Edward H. Schuchman - Publications, H-index & Citations

Edward H. Schuchman

University of Ottawa

77H指数

517论文数

2.1W被引数

收录论文 180

发表时间

Sphingomyelin-induced glucocorticoid receptor alterations lead to impaired presynaptic plasticity in acid sphingomyelinase deficient neurons 鞘磷脂诱导的糖皮质激素受体改变导致酸性鞘磷脂酶缺乏的神经元中突触前可塑性受损

Neurobiology of Disease

IF5.6

2025-07-01

OAAI

Sara Naya-Forcano; Ángel Gaudioso; Beatriz Soto-Huelin; Celia García-Vilela; César Venero; Edward H. Schuchman; José A. Esteban; María Dolores Ledesma

The cholesterol transporter NPC1 is essential for epigenetic regulation and maturation of oligodendrocyte lineage cells

NATURE COMMUNICATIONS

IF15.7

2023-07-05

OAAI

Kunkel, Thaddeus J.; Townsend, Alice; Sullivan, Kyle A.; Merlet, Jean; Schuchman, Edward H.; Jacobson, Daniel A.; Lieberman, Andrew P.

Consensus clinical management guidelines for acid sphingomyelinase deficiency (Niemann-Pick disease types A, B and A/B)

ORPHANET JOURNAL OF RARE DISEASES

IF3.5

2023-04-17

OAAI

Geberhiwot, Tarekegn; Wasserstein, Melissa; Wanninayake, Subadra; Bolton, Shaun Christopher; Dardis, Andrea; Lehman, Anna; Lidove, Olivier; Dawson, Charlotte; Giugliani, Roberto; Imrie, Jackie; Hopkin, Justin; Green, James; Corbeira, Daniel de Vicente; Madathil, Shyam; Mengel, Eugen; Ezgu, Fatih; Pettazzoni, Magali; Sjouke, Barbara; Hollak, Carla; Vanier, Marie T.; McGovern, Margaret; Schuchman, Edward

Sphingomyelin 16:0 is a therapeutic target for neuronal death in acid sphingomyelinase deficiency

CELL DEATH & DISEASE

IF9.6

2023-04-06

OAAI

Gaudioso, Angel; Jiang, Xuntian; Casas, Josefina; Schuchman, Edward H.; Ledesma, Maria Dolores

Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer's disease

NATURE COMMUNICATIONS

IF15.7

2023-03-24

OAAI

Choi, Byung Jo; Park, Min Hee; Park, Kang Ho; Han, Wan Hui; Yoon, Hee Ji; Jung, Hye Yoon; Hong, Ju Yeon; Chowdhury, Md Riad; Kim, Kyung Yeol; Lee, Jihoon; Song, Im-Sook; Pang, Minyeong; Choi, Min-Koo; Gulbins, Erich; Reichel, Martin; Kornhuber, Johannes; Hong, Chang-Won; Kim, Changho; Kim, Seung Hyun; Schuchman, Edward H. H.; Jin, Hee Kyung; Bae, Jae-sung

Joint and skeletal pathology in acid sphingomyelinase deficient mice

MOLECULAR GENETICS AND METABOLISM

IF3.5

2023-02-01

PREAI

Simonaro, Calogera M.; DeAngelis, Victor A.; Schuchman, Edward H.

Sphingomyelin 16:0 is a therapeutic target for brain pathology in acid sphingomyelinase deficiency

MOLECULAR GENETICS AND METABOLISM

IF3.5

2023-02-01

PREAI

Ledesma, Maria Dolores; Gaudioso, Angel; Jiang, Xuntian; Schuchman, Edward H.

The clinical spectrum of SMA-PME and in vitro normalization of its cellular ceramide profile

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY

IF3.9

2022-11-03

OAAI

Lee, Michelle M.; McDowell, Graeme S., V; De Vivo, Darryl C.; Friedman, Daniel; Berkovic, Samuel F.; Spanou, Maria; Dinopoulos, Argirios; Grand, Katheryn; Sanchez-Lara, Pedro A.; Allen-Sharpley, Michelle; Warman-Chardon, Jodi; Solyom, Alexander; Levade, Thierry; Schuchman, Edward H.; Bennett, Steffany A. L.; Dyment, David A.; Pearson, Toni S.

A 51-Year-Old Woman With Interstitial Lung Disease and Subsequent COVID-19 Presenting With Worsening Dyspnea

CHEST

IF8.6

2022-07-01

OAAI

Ng, Nicole; Zatakia, Jigna; Beasley, Mary B.; Chung, Michael; Balwani, Manisha; Stauffer, Chanan; Schuchman, Edward H.; Dua, Sakshi

Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer's disease mice 发现一种可改善阿尔茨海默病小鼠神经病理特征的双重作用小分子

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2022-01-13

OAAI

Park, Min Hee; Park, Kang Ho; Choi, Byung Jo; Han, Wan Hui; Yoon, Hee Ji; Jung, Hye Yoon; Lee, Jihoon; Song, Im-Sook; Lim, Dong Yu; Choi, Min-Koo; Yang-Ha Lee; Park, Cheol-Min; Wang, Ming; Jo, Jihoon; Kim, Hee-Jin; Kim, Seung Hyun; Schuchman, Edward H.; Jin, Hee Kyung; Bae, Jae-Sung

New paradigms for the treatment of lysosomal storage diseases: targeting the endocannabinoid system as a therapeutic strategy

ORPHANET JOURNAL OF RARE DISEASES

IF3.5

2021-03-25

OAAI

Schuchman, Edward H.; Ledesma, Maria D.; Simonaro, Calogera M.

Ceramides are necessary and suf fi cient for diet-induced impairment of thermogenic adipocytes

MOLECULAR METABOLISM

IF6.6

2021-03-01

OAAI

Chaurasia, Bhagirath; Ying, Li; Talbot, Chad Lamar; Maschek, John Alan; Cox, James; Schuchman, Edward H.; Hirabayashi, Yoshio; Holland, William L.; Summers, Scott A.

Modulation of the endocannabinoid receptor CB2 as a novel treatment for the lysosomal diseases

MOLECULAR GENETICS AND METABOLISM

IF3.5

2021-02-01

PREAI

Simonaro, Calogera M.; He, Xingxuan; DeAngelis, Victor; Zhu, Changzhi; Schuchman, Edward H.

The incidence of acid sphingomyelinase deficiency (ASMD) in cases of suspected Gaucher disease, genotype-phenotype correlation together with Lyso-SPM biomarker

MOLECULAR GENETICS AND METABOLISM

IF3.5

2021-02-01

PREAI

Oliva, Petra; Schwarz, Markus; Wiesinger, Thomas; Scott, Jake; Sansen, Stefaan; Mechtler, Thomas; Keutzer, Joan; Streubel, Berthold; Schuchman, Edward H.; Kasper, David C.

Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IF19.4

2020-10-15

OAAI

Gardner, Aaron, I; Haq, Iram J.; Simpson, A. John; Becker, Katrin A.; Gallagher, John; Saint-Criq, Vinciane; Verdon, Bernard; Mavin, Emily; Trigg, Alexandra; Gray, Michael A.; Koulman, Albert; McDonnell, Melissa J.; Fisher, Andrew J.; Kramer, Elizabeth L.; Clancy, John P.; Ward, Christopher; Schuchman, Edward H.; Gulbins, Erich; Brodlie, Malcolm

Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling

EMBO MOLECULAR MEDICINE

IF8.3

2020-10-05

OAAI

Bartoll, Adrian; Toledano-Zaragoza, Ana; Casas, Josefina; Guzman, Manuel; Schuchman, Edward H.; Ledesma, Maria Dolores

Apolipoprotein D-mediated preservation of lysosomal function promotes cell survival and delays motor impairment in Niemann-Pick type A disease

NEUROBIOLOGY OF DISEASE

IF5.6

2020-10-01

OAAI

Pascua-Maestro, Raquel; Corraliza-Gomez, Miriam; Fadrique-Rojo, Cristian; Ledesma, Maria D.; Schuchman, Edward H.; Sanchez, Diego; Ganfornina, Maria D.

Growth Plate Pathology in the Mucopolysaccharidosis Type VI Rat Model-An Experimental and Computational Approach

DIAGNOSTICS

IF3.3

2020-05-31

OAAI

Guevara-Morales, Johana M.; Frohbergh, Michael; Castro-Abril, Hector; Vaca-Gonzalez, Juan J.; Barrera, Luis A.; Garzon-Alvarado, Diego A.; Schuchman, Edward; Simonaro, Calogera

N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer's disease

NATURE COMMUNICATIONS

IF15.7

2020-05-12

OAAI

Lee, Ju Youn; Han, Seung Hoon; Park, Min Hee; Song, Im-Sook; Choi, Min-Koo; Yu, Eunsoo; Park, Cheol-Min; Kim, Hee-Jin; Kim, Seung Hyun; Schuchman, Edward H.; Jin, Hee Kyung; Bae, Jae-sung

Inhibition of fatty acid amide hydrolase prevents pathology in a mouse model of acid sphingomyelinase deficiency by rescuing downregulated endocannabinoid signalling

MOLECULAR GENETICS AND METABOLISM

IF3.5

2020-02-01

PREAI

Ledesma, Maria Dolores; Bartoll, Adrian; Schuchman, Edward H.

研究方向