未登录 Pan AMPK activation protects tubules in rat ischemic acute kidney injury Frikke-Schmidt, Henriette; Albarazanji, Kamal; Qi, Jenson; Frederick, David; Steffen, Janos; Kalyana-Sundaram, Shanker; Meng, Rong; Devine, Zheng Huang; Chen, Tao; Li, Qiu; Du, Fuyong; Ho, George; Liu, Jianying; Riley, Roseann; Gonzalez-Villalobos, Romer A.; Camacho, Raul C.; Nawrocki, Andrea R.; Pryor, Meghan; Lee, Min; Wong, Victoria; Matico, Rosalie; Diaz, Elsie; Krosky, Daniel; Wall, Mark; Gao, Elise; Shah, Akshay A.; Leonard, James; Erion, Mark; Pocai, Alessandro; Player, Mark R. 分享 收藏
Phase 1 Trials of PNPLA3 siRNA in I148M Homozygous Patients with MAFLD PNPLA3 siRNA在I148M纯合子MAFLD患者中的1期试验 Fabbrini, Elisa; Rady, Brian; Koshkina, Anastasiya; Jeon, Jae Yoon; Ayyar, Vivaswath S.; Gargano, Cynthia; DiProspero, Nicholas; Wendel, Susan; Hegge, Julia; Hamilton, Holly; Ding, Zhi-Ming; Afrazi, Maria; Nicholas, Anthony; Pei, Tao; Nakano, Masayoshi; Ouchi, Shohei; Saito, Yuki; Yamashita, Aimi; Tamamura, Ryo; Salazar, Hernan; Shapiro, Craig; Yoshihara, Tatsuya; Yonemura, Takuma; Inoue, Satoshi; Matsuoka, Osamu; Erion, Mark; Pocai, Alessandro; Makimura, Hideo 分享 收藏
Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists (vol 13, 942, 2022) Wu, Margaret; Carballo-Jane, Ester; Zhou, Haihong; Zafian, Peter; Dai, Ge; Liu, Mindy; Lao, Julie; Kelly, Terri; Shao, Dan; Gorski, Judith; Pissarnitski, Dmitri; Kekec, Ahmet; Chen, Ying; Previs, Stephen F.; Scapin, Giovanna; Gomez-Llorente, Yacob; Hollingsworth, Scott A.; Yan, Lin; Feng, Danqing; Huo, Pei; Walford, Geoffrey; Erion, Mark D.; Kelley, David E.; Lin, Songnian; Mu, James 分享 收藏
The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR Steffen, Janos; Ngo, Jennifer; Wang, Sheng-Ping; Williams, Kevin; Kramer, Henning F.; Ho, George; Rodriguez, Carlos; Yekkala, Krishna; Amuzie, Chidozie; Bialecki, Russell; Norquay, Lisa; Nawrocki, Andrea R.; Erion, Mark; Pocai, Alessandro; Shirihai, Orian S.; Liesa, Marc 分享 收藏
Discovery of MK-1462: GLP-1 and Glucagon Receptor Dual Agonist for the Treatment of and Diabetes MK-1462的发现: GLP-1和胰高血糖素受体双激动剂治疗糖尿病 Palani, Anandan; Nawrocki, Andrea R.; Orvieto, Federica; Bianchi, Elisabetta; Mandic, Emanuela; Pessi, Antonello; Huang, Chunhui; Deng, Qiaolin; Toussaint, Nathalie; Walsh, Erika; Reddy, Vijay; Ashley, Eric; He, Huaibing; Mumick, Sheena; Hawes, Brian; Marsh, Donald; Erion, Mark; Nargund, Ravi; Carrington, Paul E. 分享 收藏
Discovery of Insulin Receptor Partial Agonists MK-5160 and MK-1092 as Novel Basal Insulins with Potential to Improve Therapeutic Index Pissarnitski, Dmitri A.; Kekec, Ahmet; Yan, Lin; Zhu, Yuping; Feng, Danqing D.; Huo, Pei; Madsen-Duggan, Christina; Moyes, Christopher R.; Nargund, Ravi P.; Kelly, Terri; Zhang, Xiaoping; Carballo-Jane, Ester; Gorski, Judith; Zafian, Peter; Qatanani, Mo; Kaarsholm, Niels; Meng, Fanyu; Jia, Xiujuan; Lee, Keun-Joong; Wang, Weixun; Xu, Sherrie; Hohn, Michael J.; Iammarino, Michael J.; McCoy, Mark A.; Okoh, Grace A.; Liang, Yingkai; Hollingsworth, Scott A.; Erion, Mark D.; Kelley, David E.; Garbaccio, Robert M.; Zhang, Amy; Mu, James; Lin, Songnian 分享 收藏
Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists Wu, Margaret; Carballo-Jane, Ester; Zhou, Haihong; Zafian, Peter; Dai, Ge; Liu, Mindy; Lao, Julie; Kelly, Terri; Shao, Dan; Gorski, Judith; Pissarnitski, Dmitri; Kekec, Ahmet; Chen, Ying; Previs, Stephen F.; Scapin, Giovanna; Llorente, Yacob Gomez; Hollingsworth, Scott A.; Yan, Lin; Feng, Danqing; Huo, Pei; Walford, Geoffrey; Erion, Mark D.; Kelley, David E.; Lin, Songnian; Mu, James 分享 收藏
A Long-Acting PYY3-36 Analog Mediates Robust Anorectic Efficacy with Minimal Emesis in Nonhuman Primates Rangwala, Shamina M.; D'Aquino, Katharine; Zhang, Yue-Mei; Bader, Lindsay; Edwards, Wilson; Zheng, Songmao; Eckardt, Annette; Lacombe, Ann; Pick, Rebecca; Moreno, Veronica; Kang, Lijuan; Jian, Wenying; Arnoult, Eric; Case, Martin; Jenkinson, Celia; Chi, Ellen; Swanson, Ronald, V; Kievit, Paul; Grove, Kevin; Macielag, Mark; Erion, Mark D.; SinhaRoy, Ranabir; Leonard, James N. 分享 收藏
GPR119 Agonism Increases Glucagon Secretion During Insulin-Induced Hypoglycemia Li, Nina Xiaoyan; Brown, Stacey; Kowalski, Tim; Wu, Margaret; Yang, Liming; Dai, Ge; Petrov, Aleksandr; Ding, Yuyan; Dlugos, Tamara; Wood, Harold B.; Wang, Liangsu; Erion, Mark; Sherwin, Robert; Kelley, David E. 分享 收藏
Engineering Glucose Responsiveness Into Insulin (vol 67, pg 299, 2018) Kaarsholm, Niels C.; Lin, Songnian; Yan, Lin; Kelly, Theresa; van Heek, Margaret; Mu, James; Wu, Margaret; Dai, Ge; Cui, Yan; Zhu, Yonghua; Carballo-Jane, Ester; Reddy, Vijay; Zafian, Peter; Huo, Pei; Shi, Shuai; Antochshuk, Valentyn; Ogawa, Aimie; Liu, Franklin; Souza, Sandra C.; Seghezzi, Wolfgang; Duffy, Joseph L.; Erion, Mark; Nargund, Ravi P.; Kelley, David E. 分享 收藏
A glucose-responsive insulin therapy protects animals against hypoglycemia Yang, Ruojing; Wu, Margaret; Lin, Songnian; Nargund, Ravi P.; Li, Xinghai; Kelly, Theresa; Yan, Lin; Dai, Ge; Qian, Ying; Dallas-Yang, Qing; Fischer, Paul A.; Cui, Yan; Shen, Xiaolan; Huo, Pei; Feng, Danqing Dennis; Erion, Mark D.; Kelley, David E.; Mu, James 分享 收藏
Engineering Glucose Responsiveness Into Insulin Kaarsholm, Niels C.; Lin, Songnian; Yan, Lin; Kelly, Theresa; van Heek, Margaret; Mu, James; Wu, Margaret; Dai, Ge; Cui, Yan; Zhu, Yonghua; Carballo-Jane, Ester; Reddy, Vijay; Zafian, Peter; Huo, Pei; Shi, Shuai; Antochshuk, Valentyn; Ogawa, Aimie; Liu, Franklin; Souza, Sandra C.; Seghezzi, Wolfgang; Duffy, Joseph L.; Erion, Mark; Nargund, Ravi P.; Kelley, David E. 分享 收藏
Enhancing Studies of Pharmacodynamic Mechanisms via Measurements of Metabolic Flux: Fundamental Concepts and Guiding Principles for Using Stable Isotope Tracers Daurio, Natalie A.; Wang, Sheng-Ping; Chen, Ying; Zhou, Haihong; McLaren, David G.; Roddy, Thomas P.; Johns, Douglas G.; Milot, Denise; Kasumov, Takhar; Erion, Mark D.; Kelley, David E.; Previs, Stephen F. 分享 收藏
GPR120 suppresses adipose tissue lipolysis and synergizes with GPR40 in antidiabetic efficacy Satapati, Santhosh; Qian, Ying; Wu, Margaret S.; Petrov, Aleksandr; Dai, Ge; Wang, Sheng-ping; Zhu, Yonghua; Shen, Xiaolan; Muise, Eric S.; Chen, Ying; Zycband, Emanuel; Weinglass, Adam; Di Salvo, Jerry; Debenham, John S.; Cox, Jason M.; Lan, Ping; Shah, Vinit; Previs, Stephen F.; Erion, Mark; Kelley, David E.; Wang, Liangsu; Howard, Andrew D.; Shang, Jin 分享 收藏
Inhibition of Factor XIa Reduces the Frequency of Cerebral Microembolic Signals Derived from Carotid Arterial Thrombosis in Rabbits Wang, Xinkang; Kurowski, Stan; Wu, Weizhen; Castriota, Gino A.; Zhou, Xueping; Chu, Lin; Ellsworth, Kenneth P.; Chu, Donald; Edmondson, Scott; Ali, Amjad; Andre, Patrick; Seiffert, Dietmar; Erion, Mark; Gutstein, David E.; Chen, Zhu 分享 收藏
Physiological Expression of AMPK2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice AMPK2RG突变的生理性表达导致wolff-parkinson-white综合征并诱导小鼠肾损伤 Yang, Xiaodong; Mudgett, John; Bou-About, Ghina; Champy, Marie-France; Jacobs, Hugues; Monassier, Laurent; Pavlovic, Guillaume; Sorg, Tania; Herault, Yann; Petit-Demouliere, Benoit; Lu, Ku; Feng, Wen; Wang, Hongwu; Ma, Li-Jun; Askew, Roger; Erion, Mark D.; Kelley, David E.; Myers, Robert W.; Li, Cai; Guan, Hong-Ping 分享 收藏
Duodenal-Jejunal Bypass Surgery Induces Hepatic Lipidomic Alterations Associated with Ameliorated Hepatic Steatosis in Mice Shang, Jin; Castro-Perez, Jose M.; Shen, Xiaolan; Zhu, Yonghua; Liu, Haiying; Qian, Ying; Previs, Stephen; Howard, Andrew D.; Erion, Mark; Kelley, David E.; Wang, Liangsu 分享 收藏
Glucagon receptor antagonism induces increased cholesterol absorption Guan, Hong-Ping; Yang, Xiaodong; Lu, Ku; Wang, Sheng-Ping; Castro-Perez, Jose M.; Previs, Stephen; Wright, Michael; Shah, Vinit; Herath, Kithsiri; Xie, Dan; Szeto, Daphne; Forrest, Gail; Xiao, Jing Chen; Palyha, Oksana; Sun, Li-Ping; Andryuk, Paula J.; Engel, Samuel S.; Xiong, Yusheng; Lin, Songnian; Kelley, David E.; Erion, Mark D.; Davis, Harry R.; Wang, Liangsu 分享 收藏
Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents 优化GLP-1和胰高血糖素受体的共激动作用，以安全地最大程度地减轻啮齿动物的体重 Day, Jonathan W.; Gelfanov, Vasily; Smiley, David; Carrington, Paul E.; Eiermann, George; Chicchi, Gary; Erion, Mark D.; Gidda, Jas; Thornberry, Nancy A.; Tschoep, Matthias H.; Marsh, Donald J.; SinhaRoy, Ranabir; DiMarchi, Richard; Pocai, Alessandro 分享 收藏
Chronic treatment with a glucokinase activator delays the onset of hyperglycaemia and preserves beta cell mass in the Zucker diabetic fatty rat Futamura, M.; Yao, J.; Li, X.; Bergeron, R.; Tran, J. -L.; Zycband, E.; Woods, J.; Zhu, Y.; Shao, Q.; Maruki-Uchida, H.; Goto-Shimazaki, H.; Langdon, R. B.; Erion, M. D.; Eiki, J.; Zhou, Y. -P. 分享 收藏
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