, Jan H. J.

SPEN is required for Xist upregulation during initiation of X chromosome inactivation

NATURE COMMUNICATIONS

IF15.7

2021-12-01

OAAI

Robert-Finestra, Teresa; Tan, Beatrice F.; Mira-Bontenbal, Hegias; Timmers, Erika; Gontan, Cristina; Merzouk, Sarra; Giaimo, Benedetto Daniele; Dossin, Francois; van IJcken, Wilfred F. J.; Martens, John W. M.; Borggrefe, Tilman; Heard, Edith; Gribnau, Joost

CTCF chromatin residence time controls three-dimensional genome organization, gene expression and DNA methylation in pluripotent cells

NATURE CELL BIOLOGY

IF19.1

2021-07-29

PREAI

Soochit, Widia; Sleutels, Frank; Stik, Gregoire; Bartkuhn, Marek; Basu, Sreya; Hernandez, Silvia C.; Merzouk, Sarra; Vidal, Enrique; Boers, Ruben; Boers, Joachim; van der Reijden, Michael; Geverts, Bart; van Cappellen, Wiggert A.; van den Hout, Mirjam; Ozgur, Zeliha; van IJcken, Wilfred F. J.; Gribnau, Joost; Renkawitz, Rainer; Graf, Thomas; Houtsmuller, Adriaan; Grosveld, Frank; Stadhouders, Ralph; Galjart, Niels

RIF1 promotes replication fork protection and efficient restart to maintain genome stability

NATURE COMMUNICATIONS

IF15.7

2019-07-23

OAAI

Mukherjee, Chirantani; Tripathi, Vivek; Manolika, Eleni Maria; Heijink, Anne Margriet; Ricci, Giulia; Merzouk, Sarra; de Boer, H. Rudolf; Demmers, Jeroen; van Vugt, Marcel A. T. M.; Chaudhuri, Arnab Ray

A novel approach to differentiate rat embryonic stem cells in vitro reveals a role for RNF12 in activation of X chromosome inactivation

SCIENTIFIC REPORTS

IF3.9

2019-04-15

OAAI

Magaraki, Aristea; Loda, Agnese; Gontan, Cristina; Merzouk, Sarra; Sleddens-Linkels, Esther; Meek, Stephen; Baarends, Willy M.; Burdon, Tom; Gribnau, Joost

BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes BLM解旋酶抑制转录基因中G-四链体基序的重组

NATURE COMMUNICATIONS

IF15.7

2018-01-18

OAAI

van Wietmarschen, Niek; Merzouk, Sarra; Halsema, Nancy; Spierings, Diana C. J.; Guryev, Victor; Lansdorp, Peter M.

Lineage-specific regulation of imprinted X inactivation in extraembryonic endoderm stem cells

EPIGENETICS & CHROMATIN

IF3.5

2014-06-20

OAAI

Merzouk, Sarra; Deuve, Jane Lynda; Dubois, Agnes; Navarro, Pablo; Avner, Philip; Morey, Celine

Spontaneous Reactivation of Clusters of X-Linked Genes Is Associated with the Plasticity of X-Inactivation in Mouse Trophoblast Stem Cells

Stem Cells

IF3.6

2014-01-13

PREAI

Dubois, Agnes; Deuve, Jane Lynda; Navarro, Pablo; Merzouk, Sarra; Pichard, Sylvain; Commere, Pierre-Henri; Louise, Anne; Arnaud, Danielle; Avner, Philip; Morey, Celine

研究方向