Scott Layzell

University of London

H指数:4

被引数:171

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Necroptosis in both tumour and stromal compartments determines responsiveness to immunogenic cell death-based immunotherapy

肿瘤和基质区室中的坏死性凋亡决定了对免疫原性细胞死亡为基础的免疫治疗的反应性

Nature Communications

IF15.7

2026-03-010

Fernando, Winnie; Clucas, Jarama; Rizzo, Alberto; Singer, Ramsay; Goode, Emily; Tiu, Crescens; Layzell, Scott; Konecnik, Joshua; Wilson, Rebecca; John, Sidonie Wicky; Jouny, Samuel; Guppy, Naomi; Boulat, Victoire; Mannion, Jonathan; Goicoechea, Maria; Tan, Shaun; Lawson, Sam; Starling, Chris; Elshtein, Gabrielle; Ravindran, Nivedita; Montgomery, Anna B.; Andres-Ejarque, Rosa; Allen, Mark; Lumbard, Steven; Wallberg, Fredrik; Betteridge, Kai; Scrimgeour, Ross; Robertson, David; Ward, George; Sims, Martin; Smyth, Tomoko; Samson, Andre L.; Murphy, James M.; Ivankovic, Daniela Kolarevic; Arwert, Esther N.; Calado, Dinis P.; Grigoriadis, Anita; Smalley, Matthew J.; Melcher, Alan; Haider, Syed; Lawrence, Toby; Roxanis, Ioannis; Tutt, Andrew N. J.; Tenev, Tencho; Meier, Pascal

NF-κB regulated expression of A20 controls IKK dependent repression of RIPK1 induced cell death in activated T cells (Seot, 10.1038/s41418-024-01383-6, 2024)

CELL DEATH AND DIFFERENTIATION

IF15.4

2024-12-030

OAAI

A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death

RIPK1-specific的PROTAC降解剂通过增强免疫原性细胞死亡来实现有效的抗肿瘤活性

IMMUNITY

IF26.3

2024-07-013

Mannion, Jonathan; Gifford, Valentina; Bellenie, Benjamin; Fernando, Winnie; Garcia, Laura Ramos; Wilson, Rebecca; John, Sidonie Wicky; Udainiya, Savita; Patin, Emmanuel C.; Tiu, Crescens; Smith, Angel; Goicoechea, Maria; Craxton, Andrew; Vasconcelos, Nathalia Moraes de; Cheung, Kwai-Ming J.; Cundy, Nicholas J.; Pierrat, Olivier; Brennan, Alfie; Benstead-Hume, Graeme; Roumeliotis, Theodoros I.; Alexander, John; Muirhead, Gareth; Layzell, Scott; Lyu, Wenxin; Roulstone, Victoria; Baldock, Holly; Legrand, Arnaud; Gabel, Florian; Serrano-Aparicio, Natalia; Starling, Chris; Guo, Hongyan; Upton, Jason; Gyrd-Hansen, Mads; Seddon, Benedict; Roxanis, Ioannis; Harrington, Kevin; Haider, Syed; Choudhary, Jyoti S.; Haider, Swen; Tenev, Tencho; Meier, Pascal

IKK promotes naive T cell survival by repressing RIPK1-dependent apoptosis and activating NF-κB

SCIENCE SIGNALING

IF6.6

2023-06-273