未登录 Anti-TIGIT biomarker study: Inhibition of TIGIT induces loss of Tregs from tumors and requires effector function for tumor growth inhibition Argast, Gretchen M.; Cancilla, Belinda; Cattaruzza, Fiore; Yeung, Pete; le Scolan, Erwan; Harris, Rose; Lahmy, Reyhaneh; Brunner, Alayne; Wang, Min; O'Young, Gilbert; Lowe, Earth Light; Axelrod, Fumiko; Monteon, Jorge; Elechko, Jennifer; Lam, Andrew; Xie, MingHong; Gurney, Austin; Lewicki, John; Kapoun, Ann 分享 收藏
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Biomarker study of vantictumab plus paclitaxel in HER2-breast cancer patients Zhang, Chun; Henner, William R.; Wang, Min; Cattaruzza, Fiore; Yeung, Pete; O'Young, Gilbert; Liu, Yuwang; Argast, Gretchen; Xu, Lu; Uttamsingh, Shailaja; Lewicki, John; Kapoun, Ann M. 分享 收藏
Antibody against TIGIT (T cell immunoreceptor with Ig and ITIM domains) induces anti-tumor immune response and generates long-term immune memory Park, Angie Inkyung; Srivastava, Minu; Mayes, Erin; Jie, Hyun-Bae; Yun, Rui; Murriel, Christopher; Xie, Ming-hong; Lam, Andrew; Ji, May; Axelrod, Fumiko; Monteon, Jorge; Lewicki, John; Hoey, Tim; Gurney, Austin 分享 收藏
Prevalence of GITR expression and pharmacodynamic (PD) biomarkers in syngeneic tumor models treated by a GITR agonist (GITRL-Fc) Wang, Min; Cattaruzza, Fiore; Yeung, Pete; Brunner, Alayne; LeScolan, Erwan; Liu, Yuwang; Cain, Jennifer; OYoung, Gilbert; Lowe, Earth Light; Cancilla, Belinda; Harris, Rose; Hoey, Tim; Gurney, Austin; Lewicki, John; Argast, Gretchen; Kapoun, Ann M. 分享 收藏
Pharmacodynamic biomarkers for anti-TIGIT treatment and prevalence of TIGIT expression in multiple solid tumor types Cattaruzza, Fiore; Yeung, Pete; Wang, Min; Brunner, Alayne; Le Scolan, Erwan; Cain, Jennifer; Argast, Gretechen; O'Young, Gilbert; Liu, YuWang; Cancilla, Belinda; Gurney, Austin; Hoey, Tim; Lewicki, John; Kapoun, Ann 分享 收藏
Circulating Tumor Cells (CTCs) in patients with extensive stage small cell lung cancer and their association with clinical outcome Zhang, Chun; Graf, Ryon; Jendrisak, Adam; Anderson, Amanda K.; Ontiveros, Priscilla; Orr, Sarah; Chiang, Anne; Spigel, David; Rudin, Charles; Holmgren, Eric; Dupont, Jakob; Argast, Gretchen; Faoro, Leonardo; Zhou, Lei; Lewicki, John; Kapoun, Ann M. 分享 收藏
Anti-Tigit induces T cell mediated anti-tumor immune response and combines with immune checkpoint inhibitors to enhance strong and long term anti-tumor immunity Srivastava, Minu K.; Yun, Rui; Mayes, Erin; Yu, Janice; Jie, Hyun-Bae; Axelrod, Fumiko; Xie, Ming-Hong; Monteon, Jorge; Lam, Andrew; Ji, May; Liu, Yuwang; Lewicki, John; Hoey, Tim; Gurney, Austin; Park, Angie Inkyung 分享 收藏
WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death Fischer, Marcus M.; Cancilla, Belinda; Yeung, V. Pete; Cattaruzza, Fiore; Chartier, Cecile; Murriel, Christopher L.; Cain, Jennifer; Tam, Raymond; Cheng, Chieh-Yang; Evans, James W.; O'Young, Gilbert; Song, Xiaomei; Lewicki, John; Kapoun, Ann M.; Gurney, Austin; Yen, Wan-Ching; Hoey, Timothy 分享 收藏
Predictive biomarker identification for response to vantictumab (OMP-18R5; anti-Frizzled) using primary patient-derived human pancreatic tumor xenografts Zhang, Chun; Cattaruzza, Fiore; Yeung, Pete; Yen, Wan-Ching; Fischer, Marcus; Guo, Claire; Brunner, Alayne; Wang, Min; Cancilla, Belinda; Gurney, Austin; Brachmann, Rainer; Lewicki, John; Hoey, Tim; Kapoun, Ann M. 分享 收藏
Effects of anti-DLL4 treatment on non-small cell lung cancer (NSCLC) human xenograft tumors Brunner, Alayne; Cattaruzza, Fiore; Yen, Wan-Ching; Yeung, Pete; Fischer, Marcus; Cancilla, Belinda; O'Young, Gilbert; Tam, Raymond; Liu, Yu-Wang; Gurney, Austin; Lewicki, John; Hoey, Tim; Wang, Min; Kapoun, Ann M. 分享 收藏
Development of a RSPO3 CLIA-validated assay as a predictive biomarker for response to anti-RSPO3 antibody treatment in patients with solid tumors Zhang, Chun; Liu, Yuwang; Wang, Min; OYoung, Gilbert; Kavanagh, Joy; McFarlane, Cheryl; Cattaruzza, Fiore; Yeung, Pete; Cain, Jennifer; Yen, Wan-Ching; Fischer, Marcus; Cancilla, Belinda; Dobbin, Edwina; McCarthy, Michelle; Gurney, Austin; Faoro, Leonardo; Lewicki, John; Hoey, Tim; Kapoun, Ann M. 分享 收藏
GITR ligand fusion protein (GITRL-Fc) induces T cell mediated anti-tumor immune response and can combine with anti-PDL1 to enhance anti-tumor immunity and long-term immune memory Srivastava, Minu K.; Yun, Rui; Mayes, Erin; Jie, Hyun-Bae; Axelrod, Fumiko; Monteon, Jorge; Xie, Ming-Hong; Lewicki, John; Hoey, Tim; Gurney, Austin; Park, Angie Inkyung 分享 收藏
N Development of a 6-gene qPCR RUO-validated assay as a predictive biomarker for response of vantictumab (OMP-18R5; anti-frizzled) in HER2-breast cancer patients Zhang, C.; O'Young, G.; Wikstrom, K.; Davison, T.; Yeung, P.; Cattaruzza, F.; Yen, W-C; Hoey, T.; Lewicki, J.; Rachmann, R.; Kerr, P.; Hill, L.; Eason, R.; McErlean, S.; Liu, Y.; Kapoun, A. M. 分享 收藏
Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types Chartier, Cecile; Raval, Janak; Axelrod, Fumiko; Bond, Chris; Cain, Jennifer; Dee-Hoskins, Cristina; Ma, Shirley; Fischer, Marcus M.; Shah, Jalpa; Wei, Jie; Ji, May; Lam, Andrew; Stroud, Michelle; Yen, Wan-Ching; Yeung, Pete; Cancilla, Belinda; O'Young, Gilbert; Wang, Min; Kapoun, Ann M.; Lewicki, John; Hoey, Timothy; Gurney, Austin 分享 收藏
Development and validation of a biomarker for prospective selection of Notch1 activation in patients with certain advanced solid tumors in a first-in-human phase1 study of the cancer stem cell targeting antibody OMP-52M51 (anti-Notch1) Cancilla, Belinda; Tam, Raymond; Zhang, Chun; Anderson, Steve; Lewicki, John; Hoey, Tim; McCune, Bryan; Johnson, Lori; Idusogie, Esohe; Kapoun, Ann M. 分享 收藏
Discovery and evaluation of pharmacodynamic and predictive biomarkers for anti-RSPO3, a treatment that reduces tumor growth and cancer stem cell frequency in patient derived xenograft tumor models Cattaruzza, Fiore; Yeung, Pete; Yen, Wan-Ching; Brunner, Alayne; Wang, Min; Liu, YuWang; Fischer, Marcus; O'Young, Gilbert; Chartier, Cecile; Gurney, Austin; Hoey, Tim; Lewicki, John; Kapoun, Ann M. 分享 收藏
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Tarextumab (Anti-NOTCH2/3) reverses NOTCH2 and NOTCH3-dependent tumorigenicity and metastases in small cell lung cancer Shah, Jalpa; O'Young, Gilbert; Wei, Jie; Fischer, Marcus; Yen, Wan-Ching; Cancilla, Belinda; Kapoun, Ann; Lewicki, John; Cain, Jennifer; Hoey, Timothy 分享 收藏
Dual targeting of Delta-like ligand 4 (DLL4) and programmed death 1(PD1) inhibits tumor growth and generates enhanced long-term immunological memory Srivastava, Minu; Murriel, Christopher L.; Rods, Julie; Jie, Hyun-Bae; Axelrod, Fumiko; Xie, Ming-Hong; Yun, Rui; Mayes, Erin; Bentley, Trevor; Cancilla, Belinda; Tam, Raymond; Tang, Tracy; Kapoun, Ann; Lewicki, John; Hoey, Tim; Gurney, Austin; Park, Angie Inkyung 分享 收藏
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