未登录 In-depth Clinical and Biological Exploration of DNA Damage Immune Response as a Biomarker for Oxaliplatin Use in Colorectal Cancer DNA损伤免疫反应作为奥沙利铂用于结直肠癌的生物标志物的深入临床和生物学探索 Malla, Sudhir B.; Fisher, David J.; Domingo, Enric; Blake, Andrew; Hassanieh, Sylvana; Redmond, Keara L.; Richman, Susan D.; Youdell, Michael; Walker, Steven M.; Logan, Gemma E.; Chatzipli, Aikaterina; Amirkhah, Raheleh; Humphries, Matthew P.; Craig, Stephanie G.; McDermott, Ultan; Seymour, Matthew T.; Morton, Dion G.; Quirke, Philip; West, Nicholas P.; Salto-Tellez, Manuel; Kennedy, Richard D.; Johnston, Patrick G.; Tomlinson, Ian; Koelzer, Viktor H.; Campo, Letitia; Kaplan, Richard S.; Longley, Daniel B.; Lawler, Mark; Maughan, Timothy S.; Brown, Louise C.; Dunne, Philip D. 分享 收藏
FLIP(L) determines colon cancer cell fate following p53 activation Lees, Andrea; McIntyre, Alexander J. McIntyre J.; Crawford, Nyree T.; Falcone, Fiammetta; McCann, Chris; Quinn, Gerard P.; Roberts, Jamie Z.; Sessler, Thomas; Gallagher, Peter F.; Gregg, Gemma M.; McAllister, Katherine; McLaughlin, Kirsty M.; Allen, Wendy L.; Holohan, Caitriona; Egan, Laurence J.; Ryan, Aideen E.; Labonte-Wilson, Melissa; Dunne, Phillip D.; Wappett, Mark; Coye, Vicky M.; Johnston, Patrick G.; Kerr, Emma M.; Longley, Daniel B.; McDade, Simon S. 分享 收藏
The pseudo-caspase FLIP(L) regulates cell fate following p53 activation 假性半胱天冬酶翻转 (L) 调节p53激活后的细胞命运 Lees, Andrea; McIntyre, Alexander J.; Crawford, Nyree T.; Falcone, Fiammetta; McCann, Christopher; Holohan, Caitriona; Quinn, Gerard P.; Roberts, Jamie Z.; Sessler, Tamas; Gallagher, Peter F.; Gregg, Gemma M. A.; McAllister, Katherine; McLaughlin, Kirsty M.; Allen, Wendy L.; Egan, Laurence J.; Ryan, Aideen E.; Labonte-Wilson, Melissa J.; Dunne, Philip D.; Wappett, Mark; Coyle, Vicky M.; Johnston, Patrick G.; Kerr, Emma M.; Longley, Daniel B.; McDade, Simon S. 分享 收藏
RALB GTPase: A critical regulator of DR5 cell surface expression and TRAIL sensitivity in RAS mutant colorectal cancer Khawaja, Hajrah; Roberts, Jamie Z.; Javadi, Arman; O'Reilly, Paul; McArt, Darragh; Allen, Wendy L.; Morrison, Markus; Kennedy, Richard; Vitale, Nicolas; Johnston, Patrick G.; Harrison, Tim; Longley, Daniel B.; Evergren, Emma; Van Schaeybroeck, Sandra 分享 收藏
The Unfolded Protein Response: A Novel Therapeutic Target for Poor Prognostic BRAF Mutant Colorectal Cancer Forsythe, Nicholas; Refaat, Alaa; Javadi, Arman; Khawaja, Hajrah; Weir, Jessica-Anne; Emam, Heba; Allen, Wendy L.; Burkamp, Frank; Popovici, Vlad; Jithesh, Puthen V.; Isella, Claudio; Labonte, Melissa J.; Mills, Ian G.; Johnston, Patrick G.; Van Schaeybroeck, Sandra 分享 收藏
Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification Dunne, Philip D.; Alderdice, Matthew; O'Reilly, Paul G.; Roddy, Aideen C.; McCorry, Amy M. B.; Richman, Susan; Maughan, Tim; McDade, Simon S.; Johnston, Patrick G.; Longley, Daniel B.; Kay, Elaine; Mcart, Darragh G.; Lawler, Mark 分享 收藏
Targeting c-MET in gastrointestinal tumours: rationale, opportunities and challenges 在胃肠道肿瘤中靶向c-met: 原理，机遇和挑战 Bradley, Conor A.; Salto-Tellez, Manuel; Laurent-Puig, Pierre; Bardelli, Alberto; Rolfo, Christian; Tabernero, Josep; Khawaja, Hajrah A.; Lawler, Mark; Johnston, Patrick G.; Van Schaeybroeck, Sandra 分享 收藏
A Stepwise Integrated Approach to Personalized Risk Predictions in Stage III Colorectal Cancer Salvucci, Manuela; Wurstle, Maximilian L.; Morgan, Clare; Curry, Sarah; Cremona, Mattia; Lindner, Andreas U.; Bacon, Orna; Resler, Alexa J.; Murphy, Aine C.; O'Byrne, Robert; Flanagan, Lorna; Dasgupta, Sonali; Rice, Nadege; Pilati, Camilla; Zink, Elisabeth; Scholler, Lisa M.; Toomey, Sinead; Lawler, Mark; Johnston, Patrick G.; Wilson, Richard; Camilleri-Broet, Sophie; Salto-Tellez, Manuel; McNamara, Deborah A.; Kay, Elaine W.; Laurent-Puig, Pierre; Van Schaeybroeck, Sandra; Hennessy, Bryan T.; Longley, Daniel B.; Rehm, Markus; Prehn, Jochen H. M. 分享 收藏
FLIP: A Targetable Mediator of Resistance to Radiation in Non-Small Cell Lung Cancer McLaughlin, Kylie A.; Nemeth, Zsuzsanna; Bradley, Conor A.; Humphreys, Luke; Stasik, Izabela; Fenning, Catherine; Majkut, Joanna; Higgins, Catherine; Crawford, Nyree; Holohan, Caitriona; Johnston, Patrick G.; Harrison, Timothy; Hanna, Gerard G.; Butterworth, Karl T.; Prise, Kevin M.; Longley, Daniel B. 分享 收藏
Challenging the Cancer Molecular Stratification Dogma: Intratumoral Heterogeneity Undermines Consensus Molecular Subtypes and Potential Diagnostic Value in Colorectal Cancer Dunne, Philip D.; McArt, Darragh G.; Bradley, Conor A.; O'Reilly, Paul G.; Barrett, Helen L.; Cummins, Robert; O'Grady, Tony; Arthur, Ken; Loughrey, Maurice B.; Allen, Wendy L.; McDade, Simon S.; Waugh, David J.; Hamilton, Peter W.; Longley, Daniel B.; Kay, Elaine W.; Johnston, Patrick G.; Lawler, Mark; Salto-Tellez, Manuel; Van Schaeybroeck, Sandra 分享 收藏
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Retrospective evaluation of a system model of the BCL2 family of proteins as a predictive and prognostic biomarker for the clinical outcome of stage II-IV colorectal cancer patients Lindner, Andreas U.; Salvucci, Manuela; Cremona, Mattia; Monsefi, Naser; Curry, Sarah; Morgan, Clare; Resler, Alexa; O'Byrne, Robert; Bacon, Orna; Stuehler, Michael; Flanagan, Lorna; Wilson, Richard; Johnston, Patrick G.; Salto-Tellez, Manuel; Camilleri-Broet, Sophie; McNamara, Deborah A.; Hennessy, Bryan T.; Kay, Elaine W.; Laurent-Puig, Pierre; Van Schaeybroeck, Sandra; Prehn, Jochen H. M. 分享 收藏
EphA2 Expression Is a Key Driver of Migration and Invasion and a Poor Prognostic Marker in Colorectal Cancer Dunne, Philip D.; Dasgupta, Sonali; Blayney, Jaine K.; McArt, Darragh G.; Redmond, Keara L.; Weir, Jessica-Anne; Bradley, Conor A.; Sasazuki, Takehiko; Shirasawa, Senji; Wang, Tingting; Srivastava, Supriya; Ong, Chee Wee; Arthur, Ken; Salto-Tellez, Manuel; Wilson, Richard H.; Johnston, Patrick G.; Van Schaeybroeck, Sandra 分享 收藏
Delivering a research-enabled multistakeholder partnership for enhanced patient care at a population level: The Northern Ireland Comprehensive Cancer Program Lawler, Mark; Gavin, Anna; Salto-Tellez, Manuel; Kennedy, Richard D.; Van Schaeybroeck, Sandra; Wilson, Richard H.; Harkin, Denis Paul; Grayson, Margaret; Boyd, Ruth E.; Hamilton, Peter W.; McArt, Darragh G.; James, Jacqueline; Robson, Tracy; Ladner, Robert D.; Prise, Kevin M.; O'Sullivan, Joe M.; Harrison, Timothy; Murray, Liam; Johnston, Patrick G.; Waugh, David J. 分享 收藏
Development and preclinical assessment of a first-in-class small molecule inhibitor of the major cell death regulator protein FLIP Majkut, Joanna; Higgins, Catherine; Maliki, Adnan; Nemeth, Zsusannah; Blurton, Peter; Boffey, Ray; Perrior, Trevor R.; Johnston, Patrick G.; Haigh, David; Harrison, Timothy; Longley, Daniel B. 分享 收藏
HDAC Inhibition Overcomes Acute Resistance to MEK Inhibition in BRAF-Mutant Colorectal Cancer by Downregulation of c-FLIPL Carson, Robbie; Celtikci, Basak; Fenning, Cathy; Javadi, Arman; Crawford, Nyree; Perez-Carbonell, Lucia; Lawler, Mark; Longley, Daniel B.; Johnston, Patrick G.; Van Schaeybroeck, Sandra 分享 收藏
Efficient Drug Delivery and induction of Apoptosis in Colorectal Tumors Using a Death Receptor 5-Targeted Nanomedicine Schmid, Daniela; Fay, Francois; Small, Donna M.; Jaworski, Jakub; Riley, Joel S.; Tegazzini, Diana; Fenning, Cathy; Jones, David S.; Johnston, Patrick G.; Longley, Daniel B.; Scott, Christopher J. 分享 收藏
Nanoencapsulation of ABT-737 and camptothecin enhances their clinical potential through synergistic antitumor effects and reduction of systemic toxicity Schmid, D.; Jarvis, G. E.; Fay, F.; Small, D. M.; Greene, M. K.; Majkut, J.; Spence, S.; McLaughlin, K. M.; McCloskey, K. D.; Johnston, P. G.; Kissenpfennig, A.; Longley, D. B.; Scott, C. J. 分享 收藏
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