Andreas Hombach - Publications, H-index & Citations

Andreas Hombach

University of Cologne

47H指数

135论文数

6.8K被引数

收录论文 48

发表时间

Integrating binding affinity and tonic signaling enables a rational CAR design for augmented T cell function 整合结合亲和力和滋补信号可以为增强的T细胞功能提供合理的CAR设计

Journal for ImmunoTherapy of Cancer

IF10.6

2024-12-02

OAAI

Barden, Markus; Elsenbroich, Patrick Ronan; Haas, Vivian; Ertelt, Moritz; Pervan, Philip; Velas, Lukas; Gergely, Bence; Szoeor, Arpad; Harrer, Dennis Christoph; Bezler, Valerie; Holzinger, Astrid; Friis, Rasmus Ulslev Wegener; Vereb, Gyorgy; Schuetz, Gerhard J.; Schoeder, Clara T.; Hombach, Andreas A.; Abken, Hinrich

CAR and TCR form individual signaling synapses and do not cross-activate, however, can co-operate in T cell activation

FRONTIERS IN IMMUNOLOGY

IF5.9

2023-02-01

OAAI

Barden, Markus; Holzinger, Astrid; Velas, Lukas; Mezosi-Csaplar, Marianna; Szoeor, Arpad; Vereb, Gyoergy; Schuetz, Gerhard J.; Hombach, Andreas A.; Abken, Hinrich

A CD19-Anti-ErbB2 scFv Engager Protein Enables CD19-Specific CAR T Cells to Eradicate ErbB2+ Solid Cancer

CELLS

IF5.2

2023-01-07

OAAI

Hombach, Andreas A.; Ambrose, Christine; Lobb, Roy; Rennert, Paul; Abken, Hinrich

IL12 integrated into the CAR exodomain converts CD8+ T cells to poly-functional NK-like cells with superior killing of antigen-loss tumors

MOLECULAR THERAPY

IF12

2022-02-01

OAAI

Hombach, Andreas; Barden, Markus; Hannappel, Lisa; Chmielewski, Markus; Rappl, Gunter; Sachinidis, Agapios; Abken, Hinrich

Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4+T cells to reduce the latent HIV+cell reservoir

MEDICAL MICROBIOLOGY AND IMMUNOLOGY

IF3

2020-09-12

OAAI

Patasic, Lea; Seifried, Janna; Bezler, Valerie; Kaljanac, Marcell; Schneider, Irene C.; Schmitz, Heike; Tondera, Christiane; Hartmann, Jessica; Hombach, Andreas; Buchholz, Christian J.; Abken, Hinrich; Koenig, Renate; Cichutek, Klaus

IL7-IL12 Engineered Mesenchymal Stem Cells (MSCs) Improve A CAR T Cell Attack Against Colorectal Cancer Cells

CELLS

IF5.2

2020-04-03

OAAI

Hombach, Andreas A.; Geumann, Ulf; Guenther, Christine; Hermann, Felix G.; Abken, Hinrich

Blocking CD30 on T Cells by a Dual Specific CAR for CD30 and Colon Cancer Antigens Improves the CAR T Cell Response against CD30- Tumors

MOLECULAR THERAPY

IF12

2019-10-01

OAAI

Hombach, Andreas A.; Rappl, Gunter; Abken, Hinrich

CD28-ζ CAR T Cells Resist TGF-β Repression through IL-2 Signaling, Which Can Be Mimicked by an Engineered IL-7 Autocrine Loop

MOLECULAR THERAPY

IF12

2018-09-01

OAAI

Golumba-Nagy, Viktoria; Kuehle, Johannes; Hombach, Andreas A.; Abken, Hinrich

Shared target antigens on cancer cells and tissue stem cells: go or no-go for CAR T cells?

EXPERT REVIEW OF CLINICAL IMMUNOLOGY

IF3.7

2016-08-22

PREAI

Hombach, Andreas A.; Abken, Hinrich

Superior Therapeutic Index in Lymphoma Therapy: CD30+ CD34+ Hematopoietic Stem Cells Resist a Chimeric Antigen Receptor T-cell Attack

MOLECULAR THERAPY

IF12

2016-08-01

OAAI

Hombach, Andreas A.; Goergens, Andre; Chmielewski, Markus; Murke, Florian; Kimpel, Janine; Giebel, Bernd; Abken, Hinrich

OX40 costimulation by a chimeric antigen receptor abrogates CD28 and IL-2 induced IL-10 secretion by redirected CD4+ T cells

ONCOIMMUNOLOGY

IF6.3

2014-10-27

218

OAAI

Hombach, Andreas A.; Heiders, Johannes; Foppe, Marcel; Chmielewski, Markus; Abken, Hinrich

Targeting two co-operating cytokines efficiently shapes immune responses

ONCOIMMUNOLOGY

IF6.3

2014-10-27

OAAI

Hombach, Andreas A.; Abken, Hinrich

Of CARs and TRUCKs: chimeric antigen receptor (CAR) T cells engineered with an inducible cytokine to modulate the tumor stroma

IMMUNOLOGICAL REVIEWS

IF8.3

2013-12-13

318

PREAI

Chmielewski, Markus; Hombach, Andreas A.; Abken, Hinrich

Arming Cytokine-induced Killer Cells With Chimeric Antigen Receptors: CD28 Outperforms Combined CD28 OX40 Super-stimulation

MOLECULAR THERAPY

IF12

2013-12-01

112

OAAI

Hombach, Andreas A.; Rappl, Gunter; Abken, Hinrich

Antigen-specific T-cell activation independently of the MHC: chimeric antigen receptor-redirected T cells 独立于MHC的抗原特异性T细胞激活: 嵌合抗原受体重定向的T细胞

FRONTIERS IN IMMUNOLOGY

IF5.9

2013-01-01

146

OAAI

Chmielewski, Markus; Hombach, Andreas A.; Abken, Hinrich

Young T cells age during a redirected anti-tumor attack: chimeric antigen receptor-provided dual costimulation is half the battle

FRONTIERS IN IMMUNOLOGY

IF5.9

2013-01-01

OAAI

Hombach, Andreas A.; Abken, Hinrich

T Cells That Target Carcinoembryonic Antigen Eradicate Orthotopic Pancreatic Carcinomas Without Inducing Autoimmune Colitis in Mice 靶向癌胚抗原的T细胞根除小鼠原位胰腺癌而不诱导自身免疫性结肠炎

GASTROENTEROLOGY

IF25.1

2012-10-01

132

PREAI

Chmielewski, Markus; Hahn, Olga; Rappl, Gunter; Nowak, Michael; Schmidt-Wolf, Ingo H.; Hombach, Andreas A.; Abken, Hinrich

Proffered Paper: Regression of Metastatic Melanoma by Targeting Melanoma Stem Cells

EUROPEAN JOURNAL OF CANCER

IF7.1

2012-07-01

PREAI

Abken, H.; Schmidt, P.; Schlaak, M.; Hombach, A. A.; Bangard, C.; Kurschat, P.; Zigrino, P.

IL-12 Release by Engineered T Cells Expressing Chimeric Antigen Receptors Can Effectively Muster an Antigen-Independent Macrophage Response on Tumor Cells That Have Shut Down Tumor Antigen Expression

Cancer Research

IF16.6

2011-08-30

503

OAAI

Chmielewski, Markus; Kopecky, Caroline; Hombach, Andreas A.; Abken, Hinrich

CD28 Costimulation Impairs the Efficacy of a Redirected T-cell Antitumor Attack in the Presence of Regulatory T cells Which Can Be Overcome by Preventing Lck Activation

MOLECULAR THERAPY

IF12

2011-04-01

133

OAAI

Kofler, David M.; Chmielewski, Markus; Rappl, Gunter; Hombach, Anja; Riet, Tobias; Schmidt, Annette; Hombach, Andreas A.; Wendtner, Clemens-Martin; Abken, Hinrich

研究方向