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TRanscriptome ANalysis of StratifiEd CohorTs (TRANSECT) enables automated assessment of global gene regulation linked to disparate expression in user defined genes and gene sets 分层队列的转录组分析 (TRANSECT) 可以自动评估与用户定义基因和基因集的不同表达相关的全局基因调控 Toubia, John; Kusay, Yasir; Maqsood, Muneeza; Warnock, Nicholas, I; Lawrence, David M.; Bracken, Cameron P.; Gregory, Philip A.; Kan, Winnie L.; Selth, Luke A.; Conn, Simon J.; Lopez, Angel F.; Branford, Susan; Scott, Hamish S.; Kok, Chung Hoow; Goodall, Gregory J.; Schreiber, Andreas W. 分享 收藏
The β Common Cytokine Receptor Family Reveals New Functional Paradigms From Structural Complexities β共同细胞因子受体家族从结构复杂性中揭示新的功能范例 Kan, Winnie L.; Weekley, Claire M.; Nero, Tracy L.; Hercus, Timothy R.; Yip, Kwok Ho; Tumes, Damon J.; Woodcock, Joanna M.; Ross, David M.; Thomas, Daniel; Teran, David; Owczarek, Catherine M.; Liu, Nora W.; Martelotto, Luciano G.; Polo, Jose M.; Pant, Harshita; Tvorogov, Denis; Lopez, Angel F.; Parker, Michael W. 分享 收藏
CBL Variants in Chronic Myelomonocytic Leukemia Exhibit a Complex Sub-Clone Architecture with a High Frequency of RING Domain Mutations Sufficient to Induce GM-CSF Hypersensitivity CBL变体在慢性髓系单核细胞白血病中表现出复杂的亚克隆结构，并伴有高频RING结构域突变，足以诱导GM-CSF高敏感性。 Lim, Kelly; Kutyna, Monika; Kan, Winnie; Lopez, Angel F.; Brown, Anna; Yong, Agnes S. M.; Lane, Steven W.; Fong, Chun Yew; Hughes, Timothy P.; Yeung, David T.; Ross, David M.; Hiwase, Devendra; Thomas, Daniel 分享 收藏
Accelerated Closure of Diabetic Wounds by Efficient Recruitment of Fibroblasts upon Inhibiting a 14-3-3/ROCK Regulatory Axis Johan, M. Zahied; Pyne, Natasha T.; Kolesnikoff, Natasha; Poltavets, Valentina; Esmaeili, Zahra; Woodcock, Joanna M.; Lopez, Angel F.; Cowin, Allison J.; Pitson, Stuart M.; Samuel, Michael S. 分享 收藏
Dual inhibition of airway inflammation and fibrosis by common b cytokine receptor blockade Wang, Hao; Yip, Kwok Ho; Keam, Simon P.; Vlahos, Ross; Nichol, Kristy; Wark, Peter; Toubia, John; Kral, Anita C.; Cildir, Goeurokhan; Pant, Harshita; Hercus, Timothy R.; Wilson, Nick; Owczarek, Catherine; Lopez, Angel F.; Bozinovski, Steven; Tumes, Damon J. 分享 收藏
IgE receptor of mast cells signals mediator release and inflammation via adaptor protein 14-3-3ξ Yip, Kwok Ho; Chao, Jessica; Coolen, Carl; Pant, Harshita; Kral, Anita; Smith, William; Schwarz, Quenten; Grimbaldeston, Michele A.; Pitson, Stuart; Lopez, Angel F.; Woodcock, Joanna; Tumes, Damon J. 分享 收藏
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Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia 异二聚体细胞因子受体的不同组装控制白血病的Stemness程序 Kan, Winnie L.; Dhagat, Urmi; Kaufmann, Kerstin B.; Hercus, Timothy R.; Nero, Tracy L.; Zeng, Andy G. X.; Toubia, John; Barry, Emma F.; Broughton, Sophie E.; Gomez, Guillermo A.; Benard, Brooks A.; Dottore, Mara; Shing, Karen S. Cheung Tung; Boutzen, Helena; Samaraweera, Saumya E.; Simpson, Kaylene J.; Jin, Liqing; Goodall, Gregory J.; Begley, C. Glenn; Thomas, Daniel; Ekert, Paul G.; Tvorogov, Denis; D'Andrea, Richard J.; Dick, John E.; Parker, Michael W.; Lopez, Angel F. 分享 收藏
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Targeting the Human βc Receptor Inhibits Contact Dermatitis in a Transgenic Mouse Model Yip, Kwok Ho; McKenzie, Duncan; Ramshaw, Hayley S.; Chao, Jessica; McClure, Barbara J.; Raquet, Elmar; Kraushaar, Timo; Roeder, Joachim; Maxwell, Mhairi; Alhamdoosh, Monther; Hammet, Andrew; Fong, Jia Hong; Zeglinski, Kathleen; Monaghan, Katherine; Pant, Harshita; Grimbaldeston, Michele A.; Vairo, Gino; Wilson, Nicholas J.; Owczarek, Catherine M.; Hercus, Timothy R.; Lopez, Angel F.; Tumes, Damon J. 分享 收藏
Targeting human CALR-mutated MPN progenitors with a neoepitope-directed monoclonal antibody 用新表位导向的单克隆抗体靶向人CALR突变的MPN祖细胞 Tvorogov, Denis; Thompson-Peach, Chloe A. L.; Fosselteder, Johannes; Dottore, Mara; Stomski, Frank; Onnesha, Suraiya A.; Lim, Kelly; Moretti, Paul A. B.; Pitson, Stuart M.; Ross, David M.; Reinisch, Andreas; Thomas, Daniel; Lopez, Angel F. 分享 收藏
Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models Wang, Hao; Tumes, Damon J.; Hercus, Timothy R.; Yip, K. H.; Aloe, Christian; Vlahos, Ross; Lopez, Angel F.; Wilson, Nick; Owczarek, Catherine M.; Bozinovski, Steven 分享 收藏
Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia El Khawanky, Nadia; Hughes, Amy; Yu, Wenbo; Myburgh, Renier; Matschulla, Tony; Taromi, Sanaz; Aumann, Konrad; Clarson, Jade; Vinnakota, Janaki Manoja; Shoumariyeh, Khalid; Miething, Cornelius; Lopez, Angel F.; Brown, Michael P.; Duyster, Justus; Hein, Lutz; Manz, Markus G.; Hughes, Timothy P.; White, Deborah L.; Yong, Agnes S. M.; Zeiser, Robert 分享 收藏
Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers 药物再利用: 学术研究人员的误解，挑战和机遇 Begley, C. Glenn; Ashton, Mark; Baell, Jonathan; Bettess, Michael; Brown, Michael P.; Carter, Brett; Charman, William N.; Davis, Christopher; Fisher, Simon; Frazer, Ian; Gautam, Anand; Jennings, Michael P.; Kearney, Philip; Keeffe, Eloise; Kelly, Darren; Lopez, Angel F.; McGuckin, Michael; Parker, Michael W.; Rayner, Craig; Roberts, Brett; Rush, James S.; Sullivan, Mark 分享 收藏
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ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism (vol 71, pg 861, 2020) Boyle, Sarah Theresa; Poltavets, Valentina; Kular, Jasreen; Pyne, Natasha Theresa; Sandow, Jarrod John; Lewis, Alexander Charles; Murphy, Kendelle Joan; Kolesnikoff, Natasha; Moretti, Paul Andre Bartholomew; Tea, Melinda Nay; Tergaonkar, Vinay; Timpson, Paul; Pitson, Stuart Maxwell; Webb, Andrew Ian; Whitfield, Robert John; Lopez, Angel Francisco; Kochetkova, Marina; Samuel, Michael Susithiran 分享 收藏
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