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Transient Lymph Node Immune Activation by Hydrolysable Polycarbonate Nanogels Czysch, Christian; Medina-Montano, Carolina; Zhong, Zifu; Fuchs, Alexander; Stickdorn, Judith; Winterwerber, Pia; Schmitt, Sascha; Deswarte, Kim; Raabe, Marco; Scherger, Maximilian; Combes, Francis; De Vrieze, Jana; Kasmi, Sabah; Sandners, Niek N.; Lienenklaus, Stefan; Koynov, Kaloian; Raeder, Hans-Joachim; Lambrecht, Bart N.; David, Sunil A.; Bros, Matthias; Schild, Hansjorg; Grabbe, Stephan; De Geest, Bruno G.; Nuhn, Lutz 分享 收藏
Human M1 macrophages express unique innate immune response genes after mycobacterial infection to defend against tuberculosis Khan, Arshad; Zhang, Kangling; Singh, Vipul K.; Mishra, Abhishek; Kachroo, Priyanka; Bing, Tian; Won, Jong Hak; Mani, Arunmani; Papanna, Ramesha; Mann, Lovepreet K.; Ledezma-Campos, Eder; Aguillon-Duran, Genesis; Canaday, David H.; David, Sunil A.; Restrepo, Blanca, I; Viet, Nhung Nguyen; Phan, Ha; Graviss, Edward A.; Musser, James M.; Kaushal, Deepak; Gauduin, Marie Claire; Jagannath, Chinnaswamy 分享 收藏
High-Titer Neutralizing Antibodies against the SARS-CoV-2 Delta Variant Induced by Alhydroxyquim-II-Adjuvanted Trimeric Spike Antigens Counoupas, Claudio; Pino, Paco; Stella, Alberto O.; Ashley, Caroline; Lukeman, Hannah; Bhattacharyya, Nayan D.; Tada, Takuya; Anchisi, Stephanie; Metayer, Charles; Martinis, Jacopo; Aggarwal, Anupriya; Dcosta, Belinda M.; Britton, Warwick J.; Kint, Joeri; Wurm, Maria J.; Landau, Nathaniel R.; Steain, Megan; Turville, Stuart G.; Wurm, Florian M.; David, Sunil A.; Triccas, James A. 分享 收藏
Systemically Administered TLR7/8 Agonist and Antigen-Conjugated Nanogels Govern Immune Responses against Tumors 全身施用的TLR7/8激动剂和抗原缀合的纳米凝胶控制针对肿瘤的免疫应答 Stickdorn, Judith; Stein, Lara; Arnold-Schild, Danielle; Hahlbrock, Jennifer; Medina-Montano, Carolina; Bartneck, Joschka; Ziss, Tanja; Montermann, Evelyn; Kappel, Cinja; Hobernik, Dominika; Haist, Maximilian; Yurugi, Hajime; Raabe, Marco; Best, Andreas; Rajalingam, Krishnaraj; Radsak, Markus P.; David, Sunil A.; Koynov, Kaloian; Bros, Matthias; Grabbe, Stephan; Schild, Hansjoerg; Nuhn, Lutz 分享 收藏
A universal bacteriophage T4 nanoparticle platform to design multiplex SARS-CoV-2 vaccine candidates by CRISPR engineering Zhu, Jingen; Ananthaswamy, Neeti; Jain, Swati; Batra, Himanshu; Tang, Wei-Chun; Lewry, Douglass A.; Richards, Michael L.; David, Sunil A.; Kilgore, Paul B.; Sha, Jian; Drelich, Aleksandra; Tseng, Chien-Te K.; Chopra, Ashok K.; Rao, Venigalla B. 分享 收藏
Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine (vol 60, pg 9467, 2021) Jangra, S.; De Vrieze, J.; Choi, A.; Rathnasinghe, R.; Laghlali, G.; Uvyn, A.; Van Herck, S.; Nuhn, L.; Deswarte, K.; Zhong, Z.; Sanders, N. N.; Lienenklaus, S.; David, S. A.; Strohmeier, S.; Amanat, F.; Krammer, F.; Hammad, H.; Lambrecht, B. N.; Coughlan, L.; Garcia-Sastre, A.; De Geest, B. G.; Schotsaert, M. 分享 收藏
Squaric Ester-Based, pH-Degradable Nanogels: Modular Nanocarriers for Safe, Systemic Administration of Toll-like Receptor 7/8 Agonistic Immune Modulators Huppertsberg, Anne; Kaps, Leonard; Zhong, Zifu; Schmitt, Sascha; Stickdorn, Judith; Deswarte, Kim; Combes, Francis; Czysch, Christian; De Vrieze, Jana; Kasmi, Sabah; Choteschovsky, Niklas; Klefenz, Adrian; Medina-Montano, Carolina; Winterwerber, Pia; Chen, Chaojian; Bros, Matthias; Lienenklaus, Stefan; Sanders, Niek N.; Koynov, Kaloian; Schuppan, Detlef; Lambrecht, Bart N.; David, Sunil A.; De Geest, Bruno G.; Nuhn, Lutz 分享 收藏
Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine** Jangra, Sonia; De Vrieze, Jana; Choi, Angela; Rathnasinghe, Raveen; Laghlali, Gabriel; Uvyn, Annemiek; Van Herck, Simon; Nuhn, Lutz; Deswarte, Kim; Zhong, Zifu; Sanders, Niek N.; Lienenklaus, Stefan; David, Sunil A.; Strohmeier, Shirin; Amanat, Fatima; Krammer, Florian; Hammad, Hamida; Lambrecht, Bart N.; Coughlan, Lynda; Garcia-Sastre, Adolfo; De Geest, Bruno G.; Schotsaert, Michael 分享 收藏
Lipid-Polyglutamate Nanoparticle Vaccine Platform Van Lysebetten, Dorien; Malfanti, Alessio; Deswarte, Kim; Koynov, Kaloian; Golba, Bianka; Ye, Tingting; Zhong, Zifu; Kasmi, Sabah; Lamoot, Alexander; Chen, Yong; Van Herck, Simon; Lambrecht, Bart N.; Sanders, Niek N.; Lienenklaus, Stefan; David, Sunil A.; Vicent, Maria J.; De Koker, Stefaan; De Geest, Bruno G. 分享 收藏
Imidazoquinoline-Conjugated Degradable Coacervate Conjugate for Local Cancer Immunotherapy Li, Hui; Van Herck, Simon; Liu, Yongjun; Hao, Yanyun; Ding, Xiaochu; Nuhn, Lutz; Zhong, Zifu; Combes, Francis; Sanders, Niek N.; Lienenklaus, Stefan; Koker, Stefaan D.; David, Sunil A.; Wang, Yadong; De Geest, Bruno G.; Zhang, Zhiyue 分享 收藏
Potent and Prolonged Innate Immune Activation by Enzyme-Responsive Imidazoquinoline TLR7/8 Agonist Prodrug Vesicles Wang, Bi; Van Herck, Simon; Chen, Yong; Bai, Xiangyang; Zhong, Zifu; Deswarte, Kim; Lambrecht, Bart N.; Sanders, Niek N.; Lienenklaus, Stefan; Scheeren, Hans W.; David, Sunil A.; Kiessling, Fabian; Lammers, Twan; De Geest, Bruno G.; Shi, Yang 分享 收藏
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Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists De Vrieze, Jana; Louage, Benoit; Deswarte, Kim; Zhong, Zifu; De Coen, Ruben; Van Herck, Simon; Nuhn, Lutz; Frich, Camilla Kaas; Zelikin, Alexander N.; Lienenklaus, Stefan; Sanders, Niek N.; Lambrecht, Bart N.; David, Sunil A.; De Geest, Bruno G. 分享 收藏
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Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands Toll样受体7的结构分析揭示了激动性配体的详细RNA序列特异性和识别机制 Zhang, Zhikuan; Ohto, Umeharu; Shibata, Takuma; Taoka, Masato; Yamauchi, Yoshio; Sato, Ryota; Shukla, Nikunj M.; David, Sunil A.; Isobe, Toshiaki; Miyake, Kensuke; Shimizu, Toshiyuki 分享 收藏
Lymph-Node-Targeted Immune Activation by Engineered Block Copolymer Amphiphiles-TLR7/8 Agonist Conjugates Van Herck, Simon; Deswarte, Kim; Nuhn, Lutz; Zhong, Zifu; Catani, Joao Paulo Portela; Li, Yupeng; Sanders, Niek N.; Lienenklaus, Stefan; De Koker, Stefaan; Lambrecht, Bart N.; David, Sunil A.; De Geest, Bruno G. 分享 收藏
Nanoparticle-Conjugate TLR7/8 Agonist Localized Immunotherapy Provokes Safe Antitumoral Responses 纳米颗粒偶联物TLR7/8激动剂局部免疫治疗引发安全的抗肿瘤反应 Nuhn, Lutz; De Koker, Stefaan; Van Lint, Sandra; Zhong, Zifu; Catani, Joao Portela; Combes, Francis; Deswarte, Kim; Li, Yupeng; Lambrecht, Bart N.; Lienenklaus, Stefan; Sanders, Niek N.; David, Sunil A.; Tavernier, Jan; De Geest, Bruno G. 分享 收藏
Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7/8 agonist Nuhn, Lutz; Van Hoecke, Lien; Deswarte, Kim; Schepens, Bert; Li, Yupeng; Lambrecht, Bart N.; De Koker, Stefaan; David, Sunil A.; Saelens, Xavier; De Geest, Bruno G. 分享 收藏
Hyaluronic Acid Conjugates of TLR7/8 Agonists for Targeted Delivery to Secondary Lymphoid Tissue Yoo, Euna; Salyer, Alex C. D.; Brush, Michael J. H.; Li, Yupeng; Trautman, Kathryn L.; Shukla, Nikunj M.; De Beuckelaer, Ans; Lienenklaus, Stefan; Deswarte, Kim; Lambrecht, Bart N.; De Geest, Bruno G.; David, Sunil A. 分享 收藏
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