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Stefan F. Lichtenthaler

german center for neurodegenerative diseases

65H指数
326论文数
1.3W被引数
收录论文 169
发表时间
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Microglia Ablation and Downstream Effects in the Cerebrospinal Fluid Proteome小胶质细胞清除及其对脑脊液蛋白质组下游效应的影响
errProteomics
IF3.9
err2026-09-15
err0
errOAAI
errSinja Buchner; Sihui Song; Stephan A. Müller; Yun Chen; Samira Parhizkar; Stefan F. Lichtenthaler; David M. Holtzman; Mathias Jucker; Stephan A. Kaeser
err分享
err收藏
A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes一种可重复使用的人脑组织三维模型，用于研究生理和疾病相关的微胶质细胞表型
errNature Neuroscience
IF20
err2026-08-04
err0
errOAAI
errJulien Klimmt; Carolina Cardoso Gonçalves; Jessica Valentina Montgomery; Stephan A. Müller; Merle Bublitz; Severin Filser; Lars Paeger; Brigitte Nuscher; Angelika Dannert; Sigrun Roeber; Veronica Pravata; Martina Schifferer; Joshua J. Shrouder; Nathalie Schulz; Judit González-Gallego; Silvia Cappello; Thomas Misgeld; Nikolaus Plesnila; Eduardo Beltrán; Jochen Herms; Elena De Domenico; Marc D. Beyer; Joachim L. Schultze; Christian Haass; Stefan F. Lichtenthaler; Caterina Carraro; Dominik Paquet
err分享
err收藏
Spatial multi-omics identifies early synaptic pruning and context-specific dopaminergic vulnerability in synucleinopathies
errNature Communications
IF15.7
err2026-07-21
err0
errOAAI
errSvenja-Lotta Rumpf; Felix L. Strübing; Karsten Nalbach; Claudia Marina Vargiu; Giacomo Berg; Stefan F. Lichtenthaler; Piero Parchi; Pan Gao; Weilin Chen; Matthias Brendel; Johannes S. Gnörich; Alexander Bernhardt; Léa Dias Rodrigues; Günter U. Höglinger; Jochen Herms; Thomas Koeglsperger
err分享
err收藏
IgLON5 autoimmune antibodies activate Tau via neuronal hyperactivityIgLON5自身免疫抗体通过神经元过度活跃激活Tau
errScience Advances
IF12.5
err2026-05-13
err0
errOAAI
errBilge Askin; Cagla Kilic; César Cordero Gómez; Sophie Lan-Linh Duong; Alvaro Domingues-Baquero; Alexander Goihl; Karsten Nalbach; Joana Petushi; Pia Grundschöttel; Jessica Wagner; Valentine Thomas; Janne Lamberty; Emily Withers; Hanna Huber; Sabrina Huebschmann; Ekaterina Semenova; Paul Turko; Andrew G. Newman; Lisa Diez; Marc Beyer; Elena De Domenico; Peter Körtvelyessy; Dirk Reinhold; Anja Schneider; Jonas J. Neher; Thomas Ulas; Stefan F. Lichtenthaler; Benjamin R. Rost; Dietmar Schmitz; Harald Prüss; Susanne Wegmann
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err收藏
VMAT2 dysfunction impairs vesicular dopamine uptake; driving its oxidation and α-synuclein pathology in DJ-1–linked Parkinson’s neuronsVMAT2功能障碍损害囊泡多巴胺摄取；促进其氧化和DJ-1相关帕金森病神经元中α-突触核蛋白病理的产生。
errScience Advances
IF12.5
err2026-02-11
err0
errOAAI
errLeonie M. Heger; Francesco Gubinelli; Andreas J. Huber; Aida Cardona-Alberich; Matteo Rovere; Ulf Matti; Stephan A. Müller; Sankarshana R. Nagaraja; Lena Jaschkowitz; Martina Schifferer; Wolfgang Wurst; Stefan F. Lichtenthaler; Christian Behrends; Sivakumar Sambandan; Lena F. Burbulla
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err收藏
TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonismTREM2表达水平对小胶质细胞状态、代谢能力和TREM2激动功效至关重要
errNature Communications
IF15.7
err2026-01-24
err0
errOAAI
errAstrid F. Feiten; Kilian Dahm; Kai Schlepckow; Bettina van Lengerich; Jung H. Suh; Anika Reifschneider; Benedikt Wefers; Laura M. Bartos; Karin Wind-Mark; Lis de Weerd; Thomas Ulas; Elena De-Domenico; Pia Grundschöttel; Stefan Paulusch; Benjamin Tast; Tamisa Honda; Stephan A. Müller; Matthias Becker; Igor Khalin; Alessio Ricci; Arthur Liesz; Bettina Brunner; Claudia Krenner; Katrin Buschmann; Brigitte Nuscher; Lena Spieth; Niklas Junker; Stefan A. Berghoff; Sonnet S. Davis; Jonas J. Neher; Wolfgang Wurst; Nikolaus Plesnila; Joseph W. Lewcock; Mikael Simons; Stefan F. Lichtenthaler; Gilbert Di Paolo; Matthias Brendel; Anja Capell; Kathryn M. Monroe; Joachim L. Schultze; Christian Haass
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err收藏
The stroke risk gene Foxf2 maintains brain endothelial cell function via Tie2 signaling卒中风险基因Foxf2通过Tie2信号维持脑内皮细胞功能
errNature Neuroscience
IF20
err2025-12-15
err0
errOAAI
errKatalin Todorov-Völgyi; Judit González-Gallego; Stephan A. Müller; Mihail Ivilinov Todorov; Fatma Burcu Seker; Simon Frerich; Filippo M. Cernilogar; Luise Schröger; Rainer Malik; Jiayu Cao; Gemma Llovera; Stefan Roth; Ulrike Schillinger; Martina Schifferer; Azadeh Reyahi; Dennis Crusius; Liliana D. Pedro; Mikael Simons; Peter Carlsson; Ali Ertürk; Arthur Liesz; Gunnar Schotta; Nikolaus Plesnila; Stefan F. Lichtenthaler; Dominik Paquet; Martin Dichgans
err分享
err收藏
A fully iPS-cell-derived 3D model of the human blood–brain barrier for exploring neurovascular disease mechanisms and therapeutic interventions完全由iPS细胞衍生的人血脑屏障3D模型，用于探索神经血管疾病的机制和治疗干预措施
errNature Neuroscience
IF20
err2025-12-15
err0
errOAAI
errJudit González-Gallego; Katalin Todorov-Völgyi; Stephan A. Müller; Sophie Antesberger; Mihail Ivilinov Todorov; Rainer Malik; Rita Grimalt-Mirada; Carolina Cardoso Gonçalves; Martina Schifferer; Georg Kislinger; Isabel Weisheit; Barbara Lindner; Dennis Crusius; Joseph Kroeger; Mila Borri; Ali Erturk; Mark Nelson; Thomas Misgeld; Stefan F. Lichtenthaler; Martin Dichgans; Dominik Paquet
err分享
err收藏
Elenbecestat and Compound 89 Potently Inhibit BACE1 but Not BACE2 When Subchronically Dosed in Non-Human PrimatesElenbecestat和Compound 89在亚慢性给药非人灵长类动物时，强效抑制BACE1但不抑制BACE2。
errPROTEOMICS
IF3.9
err2025-11-01
err0
errOAAI
errTschirner, Sarah K.; Schmidt, Andree; Ito, Mana; Hyakkoku, Kana; Yoshimura, Akimasa; Mueller, Stephan A.; Horiguchi, Naotaka; Lichtenthaler, Stefan F.
err分享
err收藏
Neuropathy-associated Tecpr2 mutation knock-in mice reveal endolysosomal loss of function phenotypes in neurons and microglia神经病变相关Tecpr2基因突变 knock-in 小鼠揭示了神经元和小胶质细胞中的内溶酶体功能丧失表型。
errCell Death & Disease
IF9.6
err2025-10-31
err0
errOAAI
errDebjani Bhattacharya; Patricia da Silva-Buttkus; Karsten Nalbach; Lizhen Cheng; Lillian Garrett; Martin Irmler; Georg Kislinger; Georg Werner; Ramona Rodde; Christoph Lengger; Johannes Beckers; Annemarie Zimprich; Sabine M. Hölter; Valerie Gailus-Durner; Helmut Fuchs; Martin Hrabe de Angelis; Benedikt Wefers; Wolfgang Wurst; Monika S. Brill; Martina Schifferer; Stefan F. Lichtenthaler; Christian Behrends
err分享
err收藏
Multicenter evaluation of label-free quantification in human plasma on a high dynamic range benchmark set多中心对人类血浆中无标记定量在高动态范围基准集上的评估
errNature Communications
IF15.7
err2025-10-02
err0
errOAAI
errUte Distler; Han Byul Yoo; Oliver Kardell; Dana Hein; Malte Sielaff; Marian Scherer; Anna M. Jozefowicz; Christian Leps; David Gomez-Zepeda; Christine von Toerne; Juliane Merl-Pham; Teresa K. Barth; Johanna Tüshaus; Pieter Giesbertz; Torsten Müller; Georg Kliewer; Karim Aljakouch; Barbara Helm; Henry Unger; Dario L. Frey; Dominic Helm; Luisa Schwarzmüller; Oliver Popp; Di Qin; Susanne I. Wudy; Ludwig Roman Sinn; Julia Mergner; Christina Ludwig; Axel Imhof; Bernhard Kuster; Stefan F. Lichtenthaler; Jeroen Krijgsveld; Ursula Klingmüller; Philipp Mertins; Fabian Coscia; Markus Ralser; Michael Mülleder; Stefanie M. Hauck; Stefan Tenzer
err分享
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Patient-Derived Neurons Exhibit α-Synuclein Pathology and Previously Unrecognized Major Histocompatibility Complex Class I Elevation in Mitochondrial Membrane Protein–Associated Neurodegeneration患者来源的神经元表现出α-突触核蛋白病理变化以及线粒体膜蛋白相关神经退行性疾病中先前未被认识的主要组织相容性复合体I类升高。
errMovement Disorders
IF7.6
err2025-09-15
err0
errOAAI
errLeonie M. Heger MSc; Leonie Kertess PhD; Clara Kaufhold DVM; Francesco Gubinelli PhD; Aida Cardona-Alberich PhD; Gamze Özata MSc; Stephan A. Müller PhD; Sarah K. Tschirner PhD; Oliver Stehling PhD; Martina Schifferer PhD; Camille Peron MSc; Valeria Tiranti PhD; Roland Lill PhD; Arcangela Iuso PhD; Luigi Zecca MD; Michael Strupp MD; Wolfgang Oertel MD; Stefan F. Lichtenthaler PhD; Lena F. Burbulla PhD
err分享
err收藏
Privacy-preserving multicenter differential protein abundance analysis with FedProt使用FedProt进行隐私保护的多中心差异蛋白质丰度分析
errNature Computational Science
IF18.3
err2025-07-11
err0
errOAAI
errYuliya Burankova; Miriam Abele; Mohammad Bakhtiari; Christine von Toerne; Teresa K. Barth; Lisa Schweizer; Pieter Giesbertz; Johannes R. Schmidt; Stefan Kalkhof; Janina Müller-Deile; Peter A. van Veelen; Yassene Mohammed; Elke Hammer; Lis Arend; Klaudia Adamowicz; Tanja Laske; Anne Hartebrodt; Tobias Frisch; Chen Meng; Julian Matschinske; Julian Späth; Richard Röttger; Veit Schwämmle; Stefanie M. Hauck; Stefan F. Lichtenthaler; Axel Imhof; Matthias Mann; Christina Ludwig; Bernhard Kuster; Jan Baumbach; Olga Zolotareva
err分享
err收藏
Soluble VCAM-1 may serve as a pharmacodynamic CSF marker to monitor BACE2 activity in non-human primates可溶性VCAM-1可能作为药效学脑脊液标志物，用于监测非人灵长类动物中的BACE2活性。
errMolecular & Cellular Proteomics
IF5.5
err2025-06-01
err0
errOAAI
errSarah K. Tschirner; Joy Yu Zuchero; Jennifer A. Getz; Stephan A. Müller; Karsten Nalbach; Matthew E. Kennedy; Joseph W. Lewcock; Stefan F. Lichtenthaler
err分享
err收藏
Shedding new light on BACE1-mediated modulation of IL-6 signaling: Implications for neural activity and synaptic plasticity in mice
errCYTOKINE
IF3.7
err2025-06-01
err0
PREAI
errFranke, Buket Ucar; Kummer, Kai; Rose-John, Stefan; Lichtenthaler, Stefan F.; Kress, Michaela
err分享
err收藏
The late-onset Alzheimer's disease risk factor RHBDF2 is a modifier of microglial TREM2 proteolysis
errLIFE SCIENCE ALLIANCE
IF2.9
err2025-03-13
err0
errOAAI
errJocher, Georg; Ozcelik, Gozde; Mueller, Stephan A.; Hsia, Hung-En; Lastra Osua, Miranda; Hofmann, Laura, I; Assfalg, Marlene; Dinkel, Lina; Feng, Xiao; Schlepckow, Kai; Willem, Michael; Haass, Christian; Tahirovic, Sabina; Blobel, Carl P.; Lichtenthaler, Stefan F.
err分享
err收藏
Multicenter Longitudinal Quality Assessment of MS-Based Proteomics in Plasma and Serum
errJOURNAL OF PROTEOME RESEARCH
IF3.6
err2025-02-07
err0
errOAAI
errKardell, Oliver; Gronauer, Thomas; von Toerne, Christine; Merl-Pham, Juliane; Konig, Ann-Christine; Barth, Teresa K.; Mergner, Julia; Ludwig, Christina; Tueshaus, Johanna; Giesbertz, Pieter; Breimann, Stephan; Schweizer, Lisa; Mueller, Torsten; Kliewer, Georg; Distler, Ute; Gomez-Zepeda, David; Popp, Oliver; Qin, Di; Teupser, Daniel; Cox, Juergen; Imhof, Axel; Kuester, Bernhard; Lichtenthaler, Stefan F.; Krijgsveld, Jeroen; Tenzer, Stefan; Mertins, Philipp; Coscia, Fabian; Hauck, Stefanie M.
err分享
err收藏
Myeloid cell-specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2024-12-04
err0
PREAI
errDinkel, Lina; Hummel, Selina; Zenatti, Valerio; Malara, Mariagiovanna; Tillmann, Yannik; Colombo, Alessio; Monasor, Laura Sebastian; Suh, Jung H.; Logan, Todd; Roth, Stefan; Paeger, Lars; Hoffelner, Patricia; Bludau, Oliver; Schmidt, Andree; Mueller, Stephan A.; Schifferer, Martina; Nuscher, Brigitte; Njavro, Jasenka Rudan; Prestel, Matthias; Bartos, Laura M.; Wind-Mark, Karin; Slemann, Luna; Hoermann, Leonie; Kunte, Sebastian T.; Gnoerich, Johannes; Lindner, Simon; Simons, Mikael; Herms, Jochen; Paquet, Dominik; Lichtenthaler, Stefan F.; Bartenstein, Peter; Franzmeier, Nicolai; Liesz, Arthur; Grosche, Antje; Bremova-Ertl, Tatiana; Catarino, Claudia; Beblo, Skadi; Bergner, Caroline; Schneider, Susanne A.; Strupp, Michael; Di Paolo, Gilbert; Brendel, Matthias; Tahirovic, Sabina
err分享
err收藏
Proteomic Characterization of Ubiquitin Carboxyl-Terminal Hydrolase 19 Deficient Cells Reveals a Role for USP19 in the Secretion of Lysosomal Proteins
errMOLECULAR & CELLULAR PROTEOMICS
IF5.5
err2024-11-01
err0
PREAI
errBonelli, Simone; Lo Pinto, Margot; Ye, Yihong; Mueller, Stephan A.; Lichtenthaler, Stefan F.; Scilabra, Simone Dario
err分享
err收藏
Soluble form of Lingo2, an autism spectrum disorder-associated molecule, functions as an excitatory synapse organizer in neurons
errTRANSLATIONAL PSYCHIATRY
IF6.2
err2024-10-23
err0
errOAAI
errYoshida, Fumiaki; Nagatomo, Ryota; Utsunomiya, Shun; Kimura, Misaki; Shun, Shiyori; Kono, Rena; Kato, Yuma; Nao, Yosuke; Maeda, Kazuma; Koyama, Ryuta; Ikegaya, Yuji; Lichtenthaler, Stefan F.; Takatori, Sho; Takemoto, Hiroshi; Ogawa, Koichi; Ito, Genta; Tomita, Taisuke
err分享
err收藏

研究方向

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Matthias Mann
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