未登录 Antiviral profile of hepatitis B virus capsid assembly modulator ALG-001075, the parent of pevifoscorvir sodium 乙型肝炎病毒衣壳组装调节剂ALG-001075（pevifoscorvir钠的母体）的抗病毒谱 Debing, Yannick; Vanrusselt, Hannah; Liu, Cheng; Verheyen, Jordi; Degrauwe, Lars; Kum, Dieudonne Buh; Sanchez, Abel Acosta; Francisco, Adilson Carlos; Wanicek, Emma; Netter, Hans J.; Ramsland, Paul A.; Leis, Andrew; Shakeel, Shabih; Deval, Jerome; Welch, Michael; Serebryany, Vladimir; Stoycheva, Antitsa; Beigelman, Leonid; Raboisson, Pierre; Vendeville, Sandrine; Lin, Tse-, I; Blatt, Lawrence M.; Smith, David B.; Symons, Julian A.; Lecoq, Lauriane; Jekle, Andreas 分享 收藏
The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075 ALG-000184的发现和临床前概况，有效的乙型肝炎病毒衣壳组装调节剂ALG-001075的前药 Vendeville, Sandrine; Amblard, Franck; Bassit, Leda; Beigelman, Leonid N.; Blatt, Lawrence M.; Chen, Xiaoyuan; Chou, Lang; Kum, Dieudonne Buh; Chanda, Sushmita; Deval, Jerome; Geng, Xiu; Gupta, Kusum; Jekle, Andreas; Hu, Haiyang; Hu, Xiaojuan; Kang, Hyunsoon; Liu, Cheng; Liu, Jyanwei; Mcgowan, David C.; Misner, Dinah L.; Raboisson, Pierre; Sanchez, Abel Acosta; Serebryany, Vladimir; Stoycheva, Antitsa D.; Symons, Julian A.; Tan, Hua; Vanrusselt, Hannah; Williams, Caroline; Welch, Michael; Zhang, Liangliang; Zhang, Qingling; Zhang, Yafeng; Schinazi, Raymond F.; Smith, David B.; Debing, Yannick 分享 收藏
Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH Vandyck, Koen; Mcgowan, David C.; Luong, Xuan G.; Stevens, Sarah K.; Jekle, Andreas; Gupta, Kusum; Misner, Dinah L.; Chanda, Sushmita; Serebryany, Vladimir; Welch, Michael; Hu, Haiyang; Lv, Zhidan; Williams, Caroline; Maskos, Klaus; Lammens, Alfred; Stoycheva, Antitsa D.; Lin, Tse-, I; Blatt, Lawrence M.; Beigelman, Leonid N.; Symons, Julian A.; Raboisson, Pierre; Deval, Jerome 分享 收藏
Novel non-HAP class A HBV capsid assembly modulators have distinct in vitro and in vivo profiles Vanrusselt, Hannah; Kum, Dieudonne Buh; Taverniti, Valerio; Liu, Cheng; Acosta Sanchez, Abel; Corthout, Nikky; Munck, Sebastian; Baumert, Thomas F.; Beigelman, Leonid; Blatt, Lawrence M.; Symons, Julian A.; Deval, Jerome; Raboisson, Pierre; Verrier, Eloi R.; Jekle, Andreas; Vendeville, Sandrine; Debing, Yannick 分享 收藏
Class A capsid assembly modulator RG7907 clears HBV-infected hepatocytes through core-dependent hepatocyte death and proliferation Kum, Dieudonne Buh; Vanrusselt, Hannah; Acosta Sanchez, Abel; Taverniti, Valerio; Verrier, Eloi R.; Baumert, Thomas F.; Liu, Cheng; Deval, Jerome; Corthout, Nikky; Munck, Sebastian; Beigelman, Leonid; Blatt, Lawrence M.; Symons, Julian A.; Raboisson, Pierre; Jekle, Andreas; Vendeville, Sandrine; Debing, Yannick 分享 收藏
The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir Jochmans, Dirk; Liu, Cheng; Donckers, Kim; Stoycheva, Antitsa; Boland, Sandro; Stevens, Sarah K.; De Vita, Chloe; Vanmechelen, Bert; Maes, Piet; Trueb, Bettina; Ebert, Nadine; Thiel, Volker; De Jonghe, Steven; Vangeel, Laura; Bardiot, Dorothee; Jekle, Andreas; Blatt, Lawrence M.; Beigelman, Leonid; Symons, Julian A.; Raboisson, Pierre; Chaltin, Patrick; Marchand, Arnaud; Neyts, Johan; Deval, Jerome; Vandyck, Koen 分享 收藏
Mechanism of action of hepatitis B virus S antigen transport-inhibiting oligonucleotide polymer, STOPS, molecules Kao, C. Cheng; Nie, Yuchun; Ren, Suping; De Costa, N. Tilani T. S.; Pandey, Rajendra K.; Hong, Jin; Smith, David B.; Symons, Julian A.; Beigelman, Leonid; Blatt, Lawrence M. 分享 收藏
Preclinical characterization of ALG-031048, a novel STING agonist with potent anti-tumor activity in mice Jekle, Andreas; Thatikonda, Santosh; Stevens, Sarah; Williams, Caroline; Kinkade, April; Ren, Suping; Jaisinghani, Ruchika; Zhang, Qingling; Misner, Dinah; Stoycheva, Antitsa; Deval, Jerome; Mukherjee, Sucheta; Gonzalvez, Francois; Chanda, Sushmita; Smith, David B.; Symons, Julian A.; Blatt, Lawrence M.; Beigelman, Leonid 分享 收藏
Discovery of novel potent and selective inhibitors of PRMT5 with anti-tumor activity in hepatocellular carcinoma and lung pre-clinical models Gonzalvez, Francois; Vandyck, Koen; Debing, Yannick; Gupta, Kusum; Misner, Dinah; Zhang, Qingling; Liu, Jyanwei; Stoycheva, Antitsa; Stevens, Sarah; Symons, Julian; Beigelman, Leonid; Raboisson, Pierre; Deval, Jerome 分享 收藏
Respiratory syncytial virus-A dynamics and the effects of lumicitabine, a nucleoside viral replication inhibitor, in experimentally infected humans Patel, Kashyap; Kirkpatrick, Carl M.; Nieforth, Keith A.; Chanda, Sushmita; Zhang, Qingling; McClure, Matthew; Fry, John; Symons, Julian A.; Blatt, Lawrence M.; Beigelman, Leo; DeVincenzo, John P.; Huntjens, Dymphy R.; Smith, Patrick F. 分享 收藏
Antiviral Activity, Safety, and Pharmacokinetics of AL-794, a Novel Oral Influenza Endonuclease Inhibitor: Results of an Influenza Human Challenge Study 新型口服流感核酸内切酶抑制剂AL-794的抗病毒活性，安全性和药代动力学: 流感人类挑战研究的结果 Yogaratnam, Jeysen; Rito, Jennifer; Kakuda, Thomas N.; Fennema, Hein; Gupta, Kusum; Jekle, C. Andreas; Mitchell, Toni; Boyce, Malcolm; Sahgal, Omair; Balaratnam, Ganesh; Chanda, Sushmita; Van Remoortere, Pieter; Symons, Julian A.; Fry, John 分享 收藏
Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase Jordan, Paul C.; Liu, Cheng; Raynaud, Pauline; Lo, Michael K.; Spiropoulou, Christina F.; Symons, Julian A.; Beigelman, Leo; Deval, Jerome 分享 收藏
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Activation Pathway of a Nucleoside Analog Inhibiting Respiratory Syncytial Virus Polymerase Jordan, Paul C.; Stevens, Sarah K.; Tam, Yuen; Pemberton, Ryan P.; Chaudhuri, Shuvam; Stoycheva, Antitsa D.; Dyatkina, Natalia; Wang, Guangyi; Symons, Julian A.; Deval, Jerome; Beigelman, Leo 分享 收藏
Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine C-Nucleosides as Favipiravir (T-705) Analogues Wang, Guangyi; Wan, Jingiao; Hu, Yujian; Wu, Xiangyang; Prhavc, Marija; Dyatkina, Natalia; Rajwanshi, Vivek K.; Smith, David B.; Jekle, Andreas; Kinkade, April; Symons, Julian A.; Jin, Zhinan; Deval, Jerome; Zhang, Qjngling; Tam, Yuen; Chanda, Sushmita; Blatt, Lawrence; Beigelman, Leonid 分享 收藏
PAN-GENOTYPIC EVALUATION OF AL-335, A CLINICAL STAGE URIDINE ANALOGUE INHIBITOR OF HEPATITIS C VIRUS POLYMERASE Deval, J.; Fung, A.; Behera, I.; Jin, Z.; Stoycheva, A.; Blatt, L. M.; Wang, G.; Dyatkina, N.; Prhavc, M.; Symons, J. A.; Smith, D. B.; Beigelman, L. 分享 收藏
Biochemical Evaluation of the Inhibition Properties of Favipiravir and 2′-C-Methyl-Cytidine Triphosphates against Human and Mouse Norovirus RNA Polymerases Jin, Zhinan; Tucker, Kathryn; Lin, Xiaoyan; Kao, C. Cheng; Shaw, Ken; Tan, Hua; Symons, Julian; Behera, Ishani; Rajwanshi, Vivek K.; Dyatkina, Natalia; Wang, Guangyi; Beigelman, Leo; Deval, Jerome 分享 收藏
Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study DeVincenzo, John P.; McClure, Matthew W.; Symons, Julian A.; Fathi, Hosnieh; Westland, Christopher; Chanda, Sushmita; Lambkin-Williams, Rob; Smith, Patrick; Zhang, Qingling; Beigelman, Leo; Blatt, Lawrence M.; Fry, John 分享 收藏
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