未登录 Development of a Novel DNA Mono-alkylator Platform for Antibody-Drug Conjugates Thomas, Joshua D.; Yurkovetskiy, Aleksandr V.; Yin, Mao; Bodyak, Natalya D.; Tang, Shuyi; Protopopova, Marina; Kelleher, Eugene; Jones, Brian; Yang, Liping; Custar, Daniel; Catcott, Kalli C.; Demady, Damon R.; Collins, Scott D.; Xu, Ling; Bu, Charlie; Qin, Liuliang; Ter-Ovanesyan, Elena; Damelin, Marc; Toader, Dorin; Lowinger, Timothy B. 分享 收藏
Discovery and Optimization of a STING Agonist Platform for Application in Antibody Drug Conjugates Duvall, Jeremy R. R.; Thomas, Joshua D. D.; Bukhalid, Raghida A. A.; Catcott, Kalli C. C.; Bentley, Keith W. W.; Collins, Scott D. D.; Eitas, Timothy; Jones, Brian D. D.; Kelleher, Eugene W. W.; Lancaster, Kelly; Protopopova, Marina; Ray, Soumya S. S.; Ter-Ovanesyan, Elena; Xu, Ling; Yang, Liping; Zurita, Jeffrey; Damelin, Marc; Toader, Dorin; Lowinger, Timothy B. B. 分享 收藏
Dolaflexin: A Novel Antibody-Drug Conjugate Platform Featuring High Drug Loading and a Controlled Bystander Effect Yurkovetskiy, Aleksandr, V; Bodyak, Natalya D.; Yin, Mao; Thomas, Joshua D.; Clardy, Susan M.; Conlon, Patrick R.; Stevenson, Cheri A.; Uttard, Alex; Qin, LiuLiang; Gumerov, Dmitry R.; Ter-Ovanesyan, Elena; Bu, Charlie; Johnson, Alex J.; Gurijala, Venu R.; McGillicuddy, Dennis; DeVit, Michael J.; Poling, Laura L.; Protopopova, Marina; Xu, Ling; Zhang, Qingxiu; Park, Peter U.; Bergstrom, Donald A.; Lowinger, Timothy B. 分享 收藏
Systemic administration of STING agonist antibody-drug conjugates elicit potent anti-tumor immune responses with minimal induction of circulating cytokines Bukhalid, Raghida A.; Duvall, Jeremy R.; Cetinbas, Naniye Malli; Catcott, Kalli C.; Avocetien, Kenneth; Bentley, Keith W.; Bradley, Stephen; Carter, Tyler; Chin, Chen-Ni; Clardy, Susan; Collins, Scott D.; Eitas, Timothy; Jones, Brian D.; Kelleher, Eugene W.; Mosher, Rebecca; Nazzaro, Mark; Protopopova, Marina; Shaw, Pamela; Slocum, Kelly; Ter-Ovanesyan, Elena; Qin, LiuLiang; Thomas, Joshua D.; Xu, Ling; Yang, Liping; Zurita, Jeffrey; Toader, Dorin; Damelin, Marc; Lowinger, Timothy B. 分享 收藏
Moving toward Tuberculosis Elimination Critical Issues for Research in Diagnostics and Therapeutics for Tuberculosis Infection Keshavjee, Salmaan; Amanullah, Farhana; Cattamanchi, Adithya; Chaisson, Richard; Dobos, Karen M.; Fox, Gregory J.; Gendelman, Howard E.; Gordon, Richard; Hesseling, Anneke; Hoi Le Van; Kampmann, Beate; Kana, Bavesh; Khuller, Gopal; Lewinsohn, David M.; Lewinsohn, Deborah A.; Lin, Philiana Ling; Lu, Lenette Lin; Maartens, Gary; Owen, Andrew; Protopopova, Marina; Rengarajan, Jyothi; Rubin, Eric; Salgame, Padmini; Schurr, Erwin; Seddon, James A.; Swindells, Susan; Tobin, David M.; Udwadia, Zarir; Walzl, Gerhard; Srinivasan, Sudha; Rustomjee, Roxana; Nahid, Payam 分享 收藏
Unique pharmacologic properties of Dolaflexin-based ADCs-a controlled bystander effect Clardy, Susan M.; Yurkovetskiy, Alex; Yin, Mao; Gumerov, Dmitry; Xu, Ling; Ter-Ovanesyan, Elena; Bu, Charlie; Johnson, Alex; Protopopova, Marina; Zhang, Qingxiu; Bodyak, Natalya; Damelin, Marc; Lee, David H.; Bergstrom, Donald; Lowinger, Timothy B. 分享 收藏
Discovery and development of IACS-010759, a novel inhibitor of Complex I currently in phase I studies to exploit oxidative phosphorylation dependency in acute myeloid leukemia and solid tumors Di Francesco, Maria Emilia; Marszalek, Joseph R.; McAfoos, Timothy; Carroll, Christopher L.; Kang, Zhijun; Liu, Gang; Theroff, Jay P.; Bardenhager, Jennifer P.; Bandi, Madhavi L.; Molina, Jennifer R.; Gera, Sonal; Protopopova, Marina; Sun, Yuting; Do, Mary K. Geck; Feng, Ningping; Gay, Jason P.; Muller, Florian; Konopleva, Marina; Meric-Bernstam, Funda; Toniatti, Carlo; Heffernan, Timothy P.; Draetta, Giulio F.; Jones, Philip 分享 收藏
Collateral lethality: A new target for personalized oncology Lin, Yu-Hsi; Hammoudi, Naima; Satani, Nikunj; Ackroyd, Jeffrey; Khadka, Sunada; Georgiou, Dimitra; Marszalek, Joe; Sun, Yuting; Protopopova, Marina; Di Francesco, Maria E.; Czako, Barbara; Wang, Alan Y.; DePinho, Ronald A.; Muller, Florian L. 分享 收藏
An inhibitor of oxidative phosphorylation exploits cancer vulnerability Molina, Jennifer R.; Sun, Yuting; Protopopova, Marina; Gera, Sonal; Bandi, Madhavi; Bristow, Christopher; McAfoos, Timothy; Morlacchi, Pietro; Ackroyd, Jeffrey; Agip, Ahmed-Noor A.; Al-Atrash, Gheath; Asara, John; Bardenhagen, Jennifer; Carrillo, Caroline C.; Carroll, Christopher; Chang, Edward; Ciurea, Stefan; Cross, Jason B.; Czako, Barbara; Deem, Angela; Daver, Naval; de Groot, John Frederick; Dong, Jian-Wen; Feng, Ningping; Gao, Guang; Gay, Jason; Do, Mary Geck; Greer, Jennifer; Giuliani, Virginia; Han, Jing; Han, Lina; Henry, Verlene K.; Hirst, Judy; Huang, Sha; Jiang, Yongying; Kang, Zhijun; Khor, Tin; Konoplev, Sergej; Lin, Yu-Hsi; Liu, Gang; Lodi, Alessia; Lofton, Timothy; Ma, Helen; Mahendra, Mikhila; Matre, Polina; Mullinax, Robert; Peoples, Michael; Petrocchi, Alessia; Rodriguez-Canale, Jaime; Serreli, Riccardo; Shi, Thomas; Smith, Melinda; Tabe, Yoko; Theroff, Jay; Tiziani, Stefano; Xu, Quanyun; Zhang, Qi; Muller, Florian; DePinho, Ronald A.; Toniatti, Carlo; Draetta, Giulio F.; Heffernan, Timothy P.; Konopleva, Marina; Jones, Philip; Di Francesco, M. Emilia; Marszalek, Joseph R. 分享 收藏
IACS-010759, a novel inhibitor of complex I in Phase I clinical development to target OXPHOS dependent tumors Molina, Jennifer; Bandi, Madhavi; Bardenhagen, Jennifer; Bristow, Christopher; Carroll, Christopher; Chang, Edward; Cross, Jason; Daver, Naval; Feng, Ningping; Gay, Jason; Do, Mary Geck; Greer, Jennifer; Han, Jing; Hirst, Judy; Huang, Sha; Jiang, Yongying; Kang, Zhijun; Konopleva, Marina; Liu, Gang; Ma, Helen; Matre, Polina; McAfoos, Timothy; Meric-Bernstam, Funda; Morlacchi, Pietro; Muller, Florian; Protopopova, Marina; Smith, Melinda; Sonal, Sonal; Sun, Yuting; Theroff, Jay; Viale, Andrea; Xu, Quanyun; Toniatti, Carlo; Draetta, Giulio; Jones, Philip; Di Francesco, M. Emilia; Marszalek, Joseph R. 分享 收藏
Combination of anti-HER2 ADC XMT-1522 and checkpoint inhibitor pembrolizumab for treatment of NSCLC in preclinical models Bodyak, Natalya; Protopopova, Marina; Zhang, Qingxiu; Yurkovetskiy, Alex; Yin, Mao; Qin, LiuLiang; Poling, Laura L.; Mosher, Rebecca; Bergstrom, Donald A.; Lowinger, Timothy B. 分享 收藏
Title: IACS-010759 is a novel clinical candidate that targets AML cells by inducing a metabolic catastrophe through inhibition of oxidative phosphorylation Molina, Jennifer R.; Protopopova, Marina; Bandi, Madhavi; Bardenhagen, Jennifer; Bristow, Christopher; Carroll, Christopher; Chang, Edward; Feng, Ningping; Gay, Jason; Do, Mary Geck; Greer, Jennifer; Huang, Sha; Jiang, Yongying; Konopleva, Marina; Matre, Polina; Han, Jing; Kang, Zhijun; Liu, Gang; McAfoos, Timothy; Morlacchi, Pietro; Smith, Melinda; Gera, Sonal; Theroff, Jay; Xu, Quanyun; Velez, Juliana; Toniatti, Carlo; Heffernan, Timothy; Draetta, Giulio; Di Francesco, M. Emilia; Jones, Philip; Marszalek, Joseph R. 分享 收藏
Passenger deletion of ENO1 as a collateral lethality target in cancer Lin, Yu-Hsi; Satani, Nikunj; Hammoudi, Naima; Marszalek, Joe; Sun, Yuting; Protopopova, Marina; Di Francesco, Maria E.; Czako, Barbara; Wang, Alan; DePinho, Ronald A.; Muller, Florian L. 分享 收藏
Treatment of Clostridium difficile infection using SQ641, a capuramycin analogue, increases post-treatment survival and improves clinical measures of disease in a murine model Moore, John H., II; van Opstal, Edward; Kolling, Glynis L.; Shin, Jae Hyun; Bogatcheva, Elena; Nikonenko, Boris; Einck, Leo; Phipps, Andrew J.; Guerrant, Richard L.; Protopopova, Marina; Warren, Cirle Alcantara 分享 收藏
IACS-10759: A novel OXPHOS inhibitor that selectively kills tumors with metabolic vulnerabilities Protopopova, Marina; Bandi, Madhavi; Sun, Yuting; Bardenhagen, Jennifer; Bristow, Christopher; Carroll, Christopher; Chang, Edward; Feng, Ningping; Gay, Jason; Do, Mary Geck; Greer, Jennifer; Konopleva, Marina; Matre, Polina; Kang, Zhijun; Liu, Gang; Muller, Florian; Lofton, Timothy; McAfoos, Timothy; Smith, Melinda; Theroff, Jay; Han, Jing; Wu, Yuanqing; Chin, Lynda; Draetta, Giulio; Jones, Philip; Toniatti, Carlo; Di Francesco, M. Emilia; Marszalek, Joseph R. 分享 收藏
Relapsed/refractory AML responds robustly to IACS-10759, a novel OXPHOS inhibitor Protopopova, Marina; Bandi, Madhavi; Bardenhagen, Jennifer; Bristow, Christophor; Carroll, Christopher; Chang, Edward; Feng, Ningping; Gay, Jason; Do, Mary Geck; Greer, Jennifer; Konopleva, Marina; Matre, Polina; Kang, Zhijun; Liu, Gang; Muller, Florian; Lofton, Timothy; McAfoos, Timothy; Theroff, Jay; Sun, Yuting; Wu, Yuanqiang; Smith, Melinda; Chin, Lynda; Draetta, Giulio; Jones, Philip; Toniatti, Carlo; Di Francesco, M. Emilia; Marszalek, Joseph R. 分享 收藏
IACS-10759: A novel OXPHOS inhibitor which selectively kill tumors with metabolic vulnerabilities Protopopova, Marina; Bandi, Madhavi; Bardenhagen, Jennifer; Bristow, Christopher; Carroll, Christopher; Chang, Edward; Feng, Ningping; Gay, Jason; Do, Mary Geck; Greer, Jennifer; Konopleva, Marina; Matre, Polina; Kang, Zhijun; Liu, Gang; Muller, Florian; Lofton, Timothy; McAfoos, Timothy; Sun, Yuting; Smith, Melinda; Theroff, Jay; Wu, Yuanqiang; Chin, Lynda; Draetta, Giulio; Jones, Philip; Toniatti, Carlo; Di Francesco, M. Emilia; Marszalek, Joseph R. 分享 收藏
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Novel peptidic CXCR4 antagonist LY2510924 disrupts the SDF-1α/CXCR4 axis resulting in anti-AML efficacy in vivo Cho, Byung Sik; Zeng, Zhihong; Mu, Hong; McQueen, Teresa; Protopopova, Marina; Cortes, Jorge; Marszalek, Joe; Peng, Sheng-Bin; Thornton, Donald E.; Andreeff, Michael; Konopleva, Marina 分享 收藏
Identification of OXPHOS inhibitors which selectively kill tumors with specific metabolic vulnerabilities Marszalek, Joseph R.; Bandi, Madhavi; Bardenhagen, Jennifer; Bristow, Christopher; Carroll, Christopher; Chang, Edward; Feng, Ninping; Czako, Barbara; Gay, Jason; Do, Mary Geck; Greer, Jennifer; Johnson, Ryan M.; Konopleva, Marina; Kang, Zhijun; Liu, Gang; Lofton, Timothy; McAfoos, Timothy; Protopopova, Marina; Petrocchi, Alessia; Muller, Florian; Theroff, Jay; Wu, Yuanqing; Chin, Lynda; Draetta, Giulio; Jones, Philip; Toniatti, Carlo; Di Francesco, Emilia 分享 收藏
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