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Cyclin E1/CDK2 activation defines a key vulnerability to WEE1 kinase inhibition in gynecological cancers Cyclin E1/CDK2的激活定义了妇科癌症中WEE1激酶抑制的关键易损性。 Kim, Daehwan; Chung, Heekyung; Liu, Wen; Jeong, Kangjin; Ozmen, Tugba Y.; Ozmen, Furkan; Rames, Matthew J.; Kim, Sangyub; Guo, Xiao; Jameson, Nathan; de Jong, Petrus R.; Yea, Steven; Harford, Laurie; Li, Jiali; Mathews, Cara A.; Doroshow, Deborah B.; Charles, Vincent J.; Kim, Doris; Fischer, Kimberlee; Samatar, Ahmed A.; Jubb, Adrian; Bunker, Kevin D.; Blackwell, Kimberly; Simpkins, Fiona; Meric-Bernstam, Funda; Mills, Gordon B.; Harismendy, Olivier; Ma, Jianhui; Lackner, Mark R. 分享 收藏
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A genome-wide CRISPR screen reveals that antagonism of glutamine metabolism sensitizes head and neck squamous cell carcinoma to ferroptotic cell death Allevato, Michael M.; Trinh, Sally; Koshizuka, Keiichi; Nachmanson, Daniela; Nguyen, Thien-Tu C.; Yokoyama, Yumi; Wu, Xingyu; Andres, Allen; Wang, Zhiyong; Watrous, Jeramie; Molinolo, Alfredo A.; Mali, Prashant; Harismendy, Olivier; Jain, Mohit; Wild, Robert; Gutkind, J. Silvio 分享 收藏
The selective WEE1 inhibitor azenosertib shows synergistic anti-tumor activity with KRASG12C inhibitors in multiple KRASG12C models Jameson, Nathan M.; Kim, Gabriel; Lee, Catherine; Skrable, Blake; Shea, Alexandra; Abed, Monah; Harismendy, Olivier; Ma, Jianhui; Kim, Doris; Lackner, Mark R. 分享 收藏
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Complex regulatory networks influence pluripotent cell state transitions in human iPSCs Arthur, Timothy D.; Nguyen, Jennifer P.; D'Antonio-Chronowska, Agnieszka; Matsui, Hiroko; Silva, Nayara S.; Joshua, Isaac N.; Aguiar, Lana Ribeiro; Arias, Angelo D.; Benaglio, Paola; Berggren, W. Travis; Belmonte, Juan Carlos Izpisua; Borja, Victor; Cook, Megan; Deboever, Christopher; Diffenderfer, Kenneth E.; Donovan, Margaret K. R.; Farnam, Kathyjean; Fujita, Kyohei; Garcia, Melvin; Henson, Benjamin A.; Harismendy, Olivier; Jakubosky, David; Jepsen, Kristen; Li, He; Nariai, Naoki; O'Connor, Daniel T.; Okubo, Jonathan; Panopoulos, Athanasia D.; Rao, Fengwen; Reyna, Joaquin; Salgado, Bianca M.; Smith, Erin N.; Sohmer, Josh; Yost, Shawn; Luchessi, Andre D.; Greenwald, William W. Young; D'Antonio, Matteo; Pera, Martin F.; Frazer, Kelly A. 分享 收藏
Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response Pagadala, Meghana; Sears, Timothy J.; Wu, Victoria H.; Perez-Guijarro, Eva; Kim, Hyo; Castro, Andrea; Talwar, James V.; Gonzalez-Colin, Cristian; Cao, Steven; Schmiedel, Benjamin J.; Goudarzi, Shervin; Kirani, Divya; Au, Jessica; Zhang, Tongwu; Landi, Teresa; Salem, Rany M.; Morris, Gerald P.; Harismendy, Olivier; Patel, Sandip Pravin; Alexandrov, Ludmil B.; Mesirov, Jill P.; Zanetti, Maurizio; Day, Chi-Ping; Fan, Chun Chieh; Thompson, Wesley K.; Merlino, Glenn; Gutkind, J. Silvio; Vijayanand, Pandurangan; Carter, Hannah 分享 收藏
Cyclin E1 protein overexpression sensitizes ovarian cancer cells to ZN-c3, a novel, selective and oral bioavailable inhibitor of Wee1 Ma, Jianhui; Liu, Wen; Chung, Heekyung; Izadi, Hooman; DeJong, Petrus; Harismendy, Olivier; Li, Jia; Donate, Fernando; Samatar, Ahmed; Lackner, Mark; Escoubet, Laure; Bunker, Kevin; Kim, Daehwan; Jameson, Nathan; Ozmen, Tugba Yildiran; Jeong, Kangjin; Zhang, Dong; Pan, Wen-An; Mills, Gordon 分享 收藏
Maf1 is involved in coupling carbon metabolism to RNA polymerase III transcription Ciesla, Malgorzata; Towpik, Joanna; Graczyk, Damian; Oficjalska-Pham, Danuta; Harismendy, Olivier; Suleau, Audrey; Balicki, Karol; Conesa, Christine; Lefebvre, Olivier; Boguta, Magdalena 分享 收藏
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Accurate genome-wide genotyping from archival tissue to explore the contribution of common genetic variants to pre-cancer outcomes Nachmanson, Daniela; Pagadala, Meghana; Steward, Joseph; Cheung, Callie; Bruce, Lauryn Keeler; Lee, Nicole Q.; O'Keefe, Thomas J.; Lin, Grace Y.; Hasteh, Farnaz; Morris, Gerald P.; Carter, Hannah; Harismendy, Olivier 分享 收藏
ASO Visual Abstract: Co-localization of Gastrointestinal Stromal Tumors (GIST) and Peritoneal Mesothelioma: A Case Series Courelli, Asimina S.; Sharma, Ashwyn K.; Madlensky, Lisa; Choi, Yoon Young; Li, Sam; Sarno, Shirley; Kelly, Kaitlyn; Mehtsun, Winta; Horgan, Santiago; Harismendy, Olivier; Baumgartner, Joel M.; Sicklick, Jason K. 分享 收藏
Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment 肿瘤微环境中基质重塑调节树突状细胞的丰度和活性 Papadas, Athanasios; Deb, Gauri; Cicala, Alexander; Officer, Adam; Hope, Chelsea; Pagenkopf, Adam; Flietner, Evan; Morrow, Zachary T.; Emmerich, Philip; Wiesner, Joshua; Arauz, Garrett; Bansal, Varun; Esbona, Karla; Capitini, Christian M.; Matkowskyj, Kristina A.; Deming, Dustin A.; Politi, Katerina; Abrams, Scott I.; Harismendy, Olivier; Asimakopoulos, Fotis 分享 收藏
Co-Localization of Gastrointestinal Stromal Tumors (GIST) and Peritoneal Mesothelioma: A Case Series Courelli, Asimina S.; Sharma, Ashwyn K.; Madlensky, Lisa; Choi, Yoon Young; Li, Sam; Sarno, Shirley; Kelly, Kaitlyn; Mehtsun, Winta; Horgan, Santiago; Harismendy, Olivier; Baumgartner, Joel M.; Sicklick, Jason K. 分享 收藏
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A gene expression meta-analysis identifies microenvironment differences in cellular composition and cell-cell interactions associated with breast cancer invasion Officer, Adam; Dempsey, Andre; Hasteh, Farnaz; Slyper, Michal; Segerstolpe, Asa; Klughammer, Joanna; Jane-Valbuena, Judit; Rozenblatt-Rosen, Orit; Murrow, Lyndsay; Gartner, Zev; Regev, Aviv; Yau, Christina; Tamayo, Pablo; Harismendy, Olivier 分享 收藏
The tumor immune microenvironment and HER2 landscape of high-risk ductal carcinoma in situ: The DEFENSE study Glencer, Alexa; Borowsky, Alexander; Mori, Hidetoshi; Campbell, Michael; Harismendy, Olivier; Stein, Janet; Ghule, Prachi; Evans, Mark; West, Robert; Hirst, Gillian; Schindler, Nicole; Miller, Phoebe; Lee, Kyra; Weaver, Donald; Esserman, Laura 分享 收藏
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