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DB-OTO Gene Therapy for Inherited Deafness Valayannopoulos, V.; Bance, M.; Carvalho, D.S.; Greinwald, J.H.; Harvey, S.A.; Ishiyama, A.; Landry, E.C.; Löwenheim, H.; Lustig, L.R.; Manrique, M.; et al. DB-OTO基因疗法用于遗传性耳聋。N. Engl. J. Med. 2025. [Google Scholar] [CrossRef] Valayannopoulos, Vassili; Bance, Manohar; Carvalho, Daniela S.; Greinwald Jr, John H.; Harvey, Steven A.; Ishiyama, Akira; Landry, Evie C.; Lowenheim, Hubert; Lustig, Lawrence R.; Manrique, Manuel; Nash, Robert; Polo, Ruben; Pritchett, Cedric V.; Rubinstein, Jay T.; Shearer, A. Eliot; del Castillo, Ignacio; Anderson, Jeffery J.; Corrales, C. Eduardo; Quigley, Tera M.; Riggs, William J.; Weber, Peter; Wilson, Gary; Irvin, Susan C.; Hassan, Hazem E.; Chen, Yanping; Liu, Rong; Drummond, Meghan C.; Sabin, Leah R.; Musser, Bret J.; Yancopoulos, George D.; Kyratsous, Christos A.; Herman, Gary A.; Baras, Aris; Whitton, Jonathon P. 分享 收藏
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CAR T cells based on fully human T cell receptor-mimetic antibodies exhibit potent antitumor activity in vivo 基于全人源T细胞受体模拟抗体的CAR T细胞在体内表现出强大的抗肿瘤活性。 Salzler, Robert; Dilillo, David J.; Saotome, Kei; Bray, Kevin; Mohrs, Katja; Hwang, Haun; Cygan, Kamil J.; Shah, Darshit; Rye-Weller, Anna; Kundu, Kunal; Badithe, Ashok; Zhang, Xiaoqin; Garnova, Elena; Torres, Marcela; Dhanik, Ankur; Babb, Robert; Delfino, Frank J.; Thwaites, Courtney; Dudgeon, Drew; Moore, Michael J.; Meagher, Thomas Craig; Decker, Corinne E.; Owczarek, Tomasz; Gleason, John A.; Yang, Xiaoran; Suh, David; Lee, Wen-Yi; Welsh, Richard; Macdonald, Douglas; Hansen, Johanna; Guo, Chunguang; Kirshner, Jessica R.; Thurston, Gavin; Huang, Tammy; Franklin, Matthew C.; Yancopoulos, George D.; Lin, John C.; Macdonald, Lynn E.; Murphy, Andrew J.; Chen, Gang; Olsen, Olav; Olson, William C. 分享 收藏
A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Ra strengthens T cell-mediated anti-tumor therapies Wu, Jiaxi; Bloch, Nicolin; Chang, Aaron Y.; Bhavsar, Ramandeep; Wang, Qingqing; Crawford, Alison; DiLillo, David J.; Vazzana, Kristin; Mohrs, Katja; Dudgeon, Drew; Patel, Supriya; Ahmed, Hassan; Garg, Vidur; Amatulli, Michael; Antao, Olivia Q.; Yan, Yuetian; Wang, Shunhai; Ramos, Willy; Krueger, Pamela; Adler, Christina; Ni, Min; Wei, Yi; Guo, Chunguang; Macdonald, Lynn; Huang, Tammy; Ullman, Erica; Hermann, Aynur; Yancopoulos, George D.; Murphy, Andrew J.; Davis, Samuel; Olson, William C.; Lin, John C.; Smith, Eric; Zhang, Tong 分享 收藏
Dupilumab in patients with chronic spontaneous urticaria (LIBERTY-CSU CUPID): Two randomized, double-blind, placebo-controlled, phase 3 trials 慢性自发性荨麻疹患者的Dupilumab (liberte-csu CUPID): 两项随机，双盲，安慰剂对照的3期试验 Maurer, Marcus; Casale, Thomas B.; Saini, Sarbjit S.; Ben-Shoshan, Moshe; Gimenez-Arnau, Ana M.; Bernstein, Jonathan A.; Yagami, Akiko; Stjepanovic, Aleksandra; Radin, Allen; Staudinger, Heribert W.; Patel, Naimish; Amin, Nikhil; Akinlade, Bolanle; Fan, Chunpeng; Bauer, Deborah; Yancopoulos, George D.; Patel, Kiran; Mannent, Leda P.; Laws, Elizabeth 分享 收藏
Dupilumab for Eosinophilic Esophagitis in Patients 1 to 11 Years of Age Chehade, Mirna; Dellon, Evan S.; Spergel, Jonathan M.; Collins, Margaret H.; Rothenberg, Marc E.; Pesek, Robert D.; Hirano, Ikuo; Liu, Ruiqi; Laws, Elizabeth; Mortensen, Eric; Martincova, Renata; Shabbir, Arsalan; McCann, Eilish; Kamal, Mohamed A.; Kosloski, Matthew P.; Hamilton, Jennifer D.; Samuely, Carin; Lim, Wei Keat; Wipperman, Matthew F.; Farrell, Annamaria; Patel, Naimish; Yancopoulos, George D.; Glotfelty, Lila; Maloney, Jennifer 分享 收藏
Dupilumab for COPD with Blood Eosinophil Evidence of Type 2 Inflammation Bhatt, Surya P.; Rabe, Klaus F.; Hanania, Nicola A.; Vogelmeier, Claus F.; Bafadhel, Mona; Christenson, Stephanie A.; Papi, Alberto; Singh, Dave; Laws, Elizabeth; Patel, Naimish; Yancopoulos, George D.; Akinlade, Bolanle; Maloney, Jennifer; Lu, Xin; Bauer, Deborah; Bansal, Ashish; Abdulai, Raolat M.; Robinson, Lacey B. 分享 收藏
Intravitreal aflibercept 8 mg in diabetic macular oedema (PHOTON): 48-week results from a randomised, double-masked, non-inferiority, phase 2/3 trial Brown, David M.; Boyer, David S.; Do, Diana, V; Wykoff, Charles C.; Sakamoto, Taiji; Win, Peter; Joshi, Sunir; Salehi-Had, Hani; Seres, Andras; Berliner, Alyson J.; Leal, Sergio; Vitti, Robert; Chu, Karen W.; Reed, Kimberly; Rao, Rohini; Cheng, Yenchieh; Sun, Wei; Voronca, Delia; Bhore, Rafia; Schmidt-Ott, Ursula; Schmelter, Thomas; Schulze, Andrea; Zhang, Xin; Hirshberg, Boaz; Yancopoulos, George; Sivaprasad, Sobha 分享 收藏
Intravitreal aflibercept 8 mg in neovascular age-related macular degeneration (PULSAR): 48-week results from a randomised, double-masked, non-inferiority, phase 3 trial Lanzetta, Paolo; Korobelnik, Jean-Francois; Heier, Jeffrey S.; Leal, Sergio; Holz, Frank G.; Clark, W. Lloyd; Eichenbaum, David; Iida, Tomohiro; Xiaodong, Sun; Berliner, Alyson J.; Schulze, Andrea; Schmelter, Thomas; Schmidt-Ott, Ursula; Zhang, Xin; Vitti, Robert; Chu, Karen W.; Reed, Kimberly; Rao, Rohini; Bhore, Rafia; Cheng, Yenchieh; Sun, Wei; Hirshberg, Boaz; Yancopoulos, George; Wong, Tien Y. 分享 收藏
Evaluating the efficacy and safety of pozelimab in patients with CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy disease: an open-label phase 2 and 3 study Ozen, Ahmet; Chongsrisawat, Voranush; Sefer, Asena Pinar; Kolukisa, Burcu; Jalbert, Jessica J.; Meagher, Karoline A.; Brackin, Taylor; Feldman, Hagit Baris; Baris, Safa; Karakoc-Aydiner, Elif; Ergelen, Rabia; Fuss, Ivan J.; Moorman, Heather; Suratannon, Narissara; Suphapeetiporn, Kanya; Perlee, Lorah; Harari, Olivier A.; Yancopoulos, George; Lenardo, Michael J. 分享 收藏
A therapeutic strategy to target distinct sources of IgE and durably reverse allergy Limnander, Andre; Kaur, Navneet; Asrat, Seblewongel; Tasker, Carley; Boyapati, Anita; Ben, Li-Hong; Janczy, John; Pedraza, Paulina; Abreu, Pablo; Chen, Wen-Chi; Godin, Stephen; Daniel, Benjamin J.; Chin, Harvey; Deveaux, Michelle; Lorenc, Karen Rodriguez; Sirulnik, Andres; Harari, Olivier; Stahl, Neil; Sleeman, Matthew A.; Murphy, Andrew J.; Yancopoulos, George D.; Orengo, Jamie M. 分享 收藏
Sarilumab for Relapse of Polymyalgia Rheumatica during Glucocorticoid Taper Spiera, Robert F.; Unizony, Sebastian; Warrington, Kenneth J.; Sloane, Jennifer; Giannelou, Angeliki; Nivens, Michael C.; Akinlade, Bolanle; Wong, Wanling; Bhore, Rafia; Lin, Yong; Buttgereit, Frank; Devauchelle-Pensec, Valerie; Rubbert-Roth, Andrea; Yancopoulos, George D.; Marrache, Frederic; Patel, Naimish; Dasgupta, Bhaskar 分享 收藏
Garetosmab in fibrodysplasia ossificans progressiva: a randomized, double-blind, placebo-controlled phase 2 trial Garetosmab治疗进行性骨化性纤维发育不良: 一项随机、双盲、安慰剂对照2期试验 Di Rocco, Maja; Forleo-Neto, Eduardo; Pignolo, Robert J.; Keen, Richard; Orcel, Philippe; Funck-Brentano, Thomas; Roux, Christian; Kolta, Sami; Madeo, Annalisa; Bubbear, Judith S.; Tabarkiewicz, Jacek; Szczepanek, Malgorzata; Bachiller-Corral, Javier; Cheung, Angela M.; Dahir, Kathryn M.; Botman, Esmee; Raijmakers, Pieter G.; Mukaddam, Mona Al; Tile, Lianne; Portal-Celhay, Cynthia; Sarkar, Neena; Hou, Peijie; Musser, Bret J.; Boyapati, Anita; Mohammadi, Kusha; Mellis, Scott J.; Rankin, Andrew J.; Economides, Aris N.; Trotter, Dinko Gonzalez; Herman, Gary A.; O'Meara, Sarah J.; Delgizzi, Richard; Weinreich, David M.; Yancopoulos, George D.; Eekhoff, E. Marelise W.; Kaplan, Frederick S. 分享 收藏
Activin E-ACVR1C cross talk controls energy storage via suppression of adipose lipolysis in mice Adam, Rene C.; Pryce, Dwaine S.; Lee, Joseph S.; Zhao, Yuanqi; Mintah, Ivory J.; Min, Soo; Halasz, Gabor; Mastaitis, Jason; Atwal, Gurinder S.; Aykul, Senem; Idone, Vincent; Economides, Aris N.; Lotta, Luca A.; Murphy, Andrew J.; Yancopoulos, George D.; Sleeman, Mark W.; Gusarova, Viktoria 分享 收藏
Dupilumab for COPD with Type 2 Inflammation Indicated by Eosinophil Counts Dupilumab治疗COPD伴2型炎症的嗜酸性粒细胞计数 Bhatt, S. P.; Rabe, K. F.; Hanania, N. A.; Vogelmeier, C. F.; Cole, J.; Bafadhel, M.; Christenson, S. A.; Papi, A.; Singh, D.; Laws, E.; Mannent, L. P.; Patel, N.; Staudinger, H. W.; Yancopoulos, G. D.; Mortensen, E. R.; Akinlade, B.; Maloney, J.; Lu, X.; Bauer, D.; Bansal, A.; Robinson, L. B.; Abdulai, R. M. 分享 收藏
A cellular and molecular spatial atlas of dystrophic muscle 营养不良肌肉的细胞和分子空间图谱 Stec, Michael J.; Su, Qi; Adler, Christina; Zhang, Lance; Golann, David R.; Khan, Naveen P.; Panagis, Lampros; Villalta, S. Armando; Ni, Min; Wei, Yi; Walls, Johnathon R.; Murphy, Andrew J.; Yancopoulos, George D.; Atwal, Gurinder S.; Kleiner, Sandra; Halasz, Gabor; Sleeman, Mark W. 分享 收藏
Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials Yosipovitch, Gil; Mollanazar, Nicholas; Staender, Sonja; Kwatra, Shawn G.; Kim, Brian S.; Laws, Elizabeth; Mannent, Leda P.; Amin, Nikhil; Akinlade, Bolanle; Staudinger, Heribert W.; Patel, Naimish; Yancopoulos, George D.; Weinreich, David M.; Wang, Sheldon; Shi, Genming; Bansal, Ashish; O'Malley, John T. 分享 收藏
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