未登录Pharmacological inhibition of the LIF/LIFR autocrine loop reveals vulnerability of ovarian cancer cells to ferroptosis
Ebrahimi, Behnam; Viswanadhapalli, Suryavathi; Pratap, Uday P.; Rahul, Gopalam; Yang, Xue; Pitta Venkata, Prabhakar; Drel, Viktor; Santhamma, Bindu; Konda, Swapna; Li, Xiaonan; Sanchez, Alondra Lee Rodriguez; Yan, Hui; Sareddy, Gangadhara R.; Xu, Zhenming; Singh, Brij B.; Valente, Philip T.; Chen, Yidong; Lai, Zhao; Rao, Manjeet; Kost, Edward R.; Curiel, Tyler; Tekmal, Rajeshwar R.; Nair, Hareesh B.; Vadlamudi, Ratna K. .png)
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收藏Targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress (vol 3, pg 866, 2022)Liu, Xihui; Viswanadhapalli, Suryavathi; Kumar, Shourya; Lee, Tae-Kyung; Moore, Andrew; Ma, Shihong; Chen, Liping; Hsieh, Michael; Li, Mengxing; Sareddy, Gangadhara R.; Parra, Karla; Blatt, Eliot B.; Reese, Tanner C.; Zhao, Yuting; Chang, Annabel; Yan, Hui; Xu, Zhenming; Pratap, Uday P.; Liu, Zexuan; Roggero, Carlos M.; Tan, Zhenqiu; Weintraub, Susan T.; Peng, Yan; Tekmal, Rajeshwar R.; Arteaga, Carlos L.; Lippincott-Schwartz, Jennifer; Vadlamudi, Ratna K.; Ahn, Jung-Mo; Raj, Ganesh V. 分享 收藏 Small molecule inhibitor of PELP1 exhibit cytotoxic effects on breast cancer cells by blocking ribosome biogenesisYang, Xue; Nassar, Khaled Mohamed; Pratap, Uday; Gopalam, Rahul; Ebrahimi, Behnam; Panneerdoss, Durga Meenakshi; Li, Xiaonan; Yuan, Yaxia; Zhou, Daohong; Sareddy, Gangadhara R.; Tekmal, Rajeshwar R.; Rao, Manjeet; Viswanadhapalli, Suryavathi; Vadlamudi, Ratna 分享 收藏 Pharmacological inhibition of the LIF-LIFR autocrine loop reveals vulnerability of ovarian cancer to ferroptosisEbrahimi, Behnam; Viswanadhapalli, Suryavathi; Pratap, Uday P.; Gopalam, Rahul; Yang, Xue; Venkata, Prabhakar P.; Drel, Viktor; Santhamma, Bindu; Konda, Swapna; Li, Xiaonan; Sanchez, Alondra L. Rodriguez; Yan, Hui; Sareddy, Gangadhara R.; Xu, Zhenming; Singh, Brij B.; Valente, Philip T.; Chen, Yidong; Lai, Zhao; Rao, Manjeet; Kost, Edward R.; Curiel, Tyler; Tekmal, Rajeshwar R.; Nair, Hareesh B.; Vadlamudi, Ratna K. 分享 收藏 Preclinical evaluation of ERX-208, a potent inducer of ER stress for the treatment of ovarian cancerViswanadhapalli, Suryavathi; Lee, Tae-Kyung; Elmore, Scott; Sharma, Gaurav; Gopalam, Rahul; Parra, Karla; Reese, Tanner; Hsieh, Michael; Pratap, Uday P.; Yang, Xue; Ebrahimi, Behnam; Neal, Henry; Chen, Chia-Yuan; Kassees, Kara; Cervantes, Christian; Xu, Zhenming; Kost, Edward; Sareddy, Gangadhara Reddy; Tekmal, Rajeshwar R.; Ahn, Jung-Mo; Raj, Ganesh V.; Vadlamudi, Ratna K. 分享 收藏 Pharmacological inhibition of KDM1A/LSD1 enhances estrogen receptor beta-mediated tumor suppression in ovarian cancerVenkata, Prabhakar Pitta; Jayamohan, Sridharan; He, Yi; Alejo, Salvador; Johnson, Jessica D.; Palacios, Bridgitte E.; Pratap, Uday P.; Chen, Yihong; Liu, Zexuan; Zou, Yi; Lai, Zhao; Suzuki, Takayoshi; Viswanadhapalli, Suryavathi; Weintraub, Susan T.; Palakurthi, Srinath; Valente, Philip T.; Tekmal, Rajeshwar R.; Kost, Edward R.; Vadlamudi, Ratna K.; Sareddy, Gangadhara R. 分享 收藏 Preclinical Development of Brain Permeable ERβ Agonist for the Treatment of GlioblastomaPratap, Uday P.; Tidwell, Michael; Balinda, Henriette U.; Clanton, Nicholas A.; Yang, Xue; Viswanadhapalli, Suryavathi; Sareddy, Gangadhara R.; Liang, Dong; Xie, Huan; Chen, Yidong; Lai, Zhao; Tekmal, Rajeshwar R.; Mchardy, Stanton F.; Brenner, Andrew J.; Vadlamudi, Ratna K. 分享 收藏 Targeting LIF/LIFR autocrine loops with EC359 in ovarian cancer: A novel LIFR targeted therapyEbrahimi, Behnam; Viswanadhapalli, Suryavathi; Pratap, Uday P.; Gopalam, Rahul; Yang, Xue; Santhamma, Bindhu; Konda, Swapna; Li, Xiaonan; Yan, Hui; Sareddy, Gangadhara R.; Xu, Zhenming; Kost, Edward R.; Tekmal, Rajeshwar R.; Nair, Hareesh B.; Vadlamudi, Ratna K. 分享 收藏 The role of obesity in promoting the LIF/LIFR signaling in triple negative breast cancerRandolph, Lois; Sanchez, Alondra Rodriguez; Blankenship, Logan; Pratap, Uday P.; Yang, Xue; Panneerdoss, Durga Meenakshi; Konda, Swapna; Santhamma, Bindu; Sareddy, Gangadhara R.; Rao, Manjeet K.; Kost, Edward R.; Tekmal, Rajeshwar R.; Nair, Hareesh B.; Vadlamudi, Ratna K.; Viswanadhapalli, Suryavathi 分享 收藏 Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double-strand break repair and augments efficacy of temozolomide in glioblastomaAlejo, Salvador; Palacios, Bridgitte; Venkata, Prabhakar Pitta; Yi, He; Li, Wenjing; Johnson, Jessica; Jayamohan, Sridharan; Zhao, Weixing; Zheng, Siyuan; Suzuki, Takayoshi; Tekmal, Rajeshwar R.; Brenner, Andrew; Vadlamudi, Ratna K.; Sareddy, Gangadhara R. 分享 收藏 KDM1A/LSD1 inhibition enhances estrogen receptor beta mediated tumor suppression in ovarian cancerVenkata, Prabhakar P.; Jayamohan, Sridharan; He, Yi; Alejo, Salvador; Johnson, Jessica D.; Pratap, Uday P.; Viswanadhapalli, Suryavathi; Weintraub, Susan; Tekmal, Rajeshwar R.; Vadlamudi, Ratna K.; Kost, Edward; Sareddy, Gangadhara R. 分享 收藏 ERX-208 as a novel therapeutic for treating ovarian cancer by enhancing endoplasmic reticulum stressViswanadhapalli, Suryavathi; Lee, Tae-Kyung; Kassees, Kara; Sharma, Gaurav; Gopalam, Rahul; Parra, Karla; Reese, Tanner; Hsieh, Michael; Pratap, Uday P.; Yang, Xue; Ebrahimi, Behnam; Chen, Chia Yuan; Elmore, Scott Terry; Cervantes, Christian; Xu, Zhenming; Kost, Edward; Sareddy, Gangadhara Reddy; Tekmal, Rajeshwar Rao; Ann, Jung-Mo; Raj, Ganesh V.; Vadlamudi, Ratna K. 分享 收藏 Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double-strand break repair and augments the efficacy of temozolomide in glioblastomaAlejo, Salvador; Palacios, Bridgitte E.; Venkata, Prabhakar Pitta; He, Yi; Li, Wenjing; Johnson, Jessica D.; Chen, Yihong; Jayamohan, Sridharan; Pratap, Uday P.; Clarke, Kyra; Zou, Yi; Lv, Yingli; Weldon, Korri; Viswanadhapalli, Suryavathi; Lai, Zhao; Ye, Zhenqing; Chen, Yidong; Gilbert, Andrea R.; Suzuki, Takayoshi; Tekmal, Rajeshwar R.; Zhao, Weixing; Zheng, Siyuan; Vadlamudi, Ratna K.; Brenner, Andrew J.; Sareddy, Gangadhara R. 分享 收藏 A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER plus Breast CancerAltwegg, Kristin A.; Viswanadhapalli, Suryavathi; Mann, Monica; Chakravarty, Dimple; Krishnan, Samaya; Liu, Zexuan; Liu, Junhao; Pratap, Uday P.; Ebrahimi, Behnam; Sanchez, John R.; Li, Xiaonan; Ma, Shihong; Park, Ben H.; Santhamma, Bindu; Chen, Yidong; Lai, Zhao; V. Raj, Ganesh; Yuan, Yaxia; Zhou, Daohong; Sareddy, Gangadhara R.; Tekmal, Rajeshwar R.; McHardy, Stan; Huang, Tim H. -M.; Rao, Manjeet K.; Vankayalapati, Hariprasad; Vadlamudi, Ratna K. 分享 收藏 Targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stressLiu, Xihui; Viswanadhapalli, Suryavathi; Kumar, Shourya; Lee, Tae-Kyung; Moore, Andrew; Ma, Shihong; Chen, Liping; Hsieh, Michael; Li, Mengxing; Sareddy, Gangadhara R.; Parra, Karla; Blatt, Eliot B.; Reese, Tanner C.; Zhao, Yuting; Chang, Annabel; Yan, Hui; Xu, Zhenming; Pratap, Uday P.; Liu, Zexuan; Roggero, Carlos M.; Tan, Zhenqiu; Weintraub, Susan T.; Peng, Yan; Tekmal, Rajeshwar R.; Arteaga, Carlos L.; Lippincott-Schwartz, Jennifer; Vadlamudi, Ratna K.; Ahn, Jung-Mo; Raj, Ganesh, V 分享 收藏 SETDB1 interactions with PELP1 contributes to breast cancer endocrine therapy resistanceLiu, Zexuan; Liu, Junhao; Ebrahimi, Behnam; Pratap, Uday P.; He, Yi; Altwegg, Kristin A.; Tang, Weiwei; Li, Xiaonan; Lai, Zhao; Chen, Yidong; Shen, Liangfang; Sareddy, Gangadhara R.; Viswanadhapalli, Suryavathi; Tekmal, Rajeshwar R.; Rao, Manjeet K.; Vadlamudi, Ratna K. 分享 收藏 Leukemia inhibitory factor receptor inhibition reduces obesity driven progression of triple negative breast cancerViswanadhapalli, Suryavathi; Pratap, Uday P.; Ebrahimi, Behnam; Blankenship, Logan; Joshi, Jaitri; Liu, Zexuan; Altwegg, Kristin A.; Li, Xiaonan; Sareddy, Gangadhara R.; Santhamma, Bindu; Konda, Swapna; Rao, Manjeet; Kost, Edward; Tekmal, Rajeshwar R.; Nair, Hareesh B.; Vadlamudi, Ratna K. 分享 收藏 分享 收藏 KDM1A inhibition augments the efficacy of rapamycin for the treatment of endometrial cancerVenkata, Prabhakar Pitta; Chen, Yihong; Alejo, Salvador; He, Yi; Palacios, Bridgitte E.; Loeffel, Ilanna; Liu, Junhao; Pratap, Uday P.; Gray, Gabrielle; Pillai, Sureshkumar Mulampurath Achuthan; Zou, Yi; Lai, Zhao; Suzuki, Takayoshi; Viswanadhapalli, Suryavathi; Palakurthi, Srinath; Tekmal, Rajeshwar R.; Vadlamudi, Ratna K.; Kost, Edward; Sareddy, Gangadhara R. 分享 收藏 LIFR inhibition enhances the therapeutic efficacy of HDAC inhibitors in triple negative breast cancerLi, Mengxing; Viswanadhapalli, Suryavathi; Santhamma, Bindu; Pratap, Uday P.; Luo, Yiliao; Liu, Junhao; Altwegg, Kristin A.; Tang, Weiwei; Liu, Zexuan; Li, Xiaonan; Ebrahimi, Behnam; Yan, Hui; Zou, Yi; Konda, Swapna; Sareddy, Gangadhara R.; Xu, Zhenming; Chen, Yidong; Rao, Manjeet K.; Brenner, Andrew J.; Kaklamani, Virginia G.; Tekmal, Rajeshwar R.; Ahmed, Gulzar; Raj, Ganesh, V; Nickisch, Klaus J.; Nair, Hareesh B.; Vadlamudi, Ratna K. 分享 收藏 
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