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Editorial: Risankizumab in Refractory Crohn's Disease—From Real-World Effectiveness to Strategic Positioning and Early Monitoring 编辑述评： risankizumab 在难治性克罗恩病中的应用——从真实世界疗效到战略定位和早期监测

ALIMENTARY PHARMACOLOGY & THERAPEUTICS

IF6.7

2026-07-30

OAAI

Kenneth Ernest-Suárez; Frank Hoentjen

Studying vanishing dietary diversity before it is lost: the World Diet Initiative 研究消失前的饮食多样性：世界饮食计划

Nature Medicine

IF50

2026-07-15

PREAI

Quirijn de Mast; Carly V. Brown; Felistar Mwakasungura; Damalie Nakanjako; Godfrey S. Temba; Vinod Kumar; Adriyan Pramono; Tania O. Crișan; Anca Riza; Marien I. de Jonge; Natascha Wagner; Frank Hoentjen; Adaliene Versiani M. Ferreira; Anirban Chakraborty; Mauro Teixeira; Abebaw Fekadu; Ramnik J. Xavier; Bruno Sunguya; Mihai G. Netea

Increased failure of budesonide MMX for ulcerative colitis during the COVID-19 pandemic: a population-based study 溃疡性结肠炎患者布地奈德MMX在COVID-19疫情期间疗效下降：一项基于人群的研究

Therapeutic Advances in Gastroenterology

IF3.4

2026-03-30

OAAI

Stephanie Coward; Karen J. B. Martins; Scott Klarenbach; Lawrence P. Richer; Christopher Ma; Remo Panaccione; Cynthia H. Seow; Karen Kroeker; Frank Hoentjen; Laura E. Targownik; Gilaad G. Kaplan

Effectiveness and Safety of Advanced Combination Treatment in Patients With Refractory Inflammatory Bowel Disease or Concomitant Immune-Mediated Disease or Extraintestinal Manifestations: A Multicenter Canadian Study 难治性炎症性肠病或合并免疫介导性疾病或肠外表现的患者的先进联合治疗的有效性和安全性：一项多中心加拿大研究

American Journal of Gastroenterology

IF7.6

2026-02-01

PREAI

Solitano, Virginia; Ogunsakin, Ropo Ebenezer; Yuan, Yuhong; Bernstein, Charles N.; Bessissow, Talat; Bressler, Brian; Hoentjen, Frank; Van Lierop, Lisa; Leung, Yvette; Ma, Christopher; Marshall, John Kenneth; Narula, Neeraj; Alahmari, Mohammed; Mccurdy, Jeffrey D.; Murthy, Sanjay; Panaccione, Remo; Rosenfeld, Greg; Milgrom, Raquel; Silverberg, Mark; Jairath, Vipul

The Impact of Proactive Fecal Calprotectin Collection in an Outreach Protocol for Biologic-Naïve Ulcerative Colitis Patients–Ulcerative Colitis Clinical Outreach (UCCO)主动粪便钙卫蛋白收集对生物制剂初治溃疡性结肠炎患者外展方案的影响——溃疡性结肠炎临床外展（UCCO）

Diseases 2026, Vol. 14, Page 2

IF3

2025-12-22

OAAI

Scott MacKay; Denise Parsons; Candace Hagerman; Ellina Lytvyak; Levinus Dieleman; Frank Hoentjen; Karen Kroeker; Farhad Peerani; Karen Wong; Michal Gozdzik; Kunihiko Oguro; Todd McMullen; Brendan Halloran

Editorial: High-Grade Dysplasia in Colonic Inflammatory Bowel Disease Is Associated With a High Risk of Synchronous or Metachronous Colorectal Cancer—Authors' Reply 编辑评论：结肠炎性肠病中的高级别异型增生与同步或异时性结直肠癌的高风险相关——作者回复

Alimentary Pharmacology & Therapeutics

IF6.7

2025-11-24

OAAI

Monica E. W. Derks; Frank Hoentjen

Incidental Inflammatory Bowel Disease: Is Surveillance and Treatment Needed?偶发性炎症性肠病：是否需要监测和治疗？

Digestive Diseases and Sciences

IF2.5

2025-11-05

PREAI

Lisa M. A. van Lierop; Frank Hoentjen

Higher Vedolizumab Clearance Associates with Poor Therapeutic Outcomes during Intravenous Vedolizumab Maintenance Therapy in Crohn's Disease 高Vedolizumab清除率与静脉Vedolizumab维持治疗期间克罗恩病的不良治疗效果相关

INFLAMMATORY BOWEL DISEASES

IF4.3

2025-11-01

PREAI

Anjie, Suzanne, I; D'Haens, Geert R.; Baert, Filip; Bossuyt, Peter; Hoentjen, Frank; Clasquin, Esme; Molnar, Tamas; Lowenberg, Mark; Vermeire, Severine; Panetta, J. Carl; Dervieux, Thierry

Comparing the accuracy of computed tomography enterography to balloon-assisted enteroscopy in the evaluation of small bowel Crohn's disease 比较计算机断层扫描小肠成像与气囊辅助小肠镜在评估小肠克罗恩病中的准确性

JOURNAL OF THE CANADIAN ASSOCIATION OF GASTROENTEROLOGY

IF2.7

2025-11-01

OAAI

Cooper, Jared; MacKay, Scott; Reeson, Matthew; Dieleman, Levinus A.; Oguro, Kunihiko; Dang, Thuc Nhi; Kroeker, Karen, I; Wasilenko, Shawn; Gozdzik, Michal; Baumgart, Daniel C.; Hoentjen, Frank; Wong, Karen; Peerani, Farhad; Wiebe, Edward; Zepeda-Gomez, Sergio; Halloran, Brendan

Vedolizumab in early and late Crohn's disease (LOVE-CD): a phase 4 open-label cohort study Vedolizumab在早期和晚期克罗恩病中的疗效（LOVE-CD）：一项第4期开放标签队列研究

The Lancet Gastroenterology & Hepatology

IF38.6

2025-10-27

PREAI

Geert R D'Haens; Mark Löwenberg; Filip Baert; Peter Bossuyt; Tamás Molnár; Frank Hoentjen; Esmé Clasquin; Krisztina B Gecse; Melanie S Hulshoff; Gert De Hertogh; Matthias Lenfant; Lotte Oldenburg; Séverine Vermeire

High Risk of Colorectal Cancer After High-Grade Dysplasia in Inflammatory Bowel Disease Patients 炎症性肠病患者在高级别上皮内瘤变后患结直肠癌的高风险

Alimentary Pharmacology & Therapeutics

IF6.7

2025-10-24

OAAI

Monica E. W. Derks; Maarten te Groen; Lauranne A. A. P. Derikx; Iris D. Nagtegaal; Frank Hoentjen

Long-term outcomes of increased versus conventional adalimumab dose interval for patients with Crohn’s disease in stable remission: 3-year follow-up of the randomized controlled LADI trial 克罗恩病患者稳定缓解期增加与常规adalimumab剂量间隔的长期结局：随机对照LADI试验3年随访结果

Gastroenterology

IF25.1

2025-09-19

OAAI

Lisa M.A. van Lierop; Monique J.C. Devillers; C.Janneke van der Woude; Frank Hoentjen; Annemarie C. de Vries

Diagnostic Accuracy of Noninvasive Biomarkers and Imaging for Evaluating Postoperative Recurrence in Crohn’s Disease 非侵入性生物标志物和影像学在评估克罗恩病术后复发中的诊断准确性

Clinical Gastroenterology and Hepatology

IF12

2025-06-02

OAAI

Sunil Samnani; Christina M. Ray; Priyanka Gill; Levi Stein; Katherine A. Buhler; Rupert W. Leong; Rebecca L. Smith; Peter De Cruz; Gilaad G. Kaplan; Cynthia H. Seow; Cathy Lu; Leonardo Guizzetti; Frank Hoentjen; John K. Marshall; Siddharth Singh; Remo Panaccione; Kerri L. Novak; Christopher Ma

Network analysis of extraintestinal manifestations and associated autoimmune disorders in Crohn's disease and ulcerative colitis 克罗恩病和溃疡性结肠炎中肠外表现及关联自身免疫性疾病的网络分析

NPJ DIGITAL MEDICINE

IF15.1

2025-04-15

OAAI

Baumgart, Daniel C.; Cheng, C. Hing; Du, Tian X.; Parkes, Michael D.; Sadowski, Daniel C.; Wine, Eytan; Hoentjen, Frank; Halloran, Brendan P.; Montano-Loza, Aldo; Zepeda-Gomez, Sergio; Wong, Karen; Peerani, Farhad; Goebel, Randolph; Mitchell, J. Ross

Treat-to-target of endoscopic remission in patients with inflammatory bowel disease in symptomatic remission on advanced therapies (QUOTIENT): rationale, design and protocol for an open-label, multicentre, pragmatic, randomised controlled trial 治疗目标为内镜缓解：针对在接受先进疗法并处于症状缓解状态的炎症性肠病患者进行的内镜缓解研究（QUOTIENT）：一项开放标签、多中心、务实性、随机对照试验的原理、设计与方案

BMJ OPEN GASTROENTEROLOGY

IF2.9

2025-03-31

OAAI

Singh, Siddharth; Nguyen, Jasmine D.; Fudman, David, I; Gerich, Mark E.; Shah, Samir A.; Hudesman, David; Mcconnell, Ryan A.; Lukin, Dana J.; Flynn, Ann D.; Hwang, Caroline; Sprung, Brandon; Gaidos, Jill K. J.; Mattar, Mark C.; Rubin, David T.; Hashash, Jana G.; Metwally, Mark; Ali, Tauseef; Ma, Christopher; Hoentjen, Frank; Narula, Neeraj; Bessissow, Talat; Rosenfeld, Greg; Mccurdy, Jeffrey D.; Ananthakrishnan, Ashwin N.; Cross, Raymond K.; Rodriguez Gaytan, Jorge R.; Gurrola, Emily-Sophinie; Patel, Sagar; Siegel, Corey A.; Melmed, Gil Y.; Weaver, S. Alandra; Power, Sydney; Zou, Guangyong; Jairath, Vipul; Hou, Jason K.

Long-Term Effectiveness and Safety of Ustekinumab Dose Escalation in Patients with Moderate-to-Severe Ulcerative Colitis: A Multicenter Retrospective Cohort Study 中重度溃疡性结肠炎患者中乌司奴单抗剂量增加的中长期有效性与安全性：一项多中心回顾性队列研究

DIGESTIVE DISEASES AND SCIENCES

IF2.5

2025-03-17

PREAI

van Lierop, Lisa M. A.; Albino, Larissa; Rosentreter, Ryan; Thomas, Pepijn W. A.; Lu, Cathy; Siffledeen, Jesse; Kroeker, Karen I.; Ma, Christopher; Peerani, Farhad; Halloran, Brendan P.; Baumgart, Daniel C.; Dieleman, Levinus A.; Du, Lillian; Hoentjen, Frank; Wong, Karen

Relating the molecular phenotype of ulcerative colitis to the clinical course

SCIENTIFIC REPORTS

IF3.9

2025-03-11

OAAI

Madill-Thomsen, Katelynn S.; Venner, Jeffery M.; Parsons, Denise E.; Famulski, Konrad S.; Thiesen, Aducio L.; Hoque, Sami; Kroeker, Karen I.; Wong, Karen; Peerani, Farhad; Dieleman, Levinus A.; Hoentjen, Frank; Baumgart, Daniel C.; Halloran, Philip F.; Halloran, Brendan P.

The Impact of Postoperative Prophylactic Medication on Long-Term Surgical, Severe Endoscopic and Endoscopic or Radiologic Recurrence Following Primary Ileocecal Resection in Patients With Crohn's Disease

ALIMENTARY PHARMACOLOGY & THERAPEUTICS

IF6.7

2025-01-24

OAAI

ten Bokkel Huinink, Sebastiaan; Bak, Michiel T. J.; Beelen, Evelien M. J.; Erler, Nicole S.; Silverberg, Mark S.; Allez, Matthieu; Hoentjen, Frank; Bodelier, Alexander G. L.; Dijkstra, Gerard; Romberg-Camps, Marielle; de Boer, Nanne K. H.; Stassen, Laurents P. S.; de Jong, Andrea E.; West, Rachel L.; van Der Woude, C. Janneke; van Ruler, Oddeke; de Vries, Annemarie C.

Effectiveness and Safety of Advanced Combination Treatment (ACT) in patients with refractory inflammatory bowel disease or concomitant immune mediated disease or extra-intestinal manifestations: A Multi-Center Canadian Study

JOURNAL OF CROHNS & COLITIS

IF8.7

2025-01-22

PREAI

Solitano, V; Ogunsakin, R. E.; Yuan, Y.; Bernstein, C. N.; Bessisow, T.; Bressler, B.; Hoentjen, F.; van Lierop, L.; Leung, Y.; Ma, C.; Marshall, J. K.; Narula, N.; Alahmari, M.; Mccurdy, J.; Murthy, S.; Panaccione, R.; Milgrom, R.; Rosenfeld, G.; Silverberg, M.; Jairath, V

Higher clinical remission and endoscopic response with vedolizumab in early versus late Crohn's disease: data from the LOVE-CD trial

JOURNAL OF CROHNS & COLITIS

IF8.7

2025-01-22

PREAI

Oldenburg, L.; Baert, F.; Bossuyt, P.; Hoentjen, F.; Clasquin, E.; Molnar, T.; Loewenberg, M.; Vermeire, S.; D'Haens, G.

研究方向