Lee A. Dawson - Publications, H-index & Citations

Lee A. Dawson

cerevance limited

42H指数

190论文数

5.1K被引数

收录论文 50

发表时间

Discovery of Potent; Selective; and Brain-Penetrant Small Molecule CD38 Inhibitors

ACS Medicinal Chemistry Letters

IF4

2026-01-29

PREAI

Andrew J. Stott; Roland W. Bürli; Kevin J. Doyle; Louise Dickson; Richard C. Hewer; Philip Pickford; Maxine J. Roberts; Rosie Waters-Hall; Yiming Wu; Matthias Zebisch; Victor Rangel; Matthis Geitmann; Kim Matthews; Nicola L. Brice; Mark Carlton; Lee A. Dawson; Jenna R. M. Harvey

NETSseq reveals inflammatory and aging mechanisms in distinct cell types; driving cerebellar decline in ataxia telangiectasia NETSseq揭示了不同细胞类型中的炎症和衰老机制，驱动共济失调性毛细血管扩张症的小脑衰退。

Frontiers in Neuroscience

IF3.2

2025-09-01

OAAI

Giuliano G. Stirparo; Xiao Xu; Toni Thompson; Keith Page; Jenna R. M. Harvey; David Cadwalladr; Jason Lawrence; Russell J. Burley; Joel Juvvanapudi; Megan Roberts; Daniel F. Barker; Victoria Mulligan; Chloe Sherlock; Marina Lizio; Louisa Christie; Mani Mudaliar; Steven Sheardown; Brad Margus; Craig Thompson; Louise Dickson; Nicola L. Brice; Mark B. Carlton; Justin A. C. Powell; Lee A. Dawson

CVN424, a GPR6 inverse agonist, for Parkinson's ' s disease and motor fl uctuations: a double-blind, randomized, phase 2 trial

ECLINICALMEDICINE

IF10

2024-11-01

OAAI

Brice, Nicola L.; Carlton, Mark; Margolin, David H.; Bexon, Martin; Matthews, Kim L.; Dawson, Lee A.; Ellenbogen, Aaron L.; Olanow, C. Warren; Dubow, Jordan; Kieburtz, Karl

Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of β-Glucocerebrosidase

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-06-27

PREAI

Palmer, Nick; Agnew, Christopher; Benn, Caroline; Buffham, William J.; Castro, Joan N.; Chessari, Gianni; Clark, Mellissa; Cons, Benjamin D.; Coyle, Joseph E.; Dawson, Lee A.; Hamlett, Christopher C. F.; Hodson, Charlotte; Holding, Finn; Johnson, Christopher N.; Liebeschuetz, John W.; Mahajan, Pravin; McCarthy, James M.; Murray, Christopher W.; O'Reilly, Marc; Peakman, Torren; Price, Amanda; Rapti, Magdalini; Reeks, Judith; Schopf, Patrick; St-Denis, Jeffrey D.; Valenzano, Chiara; Wallis, Nicola G.; Walser, Reto; Weir, Heather; Wilsher, Nicola E.; Woodhead, Andrew; Bento, Carla F.; Tisi, Dominic

Discovery of CVN293, a Brain Permeable KCNK13 (THIK-1) Inhibitor Suitable for Clinical Assessment

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2024-04-05

PREAI

Burli, Roland W.; Doyle, Kevin J.; Dickson, Louise; Rowland, Anna; Matthews, Kim; Stott, Andrew J.; Teall, Martin; Ossola, Bernardino; Russell, Samuel G.; Harvey, Jenna R. M.; Wu, Yiming; Narayana, Lakshminarayana; Brice, Nicola L.; Carlton, Mark; Dawson, Lee A.

Differential contribution of THIK-1 K+ channels and P2X7 receptors to ATP-mediated neuroinflammation by human microglia

JOURNAL OF NEUROINFLAMMATION

IF10.1

2024-02-26

OAAI

Rifat, Ali; Ossola, Bernardino; Burli, Roland W.; Dawson, Lee A.; Brice, Nicola L.; Rowland, Anna; Lizio, Marina; Xu, Xiao; Page, Keith; Fidzinski, Pawel; Onken, Julia; Holtkamp, Martin; Heppner, Frank L.; Geiger, Joerg R. P.; Madry, Christian

Discovery and Characterization of Novel CNS-Penetrant GPR55 Agonists

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-09-14

PREAI

Hewer, Richard C.; Christie, Louisa A.; Doyle, Kevin J.; Xu, Xiao; Roberts, Maxine J.; Dickson, Louise; Cheung, Toni; Cadwalladr, David H.; Pickford, Philip; Teall, Martin; Powell, Justin A. C.; Sheardown, Steven; Narayana, Lakshminarayana; Brice, Nicola L.; Dawson, Lee A.; Carlton, Mark; Burli, Roland W.

Discovery of CVN417, a Novel Brain-Penetrant α6-Containing Nicotinic Receptor Antagonist for the Modulation of Motor Dysfunction

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-08-31

PREAI

Christie, Louisa A.; Brice, Nicola L.; Rowland, Anna; Dickson, Louise; Anand, Rishi; Teall, Martin; Doyle, Kevin J.; Narayana, Lakshminarayana; Mitchell, Christine; Harvey, Jenna R. M.; Mulligan, Victoria; Dawson, Lee A.; Cragg, Stephanie J.; Carlton, Mark; Burli, Roland W.

Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2023-03-02

OAAI

Dickson, Louise; Teall, Martin; Chevalier, Elodie; Cheung, Toni; Liwicki, Gemma M.; Mack, Stephen; Stephenson, Anne; White, Kathryn; Fosbeary, Richard; Harrison, David C.; Brice, Nicola L.; Doyle, Kevin; Ciccocioppo, Roberto; Wu, Chaobo; Almond, Sarah; Patel, Toshal R.; Mitchell, Philip; Barnes, Matt; Ayscough, Andrew P.; Dawson, Lee A.; Carlton, Mark; Burli, Roland W.

Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2022-09-06

OAAI

Tamanini, Emiliano; Miyamura, Shin; Buck, Ildiko M.; Cons, Benjamin D.; Dawson, Lee; East, Charlotte; Futamura, Takashi; Goto, Shintaro; Griffiths-Jones, Charlotte; Hashimoto, Tetsuya; Heightman, Tom D.; Ishikawa, Shunpei; Ito, Hideki; Kaneko, Yosuke; Kawato, Tatsuya; Kondo, Kazumi; Kurihara, Naoki; McCarthy, James M.; Mori, Yukiko; Nagase, Tsuyoshi; Nakaishi, Yuichiro; Reeks, Judith; Sato, Akimasa; Schopf, Patrick; Tai, Kuninori; Tamai, Taichi; Tisi, Dominic; Woolford, Alison J. -A.

The two pore potassium channel THIK-1 regulates NLRP3 inflammasome activation

GLIA

IF5.1

2022-03-30

OAAI

Drinkall, Samuel; Lawrence, Catherine B.; Ossola, Bernadino; Russell, Samuel; Bender, Clare; Brice, Nicola B.; Dawson, Lee A.; Harte, Michael; Brough, David

The role of SQSTM1 (p62) in mitochondrial function and clearance in human cortical neurons

STEM CELL REPORTS

IF5.1

2021-05-01

OAAI

Poon, Anna; Saini, Harpreet; Sethi, Siddharth; O'Sullivan, Gregory A.; Plun-Favreau, Helene; Wray, Selina; Dawson, Lee A.; McCarthy, James M.

Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation

FRONTIERS IN IMMUNOLOGY

IF5.9

2020-03-05

OAAI

Barron, Matthew R.; Gartlon, Jane; Dawson, Lee A.; Atkinson, Peter J.; Pardon, Marie-Christine

Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses

SCIENTIFIC REPORTS

IF3.9

2018-04-04

OAAI

Redondo-Castro, Elena; Faust, Dorte; Fox, Simon; Baldwin, Alex G.; Osborne, Simon; Haley, Michael J.; Karran, Eric; Nuthall, Hugh; Atkinson, Peter J.; Dawson, Lee A.; Routledge, Carol; Allan, Stuart M.; Freeman, Sally; Brownlees, Janet; Brough, David

An acute systemic immune challenge rapidly decreases tau phosphorylation in htau mice expressing murine tau

EXPERIMENTAL GERONTOLOGY

IF4.3

2017-08-01

PREAI

Barron, Matthew; Gartlon, Jane; Dawson, Lee; Atkinson, Peter; Pardon, Marie-Christine

A state of delirium: Deciphering the effect of inflammation on tau pathology in Alzheimer's disease

EXPERIMENTAL GERONTOLOGY

IF4.3

2017-08-01

OAAI

Barron, Matthew; Gartlon, Jane; Dawson, Lee A.; Atkinson, Peter J.; Pardon, Marie-Christine

Utilizing multiplex chromogenic IHC and digital image analysis to evaluate immune cell content and spatial distribution within NSCLC tumor tissue

CANCER RESEARCH

IF16.6

2017-07-01

OAAI

Sherry, Lorcan; Anderson, Mark; Cowan, Marianne; Dawson, Lee; Bystry, Richard; Green, Sarah-Jane

Pharmacological characterization of N-[(2S)5-(6-fluoro-3-pyridinyl)-2, 3-dihydro-1H-inden-2-yl]-2-propanesulfonamide: a novel, clinical AMPA receptor positive allosteric modulator

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2017-01-31

OAAI

Ward, Simon E.; Beswick, Paul; Calcinaghi, Novella; Dawson, Lee A.; Gartlon, Jane; Graziani, Francesca; Jones, Declan N. C.; Lacroix, Laurent; Mok, M. H. Selina; Oliosi, Beatrice; Pardoe, Joanne; Starr, Kathryn; Woolley, Marie L.; Harries, Mark H.

Progress in the development of neurokinin 3 modulators for the treatment of schizophrenia: molecule development and clinical progress

FUTURE MEDICINAL CHEMISTRY

IF3.4

2013-09-11

PREAI

Dawson, Lee A.; Porter, Roderick A.

GluN1 hypomorph mice exhibit wide-ranging behavioral alterations

GENES BRAIN AND BEHAVIOR

IF2.3

2012-02-09

OAAI

Barkus, C.; Dawson, L. A.; Sharp, T.; Bannerman, D. M.

研究方向