未登录 Reduced Notch signaling in hypothalamic endothelial cells mediates obesity-induced alterations in glucose uptake and insulin signaling 下丘脑内皮细胞中Notch信号通路的减弱介导了肥胖诱导的葡萄糖摄取和胰岛素信号通路的改变。 Zhu, Yiyi; Mehlkop, Oliver; Backes, Heiko; Cremer, Anna Lena; Porniece, Marta; Klemm, Paul; Steuernagel, Lukas; Chen, Weiyi; Johnen, Ronja; Wunderlich, F. Thomas; Jais, Alexander; Bruening, Jens C. 分享 收藏
Projectome-based characterization of hypothalamic peptidergic neurons in male mice 基于投影组对雄性小鼠下丘脑肽能神经元的表征 Jiao, Zhuolei; Gao, Taosha; Wang, Xiaofei; Wang, Ao; Ma, Yawen; Feng, Li; Gao, Le; Gou, Lingfeng; Zhang, Wen; Biglari, Nasim; Boxer, Emma E.; Steuernagel, Lukas; Ding, Xiaojing; Yu, Zixian; Li, Mingjuan; Gao, Mengtong; Hao, Mingkun; Zhou, Hua; Cao, Xuanzi; Li, Shuaishuai; Jiang, Tao; Qi, Jiamei; Jia, Xueyan; Feng, Zhao; Ren, Biyu; Chen, Yu; Shi, Xiaoxue; Wang, Dan; Wang, Xinran; Han, Luyao; Liang, Yikai; Qian, Liuqin; Jin, Chenxi; Huang, Jiawen; Deng, Wei; Wang, Congcong; Li, E.; Hu, Yue; Tao, Zi; Li, Humingzhu; Yu, Xiang; Xu, Min; Chang, Hung-Chun; Zhang, Yifeng; Xu, Huatai; Yan, Jun; Li, Anan; Luo, Qingming; Stoop, Ron; Sternson, Scott M.; Bruening, Jens C.; Anderson, David J.; Poo, Mu-ming; Sun, Yidi; Xu, Shengjing; Sun, Yan-Gang; Xu, Xiaohong 分享 收藏
A comprehensive spatio-cellular map of the human hypothalamus (feb, 10.1038/s41586-024-08504-8, 2025) 人类下丘脑的综合时空图 (2月，10.1038/s41586-024-08504-8，2025) Tadross, John A.; Steuernagel, Lukas; Dowsett, Georgina K. C.; Kentistou, Katherine A.; Rainbow, Kara; Hvid, Henning; Kania, Katarzyna; Polex-Wolf, Joseph; Knudsen, Lotte Bjerre; Pyke, Charles; Perry, John R. B.; Lam, Brian Y. H.; Bruening, Jens C.; Yeo, Giles S. H. 分享 收藏
Neuroprotective effect of neuron-specific deletion of the C16 ceramide synthetic enzymes in an animal model of multiple sclerosis 多发性硬化动物模型中神经元特异性C16神经酰胺合成酶缺失的神经保护作用 Amatruda, Mario; Marechal, Damien; Gacias, Mar; Wentling, Maureen; Turpin-Nolan, Sarah; Morstein, Johannes; Moniruzzaman, Mohammed; Bruening, Jens C.; Haughey, Norman J.; Trauner, Dirk H.; Casaccia, Patrizia 分享 收藏
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Development of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release Zhou, Xuehan; Stine, Carrie; Prada, Patricia Oliveira; Fusca, Debora; Assoumou, Kevin; Dernic, Jan; Bhat, Musadiq A.; Achanta, Ananya S.; Johnson, Joseph C.; Pasqualini, Amanda Loren; Jadhav, Sanjana; Bauder, Corinna A.; Steuernagel, Lukas; Ravotto, Luca; Benke, Dietmar; Weber, Bruno; Suko, Azra; Palmiter, Richard D.; Stoeber, Miriam; Kloppenburg, Peter; Bruening, Jens C.; Bruchas, Michael R.; Patriarchi, Tommaso 分享 收藏
GABAergic disinhibition from the BNST to PNOC ARC neurons promotes HFD-induced hyperphagia 从BNST到PNOC ARC神经元的gaba能抑制促进HFD诱导的食欲亢进 Sotelo-Hitschfeld, Tamara; Minere, Marielle; Klemm, Paul; Borgmann, Diba; Wnuk-Lipinski, Daria; Jais, Alexander; Jia, Xianglian; Corneliussen, Svenja; Kloppenburg, Peter; Fenselau, Henning; Bruning, Jens Claus 分享 收藏
Depletion of TBC1D4 Improves the Metabolic Exercise Response by Overcoming Genetically Induced Peripheral Insulin Resistance Springer, Christian; Binsch, Christian; Weide, Deborah; Toska, Laura; Cremer, Anna L.; Backes, Heiko; Scheel, Anna K.; Espelage, Lena; Kotzka, Joerg; Sill, Sebastian; Kurowski, Anette; Kim, Daebin; Karpinski, Sandra; Schnurr, Theresia M.; Hansen, Torben; Hartwig, Sonja; Lehr, Stefan; Cames, Sandra; Bruening, Jens C.; Lienhard, Matthias; Herwig, Ralf; Boerno, Stefan; Timmermann, Bernd; Al-Hasani, Hadi; Chadt, Alexandra 分享 收藏
Activation of GFRAL plus neurons induces hypothermia and glucoregulatory responses associated with nausea and torpor Ruud, Linda Engstrom; Font-Girones, Ferran; Zajdel, Joanna; Kern, Lara; Teixidor-Deulofeu, Julia; Manneras-Holm, Louise; Carreras, Alba; Becattini, Barbara; Bjorefeldt, Andreas; Hanse, Eric; Fenselau, Henning; Solinas, Giovanni; Bruening, Jens C.; Wunderlich, Thomas F.; Backhed, Fredrik; Ruud, Johan 分享 收藏
Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism De Solis, Alain J.; Del Rio-Martin, Almudena; Radermacher, Jan; Chen, Weiyi; Steuernagel, Lukas; Bauder, Corinna A.; Eggersmann, Fynn R.; Morgan, Donald A.; Cremer, Anna-Lena; Sue, Michael; Germer, Maximilian; Kukat, Christian; Vollmar, Stefan; Backes, Heiko; Rahmouni, Kamal; Kloppenburg, Peter; Bruening, Jens C. 分享 收藏
An Approach to Intersectionally Target Mature Enteroendocrine Cells in the Small Intestine of Mice Vossen, Christian; Schmidt, Patricia; Wunderlich, Claudia Maria; Mittenbuehler, Melanie Joyce; Tapken, Claas; Wienand, Peter; Mirabella, Paul Nicolas; Cabot, Leonie; Schumacher, Anna-Lena; Folz-Donahue, Kat; Kukat, Christian; Voigt, Ingo; Bruening, Jens C.; Fenselau, Henning; Wunderlich, F. Thomas 分享 收藏
CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice Hammerschmidt, Philipp; Steculorum, Sophie M.; Bandet, Cecile L.; Del Rio-Martin, Almudena; Steuernagel, Lukas; Kohlhaas, Vivien; Feldmann, Marvin; Varela, Luis; Majcher, Adam; Correia, Marta Quatorze; Klar, Rhena F. U.; Bauder, Corinna A.; Kaya, Ecem; Porniece, Marta; Biglari, Nasim; Sieben, Anna; Horvath, Tamas L.; Hornemann, Thorsten; Brodesser, Susanne; Bruening, Jens C. 分享 收藏
Liraglutide restores impaired associative learning in individuals with obesity Hanssen, Ruth; Rigoux, Lionel; Kuzmanovic, Bojana; Iglesias, Sandra; Kretschmer, Alina C.; Schlamann, Marc; Albus, Kerstin; Thanarajah, Sharmili Edwin; Sitnikow, Tamara; Melzer, Corina; Cornely, Oliver A.; Bruening, Jens C.; Tittgemeyer, Marc 分享 收藏
The long-lasting shadow of litter size in rodents: litter size is an underreported variable that strongly determines adult physiology Parra-Vargas, Marcela; Bouret, Sebastien G.; Bruning, Jens C.; de Moura, Egberto G.; Garland Jr, Theodore; Lisboa, Patricia C.; Ozanne, Susan E.; Patti, Mary-Elizabeth; Plagemann, Andreas; Speakman, John R.; Tena-Sempere, Manuel; Vergely, Catherine; Zeltser, Lori M.; Jimenez-Chillaron, Josep C. 分享 收藏
Habitual daily intake of a sweet and fatty snack modulates reward processing in humans Thanarajah, Sharmili Edwin; DiFeliceantonio, Alexandra G.; Albus, Kerstin; Kuzmanovic, Bojana; Rigoux, Lionel; Iglesias, Sandra; Hanssen, Ruth; Schlamann, Marc; Comely, Oliver A.; Bruening, Jens C.; Tittgemeyer, Marc; Small, Dana M. 分享 收藏
Hybrid embryonic stem cell-derived tetraploid mice show apparently normal morphological, physiological, and neurological characteristics Schwenk, F; Zevnik, B; Brüning, J; Röhl, M; Willuweit, A; Rode, A; Hennek, T; Kauselmann, G; Jaenisch, R; Kühn, R 分享 收藏
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Circulating uridine dynamically and adaptively regulates food intake in humans Hanssen, Ruth; Rigoux, Lionel; Albus, Kerstin; Kretschmer, Alina Chloe; Thanarajah, Sharmili Edwin; Chen, Weiyi; Hinze, Yvonne; Giavalisco, Patrick; Steculorum, Sophie M.; Cornely, Oliver A.; Bruening, Jens C.; Tittgemeyer, Marc 分享 收藏
Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes Teo, Jonathan D.; Marian, Oana C.; Spiteri, Alanna G.; Nicholson, Madeline; Song, Huitong; Khor, Jasmine X. Y.; McEwen, Holly P.; Ge, Anjie; Sen, Monokesh K.; Piccio, Laura; Fletcher, Jessica L.; King, Nicholas J. C.; Murray, Simon S.; Bruening, Jens C.; Don, Anthony S. 分享 收藏
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