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Safety, pharmacokinetics, and antimalarial activity of the novel plasmodium eukaryotic translation elongation factor 2 inhibitor M5717: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study and volunteer infection study McCarthy, James S.; Yalkinoglu, Ozkan; Odedra, Anand; Webster, Rebecca; Oeuvray, Claude; Tappert, Aliona; Bezuidenhout, Deon; Giddins, Marla J.; Dhingra, Satish K.; Fidock, David A.; Marquart, Louise; Webb, Lachlan; Yin, Xiaoyan; Khandelwal, Akash; Bagchus, Wilhelmina M. 分享 收藏
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Preclinical Antimalarial Combination Study of M5717, a Plasmodium falciparum Elongation Factor 2 Inhibitor, and Pyronaridine, a Hemozoin Formation Inhibitor Rottmann, Matthias; Jonat, Brian; Gumpp, Christin; Dhingra, Satish K.; Giddins, Marla J.; Yin, Xiaoyan; Badolo, Lassina; Greco, Beatrice; Fidock, David A.; Oeuvray, Claude; Spangenberg, Thomas 分享 收藏
Lipidomic profiling identifies signatures of metabolic risk Yin, Xiaoyan; Willinger, Christine M.; Keefe, Joshua; Liu, Jun; Fernandez-Ortiz, Antonio; Ibanez, Borja; Penalvo, Jose; Adourian, Aram; Chen, George; Corella, Dolores; Pamplona, Reinald; Portero-Otin, Manuel; Jove, Mariona; Courchesne, Paul; van Duijn, Cornelia M.; Fuster, Valentin; Ordovas, Jose M.; Demirkan, Ayse; Larson, Martin G.; Levy, Daniel 分享 收藏
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PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity PR间期全基因组关联荟萃分析确定了50个与心房和房室电活动相关的基因座 van Setten, Jessica; Brody, Jennifer A.; Jamshidi, Yalda; Swenson, Brenton R.; Butler, Anne M.; Campbell, Harry; Del Greco, Fabiola M.; Evans, Daniel S.; Gibson, Quince; Gudbjartsson, Daniel F.; Kerr, Kathleen F.; Krijthe, Bouwe P.; Lyytikainen, Leo-Pekka; Mueller, Christian; Mueller-Nurasyid, Martina; Nolte, Ilja M.; Padmanabhan, Sandosh; Ritchie, Marylyn D.; Robino, Antonietta; Smith, Albert V.; Steri, Maristella; Tanaka, Toshiko; Teumer, Alexander; Trompet, Stella; Ulivi, Sheila; Verweij, Niek; Yin, Xiaoyan; Arnar, David O.; Asselbergs, Folkert W.; Bader, Joel S.; Barnard, John; Bis, Josh; Blankenberg, Stefan; Boerwinkle, Eric; Bradford, Yuki; Buckley, Brendan M.; Chung, Mina K.; Crawford, Dana; den Hoed, Marcel; Denny, Josh C.; Dominiczak, Anna F.; Ehret, Georg B.; Eijgelsheim, Mark; Ellinor, Patrick T.; Felix, Stephan B.; Franco, Oscar H.; Franke, Lude; Harris, Tamara B.; Holm, Hilma; Ilaria, Gandin; Iorio, Annamaria; Kahonen, Mika; Kolcic, Ivana; Kors, Jan A.; Lakatta, Edward G.; Launer, Lenore J.; Lin, Honghuang; Lin, Henry J.; Loos, Ruth J. F.; Lubitz, Steven A.; Macfarlane, Peter W.; Magnani, Jared W.; Leach, Irene Mateo; Meitinger, Thomas; Mitchell, Braxton D.; Munzel, Thomas; Papanicolaou, George J.; Peters, Annette; Pfeufer, Arne; Pramstaller, Peter P.; Raitakari, Olli T.; Rotter, Jerome I.; Rudan, Igor; Samani, Nilesh J.; Schlessinger, David; Aldana, Claudia T. Silva; Sinner, Moritz F.; Smith, Jonathan D.; Snieder, Harold; Soliman, Elsayed Z.; Spector, Timothy D.; Stott, David J.; Strauch, Konstantin; Tarasov, Kirill V.; Thorsteinsdottir, Unnur; Uitterlinden, Andre G.; Van Wagoner, David R.; Voelker, Uwe; Voelzke, Henry; Waldenberger, Melanie; Westra, Harm Jan; Wild, Philipp S.; Zeller, Tanja; Alonso, Alvaro; Avery, Christy L.; Bandinelli, Stefania; Benjamin, Emelia J.; Cucca, Francesco; Doerr, Marcus; Ferrucci, Luigi; Gasparini, Paolo; Gudnason, Vilmundur; Hayward, Caroline; Heckbert, Susan R.; Hicks, Andrew A.; Jukema, J. Wouter; Kaeaeb, Stefan; Lehtimaki, Terho; Liu, Yongmei; Munroe, Patricia B.; Parsa, Afshin; Polasek, Ozren; Psaty, Bruce M.; Roden, Dan M.; Schnabel, Renate B.; Sinagra, Gianfranco; Stefansson, Kari; Stricker, Bruno H.; van der Harst, Pim; van Duijn, Cornelia M.; Wilson, James F.; Gharib, Sina A.; de Bakker, Paul I. W.; Isaacs, Aaron; Arking, Dan E.; Sotoodehnia, Nona 分享 收藏
Protein Biomarkers of Cardiovascular Disease and Mortality in the Community Ho, Jennifer E.; Lyass, Asya; Courchesne, Paul; Chen, George; Liu, Chunyu; Yin, Xiaoyan; Hwang, Shih-Jen; Massaro, Joseph M.; Larson, Martin G.; Levy, Daniel 分享 收藏
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Common Coding Variants in SCN10A Are Associated With the Nav1.8 Late Current and Cardiac Conduction SCN10A中常见的编码变异与Nav1.8晚期电流和心脏传导有关 Macri, Vincenzo; Brody, Jennifer A.; Arking, Dan E.; Hucker, William J.; Yin, Xiaoyan; Lin, Honghuang; Mills, Robert W.; Sinner, Moritz F.; Lubitz, Steven A.; Liu, Ching-Ti; Morrison, Alanna C.; Alonso, Alvaro; Li, Ning; Fedorov, Vadim V.; Janssen, Paul M.; Bis, Joshua C.; Heckbert, Susan R.; Dolmatova, Elena V.; Lumley, Thomas; Sitlani, Colleen M.; Cupples, L. Adrienne; Pulit, Sara L.; Newton-Cheh, Christopher; Barnard, John; Smith, Jonathan D.; Van Wagoner, David R.; Chung, Mina K.; Vlahakes, Gus J.; O'Donnell, Christopher J.; Rotter, Jerome I.; Margulies, Kenneth B.; Morley, Michael P.; Cappola, Thomas P.; Benjamin, Emelia J.; Muzny, Donna; Gibbs, Richard A.; Jackson, Rebecca D.; Magnani, Jared W.; Herndon, Caroline N.; Rich, Stephen S.; Psaty, Bruce M.; Milan, David J.; Boerwinkle, Eric; Mohler, Peter J.; Sotoodehnia, Nona; Ellinor, Patrick T. 分享 收藏
Relations of Liver Fat With Prevalent and Incident Atrial Fibrillation in the Framingham Heart Study Long, Michelle T.; Yin, Xiaoyan; Larson, Martin G.; Ellinor, Patrick T.; Lubitz, Steven A.; McManus, David D.; Magnani, Jared W.; Staerk, Laila; Ko, Darae; Helm, Robert H.; Hoffmann, Udo; Chung, Raymond T.; Benjamin, Emelia J. 分享 收藏
Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation 常见和罕见变异的大规模分析确定了12个与心房颤动相关的新基因座 Christophersen, Ingrid E.; Rienstra, Michiel; Roselli, Carolina; Yin, Xiaoyan; Geelhoed, Bastiaan; Barnard, John; Lin, Honghuang; Arking, Dan E.; Smith, Albert V.; Albert, Christine M.; Chaffin, Mark; Tucker, Nathan R.; Li, Molong; Klarin, Derek; Bihlmeyer, Nathan A.; Low, Siew-Kee; Weeke, Peter E.; Mueller-Nurasyid, Martina; Smith, J. Gustav; Brody, Jennifer A.; Niemeijer, Maartje N.; Doerr, Marcus; Trompet, Stella; Huffman, Jennifer; Gustafsson, Stefan; Schurmann, Claudia; Kleber, Marcus E.; Lyytikainen, Leo-Pekka; Seppala, Ilkka; Malik, Rainer; Horimoto, Andrea R. V. R.; Perez, Marco; Sinisalo, Juha; Aeschbacher, Stefanie; Theriault, Sebastien; Yao, Jie; Radmanesh, Farid; Weiss, Stefan; Teumer, Alexander; Choi, Seung Hoan; Weng, Lu-Chen; Clauss, Sebastian; Deo, Rajat; Rader, Daniel J.; Shah, Svati H.; Sun, Albert; Hopewell, Jemma C.; Debette, Stephanie; Chauhan, Ganesh; Yang, Qiong; Worrall, Bradford B.; Pare, Guillaume; Kamatani, Yoichiro; Hagemeijer, Yanick P.; Verweij, Niek; Siland, Joylene E.; Kubo, Michiaki; Smith, Jonathan D.; Van Wagoner, David R.; Bis, Joshua C.; Perz, Siegfried; Psaty, Bruce M.; Ridker, Paul M.; Magnani, Jared W.; Harris, Tamara B.; Launer, Lenore J.; Shoemaker, M. Benjamin; Padmanabhan, Sandosh; Haessler, Jeffrey; Bartz, Traci M.; Waldenberger, Melanie; Lichtner, Peter; Arendt, Marina; Krieger, Jose E.; Kahonen, Mika; Risch, Lorenz; Mansur, Alfredo J.; Peters, Annette; Smith, Blair H.; Lind, Lars; Scott, Stuart A.; Lu, Yingchang; Bottinger, Erwin B.; Hernesniemi, Jussi; Lindgren, Cecilia M.; Wong, Jorge A.; Huang, Jie; Eskola, Markku; Morris, Andrew P.; Ford, Ian; Reiner, Alex P.; Delgado, Graciela; Chen, Lin Y.; Chen, Yii-Der Ida; Sandhu, Roopinder K.; Li, Man; Boerwinkle, Eric; Eisele, Lewin; Lannfelt, Lars; Rost, Natalia; Anderson, Christopher D.; Taylor, Kent D.; Campbell, Archie; Magnusson, Patrik K.; Porteous, David; Hocking, Lynne J.; Vlachopoulou, Efthymia; Pedersen, Nancy L.; Nikus, Kjell; Orho-Melander, Marju; Hamsten, Anders; Heeringa, Jan; Denny, Joshua C.; Kriebel, Jennifer; Darbar, Dawood; Newton-Cheh, Christopher; Shaffer, Christian; Macfarlane, Peter W.; Heilmann-Heimbach, Stefanie; Almgren, Peter; Huang, Paul L.; Sotoodehnia, Nona; Soliman, Elsayed Z.; Uitterlinden, Andre G.; Hofman, Albert; Franco, Oscar H.; Voelker, Uwe; Joeckel, Karl-Heinz; Sinner, Moritz F.; Lin, Henry J.; Guo, Xiuqing; Dichgans, Martin; Ingelsson, Erik; Kooperberg, Charles; Melander, Olle; Loos, Ruth J. F.; Laurikka, Jari; Conen, David; Rosand, Jonathan; van der Harst, Pim; Lokki, Marja-Liisa; Kathiresan, Sekar; Pereira, Alexandre; Jukema, J. Wouter; Hayward, Caroline; Rotter, Jerome I.; Maerz, Winfried; Lehtimaki, Terho; Stricker, Bruno H.; Chung, Mina K.; Felix, Stephan B.; Gudnason, Vilmundur; Alonso, Alvaro; Roden, Dan M.; Kaeaeb, Stefan; Chasman, Daniel I.; Heckbert, Susan R.; Benjamin, Emelia J.; Tanaka, Toshihiro; Lunetta, Kathryn L.; Lubitz, Steven A.; Ellinor, Patrick T. 分享 收藏
Genetic Risk Prediction of Atrial Fibrillation Lubitz, Steven A.; Yin, Xiaoyan; Lin, Henry J.; Kolek, Matthew; Smith, J. Gustav; Trompet, Stella; Rienstra, Michiel; Rost, Natalia S.; Teixeira, Pedro L.; Almgren, Peter; Anderson, Christopher D.; Chen, Lin Y.; Engstrom, Gunnar; Ford, Ian; Furie, Karen L.; Guo, Xiuqing; Larson, Martin G.; Lunetta, Kathryn L.; Macfarlane, Peter W.; Psaty, Bruce M.; Soliman, Elsayed Z.; Sotoodehnia, Nona; Stott, David J.; Taylor, Kent D.; Weng, Lu-Chen; Yao, Jie; Geelhoed, Bastiaan; Verweij, Niek; Siland, Joylene E.; Kathiresan, Sekar; Roselli, Carolina; Roden, Dan M.; van der Harst, Pim; Darbar, Dawood; Jukema, J. Wouter; Melander, Olle; Rosand, Jonathan; Rotter, Jerome I.; Heckbert, Susan R.; Ellinor, Patrick T.; Alonso, Alvaro; Benjamin, Emelia J. 分享 收藏
Stroke as the Initial Manifestation of Atrial Fibrillation: The Framingham Heart Study Lubitz, Steven A.; Yin, Xiaoyan; McManus, David D.; Weng, Lu-Chen; Aparicio, Hugo J.; Walkey, Allan J.; Romero, Jose Rafael; Kase, Carlos S.; Ellinor, Patrick T.; Wolf, Philip A.; Seshadri, Sudha; Benjamin, Emelia J. 分享 收藏
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