未登录 Model-informed dose optimization of HFB200301, a TNFR2 agonist monoclonal antibody (mAb), in monotherapy and in combination with the anti-PD-1 mAb tislelizumab (TIS), in patients (pts) with advanced solid tumors 基于模型的剂量优化：针对HFB200301（一种TNFR2激动剂单克隆抗体（mAb））的单药治疗及其与抗PD-1单克隆抗体tislelizumab（TIS）联合治疗，在晚期实体瘤患者（pts）中的应用 Perez, D. Roda; Zugazagoitia, J.; Garralda, E.; Spira, A. I.; El-Khoueiry, A. B.; Zhao, Y.; Oppelt, P.; Lin, X.; Xie, S.; Chen, M.; Gan, J.; Wong, G.; Pollard, J. Russella; Hedrich, W.; Pallante, J.; Adrian, F.; Schweizer, L.; Shi, X.; Andtbacka, R. H. I. 分享 收藏
Phase I dose escalation study of HFB200603, a best-in-class BTLA antagonist monoclonal antibody (mAb), in monotherapy and in combination with the anti-PD-1 mAb tislelizumab (TIS) in adult patients (pts) with advanced solid tumors HFB200603的I期剂量递增研究，HFB200603是一种同类最佳BTLA拮抗剂单克隆抗体（mAb），用于单药治疗以及与抗PD-1单克隆抗体tislelizumab（TIS）联合治疗成人晚期实体瘤患者（pts）。 De Miguel, M.; Landa Magdalena, A.; Moreno Garcia, V.; Gambardella, V.; Menis, J.; Daniele, G.; El-Khoueiry, A. B.; Spira, A. I.; Gravina, A.; Olszanski, A. J.; Rapaic, O.; Li, J.; Poullain, H.; Margall, G.; Wong, G.; Hedrich, W.; Pollard, J. Russella; Gan, J.; Shi, X.; Andtbacka, R. H. I. 分享 收藏
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Integrating public single-cell transcriptomics and patient profiles to guide clinical development Russella-Pollard, Jack; Whitener, Joshua; Byck, Jordan; Manne, Monika; Alostaz, Hani; Elia, Marianna; Krukowski, Kamil; Wong, Gabrielle; Adrian, Francisco; Schweizer, Liang; Andtbacka, Robert H.; Hatzis, Christos 分享 收藏
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Intratumoral oncolytic virus V937 plus ipilimumab in patients with advanced melanoma: the phase 1b MITCI study 肿瘤内溶瘤病毒V937联合ipilimumab治疗晚期黑色素瘤: MITCI 1b期研究 Curti, Brendan D.; Richards, Jon; Hyngstrom, John R.; Daniels, Gregory A.; Faries, Mark; Feun, Lynn; Margolin, Kim A.; Hallmeyer, Sigrun; Grose, Mark; Zhang, Yiwei; Li, Anlong; Andtbacka, Robert H., I 分享 收藏
Current strategies for intratumoural immunotherapy-Beyond immune checkpoint inhibition 肿瘤内免疫治疗的当前策略-超越免疫检查点抑制 Yuan, Jianda; Khilnani, Anuradha; Brody, Joshua; Andtbacka, Robert H., I; Hu-Lieskovan, Siwen; Luke, Jason J.; Diab, Adi; Marabelle, Aurelien; Snyder, Alexandra; Cao, Z. Alexander; Hodi, F. Stephen 分享 收藏
Tilsotolimod with Ipilimumab Drives Tumor Responses in Anti-PD-1 Refractory Melanoma Haymaker, Cara; Johnson, Daniel H.; Murthy, Ravi; Bentebibel, Salah-Eddine; Uemura, Marc, I; Hudgens, Courtney W.; Safa, Houssein; James, Marihella; Andtbacka, Robert H., I; Johnson, Douglas B.; Shaheen, Montaser; Davies, Michael A.; Rahimian, Shah; Chunduru, Srinivas K.; Milton, Denai R.; Tetzlaff, Michael T.; Overwijk, Willem W.; Hwu, Patrick; Gabrail, Nashat; Agrawal, Sudhir; Doolittle, Gary; Puzanov, Igor; Markowitz, Joseph; Bernatchez, Chantale; Diab, Adi 分享 收藏
A Phase IIb Randomized Controlled Trial of the TLPLDC Vaccine as Adjuvant Therapy After Surgical Resection of Stage III/IV Melanoma: A Primary Analysis Vreeland, Timothy J.; Clifton, Guy T.; Hale, Diane F.; Chick, Robert C.; Hickerson, Annelies T.; Cindass, Jessica L.; Adams, Alexandra M.; Bohan, Phillip M. Kemp; Andtbacka, Robert H. I.; Berger, Adam C.; Jakub, James W.; Sussman, Jeffrey J.; Terando, Alicia M.; Wagner, Thomas; Peoples, George E.; Faries, Mark B. 分享 收藏
Final results from ILLUMINATE-204, a phase I/II trial of intratumoral tilsotolimod in combination with ipilimumab in PD-1 inhibitor refractory advanced melanoma Haymaker, C.; Andtbacka, R. H. I.; Johnson, D. B.; Shaheen, M. F.; Rahimian, S.; Chunduru, S.; Gabrail, N.; Doolittle, G.; Puzanov, I.; Markowitz, J.; Bernatchez, C.; Diab, A. 分享 收藏
Biodistribution, shedding, and transmissibility of the oncolytic virus talimogene laherparepvec in patients with melanoma Andtbacka, Robert H. I.; Amatruda, Thomas; Nemunaitis, John; Zager, Jonathan S.; Walker, John; Chesney, Jason A.; Liu, Kate; Hsu, Cheng-Pang; Pickett, Cheryl A.; Mehnert, Janice M. 分享 收藏
Preoperative Ultrasound Assessment of Regional Lymph Nodes in Melanoma Patients Does not Provide Reliable Nodal Staging Results From a Large Multicenter Trial Thompson, John F.; Haydu, Lauren E.; Uren, Roger F.; Andtbacka, Robert H.; Zager, Jonathan S.; Beitsch, Peter D.; Agnese, Doreen M.; Mozzillo, Nicola; Testori, Alessandro; Bowles, Tawnya L.; Hoekstra, Harald J.; Kelley, Mark C.; Sussman, Jeffrey; Schneebaum, Schlomo; Smithers, B. Mark; McKinnon, Gregory; Hsueh, Eddy; Jacobs, Lisa; Schultz, Erwin; Reintgen, Douglas; Kane, John M.; Friedman, Erica B.; Wang, Hejing; Van Kreuningen, Lisa; Schiller, Vicki; Elashoff, David A.; Elashoff, Robert; Cochran, Alistair J.; Stern, Stacey; Faries, Mark B. 分享 收藏
Similar survival of patients with multiple versus single primary melanomas based on Utah Surveillance, Epidemiology, and End Results data (1973-2011) Grossman, Douglas; Farnham, James M.; Hyngstrom, John; Klapperich, Marki E.; Secrest, Aaron M.; Empey, Sarah; Bowen, Glen M.; Wada, David; Andtbacka, Robert H. I.; Grossmann, Kenneth; Bowles, Tawnya L.; Cannon-Albright, Lisa A. 分享 收藏
X4P-001, an orally bioavailable CXCR4 antagonist, enhances immune cell infiltration and activation in the tumor microenvironment of melanoma Andtbacka, Robert H.; Pierce, Robert H.; Campbell, Jean S.; Yushak, Melinda; Milhem, Mohammed; Ross, Merrick; Grossmann, Kenneth; Sprott, Kam; Tsiroyanni, Eleni; Niland, Katie; Gan, Lu; Parasuraman, Sudha; Wang, Yan 分享 收藏
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Completion Dissection or Observation for Sentinel-Node Metastasis in Melanoma 黑色素瘤前哨淋巴结转移的完整解剖或观察 Faries, M. B.; Thompson, J. F.; Cochran, A. J.; Andtbacka, R. H.; Mozzillo, N.; Zager, J. S.; Jahkola, T.; Bowles, T. L.; Testori, A.; Beitsch, P. D.; Hoekstra, H. J.; Moncrieff, M.; Ingvar, C.; Wouters, M. W. J. M.; Sabel, M. S.; Levine, E. A.; Agnese, D.; Henderson, M.; Dummer, R.; Rossi, C. R.; Neves, R. I.; Trocha, S. D.; Wright, F.; Byrd, D. R.; Matter, M.; Hsueh, E.; MacKenzie-Ross, A.; Johnson, D. B.; Terheyden, P.; Berger, A. C.; Huston, T. L.; Wayne, J. D.; Smithers, B. M.; Neuman, H. B.; Schneebaum, S.; Gershenwald, J. E.; Ariyan, C. E.; Desai, D. C.; Jacobs, L.; McMasters, K. M.; Gesierich, A.; Hersey, P.; Bines, S. D.; Kane, J. M.; Barth, R. J.; McKinnon, G.; Farma, J. M.; Schultz, E.; Vidal-Sicart, S.; Hoefer, R. A.; Lewis, J. M.; Scheri, R.; Kelley, M. C.; Nieweg, O. E.; Noyes, R. D.; Hoon, D. S. B.; Wang, H. -J.; Elashoff, D. A.; Elashoff, R. M. 分享 收藏
The Impact of Smoking on Sentinel Node Metastasis of Primary Cutaneous Melanoma 吸烟对原发性皮肤黑色素瘤前哨淋巴结转移的影响 Jones, Maris S.; Jones, Peter C.; Stern, Stacey L.; Elashoff, David; Hoon, Dave S. B.; Thompson, John; Mozzillo, Nicola; Nieweg, Omgo E.; Noyes, Dirk; Hoekstra, Harald J.; Zager, Jonathan S.; Roses, Daniel F.; Testori, Alessandro; Coventry, Brendon J.; Smithers, Mark B.; Andtbacka, Robert; Agnese, Doreen; Schultz, Erwin; Hsueh, Eddy C.; Kelley, Mark; Schneebaum, Schlomo; Jacobs, Lisa; Bowles, Tawnya; Kashani-Sabet, Mohammed; Johnson, Douglas; Faries, Mark B. 分享 收藏
Tumor response from phase II study of combination treatment with intratumoral HF10, a replicationcompetent HSV-1 oncolytic virus, and ipilimumab in patients with stage IIIB, IIIC, or IV unresectable or metastatic melanoma Andtbacka, R.; Ross, M.; Agarwala, S. S.; Taylor, M.; Vetto, J.; Neves, R. I.; Daud, A.; Khong, H.; Ungerleider, R. S.; Welden, S.; Tanaka, M.; Grossmann, K. 分享 收藏
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