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Sergei Timofeevski

Pfizer
H指数:24
被引数:4,637

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荣誉奖项

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Discovery of PF-07265028, A Selective Small Molecule Inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) for the Treatment of Cancer
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-12-090
PRE
Gallego, Rebecca A.; Cho-Schultz, Sujin; Del Bel, Matthew; Dechert-Schmitt, Anne-Marie; Donaldson, Joyann S.; He, Mingying; Jalaie, Mehran; Kania, Rob; Matthews, Jean; Mctigue, Michele; Tuttle, Jamison B.; Risley, Hud; Zhou, Dahui; Zhou, Ru; Ahmad, Omar K.; Bernier, Louise; Berritt, Simon; Braganza, John; Chen, Zecheng; Cianfrogna, Julie A.; Collins, Michael; Jones, Cinthia Costa; Cronin, Ciaran N.; Davis, Carl; Dress, Klaus; Edwards, Martin; Farrell, William; France, Scott P.; Grable, Nicole; Johnson, Eric; Johnson, Ted W.; Jones, Rhys; Knauber, Thomas; Lafontaine, Jennifer; Loach, Richard P.; Maestre, Michael; Miller, Nichol; Moen, Mark; Monfette, Sebastien; Morse, Peter; Nager, Andrew Ross; Niosi, Mark; Richardson, Paul; Rohner, Allison K.; Sach, Neal W.; Timofeevski, Sergei; Tucker, Joseph W.; Vetelino, Beth; Zhang, Lei; Nair, Sajiv K.
Discovery of Highly Selective Inhibitors of Microtubule-Associated Serine/Threonine Kinase-like (MASTL)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-11-050
PRE
Gallego, Rebecca A.; Scales, Stephanie; Toledo, Chad; Auth, Marin; Bernier, Louise; Berry, Madeline; Brun, Sonja; Chung, Loanne; Davis, Carl; Diehl, Wade; Dress, Klaus; Eisele, Koleen; Elleraas, Jeff; Ewanicki, Jason; Fobian, Yvette; Greasley, Samantha; Greenwald, Eric C.; Johnson, Ted W.; Khamphavong, Penney; Lafontaine, Jennifer; Li, Jian; Linton, Angelica; Maestre, Michael; Miller, Nichol; Murtaza, Anwar; Patman, Ryan L.; Quinlan, Casey L.; Ramms, Dana J.; Richardson, Paul; Sach, Neal; Salomon-Ferrer, Romelia; Silva, Francisco; Timofeevski, Sergei; Tran, Phuong; Tran-Dube, Michelle; Wang, Fen; Wang, Wei; Wythes, Martin; Yang, Shouliang; Zou, Aihua; Vanarsdale, Todd; McAlpine, Indrawan
MASTL small-molecule inhibition to target mitosis for cancer therapy
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Toledo, Chad M.; Eisele, Koleen J.; Kim, Dong Hyun; Mu, Xinmeng; Brun, Sonja; Davis, Carl; Greenwald, Eric C.; Hui, Fion; He, Meilan; Yang, Yanling; Flores-Bojorquez, Ana; Li, Yuxin; Khamphavong, Penney L.; Lee, Joseph H.; Li, Jian; Ramms, Dana J.; Jones, Greg; Auth, Marin; Painter, Cory L.; Nager, Andrew; Oyer, Jon; Timofeevski, Sergei L.; Pierceall, William E.; Murtaza, Anwar; Heyen, Jonathan R.; Gallego, Rebecca; Quinlan, Casey; McAlpine, Indrawan; VanArsdale, Todd L.
Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-03-2019
PRE
Gallego, Rebecca A.; Bernier, Louise; Chen, Hui; Cho-Schultz, Sujin; Chung, Loanne; Collins, Michael; Del Bel, Matthew; Elleraas, Jeff; Jones, Cinthia Costa; Cronin, Ciaran N.; Edwards, Martin; Fang, Xu; Fisher, Timothy; He, Mingying; Hoffman, Jacqui; Huo, Ruiduan; Jalaie, Mehran; Johnson, Eric; Johnson, Ted W.; Kania, Robert S.; Kraus, Manfred; Lafontaine, Jennifer; Le, Phuong; Liu, Tongnan; Maestre, Michael; Matthews, Jean; McTigue, Michele; Miller, Nichol; Mu, Qiming; Qin, Xulong; Ren, Shijian; Richardson, Paul; Rohner, Allison; Sach, Neal; Shao, Li; Smith, Graham; Su, Ruirui; Sun, Bin; Timofeevski, Sergei; Tran, Phuong; Wang, Shuiwang; Wang, Wei; Zhou, Ru; Zhu, Jinjiang; Nair, Sajiv K.
A HIGHLY-SELECTIVE HPK1 INHIBITOR ENHANCES T CELL RECEPTOR SIGNALING AND T CELL ACTIVATION POTENTIAL, INCREASING ANTIGEN RECOGNITION AND EFFICACY OF PD-1 THERAPY
JOURNAL FOR IMMUNOTHERAPY OF CANCER
IF10.6
2022-12-080
OA
Nager, Andrew; Schaer, David; Gallego, Rebecca; Hendrickson, Eleanore; Timofeevski, Sergei; Li, Manqing; Rohner, Allison; Seelige, Ruth; Stoner, Samuel; Dillon, Christopher; Cuenca, Paulina; Jones, Cinthia; Firdaus, Sarah; Amezquita, Robert; Restaino, Clifford; Bartlett, Derek; Fisher, Timothy
INHIBITION OF P21-ACTIVATED KINASE 4 (PAK4) REVERTS IMMUNE EXCLUSION AND RESTORES ANTITUMOR IMMUNITY IN THE TUMOR MICROENVIRONMENT
JOURNAL FOR IMMUNOTHERAPY OF CANCER
IF10.6
2021-11-100
OA
Zhou, Yu 'Jerry'; Chu, Gina; Hendrickson, Eleanore; Gullo-Brown, Johnni; Chavez, Brandy; McAlpine, Indrawan; Rui, Eugene; Doran, Shawn; Timofeevski, Sergei; Heyen, Jonathan; Kinong, Jennifer; Tang, Szu-Yu; Oyer, Jon; Rayannavar, Vinayak; Nager, Andrew; Ching, Keith; Shi, Stephanie; Bhadra, Rajarshi; Dillon, Christopher; Gururajan, Murali
Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-12-2426
PREAI
Cheng, Hengmiao; Orr, Suvi T. M.; Bailey, Simon; Brooun, Alexei; Chen, Ping; Deal, Judith G.; Deng, Yali L.; Edwards, Martin P.; Gallego, Gary M.; Grodsky, Neil; Huang, Buwen; Jalaie, Mehran; Kaiser, Stephen; Kania, Robert S.; Kephart, Susan E.; Lafontaine, Jennifer; Ornelas, Martha A.; Pairish, Mason; Planken, Simon; Shen, Hong; Sutton, Scott; Zehnder, Luke; Almaden, Chau D.; Bagrodia, Shubha; Falk, Matthew D.; Gukasyan, Hovhannes J.; Ho, Caroline; Kang, Xiaolin; Kosa, Rachel E.; Liu, Ling; Spilker, Mary E.; Timofeevski, Sergei; Visswanathan, Ravi; Wang, Zhenxiong; Meng, Fanxiu; Ren, Shijian; Shao, Li; Xu, Feng; Kath, John C.
Characterization of Specific N-α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2020-04-1023
OAAI
Kung, Pei-Pei; Bingham, Patrick; Burke, Benjamin J.; Chen, Qiuxia; Cheng, Xuemin; Deng, Ya-Li; Dou, Dengfeng; Feng, Junli; Gallego, Gary M.; Gehring, Michael R.; Grant, Stephan K.; Greasley, Samantha; Harris, Anthony R.; Maegley, Karen A.; Meier, Jordan; Meng, Xiaoyun; Montano, Jose L.; Morgan, Barry A.; Naughton, Brigitte S.; Palde, Prakash B.; Paul, Thomas A.; Richardson, Paul; Sakata, Sylvie; Shaginian, Alex; Sonnenburg, William K.; Subramanyam, Chakrapani; Timofeevski, Sergei; Wan, Jinqiao; Yan, Wen; Stewart, Albert E.
Sequential ALK Inhibitors Can Select for Lorlatinib-Resistant Compound ALK Mutations in ALK-Positive Lung Cancer
CANCER DISCOVERY
IF33.3
2018-05-31237
OAAI
Yoda, Satoshi; Lin, Jessica J.; Lawrence, Michael S.; Burke, Benjamin J.; Friboulet, Luc; Langenbucher, Adam; Dardaei, Leila; Prutisto-Chang, Kylie; Dagogo-Jack, Ibiayi; Timofeevski, Sergei; Hubbeling, Harper; Gainor, Justin F.; Ferris, Lorin A.; Riley, Amanda K.; Kattermann, Krystina E.; Timonina, Daria; Heist, Rebecca S.; Iafrate, A. John; Benes, Cyril H.; Lennerz, Jochen K.; Mino-Kenudson, Mari; Engelman, Jeffrey A.; Johnson, Ted W.; Hata, Aaron N.; Shaw, Alice T.
Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F
NEW ENGLAND JOURNAL OF MEDICINE
IF78.5
2016-01-07427
OA
Shaw, Alice T.; Friboulet, Luc; Leshchiner, Ignaty; Gainor, Justin F.; Bergqvist, Simon; Brooun, Alexei; Burke, Benjamin J.; Deng, Ya-Li; Liu, Wei; Dardaei, Leila; Frias, Rosa L.; Schultz, Kate R.; Logan, Jennifer; James, Leonard P.; Smeal, Tod; Timofeevski, Sergei; Katayama, Ryohei; Iafrate, A. John; Le, Long; McTigue, Michele; Getz, Gad; Johnson, Ted W.; Engelman, Jeffrey A.
PF-06463922, a novel next generation ALK/ROS1 inhibitor, overcomes resistance to 1st and 2nd generation ALK inhibitors in pre-clinical models
CANCER RESEARCH
IF16.6
2015-08-010
PRE
Friboulet, Luc; Zou, Helen; Kodack, David P.; Engstrom, Lars D.; Li, Qiuhua; West, Melissa; Tang, Ruth W.; Wang, Hui; Tsaparikos, Konstantinos; Wang, Jinwei; Timofeevski, Sergei; Dinh, Dac M.; Hieu Lam; Lam, Justine L.; Yamazaki, Shinji; Hu, Wenyue; Patel, Bhushankumar; Bezwada, Divya; Mahmood, Sidra; Lifshits, Eugene; Affolter, Timothy; Lappin, Patrick B.; Gukasyan, Hovhannes; Lee, Nathan; Deng, Shibing; Jain, Rakesh K.; Johnson, Ted W.; Shaw, Alice T.; Fantin, Valeria R.; Smeal, Tod
PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations

PF-06463922是一种有效且选择性的新一代ROS1/ALK抑制剂，能够阻断对克唑替尼耐药的ROS1突变

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2015-03-02263
OAAI
Zou, Helen Y.; Li, Qiuhua; Engstrom, Lars D.; West, Melissa; Appleman, Vicky; Wong, Katy A.; McTigue, Michele; Deng, Ya-Li; Liu, Wei; Brooun, Alexei; Timofeevski, Sergei; McDonnell, Scott R. P.; Jiang, Ping; Falk, Matthew D.; Lappin, Patrick B.; Affolter, Timothy; Nichols, Tim; Hu, Wenyue; Lam, Justine; Johnson, Ted W.; Smeal, Tod; Charest, Al; Fantin, Valeria R.
Discovery of (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2014-06-03524
PREAI
Johnson, Ted W.; Richardson, Paul F.; Bailey, Simon; Brooun, Alexei; Burke, Benjamin J.; Collins, Michael R.; Cui, J. Jean; Deal, Judith G.; Deng, Ya-Li; Dinh, Dac; Engstrom, Lars D.; He, Mingying; Hoffman, Jacqui; Hoffman, Robert L.; Huang, Qinhua; Kania, Robert S.; Kath, John C.; Lam, Hieu; Lam, Justine L.; Le, Phuong T.; Lingardo, Laura; Liu, Wei; McTigue, Michele; Palmer, Cynthia L.; Sach, Neal W.; Smeal, Tod; Smith, Graham L.; Stewart, Albert E.; Timofeevski, Sergei; Zhu, Huichun; Zhu, Jinjiang; Zou, Helen Y.; Edwards, Martin P.
Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2014-02-06110
OA
Huang, Qinhua; Johnson, Ted W.; Bailey, Simon; Brooun, Alexei; Bunker, Kevin D.; Burke, Benjamin J.; Collins, Michael R.; Cook, Andrew S.; Cui, J. Jean; Dack, Kevin N.; Deal, Judith G.; Deng, Ya-Li; Dinh, Dac; Engstrom, Lars D.; He, Mingying; Hoffman, Jacqui; Hoffman, Robert L.; Johnson, Patrick S.; Kania, Robert S.; Lam, Hieu; Lam, Justine L.; Le, Phuong T.; Li, Qiuhua; Lingardo, Laura; Liu, Wei; Lu, Melissa West; McTigue, Michele; Palmer, Cynthia L.; Richardson, Paul F.; Sach, Neal W.; Shen, Hong; Smeal, Tod; Smith, Graham L.; Stewart, Albert E.; Timofeevski, Sergei; Tsaparikos, Konstantinos; Wang, Hui; Zhu, Huichun; Zhu, Jinjiang; Zou, Helen Y.; Edwards, Martin P.
PF-06463922, a novel ROS1/ALK inhibitor, demonstrates sub-nanomolar potency against oncogenic ROS1 fusions and capable of blocking the resistant ROS1G2032R mutant in preclinical tumor models.
MOLECULAR CANCER THERAPEUTICS
IF5.5
2013-11-017
PRE
Zou, Helen Y.; Engstrom, Lars R.; Li, Qiuhua; Lu, Melissa West; Tang, Ruth Wei; Wang, Hui; Tsaparikos, Konstantinos; Timofeevski, Sergei; Lam, Justine; Yamazaki, Shinji; Hu, Wenyue; Gukasyan, Hovhannes; Lee, Nathan; Johnson, Ted W.; Fantin, Valeria; Smeal, Tod
PF-06463922, a novel brain-penetrating small molecule inhibitor of ALK/ROS1 with potent activity against a broad spectrum of ALK resistant mutations in preclinical models in vitro and in vivo
MOLECULAR CANCER THERAPEUTICS
IF5.5
2013-11-016
PRE
Zou, Helen Y.; Engstrom, Lars R.; Li, Qiuhua; Lu, Melissa West; Tang, Ruth Wei; Wang, Hui; Tsaparikos, Konstantinos; Wang, Jinwei; Timofeevski, Sergei; Dinh, Dac M.; Lam, Hieu; Lam, Justine; Yamazaki, Shinji; Hu, Wenyue; Affolter, Timothy; Lappin, Patrick B.; Gukasyan, Hovhannes; Lee, Nathan; Tursi, Jennifer M.; Johnson, Ted W.; Fantin, Valeria; Smeal, Tod

研究方向

暂未获取到该数据
M
Michele McTigue
H 指数:29论文数:100被引数:7,382
T
Ted W. Johnson
H 指数:28论文数:83被引数:5,436
H
Helen Y. Zou
H 指数:23论文数:94被引数:5,769
Q
Qiuhua Li
H 指数:30论文数:147被引数:5,632
T
Tod Smeal
H 指数:42论文数:188被引数:1.7万
A
Alexei Brooun
H 指数:28论文数:127被引数:6,027
Y
Ya‐Li Deng
H 指数:14论文数:52被引数:2,028
S
Shinji Yamazaki
H 指数:34论文数:226被引数:6,087
J
Justine L. Lam
H 指数:16论文数:58被引数:2,056
L
Lars D. Engstrom
H 指数:17论文数:169被引数:4,327