未登录 SARS-CoV-2 Infection of Human Lung Air-Liquid Interface Cultures Reveals Basal Cells as Relevant Targets SARS-CoV-2感染人肺气-液界面培养物揭示了基底细胞为相关靶点 Baumgardt, Morris; Obermayer, Benedikt; Balazs, Anita; Loewa, Anna; Wyler, Emanuel; Alves, Luiz Gustavo Teixeira; Hellwig, Katharina; Beule, Dieter; Landthaler, Markus; Mueller, Marcel A.; Drosten, Christian; Mall, Marcus A.; Hippenstiel, Stefan; Hoenzke, Katja 分享 收藏
Clinical safety and pharmacokinetics of a novel oral niclosamide formulation compared with marketed niclosamide chewing tablets in healthy volunteers: A three-part randomized, double-blind, placebo-controlled trial 一种新型口服氯硝柳胺制剂的临床安全性及药代动力学研究，与市售氯硝柳胺咀嚼片在健康受试者中的比较：一项三部分随机、双盲、安慰剂对照试验 Walther, Niklas; Schultz-Heienbrok, Robert; Stass, Heino; Corman, Victor M.; Gassen, Nils C.; Mueller, Marcel A.; Drosten, Christian; Witzenrath, Martin; Lee, Hweeling; Posch, Maximilian G. 分享 收藏
Ongoing Evolution of Middle East Respiratory Syndrome Coronavirus, Saudi Arabia, 2023-2024 Hassan, Ahmed M.; Muehlemann, Barbara; Al-Subhi, Tagreed L.; Rodon, Jordi; El-Kafrawy, Sherif A.; Memish, Ziad; Melchert, Julia; Bleicker, Tobias; Mauno, Tiina; Perlman, Stanley; Zumla, Alimuddin; Jones, Terry C.; Mueller, Marcel A.; Corman, Victor M.; Drosten, Christian; Azhar, Esam I. 分享 收藏
ACE2-independent sarbecovirus cell entry can be supported by TMPRSS2-related enzymes and can reduce sensitivity to antibody-mediated neutralization Zhang, Lu; Cheng, Hsiu-Hsin; Krueger, Nadine; Hoernich, Bojan; Graichen, Luise; Hahn, Alexander S.; Schulz, Sebastian R.; Jaeck, Hans-Martin; Stankov, Metodi V.; Behrens, Georg M. N.; Mueller, Marcel A.; Drosten, Christian; Moerer, Onnen; Winkler, Martin Sebastian; Qian, Zhaohui; Poehlmann, Stefan; Hoffmann, Markus 分享 收藏
Biphasic MERS-CoV Incidence in Nomadic Dromedaries with Putative Transmission to Humans, Kenya, 2022-2023 Ogoti, Brian Maina; Riitho, Victor; Wildemann, Johanna; Mutono, Nyamai; Tesch, Julia; Rodon, Jordi; Harichandran, Kaneemozhe; Emanuel, Jackson; Moencke-Buchner, Elisabeth; Kiambi, Stella; Oyugi, Julius; Mureithi, Marianne; Corman, Victor M.; Drosten, Christian; Thumbi, Samuel M.; Mueller, Marcel A. 分享 收藏
A bead-based multiplex assay covering all coronaviruses pathogenic for humans for sensitive and specific surveillance of SARS-CoV-2 humoral immunity Stern, Daniel; Meyer, Tanja C.; Treindl, Fridolin; Mages, Hans Werner; Krueger, Maren; Skiba, Martin; Krueger, Jan Philipp; Zobel, Christian M.; Schreiner, Maximilian; Grossegesse, Marica; Rinner, Thomas; Peine, Caroline; Stoliaroff-Pepin, Anna; Harder, Thomas; Hofmann, Natalie; Michel, Janine; Nitsche, Andreas; Stahlberg, Silke; Kneuer, Antje; Sandoni, Anna; Kubisch, Ulrike; Schlaud, Martin; Mankertz, Annette; Schwarz, Tatjana; Corman, Victor M.; Mueller, Marcel A.; Drosten, Christian; de la Rosa, Kathrin; Schaade, Lars; Dorner, Martin B.; Dorner, Brigitte G. 分享 收藏
Characterization of intrinsic and effective fitness changes caused by temporarily fixed mutations in the SARS-CoV-2 spike E484 epitope and identification of an epistatic precondition for the evolution of E484A in variant Omicron Schroeder, Simon; Richter, Anja; Veith, Talitha; Emanuel, Jackson; Gudermann, Luca; Friedmann, Kirstin; Jeworowski, Lara M.; Muehlemann, Barbara; Jones, Terry C.; Mueller, Marcel A.; Corman, Victor M.; Drosten, Christian 分享 收藏
Functional comparisons of the virus sensor RIG-I from humans, the microbat Myotis daubentonii, and the megabat Rousettus aegyptiacus, and their response to SARS-CoV-2 infection Schoen, Andreas; Hoelzer, Martin; Mueller, Marcel A.; Wallerang, Kai B.; Drosten, Christian; Marz, Manja; Lamp, Benjamin; Weber, Friedemann 分享 收藏
ORF3c is expressed in SARS-CoV-2-infected cells and inhibits innate sensing by targeting MAVS ORF3c在SARS-CoV-2-infected细胞中表达，并通过靶向MAVS抑制先天感知 Mueller, Martin; Herrmann, Alexandra; Fujita, Shigeru; Uriu, Keiya; Kruth, Carolin; Strange, Adam; Kolberg, Jan E.; Schneider, Markus; Ito, Jumpei; Mueller, Marcel A.; Drosten, Christian; Ensser, Armin; Sato, Kei; Sauter, Daniel 分享 收藏
Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection Mhlekude, Baxolele; Postmus, Dylan; Stenzel, Saskia; Weiner, January; Jansen, Jenny; Zapatero-Belinchon, Francisco J.; Olmer, Ruth; Richter, Anja; Heinze, Julian; Heinemann, Nicolas; Muehlemann, Barbara; Schroeder, Simon; Jones, Terry C.; Mueller, Marcel A.; Drosten, Christian; Pich, Andreas; Thiel, Volker; Martin, Ulrich; Niemeyer, Daniela; Gerold, Gisa; Beule, Dieter; Goffinet, Christine 分享 收藏
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Nonproductive exposure of PBMCs to SARS-CoV-2 induces cell-intrinsic innate immune responses Kazmierski, Julia; Friedmann, Kirstin; Postmus, Dylan; Emanuel, Jackson; Fischer, Cornelius; Jansen, Jenny; Richter, Anja; Bosquillon de Jarcy, Laure; Schueler, Christiane; Sohn, Madlen; Sauer, Sascha; Drosten, Christian; Saliba, Antoine-Emmanuel; Sander, Leif Erik; Mueller, Marcel A.; Niemeyer, Daniela; Goffinet, Christine 分享 收藏
Increased neutralization and IgG epitope identification after MVA-MERS-S booster vaccination against Middle East respiratory syndrome Fathi, Anahita; Dahlke, Christine; Krahling, Verena; Kupke, Alexandra; Okba, Nisreen M. A.; Raadsen, Matthijs P.; Heidepriem, Jasmin; Muller, Marcel A.; Paris, Grigori; Lassen, Susan; Kluver, Michael; Volz, Asisa; Koch, Till; Ly, My L.; Friedrich, Monika; Fux, Robert; Tscherne, Alina; Kalodimou, Georgia; Schmiedel, Stefan; Corman, Victor M.; Hesterkamp, Thomas; Drosten, Christian; Loeffler, Felix F.; Haagmans, Bart L.; Sutter, Gerd; Becker, Stephan; Addo, Marylyn M. 分享 收藏
Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages 由于缺乏ACE2水平，人肺对SARS-CoV-2的允许性有限，但病毒诱导的炎性巨噬细胞扩张 Hoenzke, Katja; Obermayer, Benedikt; Mache, Christin; Fathykova, Diana; Kessler, Mirjana; Doekel, Simon; Wyler, Emanuel; Baumgardt, Morris; Loewa, Anna; Hoffmann, Karen; Graff, Patrick; Schulze, Jessica; Mieth, Maren; Hellwig, Katharina; Demir, Zeynep; Biere, Barbara; Brunotte, Linda; Mecate-Zambrano, Angeles; Bushe, Judith; Dohmen, Melanie; Hinze, Christian; Elezkurtaj, Sefer; Toennies, Mario; Bauer, Torsten T.; Eggeling, Stephan; Hong-Linh Tran; Schneider, Paul; Neudecker, Jens; Rueckert, Jens C.; Schmidt-Ott, Kai M.; Busch, Jonas; Klauschen, Frederick; Horst, David; Radbruch, Helena; Radke, Josefine; Heppner, Frank; Corman, Victor M.; Niemeyer, Daniela; Mueller, Marcel A.; Goffinet, Christine; Mothes, Ronja; Pascual-Reguant, Anna; Hauser, Anja Erika; Beule, Dieter; Landthaler, Markus; Ludwig, Stephan; Suttorp, Norbert; Witzenrath, Martin; Gruber, Achim D.; Drosten, Christian; Sander, Leif-Erik; Wolff, Thorsten; Hippenstiel, Stefan; Hocke, Andreas C. 分享 收藏
Cutting Edge: Serum but Not Mucosal Antibody Responses Are Associated with Pre-Existing SARS-CoV-2 Spike Cross-Reactive CD4+ T Cells following BNT162b2 Vaccination in the Elderly Meyer-Arndt, Lil; Schwarz, Tatjana; Loyal, Lucie; Henze, Larissa; Kruse, Beate; Dingeldey, Manuela; Guercan, Kubrah; Uyar-Aydin, Zehra; Mueller, Marcel A.; Drosten, Christian; Paul, Friedemann; Sander, Leif E.; Demuth, Ilja; Lauster, Roland; Giesecke-Thiel, Claudia; Braun, Julian; Corman, Victor M.; Thiel, Andreas 分享 收藏
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Impact of dexamethasone on SARS-CoV-2 concentration kinetics and antibody response in hospitalized COVID-19 patients: results from a prospective observational study 地塞米松对住院新型冠状病毒肺炎患者SARS-CoV-2浓度动力学及抗体反应的影响：一项前瞻性观察研究的结果 Muehlemann, Barbara; Thibeault, Charlotte; Hillus, David; Helbig, Elisa T.; Lippert, Lena J.; Tober-Lau, Pinkus; Schwarz, Tatjana; Mueller, Marcel A.; Witzenrath, Martin; Suttorp, Norbert; Sander, Leif E.; Drosten, Christian; Jones, Terry C.; Corman, Victor M.; Kurth, Florian 分享 收藏
Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5 Schroeder, Simon; Mache, Christin; Kleine-Weber, Hannah; Corman, Victor M.; Muth, Doreen; Richter, Anja; Fatykhova, Diana; Memish, Ziad A.; Stanifer, Megan L.; Boulant, Steeve; Gultom, Mitra; Dijkman, Ronald; Eggeling, Stephan; Hocke, Andreas; Hippenstiel, Stefan; Thiel, Volker; Poehlmann, Stefan; Wolff, Thorsten; Mueller, Marcel A.; Drosten, Christian 分享 收藏
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals Gassen, Nils C.; Papies, Jan; Bajaj, Thomas; Emanuel, Jackson; Dethloff, Frederik; Chua, Robert Lorenz; Trimpert, Jakob; Heinemann, Nicolas; Niemeyer, Christine; Weege, Friderike; Hoenzke, Katja; Aschman, Tom; Heinz, Daniel E.; Weckmann, Katja; Ebert, Tim; Zellner, Andreas; Lennarz, Martina; Wyler, Emanuel; Schroeder, Simon; Richter, Anja; Niemeyer, Daniela; Hoffmann, Karen; Meyer, Thomas F.; Heppner, Frank L.; Corman, Victor M.; Landthaler, Markus; Hocke, Andreas C.; Morkel, Markus; Osterrieder, Nikolaus; Conrad, Christian; Eils, Roland; Radbruch, Helena; Giavalisco, Patrick; Drosten, Christian; Mueller, Marcel A. 分享 收藏
Impaired performance of SARS-CoV-2 antigen-detecting rapid diagnostic tests at elevated and low temperatures Haage, Verena; de Oliveira-Filho, Edmilson Ferreira; Moreira-Soto, Andres; Kuhne, Arne; Fischer, Carlo; Sacks, Jilian A.; Corman, Victor Max; Muller, Marcel A.; Drosten, Christian; Drexler, Jan Felix 分享 收藏
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