Juan C. Engel - Publications, H-index & Citations

Juan C. Engel

University of California San Francisco

40H指数

101论文数

5.5K被引数

收录论文 23

发表时间

Mechanistic Exploration of N,N′-Disubstituted Diamines as Promising Chagas Disease Treatments N,N′-双取代二胺作为有前景的恰加斯病治疗药物的机制探索

Pharmaceuticals

IF4.8

2026-01-10

OAAI

Alejandro I. Recio-Balsells; Chantal Reigada; María Gabriela Mediavilla; Esteban Panozzo-Zénere; Miguel Villarreal Parra; Patricia S. Doyle; Juan C. Engel; Claudio A. Pereira; Julia A. Cricco; Guillermo R. Labadie

Diversity-Oriented Synthesis Yields a New Drug Lead for Treatment of Chagas Disease

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2014-01-03

OAAI

Dandapani, Sivaraman; Germain, Andrew R.; Jewett, Ivan; le Quement, Sebastian; Marie, Jean-Charles; Muncipinto, Giovanni; Duvall, Jeremy R.; Carmody, Leigh C.; Perez, Jose R.; Engel, Juan C.; Gut, Jiri; Kellar, Danielle; Siqueira-Neto, Jair Lage; McKerrow, James H.; Kaiser, Marcel; Rodriguez, Ana; Palmer, Michelle A.; Foley, Michael; Schreiber, Stuart L.; Munoz, Benito

Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51

PLOS NEGLECTED TROPICAL DISEASES

IF3.4

2012-07-31

OAAI

Gunatilleke, Shamila S.; Calvet, Claudia M.; Johnston, Jonathan B.; Chen, Chiung-Kuang; Erenburg, Grigori; Gut, Jiri; Engel, Juan C.; Ang, Kenny K. H.; Mulvaney, Joseph; Chen, Steven; Arkin, Michelle R.; McKerrow, James H.; Podust, Larissa M.

The Trypanosoma cruzi Protease Cruzain Mediates Immune Evasion

PLOS PATHOGENS

IF4.9

2011-09-01

115

OAAI

Doyle, Patricia S.; Zhou, Yuan M.; Hsieh, Ivy; Greenbaum, Doron C.; McKerrow, James H.; Engel, Juan C.

A Screen against Leishmania Intracellular Amastigotes: Comparison to a Promastigote Screen and Identification of a Host Cell-Specific Hit

PLOS NEGLECTED TROPICAL DISEASES

IF3.4

2011-07-19

163

OAAI

De Muylder, Geraldine; Ang, Kenny K. H.; Chen, Steven; Arkin, Michelle R.; Engel, Juan C.; McKerrow, James H.

Mining a Cathepsin Inhibitor Library for New Antiparasitic Drug Leads

PLOS NEGLECTED TROPICAL DISEASES

IF3.4

2011-05-03

OAAI

Ang, Kenny K. H.; Ratnam, Joseline; Gut, Jiri; Legac, Jennifer; Hansell, Elizabeth; Mackey, Zachary B.; Skrzypczynska, Katarzyna M.; Debnath, Anjan; Engel, Juan C.; Rosenthal, Philip J.; McKerrow, James H.; Arkin, Michelle R.; Renslo, Adam R.

Liver Cytochrome P450 3A Endoplasmic Reticulum-associated Degradation A MAJOR ROLE FOR THE p97 AAA ATPase IN CYTOCHROME P450 3A EXTRACTION INTO THE CYTOSOL

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2011-02-01

OAAI

Acharya, Poulomi; Liao, Mingxiang; Engel, Juan C.; Correia, Maria Almira

Liver Cytochrome P450 3A Ubiquitination in Vivo by gp78/Autocrine Motility Factor Receptor and C Terminus of Hsp70-interacting Protein (CHIP) E3 Ubiquitin Ligases PHYSIOLOGICAL AND PHARMACOLOGICAL RELEVANCE

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2010-11-01

OAAI

Kim, Sung-Mi; Acharya, Poulomi; Engel, Juan C.; Correia, Maria Almira

Image-Based High-Throughput Drug Screening Targeting the Intracellular Stage of Trypanosoma cruzi, the Agent of Chagas' Disease

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2010-08-01

106

OAAI

Engel, Juan C.; Ang, Kenny K. H.; Chen, Steven; Arkin, Michelle R.; McKerrow, James H.; Doyle, Patricia S.

A Nonazole CYP51 Inhibitor Cures Chagas' Disease in a Mouse Model of Acute Infection

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2010-06-01

OAAI

Doyle, Patricia S.; Chen, Chiung-Kuang; Johnston, Jonathan B.; Hopkins, Stephanie D.; Leung, Siegfried S. F.; Jacobson, Matthew P.; Engel, Juan C.; McKerrow, James H.; Podust, Larissa M.

Nonpeptidic Tetrafluorophenoxymethyl Ketone Cruzain Inhibitors as Promising New Leads for Chagas Disease Chemotherapy

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2010-01-20

124

OAAI

Brak, Katrien; Kerr, Iain D.; Barrett, Kimberly T.; Fuchi, Nobuhiro; Debnath, Moumita; Ang, Kenny; Engel, Juan C.; McKerrow, James H.; Doyle, Patricia S.; Brinen, Linda S.; Ellman, Jonathan A.

RETRACTED: Hepatic CYP3A Suppression by High Concentrations of Proteasomal Inhibitors: A Consequence of Endoplasmic Reticulum (ER) Stress Induction, Activation of RNA-Dependent Protein Kinase-Like ER-Bound Eukaryotic Initiation Factor 2α (eIF2α)-Kinase (PERK) and General Control Nonderepressible-2 eIF2α Kinase (GCN2), and Global Translational Shutoff (Retracted article. See vol. 100, pg. 82, 2021)

MOLECULAR PHARMACOLOGY

IF3

2009-09-01

OAAI

Acharya, Poulomi; Engel, Juan C.; Correia, Maria Almira

Drugs targeting parasite lysosomes

CURRENT PHARMACEUTICAL DESIGN

IF2.8

2008-03-01

PREAI

Doyle, Patricia S.; Sajid, Mohamed; O'Brien, Theresa; DuBois, Kelly; Engel, Juan C.; Mackey, Zachary B.; Reed, Sharon

A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2007-11-01

169

OAAI

Doyle, Patricia S.; Zhou, Yuan M.; Engel, Juan C.; McKerrow, James H.

Cathepsin Cs are key for the intracellular survival of the protozoan parasite, Toxoplasma gondii

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2007-02-01

OAAI

Que, Xuchu; Engel, Juan C.; Ferguson, David; Wunderlich, Annette; Tomavo, Stanislas; Reed, Sharon L.

Development of α-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2005-03-01

PREAI

Choe, Y; Brinen, LS; Price, MS; Engel, JC; Lange, M; Grisostomi, C; Weston, SG; Pallai, PV; Cheng, H; Hardy, LW; Hartsough, DS; McMakin, M; Tilton, RF; Baldino, CM; Craik, CS

LdARF1 in trafficking and structural maintenance of the trans-Golgi cisternal network in the protozoan pathogen Leishmania donovani

TRAFFIC

IF2.5

2004-09-21

PREAI

Porter-Kelley, JM; Gerald, NJ; Engel, JC; Ghedin, E; Dwyer, DM

Analysis of 6-(2,2-dichloroacetamido)chrysene interaction with the hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2003-05-10

PREAI

Medrano, FJ; Wenck, MA; Engel, JC; Craig, SP