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A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M1 receptor agonist HTL0018318 in patients with mild-to-moderate Alzheimer's disease 选择性毒蕈碱M1受体激动剂HTL0018318在轻中度阿尔茨海默病患者中的安全性和初步药效学1b/2a期多中心研究 Nathan, Pradeep. J. J.; Millais, S. Babli; Godwood, Alex; Dewit, Odile; Cross, David. M. M.; Liptrot, Janet; Ruparelia, Bharat; Jones, Stephen Paul; Bakker, Geor; Maruff, Paul. T. T.; Light, Gregory. A. A.; Brown, Alastair J. H.; Weir, Malcolm Peter; Congreve, Miles; Tasker, Tim 分享 收藏
Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits (Sep, 10.1038/s41467-021-25280-5, 2021) Palacios-Filardo, Jon; Udakis, Matt; Brown, Giles A.; Tehan, Benjamin G.; Congreve, Miles S.; Nathan, Pradeep J.; Brown, Alastair J. H.; Mellor, Jack R. 分享 收藏
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Convergent and Discriminant Validity of Default Mode Network and Limbic Network Perfusion in Amnestic Mild Cognitive Impairment Patients Quattrini, Giulia; Marizzoni, Moira; Pizzini, Francesca B.; Galazzo, Ilaria Boscolo; Aiello, Marco; Didic, Mira; Soricelli, Andrea; Albani, Diego; Romano, Melissa; Blin, Olivier; Forloni, Gianluigi; Golay, Xavier; Jovicich, Jorge; Nathan, Pradeep J.; Richardson, Jill C.; Salvatore, Marco; Frisoni, Giovanni B.; Pievani, Michela 分享 收藏
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Safety, pharmacokinetics and pharmacodynamics of HTL0009936, a selective muscarinic M1-acetylcholine receptor agonist: A randomized cross-over trial Bakker, Charlotte; Prins, Samantha; Liptrot, Jan; Hart, Ellen P.; Klaassen, Erica S.; Brown, Giles A.; Brown, Alastair; Congreve, Miles; Weir, Malcolm; Marshall, Fiona H.; Stevens, Jasper; Cross, David M.; Tasker, Tim; Nathan, Pradeep J.; Groeneveld, Geert Jan 分享 收藏
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Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M1 receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending dose study Bakker, Charlotte; Tasker, Tim; Liptrot, Jan; Hart, Ellen P.; Klaassen, Erica S.; Doll, Robert Jan; Brown, Giles A.; Brown, Alastair; Congreve, Miles; Weir, Malcolm; Marshall, Fiona H.; Cross, David M.; Groeneveld, Geert Jan; Nathan, Pradeep J. 分享 收藏
First-in-man study to investigate safety, pharmacokinetics and exploratory pharmacodynamics of HTL0018318, a novel M1-receptor partial agonist for the treatment of dementias Bakker, Charlotte; Tasker, Tim; Liptrot, Jan; Hart, Ellen P.; Klaassen, Erica S.; Prins, Samantha; Doef, Thalia F.; Brown, Giles A.; Brown, Alastair; Congreve, Miles; Weir, Malcolm; Marshall, Fiona H.; Cross, David M.; Groeneveld, Geert Jan; Nathan, Pradeep J. 分享 收藏
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Normative data from linear and nonlinear quantile regression in CANTAB: Cognition in mid-to-late life in an epidemiological sample Abbott, Rosemary A.; Skirrow, Caroline; Jokisch, Martha; Timmers, Maarten; Streffer, Johannes; van Nueten, Luc; Krams, Michael; Winkler, Angela; Pundt, Noreen; Nathan, Pradeep J.; Rock, Philippa; Cormack, Francesca K.; Weimar, Christian 分享 收藏
New approaches in psychiatric drug development van der Doef, Thalia F.; Domingo, Silvia Zaragoza; Jacobs, Gabriel E.; Drevets, Wayne C.; Marston, Hugh M.; Nathan, Pradeep J.; Tome, Maria B.; Tamminga, Carol A.; van Gerven, Joop M. A.; Kas, Martien J. H. 分享 收藏
Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype (vol 41, pg 2647, 2016) Ziauddeen, Hisham; Nestor, Liam J.; Subramaniam, Naresh; Dodds, Chris; Nathan, Pradeep J.; Miller, Sam R.; Sarai, Bhopinder K.; Maltby, Kay; Fernando, Disala; Warren, Liling; Hosking, Louise K.; Waterworth, Dawn; Korzeniowska, Anna; Win, Beta; Richards, Duncan B.; Johnson, Lakshmi Vasist; Fletcher, Paul C.; Bullmore, Edward T. 分享 收藏
The effects of glycine on auditory mismatch negativity in schizophrenia Greenwood, Lisa-Marie; Leung, Sumie; Michie, Patricia T.; Green, Amity; Nathan, Pradeep J.; Fitzgerald, Paul; Johnston, Patrick; Solowij, Nadia; Kulkarni, Jayashri; Croft, Rodney J. 分享 收藏
Memory Correlates of Alzheimer's Disease Cerebrospinal Fluid Markers: A Longitudinal Cohort Study Reijs, Babette L. R.; Ramakers, Inez H. G. B.; Kohler, Sebastian; Teunissen, Charlotte E.; Koel-Simmelink, Marleen; Nathan, Pradeep J.; Tsolaki, Magda; Wahlund, Lars-Olof; Waldemar, Gunhild; Hausner, Lucrezia; Vandenberghe, Rik; Johannsen, Peter; Blackwell, Andrew; Vanderstichele, Hugo; Verhey, Frans; Visser, Pieter Jelle 分享 收藏
Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI) 遗忘型轻度认知障碍 (MCI) 患者脑脊液生物标志物、海马体积与认知功能的关系 Nathan, Pradeep J.; Lim, Yen Ying; Abbott, Rosemary; Galluzzi, Samantha; Marizzoni, Moira; Babiloni, Claudio; Albani, Diego; Bartres-Faz, David; Didic, Mira; Farotti, Lucia; Parnetti, Lucilla; Salvadori, Nicola; Mueller, Bernhard W.; Forloni, Gianluigi; Girtler, Nicola; Hensch, Tilman; Jovicich, Jorge; Leeuwis, Annebet; Marra, Camillo; Luis Molinuevo, Jose; Nobili, Flavio; Pariente, Jeremie; Payoux, Pierre; Ranjeva, Jean-Philippe; Rolandi, Elena; Rossini, Paolo Maria; Schoenknecht, Peter; Soricelli, Andrea; Tsolaki, Magda; Visser, Pieter Jelle; Wiltfang, Jens; Richardson, Jill C.; Bordet, Regis; Blin, Olivier; Frisoni, Giovanni B. 分享 收藏
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