未登录 Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling Eyre, Rachel; Alferez, Denis G.; Santiago-Gomez, Angelica; Spence, Kath; McConnell, James C.; Hart, Claire; Simoes, Bruno M.; Lefley, Diane; Tulotta, Claudia; Storer, Joanna; Gurney, Austin; Clarke, Noel; Brown, Mick; Howell, Sacha J.; Sims, Andrew H.; Farnie, Gillian; Ottewell, Penelope D.; Clarke, Robert B. 分享 收藏
Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations Flanagan, Dustin J.; Barker, Nick; Di Costanzo, Natasha S.; Mason, Elizabeth A.; Gurney, Austin; Meniel, Valerie S.; Koushyar, Sarah; Austin, Chloe R.; Ernst, Matthias; Pearson, Helen B.; Boussioutas, Alex; Clevers, Hans; Phesse, Toby J.; Vincan, Elizabeth 分享 收藏
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Anti-TIGIT biomarker study: Inhibition of TIGIT induces loss of Tregs from tumors and requires effector function for tumor growth inhibition Argast, Gretchen M.; Cancilla, Belinda; Cattaruzza, Fiore; Yeung, Pete; le Scolan, Erwan; Harris, Rose; Lahmy, Reyhaneh; Brunner, Alayne; Wang, Min; O'Young, Gilbert; Lowe, Earth Light; Axelrod, Fumiko; Monteon, Jorge; Elechko, Jennifer; Lam, Andrew; Xie, MingHong; Gurney, Austin; Lewicki, John; Kapoun, Ann 分享 收藏
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GITRL-Fc biomarker and mechanism study: GITRL-Fc reduces Treg frequency in tumors and requires effector function for inhibition of tumor growth Gitrl-fc生物标志物和机制研究: gitrl-fc降低肿瘤中Treg频率，并需要效应子功能来抑制肿瘤生长 Argast, Gretchen M.; Cancilla, Belinda; Cattaruzza, Fiore; Yeung, Pete; Lahmy, Reyhaneh; Le Scolan, Erwan; Harris, Rose; Brunner, Alayne; Wang, Min; Axelrod, Fumiko; Monteon, Jorge; Elechko, Jennifer; Lam, Andrew; Xie, MingHong; Lowe, Earth Light; O'Young, Gilbert; Gurney, Austin; Kapoun, Ann M. 分享 收藏
Antibody against TIGIT (T cell immunoreceptor with Ig and ITIM domains) induces anti-tumor immune response and generates long-term immune memory Park, Angie Inkyung; Srivastava, Minu; Mayes, Erin; Jie, Hyun-Bae; Yun, Rui; Murriel, Christopher; Xie, Ming-hong; Lam, Andrew; Ji, May; Axelrod, Fumiko; Monteon, Jorge; Lewicki, John; Hoey, Tim; Gurney, Austin 分享 收藏
Prevalence of GITR expression and pharmacodynamic (PD) biomarkers in syngeneic tumor models treated by a GITR agonist (GITRL-Fc) Wang, Min; Cattaruzza, Fiore; Yeung, Pete; Brunner, Alayne; LeScolan, Erwan; Liu, Yuwang; Cain, Jennifer; OYoung, Gilbert; Lowe, Earth Light; Cancilla, Belinda; Harris, Rose; Hoey, Tim; Gurney, Austin; Lewicki, John; Argast, Gretchen; Kapoun, Ann M. 分享 收藏
Pharmacodynamic biomarkers for anti-TIGIT treatment and prevalence of TIGIT expression in multiple solid tumor types Cattaruzza, Fiore; Yeung, Pete; Wang, Min; Brunner, Alayne; Le Scolan, Erwan; Cain, Jennifer; Argast, Gretechen; O'Young, Gilbert; Liu, YuWang; Cancilla, Belinda; Gurney, Austin; Hoey, Tim; Lewicki, John; Kapoun, Ann 分享 收藏
Anti-Tigit induces T cell mediated anti-tumor immune response and combines with immune checkpoint inhibitors to enhance strong and long term anti-tumor immunity Srivastava, Minu K.; Yun, Rui; Mayes, Erin; Yu, Janice; Jie, Hyun-Bae; Axelrod, Fumiko; Xie, Ming-Hong; Monteon, Jorge; Lam, Andrew; Ji, May; Liu, Yuwang; Lewicki, John; Hoey, Tim; Gurney, Austin; Park, Angie Inkyung 分享 收藏
WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death Fischer, Marcus M.; Cancilla, Belinda; Yeung, V. Pete; Cattaruzza, Fiore; Chartier, Cecile; Murriel, Christopher L.; Cain, Jennifer; Tam, Raymond; Cheng, Chieh-Yang; Evans, James W.; O'Young, Gilbert; Song, Xiaomei; Lewicki, John; Kapoun, Ann M.; Gurney, Austin; Yen, Wan-Ching; Hoey, Timothy 分享 收藏
Predictive biomarker identification for response to vantictumab (OMP-18R5; anti-Frizzled) using primary patient-derived human pancreatic tumor xenografts Zhang, Chun; Cattaruzza, Fiore; Yeung, Pete; Yen, Wan-Ching; Fischer, Marcus; Guo, Claire; Brunner, Alayne; Wang, Min; Cancilla, Belinda; Gurney, Austin; Brachmann, Rainer; Lewicki, John; Hoey, Tim; Kapoun, Ann M. 分享 收藏
Effects of anti-DLL4 treatment on non-small cell lung cancer (NSCLC) human xenograft tumors Brunner, Alayne; Cattaruzza, Fiore; Yen, Wan-Ching; Yeung, Pete; Fischer, Marcus; Cancilla, Belinda; O'Young, Gilbert; Tam, Raymond; Liu, Yu-Wang; Gurney, Austin; Lewicki, John; Hoey, Tim; Wang, Min; Kapoun, Ann M. 分享 收藏
Development of a RSPO3 CLIA-validated assay as a predictive biomarker for response to anti-RSPO3 antibody treatment in patients with solid tumors Zhang, Chun; Liu, Yuwang; Wang, Min; OYoung, Gilbert; Kavanagh, Joy; McFarlane, Cheryl; Cattaruzza, Fiore; Yeung, Pete; Cain, Jennifer; Yen, Wan-Ching; Fischer, Marcus; Cancilla, Belinda; Dobbin, Edwina; McCarthy, Michelle; Gurney, Austin; Faoro, Leonardo; Lewicki, John; Hoey, Tim; Kapoun, Ann M. 分享 收藏
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GITR ligand fusion protein (GITRL-Fc) induces T cell mediated anti-tumor immune response and can combine with anti-PDL1 to enhance anti-tumor immunity and long-term immune memory Srivastava, Minu K.; Yun, Rui; Mayes, Erin; Jie, Hyun-Bae; Axelrod, Fumiko; Monteon, Jorge; Xie, Ming-Hong; Lewicki, John; Hoey, Tim; Gurney, Austin; Park, Angie Inkyung 分享 收藏
The bone metastatic niche promotes breast cancer stem cell activity via IL-1β-Wnt signalling Eyre, R.; Spence, K.; Alferez, D.; Santiago-Gomez, A.; Hart, C.; Simoes, B.; Brown, M.; Gurney, A.; Farnie, G.; Clarke, R. 分享 收藏
Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types Chartier, Cecile; Raval, Janak; Axelrod, Fumiko; Bond, Chris; Cain, Jennifer; Dee-Hoskins, Cristina; Ma, Shirley; Fischer, Marcus M.; Shah, Jalpa; Wei, Jie; Ji, May; Lam, Andrew; Stroud, Michelle; Yen, Wan-Ching; Yeung, Pete; Cancilla, Belinda; O'Young, Gilbert; Wang, Min; Kapoun, Ann M.; Lewicki, John; Hoey, Timothy; Gurney, Austin 分享 收藏
Discovery and evaluation of pharmacodynamic and predictive biomarkers for anti-RSPO3, a treatment that reduces tumor growth and cancer stem cell frequency in patient derived xenograft tumor models Cattaruzza, Fiore; Yeung, Pete; Yen, Wan-Ching; Brunner, Alayne; Wang, Min; Liu, YuWang; Fischer, Marcus; O'Young, Gilbert; Chartier, Cecile; Gurney, Austin; Hoey, Tim; Lewicki, John; Kapoun, Ann M. 分享 收藏
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