David M. Frucht - Publications, H-index & Citations

David M. Frucht

us food & drug administration (fda)

32H指数

92论文数

1.0W被引数

收录论文 31

发表时间

A new STAT3-based potency assay for human G-CSF analog therapeutics 一种基于STAT3的人类G-CSF类似物疗法效力测定方法

Journal of Pharmaceutical and Biomedical Analysis

IF3.1

2025-07-07

PREAI

Tao Xie; Weiming Ouyang; Yaqin Zhang; Phillip Angart; Patrick J. Lynch; David M. Frucht

Development of a New Cell-Based AP-1 Gene Reporter Potency Assay for Anti-Anthrax Toxin Therapeutics

TOXINS

IF4

2023-08-28

OAAI

Ouyang, Weiming; Xie, Tao; Fang, Hui; Frucht, David M.

Interchangeability of the Assays Used to Assess the Activity of Anti-SARS-CoV-2 Monoclonal Antibodies

VIRUSES-BASEL

IF3.5

2023-08-05

OAAI

Hickerson, Brady T.; Khalenkov, Alexey M.; Xie, Tao; Frucht, David M.; Scott, Dorothy E.; Ilyushina, Natalia A.

Hierarchy of protein tyrosine kinases in interleukin-2 (IL2) signaling: Activation of Syk depends on Jak3; However, neither Syk nor Lck is required for IL-2-mediated STAT activation

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-28

OAAI

Zhou, YJ; Magnuson, KS; Cheng, TP; Gadina, M; Frucht, DM; Galon, J; Candotti, F; Geahlen, RL; Changelian, PS; O'Shea, JJ

The ELISA Detectability and Potency of Pegfilgrastim Decrease in Physiological Conditions: Key Roles for Aggregation and Individual Variability

SCIENTIFIC REPORTS

IF3.9

2020-02-12

OAAI

Xie, Tao; Fang, Hui; Ouyang, Weiming; Angart, Phillip; Chiang, Meng-Jung; Bhirde, Ashwinkumar A.; Sheikh, Faruk; Lynch, Patrick; Shah, Ankit B.; Patil, Sharadrao M.; Chen, Kang; Shen, Meiyu; Agarabi, Cyrus; Donnelly, Raymond P.; Brorson, Kurt; Schrieber, Sarah J.; Howard, Kristina E.; Rogstad, Sarah M.; Frucht, David M.

Erk1/2 inactivation promotes a rapid redistribution of COP1 and degradation of COP1 substrates

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-02-10

OAAI

Ouyang, Weiming; Guo, Pengfei; Takeda, Kazuyo; Fu, Qiong; Fang, Hui; Frucht, David M.

Anthrax lethal toxin rapidly reduces c-Jun levels by inhibiting c-Jun gene transcription and promoting c-Jun protein degradation

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2017-10-01

OAAI

Ouyang, Weiming; Guo, Pengfei; Fang, Hui; Frucht, David M.

Gastric pH and Toxin Factors Modulate Infectivity and Disease Progression After Gastrointestinal Exposure to Bacillus anthracis

JOURNAL OF INFECTIOUS DISEASES

IF4.5

2017-09-15

OAAI

Xie, Tao; Rotstein, David; Sun, Chen; Fang, Hui; Frucht, David M.

Passive Immunotherapy Protects against Enteric Invasion and Lethal Sepsis in a Murine Model of Gastrointestinal Anthrax 被动免疫疗法可预防胃肠道炭疽小鼠模型的肠道侵袭和致死性败血症

TOXINS

IF4

2015-09-29

OAAI

Huang, Bruce; Xie, Tao; Rotstein, David; Fang, Hui; Frucht, David M.

Correlating Interleukin-12 Stimulated Interferon-γ Production and the Absence of Ectodermal Dysplasia and Anhidrosis (EDA) in Patients with Mutations in NF-κB Essential Modulator (NEMO)

JOURNAL OF CLINICAL IMMUNOLOGY

IF5.7

2014-02-28

PREAI

Haverkamp, Margje H.; Marciano, Beatriz E.; Frucht, David M.; Jain, Ashish; van de Vosse, Esther; Holland, Steven M.

Anthrax Lethal Toxin Inhibits Translation of Hypoxia-inducible Factor 1α and Causes Decreased Tolerance to Hypoxic Stress

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2014-02-01

OAAI

Ouyang, Weiming; Torigoe, Chikako; Fang, Hui; Xie, Tao; Frucht, David M.

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

NATURE IMMUNOLOGY

IF27.6

2013-10-28

533

OAAI

Lucas, Carrie L.; Kuehn, Hye Sun; Zhao, Fang; Niemel, Julie E.; Deenick, Elissa K.; Palendira, Umaimainthan; Avery, Danielle T.; Moens, Leen; Cannons, Jennifer L.; Lanai, Matthew Bianca; Stoddard, Jennifer; Ouyane, Weiming; Frucht, David M.; Rao, V. Koneti; Atkinson, T. Prescott; Agharahimi, Anahita; Hussey, Ashleigh A.; Folioll, Les R.; Olivier, Kenneth N.; Fleisher, Thomas A.; Pittaluga, Stefania; Holland, Steven M.; Cohen, Jeffrey I.; Oliveira, Joao B.; Tangye, Stuart G.; Schwartzberg, Pamela L.; Lenardol, Michael J.; Uzel, Gulbu

The Effects of Anthrax Lethal Toxin on Host Barrier Function

TOXINS

IF4

2011-06-14

OAAI

Xie, Tao; Auth, Roger D.; Frucht, David M.

Neutrophil Elastase Mediates Pathogenic Effects of Anthrax Lethal Toxin in the Murine Intestinal Tract

JOURNAL OF IMMUNOLOGY

IF3.4

2010-11-01

OAAI

Fang, Hui; Sun, Chen; Xu, Lixin; Owen, Robert J.; Auth, Roger D.; Snoy, Philip J.; Frucht, David M.

Tpl2 kinase regulates T cell interferon-γ production and host resistance to Toxoplasma gondii

JOURNAL OF EXPERIMENTAL MEDICINE

IF10.6

2008-11-10

OAAI

Watford, Wendy T.; Hissong, Bruce D.; Durant, Lydia R.; Yamane, Hidehiro; Muul, Linda M.; Kanno, Yuka; Tato, Cristina M.; Ramos, Haydee L.; Berger, Alan E.; Mielke, Lisa; Pesu, Marko; Solomon, Benjamin; Frucht, David M.; Paul, William E.; Sher, Alan; Jankovic, Dragana; Tsichlis, Philip N.; O'Shea, John J.

Anthrax lethal toxin increases superoxide production in murine neutrophils via differential effects on MAPK signaling pathways

JOURNAL OF IMMUNOLOGY

IF3.4

2008-03-15

OAAI

Xu, Lixin; Fang, Hui; Frucht, David M.

STAT3 mutations in the hyper-IgE syndrome

NEW ENGLAND JOURNAL OF MEDICINE

IF78.5

2007-10-18

1.0K

OAAI

Holland, Steven M.; Deleo, Frank R.; Elloumi, Houda Z.; Hsu, Amy P.; Uzel, Gulbu; Brodsky, Nina; Freeman, Alexandra F.; Demidowich, Andrew; Davis, Joie; Turner, Maria L.; Anderson, Victoria L.; Darnell, Dirk N.; Welch, Pamela A.; Kuhns, Douglas B.; Frucht, David M.; Malech, Harry L.; Gallin, John I.; Kobayashi, Scott D.; Whitney, Adeline R.; Voyich, Jovanka M.; Musser, James M.; Woellner, Cristina; Schaeffer, Alejandro A.; Puck, Jennifer M.; Grimbacher, Bodo

X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production

JOURNAL OF EXPERIMENTAL MEDICINE

IF10.6

2006-07-03

239

OAAI

Filipe-Santos, Orchidee; Bustamante, Jacinta; Haverkamp, Margje H.; Vinolo, Emilie; Ku, Cheng-Lung; Puel, Anne; Frucht, David M.; Christel, Karin; von Bernuth, Horst; Jouanguy, Emmanuelle; Feinberg, Jacqueline; Durandy, Anne; Senechal, Brigitte; Chapgier, Ariane; Vogt, Guillaume; de Beaucoudrey, Ludovic; Fieschi, Claire; Picard, Capucine; Garfa, Meriem; Chemli, Jalel; Bejaoui, Mohamed; Tsolia, Maria N.; Kutukculer, Necil; Plebani, Alessandro; Notarangelo, Luigi; Bodemer, Christine; Geissmann, Frederic; Israel, Alain; Veron, Michel; Knackstedt, Maike; Barbouche, Ridha; Abel, Laurent; Magdorf, Klaus; Gendrel, Dominique; Agou, Fabrice; Holland, Steven M.; Casanova, Jean-Laurent

Anthrax lethal toxin has direct and potent inhibitory effects on B cell proliferation and immunoglobulin production

JOURNAL OF IMMUNOLOGY

IF3.4

2006-05-15

100

OAAI

Fang, Hui; Xu, Lixin; Chen, Trina Y.; Cyr, Julianne M.; Frucht, David M.

HIV regulation of the IL-7R: a viral mechanism for enhancing HIV-1 replication in human macrophages in vitro

JOURNAL OF LEUKOCYTE BIOLOGY

IF3.1

2006-04-13

PREAI

Zhang, Mingjie; Drenkow, Jorg; Lankford, Carla S. R.; Frucht, David M.; Rabin, Ronald L.; Gingeras, Thomas R.; Venkateshan, Chettemegre; Schwartzkopff, Franziska; Clouse, Kathleen A.; Dayton, Andrew I.

研究方向