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管

管敏鑫 (Min‐Xin Guan)

the fourth affiliated hospital of school of medicine

57H指数
325论文数
1.1W被引数
收录论文 139
发表时间
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Deficient mitochondrial tRNA modifications arising from TRMU mutation led to the liver-specific failure
errJournal of Biological Chemistry
IF3.9
err2026-01-22
err0
errOAAI
errXiao He; Qinghai Zhang; Chao Chen; Yutao Wu; Kai Wang; Shihao Yao; Haiyan Sun; Min-Xin Guan
err分享
err收藏
A Glial Hub-and-Spoke Circuitry in C. elegans orchestrates bidirectional thermosensation秀丽隐杆线虫中的神经中枢和辐条电路协调双向热补偿
errNature Communications
IF15.7
err2026-01-21
err0
errOAAI
errLinhui Zhu; Rong Li; Mengyi Qian; Fangjin Lv; Huitao Hong; Yumeng Li; Yongqi Zhou; Zhou Li; Jing Lei; Wenjuan Zou; Min-Xin Guan; Yongming Zhang; Guohua Zhao; Huan Ma; Jianke Gong; Lijun Kang
err分享
err收藏
Pathogenic Mechanism of the KCNQ4 Gene Variant in Hearing Loss and Functional Validation in a Zebrafish ModelKCNQ4基因变异在听力损失中的致病机制及斑马鱼模型中的功能验证
errFASEB JOURNAL
IF4.2
err2025-12-10
err0
PREAI
errJia, Hui; Liu, Xiaowen; Chen, Hui; Wang, Yanli; Guan, Min-Xin; Guo, Yufen
err分享
err收藏
Leber’s hereditary optic neuropathy-associated ND1 3733G> C mutation ameliorates the mitochondrial quality control and cellular homeostasisLeber’s hereditary optic neuropathy-associated ND1 3733G> C突变改善了线粒体质量控制及细胞稳态
errJournal of Biological Chemistry
IF3.9
err2025-07-08
err0
PREAI
errMeiheriayi Yasheng; Yanchun Ji; Yunfan He; Qiuzi Yi; Huanhuan Zhang; Wenqi Shan; Kai Wang; Juanjuan Zhang; Ya Li; Feilong Meng; Minglian Zhang; Jun Qin Mo; Shihui Wei; Min-Xin Guan
err分享
err收藏
Mitochondrial tRNA processing defects reprogram mitochondrial and cellular homeostasis线粒体tRNA加工缺陷重编程线粒体和细胞稳态
errJournal of Biological Chemistry
IF3.9
err2025-07-01
err0
errOAAI
errGao Zhu; Yunfan He; Xincheng Li; Yun Xiao; Huisen Zhan; Maoli Duan; Min-Xin Guan
err分享
err收藏
Impact of POU3F4 mutation on cochlear development and auditory function
errCELL COMMUNICATION AND SIGNALING
IF8.9
err2025-03-05
err0
errOAAI
errDang, Jiong; Bian, Panpan; Chen, Chao; Chen, Chi; Shan, Wenqi; Cai, Luhang; Li, Yong; Tan, Huan; Xu, Baicheng; Guan, Minxin; Guo, Yufen
err分享
err收藏
Deafness-associated mitochondrial 12S rRNA mutation reshapes mitochondrial and cellular homeostasis
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2025-02-01
err0
errOAAI
errHe, Yunfan; Tang, Zhining; Zhu, Gao; Cai, Luhang; Chen, Chao; Guan, Min-Xin
err分享
err收藏
Mutation of CRYAB encoding a conserved mitochondrial chaperone and antiapoptotic protein causes hereditary optic atrophy
errJCI INSIGHT
IF6.1
err2024-11-19
err0
errOAAI
errWang, Chenghui; Zhang, Liyao; Nie, Zhipeng; Liang, Min; Liu, Hanqing; Yi, Qiuzi; Wang, Chunyan; Ai, Cheng; Zhang, Juanjuan; Gao, Yinglong; Ji, Yanchun; Guan, Min-Xin; Ai, Cheng; Zhang, Juanjuan; Gao, Yinglong; Ji, Yanchun; Guan, Min-Xin
err分享
err收藏
SpliceTransformer predicts tissue-specific splicing linked to human diseases
errNATURE COMMUNICATIONS
IF15.7
err2024-10-23
err0
errOAAI
errYou, Ningyuan; Liu, Chang; Gu, Yuxin; Wang, Rong; Jia, Hanying; Zhang, Tianyun; Jiang, Song; Shi, Jinsong; Chen, Ming; Guan, Min-Xin; Sun, Siqi; Pei, Shanshan; Liu, Zhihong; Shen, Ning
err分享
err收藏
Mitochondrial tRNAGlu 14693A>G Mutation, an Enhancer to the Phenotypic Expression of Leber's Hereditary Optic Neuropathy
errADVANCED SCIENCE
IF14.1
err2024-09-12
err0
errOAAI
errJin, Lihao; Gan, Dingyi; He, Wentao; Wu, Na; Xiang, Shuchenlu; Wei, Yinsheng; Eriani, Gilbert; Ji, Yanchun; Guan, Min-xin; Wang, Meng
err分享
err收藏
Deafness-associated tRNAPhe mutation impaired mitochondrial and cellular integrity
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-05-01
err0
errOAAI
errChen, Xiaowan; Meng, Feilong; Chen, Chao; Li, Shujuan; Chou, Zhiqiang; Xu, Baicheng; Mo, Jun Q.; Guo, Yufen; Guan, Min-Xin
err分享
err收藏
Induced pluripotent stem cells: ex vivo models for human diseases due to mitochondrial DNA mutations
errJOURNAL OF BIOMEDICAL SCIENCE
IF12.1
err2023-09-22
err5
errOAAI
errChen, Chao; Guan, Min-Xin
err分享
err收藏
Optimized allotopic expression of mitochondrial ND6 transgene restored complex I and apoptosis deficiencies caused by LHON-linked ND6 14484T > C mutation
errJOURNAL OF BIOMEDICAL SCIENCE
IF12.1
err2023-08-03
err6
errOAAI
errWang, Jing; Ji, Yanchun; Ai, Cheng; Chen, Jia-Rong; Gan, Dingyi; Zhang, Juanjuan; Mo, Jun Q.; Guan, Min-Xin
err分享
err收藏
cdh23 affects congenital hearing loss through regulating purine metabolism
errFRONTIERS IN MOLECULAR NEUROSCIENCE
IF3.8
err2023-07-27
err6
errOAAI
errYang, Shu; Xie, Bing-Lin; Dong, Xiao-ping; Wang, Ling-xiang; Zhu, Gang-hua; Wang, Tian; Wu, Wei-jing; Lai, Ruo-sha; Tao, Rong; Guan, Min-xin; Chen, Fang-yi; Tan, Dong-hui; Deng, Zhong; Xie, Hua-ping; Zeng, Yong; Xiao, Zi-an; Xie, Ding-hua
err分享
err收藏
The deafness-associated mitochondrial DNA mutation at position 7445, which affects tRNASer(UCN) precursor processing, has long-range effects on NADH dehydrogenase subunit ND6 gene expression
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err197
errOAAI
errGuan, MX; Enriquez, JA; Fischel-Ghodsian, N; Puranam, RS; Lin, CP; Maw, MA; Attardi, G
err分享
err收藏
A human mitochondrial GTP binding protein related to tRNA modification may modulate phenotypic expression of the deafness-associated mitochondrial 12S rRNA mutation
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err108
errOAAI
errLi, XM; Guan, MX
err分享
err收藏
Human Mitochondrial Leucyl-tRNA Synthetase Corrects Mitochondrial Dysfunctions Due to the tRNALeu(UUR) A3243G Mutation, Associated with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Symptoms and Diabetes人线粒体亮氨酰-tRNA合成酶纠正由tRNALeu(UUR) A3243G突变引起的线粒体功能障碍，与线粒体脑肌病，乳酸性酸中毒，中风样症状和糖尿病相关
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-20
err123
errOAAI
errLi, Ronghua; Guan, Min-Xin
err分享
err收藏
A Hypertension-Associated tRNAAla Mutation Alters tRNA Metabolism and Mitochondrial Function
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-17
err53
errOAAI
errJiang, Pingping; Wang, Meng; Xue, Ling; Xiao, Yun; Yu, Jialing; Wang, Hui; Yao, Juan; Liu, Hao; Peng, Yanyan; Liu, Hanqing; Li, Haiying; Chen, Ye; Guan, Min-Xin
err分享
err收藏
Human Mitochondrial Leucyl-tRNA Synthetase Corrects Mitochondrial Dysfunctions Due to the tRNALeu(UUR) A3243G Mutation, Associated with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Symptoms and Diabetes (vol 30, pg 2147, 2010)
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-17
err0
errOAAI
errLi, Ronghua; Guan, Min-Xin
err分享
err收藏
Emerging functions of mitochondria-encoded noncoding RNAs
errTRENDS IN GENETICS
IF16.3
err2023-02-01
err33
errOAAI
errRen, Bingbing; Guan, Min-Xin; Zhou, Tianhua; Cai, Xiujun; Shan, Ge
err分享
err收藏

研究方向

线粒体分子遗传学母性遗传病致病机制临床转化研究Leber遗传性视神经病变原发性高血压tRNA碱基修饰机制及其在线粒体疾病发病中的作用
合作学者
合作期刊
D
Douglas C. Wallace
H 指数: 134 · 论文数: 606
X
Xavier Estivill
H 指数: 128 · 论文数: 869
李
李晓明 (Xiaoming Li)
H 指数: 102 · 论文数: 926
T
Tsutomu Suzuki
H 指数: 98 · 论文数: 1.3K
陈
陈灰 (Hui Chen)
H 指数: 96 · 论文数: 2.2K
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