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收藏The Renal Outer Medullary Potassium Channel Inhibitor, MK-7145, Lowers Blood Pressure, and Manifests Features of Bartter's Syndrome Type II Phenotypes
Hampton, Caryn; Zhou, Xiaoyan; Priest, Birgit T.; Pai, Lee-Yuh; Felix, John P.; Thomas-Fowlkes, Brande; Liu, Jessica; Kohler, Martin; Xiao, Jianying; Corona, Aaron; Price, Olga; Gill, Charles; Shah, Kashmira; Rasa, Cordelia; Tong, Vince; Owens, Karen; Ormes, James; Tang, Haifeng; Roy, Sophie; Sullivan, Kathleen A.; Metzger, Joseph M.; Alonso-Galicia, Magdalena; Kaczorowski, Gregory J.; Pasternak, Alexander; Garcia, Maria L.
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收藏Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure
Tang, Haifeng; Zhu, Yuping; Teumelsan, Nardos; Walsh, Shawn P.; Shahripour, Aurash; Priest, Birgit T.; Swensen, Andrew M.; Felix, John P.; Brochu, Richard M.; Bailey, Timothy; Thomas-Fowlkes, Brande; Pai, Lee-Yuh; Hampton, Caryn; Corona, Aaron; Hernandez, Melba; Metzger, Joseph; Forrest, Michael; Zhou, Xiaoyan; Owens, Karen; Tong, Vincent; Parmee, Emma; Roy, Sophie; Kaczorowski, Gregory J.; Yang, Lihu; Alonso-Galicia, Magdalena; Garcia, Maria L.; Pasternak, Alexander
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收藏Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation
Walsh, Shawn P.; Shahripour, Aurash; Tang, Haifeng; Teumelsan, Nardos; Frie, Jessica; Zhu, Yuping; Priest, Birgit T.; Swensen, Andrew M.; Liu, Jessica; Margulis, Michael; Visconti, Richard; Weinglass, Adam; Felix, John P.; Brochu, Richard M.; Bailey, Timothy; Thomas-Fowlkes, Brande; Alonso-Galicia, Magdalena; Zhou, Xiaoyan; Pai, Lee-Yuh; Corona, Aaron; Hampton, Caryn; Hernandez, Melba; Bentley, Ross; Chen, Jing; Shah, Kashmira; Metzger, Joseph; Forrest, Michael; Owens, Karen; Tong, Vincent; Ha, Sookhee; Roy, Sophie; Kaczorowski, Gregory J.; Yang, Lihu; Parmee, Emma; Garcia, Maria L.; Sullivan, Kathleen; Pasternak, Alexander
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收藏Acute hemodynamic and renal effects of glucagon-like peptide 1 analog and dipeptidyl peptidase-4 inhibitor in rats胰高血糖素样肽1类似物和二肽基peptidase-4抑制剂对大鼠的急性血流动力学和肾脏作用
Zhou, Xiaoyan; Huang, Chin-hu; Lao, Julie; Pocai, Alessandro; Forrest, Gail; Price, Olga; Roy, Sophie; Kelley, David E.; Sullivan, Kathleen A.; Forrest, Michael J.
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收藏Pharmacologic Inhibition of the Renal Outer Medullary Potassium Channel Causes Diuresis and Natriuresis in the Absence of Kaliuresis
Garcia, Maria L.; Priest, Birgit T.; Alonso-Galicia, Magdalena; Zhou, Xiaoyan; Felix, John P.; Brochu, Richard M.; Bailey, Timothy; Thomas-Fowlkes, Brande; Liu, Jessica; Swensen, Andrew; Pai, Lee-Yuh; Xiao, Jianying; Hernandez, Melba; Hoagland, Kimberly; Owens, Karen; Tang, Haifeng; de Jesus, Reynalda K.; Roy, Sophie; Kaczorowski, Gregory J.; Pasternak, Alexander
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收藏Heterozygous Disruption of Renal Outer Medullary Potassium Channel in Rats Is Associated With Reduced Blood Pressure
Zhou, Xiaoyan; Zhang, Zuo; Shin, Myung Kyun; Horwitz, Sarah Beth; Levorse, John M.; Zhu, Lei; Sharif-Rodriguez, Wanda; Streltsov, Denis Y.; Dajee, Maya; Hernandez, Melba; Pan, Yi; Urosevic-Price, Olga; Wang, Li; Forrest, Gail; Szeto, Daphne; Zhu, Yonghua; Cui, Yan; Michael, Bindhu; Balogh, Leslie Ann; Welling, Paul A.; Wade, James B.; Roy, Sophie; Sullivan, Kathleen A.
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收藏Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics
Tang, Haifeng; Walsh, Shawn P.; Yan, Yan; de Jesus, Reynalda K.; Shahripour, Aurash; Teumelsan, Nardos; Zhu, Yuping; Ha, Sookhee; Owens, Karen A.; Thomas-Fowlkes, Brande S.; Felix, John P.; Liu, Jessica; Kohler, Martin; Priest, Birgit T.; Bailey, Timothy; Brochu, Richard; Alonso-Galicia, Magdalena; Kaczorowski, Gregory J.; Roy, Sophie; Yang, Lihu; Mills, Sander G.; Garcia, Maria L.; Pasternak, Alexander
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收藏Potent and Selective Inhibitors of Long Chain L-2-Hydroxy Acid Oxidase Reduced Blood Pressure in DOCA Salt-Treated Rats
Barawkar, Dinesh A.; Meru, Ashwin; Bandyopadhyay, Anish; Banerjee, Abir; Deshpande, Anil M.; Athare, Chandrashekhar; Koduru, Chandrasekhar; Khose, Goraksha; Gundu, Jayasagar; Mahajan, Koshu; Patil, Pradeep; Kandalkar, Sachin R.; Niranjan, Sanjay; Bhosale, Shubhangi; De, Siddhartha; Mulchopadhyay, Sudit; Chaudhary, Sumit; Koul, Summon; Singh, Umesh; Chugh, Anita; Palle, Venkata P.; Mookhtiar, Kasim A.; Vacca, Joseph; Chakravarty, Prasun K.; Nargund, Ravi P.; Wright, Samuel D.; Roy, Sophie; Graziano, Michael P.; Singh, Sheo B.; Cully, Doris; Cai, Tian-Quan
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收藏Discovery of a Highly Potent, Selective, and Bioavailable Soluble Epoxide Hydrolase Inhibitor with Excellent Ex Vivo Target Engagement
Shen, Hong C.; Ding, Fa-Xiang; Wang, Siyi; Deng, Qiaolin; Zhang, Xiaoping; Chen, Yuli; Zhou, Gaochao; Xu, Suoyu; Chen, Hsuan-Shen; Tong, Xinchun; Tong, Vincent; Mitra, Kaushik; Kumar, Sanjeev; Tsai, Christine; Stevenson, Andra S.; Pai, Lee-Yuh; Alonso-Galicia, Magdalena; Chen, Xiaoli; Soisson, Stephen M.; Roy, Sophie; Zhang, Bei; Tata, James R.; Berger, Joel P.; Colletti, Steven L.
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