Philip A. Botham - Publications, H-index & Citations

Philip A. Botham

Syngenta

33H指数

119论文数

3.6K被引数

收录论文 23

发表时间

Considerations Related to Dose Selection for Regulatory Animal Testing

Current Opinion in Toxicology

IF3.6

2026-01-20

PREAI

Bennard van Ravenzwaay; Richard W. Lewis; Fiona Sewell; Sue Marty; Philip A. Botham

Analysis of health concerns not addressed by REACH for low tonnage chemicals and opportunities for new approach methodology 低吨位化学品REACH未解决的健康问题分析和新方法方法的机会

ARCHIVES OF TOXICOLOGY

IF6.9

2023-09-27

OAAI

Botham, Philip; Cronin, Mark T. D.; Currie, Richard; Doe, John; Funk-Weyer, Dorothee; Gant, Timothy W.; Leist, Marcel; Marty, Sue; van Ravenzwaay, Bennard; Westmoreland, Carl

Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - Part IV: the ECETOC and CLE Proposal for a Thyroid Function-Related Neurodevelopmental Toxicity Testing and Assessment Scheme (Thyroid-NDT-TAS)

CRITICAL REVIEWS IN TOXICOLOGY

IF4.1

2023-08-09

OAAI

Melching-Kollmuss, Stephanie; Bothe, Kathrin; Charlton, Alex; Gangadharan, Babunilayam; Ghaffari, Rashin; Jacobi, Sylvia; Marty, Sue; Marxfeld, Heike-Antje; McInnes, Elizabeth F. F.; Sauer, Ursula G. G.; Sheets, Larry P. P.; Strupp, Christian; Tinwell, Helen; Wiemann, Christiane; Botham, Philip A. A.; van Ravenzwaay, Bennard

Applying genomics in regulatory toxicology: a report of the ECETOC workshop on omics threshold on non-adversity

ARCHIVES OF TOXICOLOGY

IF6.9

2023-06-09

OAAI

Gant, Timothy W.; Auerbach, Scott S.; Von Bergen, Martin; Bouhifd, Mounir; Botham, Philip A.; Caiment, Florian; Currie, Richard A.; Harrill, Joshua; Johnson, Kamin; Li, Dongying; Rouquie, David; van Ravenzwaay, Ben; Sistare, Frank; Tralau, Tewes; Viant, Mark R.; van de Laan, Jan Willem; Yauk, Carole

Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny-part III: how is substance-mediated thyroid hormone imbalance in pregnant/lactating rats or their progeny related to neurodevelopmental effects?

CRITICAL REVIEWS IN TOXICOLOGY

IF4.1

2022-12-15

OAAI

Marty, M. Sue; Sauer, Ursula G.; Charlton, Alex; Ghaffari, Rashin; Guignard, Davy; Hallmark, Nina; Hannas, Bethany R.; Jacobi, Sylvia; Marxfeld, Heike-Antje; Melching-Kollmuss, Stephanie; Sheets, Larry P.; Urbisch, Daniel; Botham, Philip A.; van Ravenzwaay, Bennard

A framework for chemical safety assessment incorporating new approach methodologies within REACH 纳入新方法方法的化学品安全评估框架

ARCHIVES OF TOXICOLOGY

IF6.9

2022-02-01

OAAI

Ball, Nicholas; Bars, Remi; Botham, Philip A.; Cuciureanu, Andreea; Cronin, Mark T. D.; Doe, John E.; Dudzina, Tatsiana; Gant, Timothy W.; Leist, Marcel; van Ravenzwaay, Bennard

Assessing chemical carcinogenicity: hazard identification, classification, and risk assessment. Insight from a Toxicology Forum state-of-the-science workshop

CRITICAL REVIEWS IN TOXICOLOGY

IF4.1

2022-01-04

OAAI

Felter, Susan P.; Bhat, Virunya S.; Botham, Philip A.; Bussard, David A.; Casey, Warren; Hayes, A. Wallace; Hilton, Gina M.; Magurany, Kelly A.; Sauer, Ursula G.; Ohanian, Edward, V

Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - part II: how can key events of relevant adverse outcome pathways be addressed in toxicological assessments?

CRITICAL REVIEWS IN TOXICOLOGY

IF4.1

2021-06-02

OAAI

Marty, Sue; Beekhuijzen, Manon; Charlton, Alex; Hallmark, Nina; Hannas, Bethany R.; Jacobi, Sylvia; Melching-Kollmuss, Stephanie; Sauer, Ursula G.; Sheets, Larry P.; Strauss, Volker; Urbisch, Daniel; Botham, Philip A.; van Ravenzwaay, Bennard

Paraquat pharmacokinetics in primates and extrapolation to humans 百草枯在灵长类动物中的药代动力学和对人类的推断

TOXICOLOGY AND APPLIED PHARMACOLOGY

IF3.4

2021-04-01

OAAI

Stevens, Alexander J.; Campbell Jr, Jerry L.; Travis, Kim Z.; Clewell III, Harvey J.; Hinderliter, Paul M.; Botham, Philip A.; Cook, Andrew R.; Minnema, Daniel J.; Wolf, Douglas C.

Integration of paraquat pharmacokinetic data across species using PBPK modelling

TOXICOLOGY AND APPLIED PHARMACOLOGY

IF3.4

2021-04-01

OAAI

Campbell Jr, Jerry L.; Travis, Kim Z.; Clewell III, Harvey J.; Stevens, Alexander J.; Hinderliter, Paul M.; Andersen, Melvin E.; Botham, Philip A.; Cook, Andrew R.; Minnema, Daniel J.; Wolf, Douglas C.

Toward a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - part I: which parameters from human studies are most relevant for toxicological assessments?

CRITICAL REVIEWS IN TOXICOLOGY

IF4.1

2020-12-11

OAAI

Sauer, Ursula G.; Asiimwe, Alex; Botham, Philip A.; Charlton, Alex; Hallmark, Nina; Jacobi, Sylvia; Marty, Sue; Melching-Kollmuss, Stephanie; Palha, Joana A.; Strauss, Volker; van Ravenzwaay, Bennard; Swaen, Gerard

Hazard identification, classification, and risk assessment of carcinogens: too much or too little? - Report of an ECETOC workshop

CRITICAL REVIEWS IN TOXICOLOGY

IF4.1

2020-03-05

OAAI

Felter, Susan P.; Boobis, Alan R.; Botham, Philip A.; Brousse, Alice; Greim, Helmut; Hollnagel, Heli M.; Sauer, Ursula G.

Neurotoxicity of paraquat and paraquat-induced mechanisms of developing Parkinson's disease

LABORATORY INVESTIGATION

IF4.2

2016-09-01

OAAI

Cook, Andrew R.; Botham, Philip A.; Breckenridge, Charles B.; Minnema, Daniel J.; Sturgess, Nicholas C.; Travis, Kim Z.

Dietary administration of diquat for 13 weeks does not result in a loss of dopaminergic neurons in the substantia nigra of C57BL/6J mice

REGULATORY TOXICOLOGY AND PHARMACOLOGY

IF3.5

2016-03-01

OAAI

Minnema, Daniel J.; Travis, Kim Z.; Breckenridge, Charles B.; Sturgess, Nicholas C.; Butt, Mark; Wolf, Jeffrey C.; Zadory, Dan; Herberth, Mark T.; Watson, Scott L.; Cook, Andrew R.; Botham, Philip A.

Regulation of non-relevant metabolites of plant protection products in drinking and groundwater in the EU: Current status and way forward

REGULATORY TOXICOLOGY AND PHARMACOLOGY

IF3.5

2015-10-01

PREAI

Laabs, V.; Leake, C.; Botham, P.; Melching-Kollmuss, S.

Untitled

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

IF2.8

2014-07-17

OAAI

Cook, A.; Breckenridge, C.; Sturgess, N.; Minnema, D.; Travis, K.; Botham, P.

Dietary administration of paraquat for 13 weeks does not result in a loss of dopaminergic neurons in the substantia nigra of C57BL/6J mice 百草枯的饮食给药13周不会导致C57BL/6J小鼠黑质中多巴胺能神经元的损失

REGULATORY TOXICOLOGY AND PHARMACOLOGY

IF3.5

2014-03-01

OAAI

Minnema, Daniel J.; Travis, Kim Z.; Breckenridge, Charles B.; Sturgess, Nicholas C.; Butt, Mark; Wolf, Jeffrey C.; Zadory, Dan; Beck, Melissa J.; Mathews, James M.; Tisdel, Merrill O.; Cook, Andrew R.; Botham, Philip A.; Smith, Lewis L.

Pharmacokinetic, neurochemical, stereological and neuropathological studies on the potential effects of paraquat in the substantia nigra pars compacta and striatum of male C57BL/6J mice 百草枯对雄性C57BL/6J小鼠黑质致密部和纹状体的潜在影响的药代动力学，神经化学，体视学和神经病理学研究

NEUROTOXICOLOGY

IF3.9

2013-07-01

OAAI

Breckenridge, Charles B.; Sturgess, Nicholas C.; Butt, Mark; Wolf, Jeffrey C.; Zadory, Dan; Beck, Melissa; Mathews, James M.; Tisdel, Merrill O.; Minnema, Daniel; Travis, Kim Z.; Cook, Andrew R.; Botham, Philip A.; Smith, Lewis L.

A comparative study of the sensitivity of the 3-induction and 9-induction Buehler test procedures for assessing skin sensitisation potential

FOOD AND CHEMICAL TOXICOLOGY

IF3.5

2005-01-01

PREAI

Botham, P; Urtizberea, M; Wiemann, C; Manciaux, X; Tilbury, L; Vohr, HW; Allen, S; Carmichael, NG; de Jouffrey, S

IRAG working group 3 - Cell function-based assays

FOOD AND CHEMICAL TOXICOLOGY

IF3.5

1997-01-01

PREAI

Botham, P; Osborne, R; Atkinson, K; Carr, G; Cottin, M; VanBuskirk, RG

研究方向