未登录 Alzheimer's disease research and development: a call for a new research roadmap 阿尔茨海默病研究与开发: 呼吁制定新的研究路线图 Feldman, Howard H.; Haas, Magali; Gandy, Sam; Schoepp, Darryle D.; Cross, Alan J.; Mayeux, Richard; Sperling, Reisa A.; Fillit, Howard; van de Hoef, Diana L.; Dougal, Sonya; Nye, Jeffrey S. 分享 收藏
Translating Glutamate: From Pathophysiology to Treatment Javitt, Daniel C.; Schoepp, Darryle; Kalivas, Peter W.; Volkow, Nora D.; Zarate, Carlos; Merchant, Kalpana; Bear, Mark F.; Umbricht, Daniel; Hajos, Mihaly; Potter, William Z.; Lee, Chi-Ming 分享 收藏
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Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized phase 2 clinical trial (vol 13, pg 1102, 2007) Patil, Sandeep T.; Zhang, Lu; Martenyi, Ferenc; Lowe, Stephen L.; Jackson, Kimberley A.; Andreev, Boris V.; Avedisova, Alla S.; Bardenstein, Leonid M.; Gurovich, Issak Y.; Morozova, Margarita A.; Mosolov, Sergey N.; Neznanov, Nikolai G.; Reznik, Alexander M.; Smulevich, Anatoly B.; Tochilov, Vladimir A.; Johnson, Bryan G.; Monn, James A.; Schoepp, Darryle D. 分享 收藏
Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial 激活mGlu2/3受体作为治疗精神分裂症的新方法: 一项随机2期临床试验 Patil, Sandeep T.; Zhang, Lu; Martenyi, Ferenc; Lowe, Stephen L.; Jackson, Kimberley A.; Andreev, Boris V.; Avedisova, Alla S.; Bardenstein, Leonid M.; Gurovich, Issak Y.; Morozova, Margarita A.; Mosolov, Sergey N.; Neznanov, Nikolai G.; Reznik, Alexander M.; Smulevich, Anatoly B.; Tochilov, Vladimir A.; Johnson, Bryan G.; Monn, James A.; Schoepp, Darryle D. 分享 收藏
Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist:: In vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY404039) Rorick-Kehn, Linda M.; Johnson, Bryan G.; Burkey, Jennifer L.; Wright, Rebecca A.; Calligaro, David O.; Marek, Gerard J.; Nisenbaum, Eric S.; Catlow, John T.; Kingston, Ann E.; Giera, Deborah D.; Herin, Marc F.; Monn, James A.; McKinzie, David L.; Schoepp, Darryle D. 分享 收藏
In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders Rorick-Kehn, Linda M.; Johnson, Bryan G.; Knitowski, Karen M.; Salhoff, Craig R.; Witkin, Jeffrey M.; Perry, Kenneth W.; Griffey, Kelly I.; Tizzano, Joseph P.; Monn, James A.; McKinzie, David L.; Schoepp, Darryle D. 分享 收藏
Synthesis and metabotropic glutamate receptor activity of S-oxidized variants of (-)-4-amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate: Identification of potent, selective, and orally bioavailable agonists for mGlu2/3 receptors Monn, James A.; Massey, Steven M.; Valli, Matthew J.; Henry, Steven S.; Stephenson, Gregory A.; Bures, Mark; Herin, Marc; Catlow, John; Giera, Deborah; Wright, Rebecca A.; Johnson, Bryan G.; Andis, Sherri L.; Kingston, Ann; Schoepp, Darryle D. 分享 收藏
Pharmacological characterization of the competitive GLUK5 receptor antagonist decahydroisoquinoline LY466195 in vitro and in vivo Weiss, Brianne; Alt, Andrew; Ogden, Ann Marie; Gates, Mary; Dieckman, Donna K.; Clemens-Smith, Amy; Ho, Ken H.; Jarvie, Keith; Rizkalla, Geihan; Wright, Rebecca A.; Calligaro, David O.; Schoepp, Darryle; Mattiuz, Edward L.; Stratford, Robert E.; Johnson, Bryan; Salhoff, Craig; Katofiasc, Mary; Phebus, Lee A.; Schenck, Kathryn; Cohen, Marlene; Filla, Sandra A.; Ornstein, Paul L.; Johnson, Kirk W.; Bleakman, David 分享 收藏
Neuroprotective actions of novel and potent ligands of group I and group II metabotropic glutamate receptors Kingston, AE; O'Neill, MJ; Bond, A; Bruno, V; Battaglia, G; Nicoletti, F; Harris, JR; Clark, BP; Monn, JA; Lodge, D; Schoepp, DD 分享 收藏
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Synaptic activity regulates interstitial fluid amyloid-β levels in vivo 突触活性调节体内间质液淀粉样蛋白-β 水平 Cirrito, JR; Yamada, KA; Finn, MB; Sloviter, RS; Bales, KR; May, PC; Schoepp, DD; Paul, SM; Mennerick, S; Holtzman, DM 分享 收藏
C3′-cis-substituted carboxycyclopropyl glycines as metabotropic glutamate 2/3 receptor agonists:: Synthesis and SAR studies González, R; Collado, I; de Uralde, BL; Marcos, A; Martín-Cabrejas, LM; Pedregal, C; Blanco-Urgoiti, J; Pérez-Castells, J; Fernández, MA; Andis, SL; Johnson, BG; Wright, RA; Schoepp, DD; Monn, JA 分享 收藏
Dipeptides as effective prodrugs of the unnatural amino acid (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740), a selective group II metabotropic glutamate receptor agonist Bueno, AB; Collado, I; de Dios, A; Domínguez, C; Martín, JA; Martín, LM; Martínez-Grau, MA; Montero, C; Pedregal, C; Catlow, J; Coffey, DS; Clay, MP; Dantzig, AH; Lindstrom, T; Monn, JA; Jiang, HY; Schoepp, DD; Stratford, RE; Tabas, LB; Tizzano, JP; Wright, RA; Herin, MF 分享 收藏
Methyl substitution of 2-aminobicyclo[3.1.0]hexane 2,6-dicarboxylate (LY354740) determines functional activity at metabotropic glutamate receptors: Identification of a subtype selective mGlu2 receptor agonist Dominguez, C; Prieto, L; Valli, MJ; Massey, SM; Bures, M; Wright, RA; Johnson, BG; Andis, SL; Kingston, A; Schoepp, DD; Monn, JA 分享 收藏
Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s) Johnson, MP; Barda, D; Britton, TC; Emkey, R; Hornback, WJ; Jagdmann, GE; McKinzie, DL; Nisenbaum, ES; Tizzano, JP; Schoepp, DD 分享 收藏
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(2S,1′S,2′R,3′R)-2-(2′-carboxy-3′-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity Collado, I; Pedregal, C; Bueno, AB; Marcos, A; González, R; Blanco-Urgoiti, J; Pérez-Castells, J; Schoepp, DD; Wright, RA; Johnson, BG; Kingston, AE; Moher, ED; Hoard, DW; Griffey, KI; Tizzano, JP 分享 收藏
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