Yuichi Hashimoto - Publications, H-index & Citations

Yuichi Hashimoto

Hokkaido University

68H指数

727论文数

1.8W被引数

收录论文 142

发表时间

Phthalimide: a potential warhead for switchable and bioorthogonal conjugation 邻苯二甲酰亚胺：一种用于可切换和生物正交偶联的潜在弹头

Chem. Commun.

IF4.2

2025-08-06

PREAI

Kosuke Chiba; Takumi Yoshida; Kana Okada; Minoru Ishikawa †; Yuichi Hashimoto; Satoshi Obika; Takao Yamaguchi

Transforming growth factor β2 is a neuronal death-inducing ligand for amyloid-β precursor protein

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Hashimoto, Y; Chiba, T; Yamada, M; Nawa, M; Kanekura, K; Suzuki, H; Terashita, K; Aiso, S; Nishimoto, I; Matsuoka, M

The Peroxisome Proliferator-Activated Receptor γ/Retinoid X Receptor α Heterodimer Targets the Histone Modification Enzyme PR-Set7/Setd8 Gene and Regulates Adipogenesis through a Positive Feedback Loop 过氧化物酶体增殖物激活受体 γ/类维生素a X受体 α 异二聚体靶向组蛋白修饰酶PR-Set7/Setd8基因，并通过正反馈回路调节脂肪生成

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-21

180

OAAI

Wakabayashi, Ken-ichi; Okamura, Masashi; Tsutsumi, Shuichi; Nishikawa, Naoko S.; Tanaka, Toshiya; Sakakibara, Iori; Kitakami, Jun-ichi; Ihara, Sigeo; Hashimoto, Yuichi; Hamakubo, Takao; Kodama, Tatsuhiko; Aburatani, Hiroyuki; Sakai, Juro

Design, synthesis and structure-activity relationship of 4-(1,1,1,3,3,3-hexafluoro-2-hydroxyisoprop-2-yl)phenylsilane derivatives as liver X receptor agonists

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2022-07-01

OAAI

Namba, Nao; Noguchi-Yachide, Tomomi; Matsumoto, Yuichiro; Hashimoto, Yuichi; Fujii, Shinya

Conversion of a PROTAC Mutant Huntingtin Degrader into Small-Molecule Hydrophobic Tags Focusing on Drug-like Properties 将PROTAC突变体亨廷顿降解剂转化为关注药物样特性的小分子疏水标签

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2022-02-16

OAAI

Hirai, Keigo; Yamashita, Hiroko; Tomoshige, Shusuke; Mishima, Yugo; Niwa, Tatsuya; Ohgane, Kenji; Ishii, Mayumi; Kanamitsu, Kayoko; Ikemi, Yui; Nakagawa, Shinsaku; Taguchi, Hideki; Sato, Shinichi; Hashimoto, Yuichi; Ishikawa, Minoru

Improvement in aqueous solubility of achiral symmetric cyclofenil by modification to a chiral asymmetric analog

SCIENTIFIC REPORTS

IF3.9

2021-06-16

OAAI

Morimoto, Junki; Miyamoto, Kazunori; Ichikawa, Yuki; Uchiyama, Masanobu; Makishima, Makoto; Hashimoto, Yuichi; Ishikawa, Minoru

Dye-Sensitized Solar Cell (DSSC): Effects on Light Quality, Microclimate, and Growth of Orthosiphon stamineus in Tropical Climatic Condition

AGRONOMY-BASEL

IF3.4

2021-03-26

OAAI

Roslan, N.; Ya'acob, M. E.; Jamaludin, D.; Hashimoto, Y.; Othman, M. H.; Iskandar, A. Noor; Ariffin, M. R.; Ibrahim, M. H.; Mailan, J.; Jamaluddin, A. H.; Mail, M. F.; Aliah, B. S. N.; Lu, L.

Restoration of the reduced CLSP activity alleviates memory impairment in Alzheimer disease

TRANSLATIONAL PSYCHIATRY

IF6.2

2021-01-13

OAAI

Hashimoto, Yuichi; Kusakari, Shinya; Nawa, Mikiro; Okamoto, Koichi; Toyama, Yuka; Matsuoka, Masaaki

Bisphosphonate esters interact with HMG-CoA reductase membrane domain to induce its degradation

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2020-07-01

PREAI

Toyota, Yosuke; Yoshioka, Hiromasa; Sagimori, Ikuya; Hashimoto, Yuichi; Ohgane, Kenji

A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate 一种关键的哺乳动物胆固醇合成酶，角鲨烯单加氧酶，被其底物变构稳定

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-03-13

OAAI

Yoshioka, Hiromasa; Coates, Hudson W.; Chua, Ngee Kiat; Hashimoto, Yuichi; Brown, Andrew J.; Ohgane, Kenji

Phosphine boranes as less hydrophobic building blocks than alkanes and silanes: Structure-property relationship and estrogen-receptor-modulating potency of 4-phosphinophenol derivatives

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2020-02-01

PREAI

Saito, Hiroki; Matsumoto, Yuichiro; Hashimoto, Yuichi; Fujii, Shinya

Luciferase-based HMG-CoA reductase degradation assay for activity and selectivity profiling of oxy(lano)sterols 基于荧光素酶的hmg-coa还原酶降解测定法用于氧 (lano) 固醇的活性和选择性分析

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2020-02-01

PREAI

Sagimori, Ikuya; Yoshioka, Hiromasa; Hashimoto, Yuichi; Ohgane, Kenji

Application of protein knockdown strategy targeting β-sheet structure to multiple disease-associated polyglutamine proteins

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2020-01-01

PREAI

Yamashita, Hiroko; Tomoshige, Shusuke; Nomura, Sayaka; Ohgane, Kenji; Hashimoto, Yuichi; Ishikawa, Minoru

Structure-activity relationship study of estrogen receptor down-regulators with a diphenylmethane skeleton

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2019-05-01

PREAI

Nanjyo, Shun; Ohgane, Kenji; Yoshioka, Hiromasa; Makishima, Makoto; Hashimoto, Yuichi; Noguchi-Yachide, Tomomi

Development of novel silanol-based human pregnane X receptor (PXR) agonists with improved receptor selectivity

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2018-08-01

PREAI

Toyama, Hirozumi; Shirakawa, Hitoshi; Komai, Michio; Hashimoto, Yuichi; Fujii, Shinya

Novel Nonsteroidal Progesterone Receptor (PR) Antagonists with a Phenanthridinone Skeleton

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2018-06-23

OAAI

Nishiyama, Yuko; Mori, Shuichi; Makishima, Makoto; Fujii, Shinya; Kagechika, Hiroyuki; Hashimoto, Yuichi; Ishikawa, Minoru

Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP30

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2017-09-25

PREAI

Sato, Yusuke; Okatsu, Kei; Saeki, Yasushi; Yamano, Koji; Matsuda, Noriyuki; Kaiho, Ai; Yamagata, Atsushi; Goto-Ito, Sakurako; Ishikawa, Minoru; Hashimoto, Yuichi; Tanaka, Keiji; Fukai, Shuya

Discovery of Small Molecules that Induce the Degradation of Huntingtin

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2017-08-09

PREAI

Tomoshige, Shusuke; Nomura, Sayaka; Ohgane, Kenji; Hashimoto, Yuichi; Ishikawa, Minoru

Synthesis and evaluation of novel dual BRD4/HDAC inhibitors

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2017-07-01

PREAI

Amemiya, Seika; Yamaguchi, Takao; Hashimoto, Yuichi; Noguchi-Yachide, Tomomi