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Contribution of rare chromosome 22q11.2 copy number variants to non-syndromic bicuspid aortic valve Digregorio, Helene; Mansoorshahi, Sara; Carlisle, Steven G.; Pensa, Catherina Tovar; Watts, Abi; Mcneely, Courtney; Sabate-Rotes, Anna; Yetman, Anji; Michelena, Hector, I; De Backer, Julie F. A.; Mosquera, Laura Muino; Bissell, Malenka M.; Andreassi, Maria Grazia; Foffa, Ilenia; Hui, Dawn S.; Caffarelli, Anthony; Kim, Yuli Y.; Citro, Rodolfo; De Marco, Margot; Tretter, Justin T.; Mcbride, Kim L.; Body, Simon C.; Milewicz, Dianna M.; Prakash, Siddharth K.; EBAV Investigators 分享 收藏
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Whole-exome sequencing uncovers the genetic complexity of bicuspid aortic valve in families with early-onset complications Mansoorshahi, Sara; Yetman, Anji T.; Bissell, Malenka M.; Kim, Yuli Y.; Michelena, Hector I.; De Backer, Julie; Mosquera, Laura Muino; Hui, Dawn S.; Caffarelli, Anthony; Andreassi, Maria G.; Foffa, Ilenia; Guo, Dongchuan; Citro, Rodolfo; De Marco, Margot; Tretter, Justin T.; Morris, Shaine A.; Body, Simon C.; Chong, Jessica X.; Bamshad, Michael J.; Milewicz, Dianna M.; Prakash, Siddharth K. 分享 收藏
Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis 组织细胞外囊泡的多组学鉴定动脉粥样硬化和钙化性主动脉瓣狭窄的独特调节剂 Blaser, Mark C.; Buffolo, Fabrizio; Halu, Arda; Turner, Mandy E.; Schlotter, Florian; Higashi, Hideyuki; Pantano, Lorena; Clift, Cassandra L.; Saddic, Louis A.; Atkins, Samantha K.; Rogers, Maximillian A.; Pham, Tan; Vromman, Amelie; Shvartz, Eugenia; Sukhova, Galina K.; Monticone, Silvia; Camussi, Giovanni; Robson, Simon C.; Body, Simon C.; Muehlschlegel, Jochen D.; Singh, Sasha A.; Aikawa, Masanori; Aikawa, Elena 分享 收藏
Novel Association of the NOTCH Pathway Regulator MIB1 Gene With the Development of Bicuspid Aortic Valve Tessler, Idit; Albuisson, Juliette; Pineiro-Sabaris, Rebeca; Verstraeten, Aline; Kaya, Hatem Elif Kamber; Siguero-Alvarez, Marcos; Goudot, Guillaume; MacGrogan, Donal; Luyckx, Ilse; Shpitzen, Shoshana; Levin, Galina; Kelman, Guy; Reshef, Noga; Mananet, Hugo; Holdcraft, Jake; Muehlschlegel, Jochen D.; Peloso, Gina M.; Oppenheim, Olya; Cheng, Charles; Mazzella, Jean-Michael; Andelfinger, Gregor; Mital, Seema; Eriksson, Per; Billon, Clarisse; Heydarpour, Mahyar; Dietz, Harry C.; Jeunemaitre, Xavier; Leitersdorf, Eran; Sprinzak, David; Blacklow, Stephen C.; Body, Simon C.; Carmi, Shai; Loeys, Bart; de la Pompa, Jose Luis; Gilon, Dan; Messas, Emmanuel; Durst, Ronen 分享 收藏
Multi-omics And Single Nucleus Transcriptomics Reveal Aberrant Adaptive Immune Responses In Human Bicuspid Aortic Valves Blaser, Mark C.; Reichart, Daniel; Sonawane, Abhijeet; Schlotter, Florian; Halu, Arda; Passos, Livia Silva A.; DeLaughter, Daniel; Zhou, Wunan; Blankstein, Ron; Di Carli, Marcelo; Nunes, Maria D.; Billaud, Marie; Sabe, Ashraf A.; Robson, Simon; Body, Simon C.; Muehlschlegel, Jochen D.; Seidman, Jonathan G.; Seidman, Christine E.; Aikawa, Masanori; Singh, Sasha A.; Aikawa, Elena 分享 收藏
Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity Iqbal, Farwah; Schlotter, Florian; Becker-Greene, Dakota; Lupieri, Adrien; Goettsch, Claudia; Hutcheson, Joshua D.; Rogers, Maximillian A.; Itoh, Shinsuke; Halu, Arda; Lee, Lang Ho; Blaser, Mark C.; Mlynarchik, Andrew K.; Hagita, Sumihiko; Kuraoka, Shiori; Chen, Hao Yu; Engert, James C.; Passos, Livia S. A.; Jha, Prabhash K.; Osborn, Eric A.; Jaffer, Farouc A.; Body, Simon C.; Robson, Simon C.; Thanassoulis, George; Aikawa, Masanori; Singh, Sasha A.; Sonawane, Abhijeet R.; Aikawa, Elena 分享 收藏
A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling 通过单细胞和蛋白质组学分析鉴定的人类钙化主动脉瓣间质细胞内的疾病驱动群体 Decano, Julius L.; Iwamoto, Yukio; Goto, Shinji; Lee, Janey Y.; Matamalas, Joan T.; Halu, Arda; Blaser, Mark; Lee, Lang Ho; Pieper, Brett; Chelvanambi, Sarvesh; Silva-Nicolau, Jessica; Bartoli-Leonard, Francesca; Higashi, Hideyuki; Shibata, Haruki; Vyas, Payal; Wang, Jianguo; Gostjeva, Elena; Body, Simon C.; Singh, Sasha A.; Aikawa, Masanori; Aikawa, Elena 分享 收藏
Genome-wide association study reveals novel genetic loci: a new polygenic risk score for mitral valve prolapse Roselli, Carolina; Yu, Mengyao; Nauffal, Victor; Georges, Adrien; Yang, Qiong; Love, Katie; Weng, Lu-Chen; Delling, Francesca N.; Maurya, Svetlana R.; Schrolkamp, Maren; Tfelt-Hansen, Jacob; Hagege, Albert; Jeunemaitre, Xavier; Debette, Stephanie; Amouyel, Philippe; Guan, Wyliena; Muehlschlegel, Jochen D.; Body, Simon C.; Shah, Svati; Samad, Zainab; Kyryachenko, Sergiy; Haynes, Carol; Rienstra, Michiel; Le Tourneau, Thierry; Probst, Vincent; Roussel, Ronan; Wijdh-Den Hamer, Inez J.; Siland, Joylene E.; Knowlton, Kirk U.; Schott, Jean Jacques; Levine, Robert A.; Benjamin, Emelia J.; Vasan, Ramachandran S.; Horne, Benjamin D.; Muhlestein, Joseph B.; Benfari, Giovanni; Enriquez-Sarano, Maurice; Natale, Andrea; Mohanty, Sanghamitra; Trivedi, Chintan; Shoemaker, Moore B.; Yoneda, Zachary T.; Wells, Quinn S.; Baker, Michael T.; Farber-Eger, Eric; Michelena, Hector, I; Lundby, Alicia; Norris, Russell A.; Slaugenhaupt, Susan A.; Dina, Christian; Lubitz, Steven A.; Bouatia-Naji, Nabila; Ellinor, Patrick T.; Milan, David J. 分享 收藏
ApoC-III is a novel inducer of calcification in human aortic valves Schlotter, Florian; Freitas, Renata C. C. de; Rogers, Maximillian A.; Blaser, Mark C.; Wu, Pin-Jou; Higashi, Hideyuki; Halu, Arda; Iqbal, Farwah; Andraski, Allison B.; Rodia, Cayla N.; Kuraoka, Shiori; Wen, Jennifer R.; Creager, Michael; Tan Pham; Hutcheson, Joshua D.; Body, Simon C.; Kohan, Alison B.; Sacks, Frank M.; Aikawa, Masanori; Singh, Sasha A.; Aikawa, Elena 分享 收藏
Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis Rogers, Maximillian A.; Buffolo, Fabrizio; Schlotter, Florian; Atkins, Samantha K.; Lee, Lang H.; Halu, Arda; Blaser, Mark C.; Tsolaki, Elena; Higashi, Hideyuki; Luther, Kristin; Daaboul, George; Bouten, Carlijn V. C.; Body, Simon C.; Singh, Sasha A.; Bertazzo, Sergio; Libby, Peter; Aikawa, Masanori; Aikawa, Elena 分享 收藏
Association of Factor V Leiden With Subsequent Atherothrombotic Events A GENIUS-CHD Study of Individual Participant Data Mahmoodi, Bakhtawar K.; Tragante, Vinicius; Kleber, Marcus E.; Holmes, Michael V.; Schmidt, Amand F.; McCubrey, Raymond O.; Howe, Laurence J.; Direk, Kenan; Allayee, Hooman; Baranova, Ekaterina V.; Braund, Peter S.; Delgado, Graciela E.; Eriksson, Niclas; Gijsberts, Crystel M.; Gong, Yan; Hartiala, Jaana; Heydarpour, Mahyar; Pasterkamp, Gerard; Kotti, Salma; Kuukasjarvi, Pekka; Lenzini, Petra A.; Levin, Daniel; Lyytikainen, Leo-Pekka; Muehlschlegel, Jochen D.; Nelson, Christopher P.; Nikus, Kjell; Pilbrow, Anna P.; Wilson Tang, W. H.; van der Laan, Sander W.; van Setten, Jessica; Vilmundarson, Ragnar O.; Deanfield, John; Deloukas, Panos; Dudbridge, Frank; James, Stefan; Mordi, Ify R.; Teren, Andrej; Bergmeijer, Thomas O.; Body, Simon C.; Bots, Michiel; Burkhardt, Ralph; Cooper-DeHoff, Rhonda M.; Cresci, Sharon; Danchin, Nicolas; Doughty, Robert N.; Grobbee, Diederick E.; Hagstrom, Emil; Hazen, Stanley L.; Held, Claes; Hoefer, Imo E.; Hovingh, G. Kees; Johnson, Julie A.; Kaczor, Marcin P.; Kahonen, Mika; Klungel, Olaf H.; Laurikka, Jari O.; Lehtimaki, Terho; van der Zee, Anke H.; McPherson, Ruth; Palmer, Colin N.; Kraaijeveld, Adriaan O.; Pepine, Carl J.; Sanak, Marek; Sattar, Naveed; Scholz, Markus; Simon, Tabassome; Spertus, John A.; Stewart, Alexandre F. R.; Szczeklik, Wojciech; Thiery, Joachim; Visseren, Frank L. J.; Waltenberger, Johannes; Richards, A. Mark; Lang, Chim C.; Cameron, Vicky A.; akerblom, Axel; Pare, Guillaume; Maerz, Winfried; Samani, Nilesh J.; Hingorani, Aroon D.; ten Berg, Jurrien M.; Wallentin, Lars; Asselbergs, Folkert W.; Patel, Riyaz S. 分享 收藏
Characterizing Risks Associated With Mitral Annular Calcification in Mitral Valve Replacement Kaneko, Tsuyoshi; Hirji, Sameer; Percy, Edward; Aranki, Sary; McGurk, Siobhan; Body, Simon; Heydarpour, Mahyar; Mallidi, Hari; Singh, Steve; Pelletier, Marc; Rawn, James; Shekar, Prem 分享 收藏
Defects in the Exocyst-Cilia Machinery Cause Bicuspid Aortic Valve Disease and Aortic Stenosis Fulmer, Diana; Toomer, Katelynn; Guo, Lilong; Moore, Kelsey; Glover, Janiece; Moore, Reece; Stairley, Rebecca; Lobo, Glenn; Zuo, Xiaofeng; Dang, Yujing; Su, Yanhui; Fogelgren, Ben; Gerard, Patrick; Chung, Dongjun; Heydarpour, Mahyar; Mukherjee, Rupak; Body, Simon C.; Norris, Russell A.; Lipschutz, Joshua H. 分享 收藏
Aortopathy and regurgitation in bicuspid valve patients increase the risk of aortopathy in relatives Dayan, Victor; Zuasnabar, Ana; Citro, Rodolfo; Bossone, Eduardo; Michelena, Hector I.; Parma, Gabriel; Bellino, Michele; Olascoaga, Alicia; Florio, Lucia; Body, Simon 分享 收藏
Primary cilia defects causing mitral valve prolapse Toomer, Katelynn A.; Yu, Mengyao; Fulmer, Diana; Guo, Lilong; Moore, Kelsey S.; Moore, Reece; Drayton, Ka'la D.; Glover, Janiece; Peterson, Neal; Ramos-Ortiz, Sandra; Drohan, Alex; Catching, Breiona J.; Stairley, Rebecca; Wessels, Andy; Lipschutz, Joshua H.; Delling, Francesca N.; Jeunemaitre, Xavier; Dina, Christian; Collins, Ryan L.; Brand, Harrison; Talkowski, Michael E.; del Monte, Federica; Mukherjee, Rupak; Awgulewitsch, Alexander; Body, Simon; Hardiman, Gary; Hazard, E. Starr; da Silveira, Willian A.; Wang, Baolin; Leyne, Maire; Durst, Ronen; Markwald, Roger R.; Le Scouarnec, Solena; Hagege, Albert; Le Tourneau, Thierry; Kohl, Peter; Rog-Zielinska, Eva A.; Ellinor, Patrick T.; Levine, Robert A.; Milan, David J.; Schott, Jean-Jacques; Bouatia-Naji, Nabila; Slaugenhaupt, Susan A.; Norris, Russell A. 分享 收藏
Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events A GENIUS-CHD Study of Individual Participant Data Patel, Riyaz S.; Schmidt, Amand F.; Tragante, Vinicius; McCubrey, Raymond O.; Holmes, Michael, V; Howe, Laurence J.; Direk, Kenan; Akerblom, Axel; Leander, Karin; Virani, Salim S.; Kaminski, Karol A.; Muehlschlegel, Jochen D.; Dube, Marie-Pierre; Allayee, Hooman; Almgren, Peter; Alver, Maris; Baranova, Ekaterina, V; Behlouli, Hassan; Boeckx, Bram; Braund, Peter S.; Breitling, Lutz P.; Delgado, Graciela; Duarte, Nubia E.; Dufresne, Line; Eriksson, Niclas; Foco, Luisa; Gijsberts, Crystel M.; Gong, Yan; Hartiala, Jaana; Heydarpour, Mahyar; Hubacek, Jaroslav A.; Kleber, Marcus; Kofink, Daniel; Kuukasjarvi, Pekka; Lee, Vei-Vei; Leiherer, Andreas; Lenzini, Petra A.; Levin, Daniel; Lyytikainen, Leo-Pekka; Martinelli, Nicola; Mons, Ute; Nelson, Christopher P.; Nikus, Kjell; Pilbrow, Anna P.; Ploski, Rafal; Sun, Yan, V; Tanck, Michael W. T.; Tang, W. H. Wilson; Trompet, Stella; van der Laan, Sander W.; van Setten, Jessica; Vilmundarson, Ragnar O.; Anselmi, Chiara Viviani; Vlachopoulou, Efthymia; Boerwinkle, Eric; Briguori, Carlo; Carlquist, John F.; Carruthers, Kathryn F.; Casu, Gavino; Deanfield, John; Deloukas, Panos; Dudbridge, Frank; Fitzpatrick, Natalie; Gigante, Bruna; James, Stefan; Lokki, Marja-Liisa; Lotufo, Paulo A.; Marziliano, Nicola; Mordi, Ify R.; Muhlestein, Joseph B.; Cheh, Chris Newton; Pitha, Jan; Saely, Christoph H.; Samman-Tahhan, Ayman; Sandesara, Pratik B.; Teren, Andrej; Timmis, Adam; Van de Werf, Frans; Wauters, Els; Wilde, Arthur A. M.; Ford, Ian; Stott, David J.; Algra, Ale; Andreassi, Maria G.; Ardissino, Diego; Arsenault, Benoit J.; Ballantyne, Christie M.; Bergmeijer, Thomas O.; Bezzina, Connie R.; Body, Simon C.; Bogaty, Peter; de Borst, Gert J.; Brenner, Hermann; Burkhardt, Ralph; Carpeggiani, Clara; Condorelli, Gianluigi; Cooper-DeHoff, Rhonda M.; Cresci, Sharon; de Faire, Ulf; Doughty, Robert N.; Drexel, Heinz; Engert, James C.; Fox, Keith A. A.; Girelli, Domenico; Hagstrom, Emil; Hazen, Stanley L.; Held, Claes; Hemingway, Harry; Hoefer, Imo E.; Hovingh, G. Kees; Johnson, Julie A.; De Jong, Pim A.; Jukema, J. Wouter; Kaczor, Marcin P.; Kahonen, Mika; Kettner, Jiri; Kiliszek, Marek; Klungel, Olaf H.; Lagerqvist, Bo; Lambrechts, Diether; Laurikka, Jari O.; Lehtimaki, Terho; Lindholm, Daniel; Mahmoodi, Bakhtawar K.; Maitland-van der Zee, Anke H.; McPherson, Ruth; Melander, Olle; Metspalu, Andres; Pepinski, Witold; Olivieri, Oliviero; Opolski, Grzegorz; Palmer, Colin N.; Pasterkamp, Gerard; Pepine, Carl J.; Pereira, Alexandre C.; Note, Louise; Quyyumi, Arshed A.; Richards, A. Mark; Sanak, Marek; Scholz, Markus; Siegbahn, Agneta; Sinisalo, Juha; Smith, J. Gustav; Spertus, John A.; Stewart, Alexandre F. R.; Szczeklik, Wojciech; Szpakowicz, Anna; ten Berg, Jurrien M.; Thanassoulis, George; Thieiy, Joachim; van der Graaf, Yolanda; Visseren, Frank L. J.; Waltenberger, Johannes; Van der Harst, Pim; Tardif, Jean-Claude; Sattar, Naveed; Lang, Chim C.; Pare, Guillaume; Brophy, James M.; Anderson, Jeffrey L.; Maerz, Winfried; Wallentin, Lars; Cameron, Vicky A.; Horne, Benjamin D.; Samani, Nilesh J.; Hingorani, Aroon D.; Asselbergs, Folkert W. 分享 收藏
Subsequent Event Risk in Individuals With Established Coronary Heart Disease Design and Rationale of the GENIUS-CHD Consortium Patel, Riyaz S.; Tragante, Vinicius; Schmidt, Amand F.; McCubrey, Raymond O.; Holmes, Michael, V; Howe, Laurence J.; Direk, Kenan; Akerblom, Axel; Leander, Karin; Virani, Salim S.; Kaminski, Karol A.; Muehlschlegel, Jochen D.; Allayee, Hooman; Almgren, Peter; Alver, Maris; Baranova, Ekaterina, V; Behloui, Hassan; Boeckx, Bram; Braund, Peter S.; Breitling, Lutz P.; Delgado, Graciela; Duarte, Nubia E.; Dube, Marie-Pierre; Dufresne, Line; Eriksson, Niclas; Foco, Luisa; Scholz, Markus; Gijsberts, Crystel M.; Glinge, Charlotte; Gong, Yan; Hartiala, Jaana; Heydarpour, Mahyar; Hubacek, Jaroslav A.; Kleber, Marcus; Kofink, Daniel; Kotti, Salma; Kuukasjarvi, Pekka; Lee, Vei-Vei; Leiherer, Andreas; Lenzini, Petra A.; Levin, Daniel; Lyytikainen, Leo-Pekka; Martinelli, Nicola; Mons, Ute; Nelson, Christopher P.; Nikus, Kjell; Pilbrow, Anna P.; Ploski, Rafal; Sun, Yan, V; Tanck, Michael W. T.; Tang, W. H. Wilson; Trompet, Stella; van der Laan, Sander W.; Van Setten, Jessica; Vilmundarson, Ragnar O.; Anselmi, Chiara Viviani; Vlachopoulou, Efthymia; Al Ali, Lawien; Boerwinkle, Eric; Briguori, Carlo; Carlquist, John F.; Carruthers, Kathryn F.; Casu, Gavino; Deanfield, John; Deloukas, Panos; Dudbridge, Frank; Engstrom, Thomas; Fitzpatrick, Natalie; Fox, Kim; Gigante, Bruna; James, Stefan; Lokki, Marja-Liisa; Lotufo, Paulo A.; Marziliano, Nicola; Mordi, Ify R.; Muhlestein, Joseph B.; Newton-Cheh, Christopher; Pitha, Jan; Saely, Christoph H.; Samman-Tahhan, Ayman; Sandesara, Pratik B.; Teren, Andrej; Timmis, Adam; Van de Werf, Frans; Wauters, Els; Wilde, Arthur A. M.; Ford, Ian; Stott, David J.; Algra, Ale; Andreassi, Maria G.; Ardissino, Diego; Arsenault, Benoit J.; Ballantyne, Christie M.; Bergmeijer, Thomas O.; Bezzina, Connie R.; Body, Simon C.; Boersma, Eric H.; Bogaty, Peter; Bots, Michiel L.; Brenner, Hermann; Brugts, Jasper J.; Burkhardt, Ralph; Carpeggiani, Clara; Condorelli, Gianluigi; Cooper-DeHoff, Rhonda M.; Cresci, Sharon; Danchin, Nicolas; de Faire, Ulf; Doughty, Robert N.; Drexel, Heinz; Engert, James C.; Fox, Keith A. A.; Girelli, Domenico; Grobbee, Diederick E.; Hagstrom, Emil; Hazen, Stanley L.; Held, Claes; Hemingway, Harry; Hoefer, Imo E.; Hovingh, G. Kees; Jabbari, Reza; Johnson, Julie A.; Jukema, J. Wouter; Kaczor, Marcin P.; Kahonen, Mika; Kettner, Jiri; Kiliszek, Marek; Klungel, Olaf H.; Lagerqvist, Bo; Lambrechts, Diether; Laurikka, Jari O.; Lehtimaki, Terho; Lindholm, Daniel; Mahmoodi, B. K.; Maitland-van der Zee, Anke H.; McPherson, Ruth; Melander, Olle; Metspalu, Andres; Niemcunowicz-Janica, Anna; Olivieri, Oliviero; Opolski, Grzegorz; Palmer, Colin N.; Pasterkamp, Gerard; Pepine, Carl J.; Pereira, Alexandre C.; Pilote, Louise; Quyyumi, Arshed A.; Richards, A. Mark; Sanak, Marek; Siegbahn, Agneta; Simon, Tabassome; Sinisalo, Juha; Smith, J. Gustav; Spertus, John A.; Stender, Steen; Stewart, Alexandre F. R.; Szczeklik, Wojciech; Szpakowicz, Anna; Tardif, Jean-Claude; ten Berg, Jurrien M.; Tfelt-Hansen, Jacob; Thanassoulis, George; Thiery, Joachim; Torp-Pedersen, Christian; van der Graaf, Yolanda; Visseren, Frank L. J.; Waltenberger, Johannes; Weeke, Peter E.; Van der Harst, Pim; Lang, Chim C.; Sattar, Naveed; Cameron, Vicky A.; Anderson, Jeffrey L.; Brophy, James M.; Pare, Guillaume; Horne, Benjamin D.; Marz, Winfried; Wallentin, Lars; Samani, Nilesh J.; Hingorani, Aroon D.; Asselbergs, Folkert W. 分享 收藏
The exocyst acting through the primary cilium is necessary for renal ciliogenesis, cystogenesis, and tubulogenesis Zuo, Xiaofeng; Lobo, Glenn; Fulmer, Diana; Guo, Lilong; Dang, Yujing; Su, Yanhui; Ilatovskaya, Dada, V; Nihalani, Deepak; Rohrer, Barbel; Body, Simon C.; Norris, Russell A.; Lipschutz, Joshua H. 分享 收藏
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