未登录 Cyclin E1/CDK2 activation defines a key vulnerability to WEE1 kinase inhibition in gynecological cancers Cyclin E1/CDK2的激活定义了妇科癌症中WEE1激酶抑制的关键易损性。 Kim, Daehwan; Chung, Heekyung; Liu, Wen; Jeong, Kangjin; Ozmen, Tugba Y.; Ozmen, Furkan; Rames, Matthew J.; Kim, Sangyub; Guo, Xiao; Jameson, Nathan; de Jong, Petrus R.; Yea, Steven; Harford, Laurie; Li, Jiali; Mathews, Cara A.; Doroshow, Deborah B.; Charles, Vincent J.; Kim, Doris; Fischer, Kimberlee; Samatar, Ahmed A.; Jubb, Adrian; Bunker, Kevin D.; Blackwell, Kimberly; Simpkins, Fiona; Meric-Bernstam, Funda; Mills, Gordon B.; Harismendy, Olivier; Ma, Jianhui; Lackner, Mark R. 分享 收藏
PAVO: A phase-II, open label, single arm study of niraparib in patients with locally advanced/metastatic PALB2 mutated tumors Zhang, Tian; Weart, Thomas; Weiss, Matthias; Murray, Drew; Jhawer, Minaxi; Huynh, Edward; Kato, Shumei; Cummings, Amy; Usha, Lydia; Bhinder, Arvinder; Desai, Rajiv; Johnson, Brad; Avadhani, Anjali; Vibat, Cecile Rose T.; Lopez, Lauren; Driscoll, Brynna; Ward, Annajane; Rice, Christie K.; Donovan, Blathnaid; Sherrin, Scott; Robble, Mykel; O'Leary, Stephanie; Blackwell, Kimberly; Aziez, Amine; Petrone, Stephanie; Harnden, Kathleen; Strickland, Kimberly; Reid, Sonya; Robson, Mark; Paulson, Andrew S.; Dowlati, Afshin 分享 收藏
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A platform of CDK4/6 inhibitor-resistant patient-derived breast cancer organoids illuminates mechanisms of resistance and therapeutic vulnerabilities Hanker, Ariella B.; Chatterjee, Sumanta; Wang, Yunguan; Ye, Dan; Sudhan, Dhivya R.; Larsen, Brian M.; Smith, Lauren C.; Zhang, Yilin; Kandagatla, Vishal; Majmudar, Kuntal; Renzulli, Ezequiel; Mendiratta, Saurabh; Blackwell, Kimberly; Welm, Alana L.; Sahoo, Sunati; Unni, Nisha; Lewis, Cheryl M.; Wang, Tao; Carlos, Ameen A. Salahudeen; Arteaga, Carlos L. 分享 收藏
Glembatumumab vedotin for patients with metastatic, gpNMB overexpressing, triple-negative breast cancer (METRIC): a randomized multicenter study Vahdat, Linda T.; Schmid, Peter; Forero-Torres, Andres; Blackwell, Kimberly; Telli, Melinda L.; Melisko, Michelle; Mobus, Volker; Cortes, Javier; Montero, Alberto J.; Ma, Cynthia; Nanda, Rita; Wright, Gail S.; He, Yi; Hawthorne, Thomas; Bagley, Rebecca G.; Halim, Abdel-Baset; Turner, Christopher D.; Yardley, Denise A. 分享 收藏
A phase Ib study of capecitabine and ziv-aflibercept followed by a phase II single-arm expansion cohort in chemotherapy refractory metastatic colorectal cancer Strickler, John H.; Rushing, Christel N.; Niedzwiecki, Donna; McLeod, Abigail; Altomare, Ivy; Uronis, Hope E.; Hsu, S. David; Zafar, S. Yousuf; Morse, Michael A.; Chang, David Z.; Wells, James L.; Blackwell, Kimberly L.; Marcom, P. Kelly; Arrowood, Christy; Bolch, Emily; Haley, Sherri; Rangwala, Fatima A.; Hatch, Ace J.; Nixon, Andrew B.; Hurwitz, Herbert, I 分享 收藏
Updated results from MONALEESA-2, a phase III trial of first-line ribociclib plus letrozole versus placebo plus letrozole in hormone receptor-positive, HER2-negative advanced breast cancer (vol 29, pg 1541, 2018) Hortobagyi, G. N.; Stemmer, S. M.; Burris, H. A.; Yap, Y. S.; Sonke, G. S.; Paluch-Shimon, S.; Campone, M.; Petrakova, K.; Blackwell, K. L.; Winer, E. P.; Janni, W.; Verma, S.; Conte, P.; Arteaga, C. L.; Cameron, D. A.; Mondal, S.; Su, F.; Miller, M.; Elmeliegy, M.; Germa, C.; O'Shaughnessy, J. 分享 收藏
Metastatic breast cancers have reduced immune cell recruitment but harbor increased macrophages relative to their matched primary tumors Zhu, Li; Narloch, Jessica L.; Onkar, Sayali; Joy, Marion; Broadwater, Gloria; Luedke, Catherine; Hall, Allison; Kim, Rim; Pogue-Geile, Katherine; Sammons, Sarah; Nayyar, Naema; Chukwueke, Ugonma; Brastianos, Priscilla K.; Anders, Carey K.; Soloff, Adam C.; Vignali, Dario A. A.; Tseng, George C.; Emens, Leisha A.; Lucas, Peter C.; Blackwell, Kimberly L.; Oesterreich, Steffi; Lee, Adrian, V 分享 收藏
Vaccine-Induced Memory CD8+ T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study Crosby, Erika J.; Gwin, William R.; Blackwell, Kimberly; Marcom, Paul Kelly; Chang, Serena; Maecker, Holden T.; Broadwater, Gloria; Hyslop, Terry M.; Kim, Sungjin; Rogatko, Andre; Lubkov, Veronica; Snyder, Joshua C.; Osada, Takuya; Hobeika, Amy C.; Morse, Michael A.; Lyerly, Herbert Kim; Hartman, Zachary C. 分享 收藏
Examination and prognostic implications of the unique microenvironment of breast cancer brain metastases Sambade, Maria J.; Prince, Grace; Deal, Allison M.; Trembath, Dimitri; McKee, Megan; Garrett, Amy; Keith, Kevin; Ramirez, Juanita; Midkiff, Bentley; Blackwell, Kimberly; Sammons, Sarah; Leone, Jose Pablo; Brufsky, Adam; Morikawa, Aki; Brogi, Edi; Seidman, Andrew; Ewend, Matthew; Carey, Lisa A.; Moschos, Stergios J.; Hamilton, Ronald L.; Vincent, Benjamin; Anders, Carey 分享 收藏
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Phase 1 study of seviteronel, a selective CYP17 lyase and androgen receptor inhibitor, in women with estrogen receptor-positive or triple-negative breast cancer Bardia, Aditya; Gucalp, Ayca; DaCosta, Noashir; Gabrail, Nashat; Danso, Michael; Ali, Haythem; Blackwell, Kimberly L.; Carey, Lisa A.; Eisner, Joel R.; Baskin-Bey, Edwina S.; Traina, Tiffany A. 分享 收藏
Safety and efficacy of alternating treatment with EP2006, a filgrastim biosimilar, and reference filgrastim: a phase III, randomised, double-blind clinical study in the prevention of severe neutropenia in patients with breast cancer receiving myelosuppressive chemotherapy Blackwell, K.; Gascon, P.; Krendyukov, A.; Gattu, S.; Li, Y.; Harbeck, N. 分享 收藏
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Neratinib Efficacy and Circulating Tumor DNA Detection of HER2 Mutations in HER2 Nonamplified Metastatic Breast Cancer Ma, Cynthia X.; Bose, Ron; Gao, Feng; Freedman, Rachel A.; Telli, Melinda L.; Kimmick, Gretchen; Winer, Eric; Naughton, Michael; Goetz, Matthew P.; Russell, Christy; Tripathy, Debu; Cobleigh, Melody; Forero, Andres; Pluard, Timothy J.; Anders, Carey; Niravath, Polly Ann; Thomas, Shana; Anderson, Jill; Bumb, Caroline; Banks, Kimberly C.; Lanman, Richard B.; Bryce, Richard; Lalani, Alshad S.; Pfeifer, John; Hayes, Daniel F.; Pegram, Mark; Blackwell, Kimberly; Bedard, Philippe L.; Al-Kateb, Hussam; Ellis, Matthew J. C. 分享 收藏
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Circulating tumor DNA (ctDNA) sequencing for HER2 mutation (HER2mut) screening and response monitoring to neratinib in metastatic breast cancer (MBC) Ma, Cynthia; Bose, Ron; Gao, Feng; Freedman, Rachel; Telli, Melinda; Kimmick, Gretchen; Winer, Eric; Naughton, Michael; Goetz, Matthew; Russell, Christy; Tripathy, Debu; Cobleigh, Melody; Forero, Andres; Pluard, Timothy; Anders, Carey; Thomas, Shana; Anderson, Jill; Bumb, Caroline; Banks, Kimberly; Lanman, Richard; Bryce, Richard; Lalani, Alshad; Pfeifer, John; Hays, Daniel; Pegram, Mark; Blackwell, Kimberly; Bedard, Philippe; Al-Kateb, Hussam; Ellis, Matthew 分享 收藏
Biopsy of enlarging lesions after stereotactic radiosurgery for brain metastases frequently reveals radiation necrosis Narloch, Jessica L.; Farber, S. Harrison; Sammons, Sarah; McSherry, Frances; Herndon, James E.; Hoang, Jenny K.; Yin, Fang-Fang; Sampson, John H.; Fecci, Peter E.; Blackwell, Kimberly L.; Kirkpatrick, John P.; Kim, Grace J. 分享 收藏
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