未登录 Peptide-HLA-based immunotherapeutics platforms for direct modulation of antigen-specific T cells Seidel, Ronald D.; Merazga, Zohra; Thapa, Dharma Raj; Soriano, Jonathan; Spaulding, Emily; Vakkasoglu, Ahmet S.; Ruthardt, Paige; Bautista, Wynona; Quayle, Steven N.; Kiener, Peter A.; Low, Simon; Ross, John F.; Cemerski, Saso; Suri, Anish; Almo, Steven C.; Chaparro, Rodolfo J. 分享 收藏
CUE-101, a Novel E7-pHLA-IL2-Fc Fusion Protein, Enhances Tumor Antigen-Specific T-Cell Activation for the Treatment of HPV16-Driven Malignancies Quayle, Steven N.; Girgis, Natasha; Thapa, Dharma R.; Merazga, Zohra; Kemp, Melissa M.; Histed, Alex; Zhao, Fan; Moreta, Miguel; Ruthardt, Paige; Hulot, Sandrine; Nelson, Alyssa; Kraemer, Lauren D.; Beal, Dominic R.; Witt, Luke; Ryabin, Jessica; Soriano, Jonathan; Haydock, Mark; Spaulding, Emily; Ross, John F.; Kiener, Peter A.; Almo, Steven; Chaparro, Rodolfo; Seidel, Ronald; Suri, Anish; Cemerski, Saso; Pienta, Kenneth J.; Simcox, Mary Ellen 分享 收藏
Monoclonal antibody therapeutics with up to five specificities Functional enhancement through fusion of target-specific peptides 具有多达5种特异性的单克隆抗体疗法通过融合靶标特异性肽来增强功能 LaFleur, David W.; Abramyan, Donara; Kanakaraj, Palanisamy; Smith, Rodger G.; Shah, Rutul R.; Wang, Geping; Yao, Xiao-Tao; Kankanala, Spandana; Boyd, Ernie; Zaritskaya, Liubov; Nam, Viktoriya; Puffer, Bridget A.; Buasen, Pete; Kaithamana, Shashi; Burnette, Andrew F.; Krishnamurthy, Rajesh; Patel, Dimki; Roschke, Viktor V.; Kiener, Peter A.; Hilbert, David M.; Barbas, Carlos F., III 分享 收藏
Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis 使用新型双特异性抗体同时靶向TNF和Ang2可增强关节炎体内模型的功效 Kanakaraj, Palanisamy; Puffer, Bridget A.; Yao, Xiao-Tao; Kankanala, Spandana; Boyd, Ernest; Shah, Rutul R.; Wang, Geping; Patel, Dimki; Krishnamurthy, Rajesh; Kaithamana, Shashi; Smith, Rodger G.; LaFleur, David W.; Barbas, Carlos F., III; Hilbert, David M.; Kiener, Peter A.; Roschke, Viktor V. 分享 收藏
Targeting the junction of CεmX and ε-migis for the specific depletion of mIgE-expressing B cells (vol 52, pg 279, 2012) Chowdhury, Partha S.; Chen, Yan; Yang, Chunning; Cook, Kimberly E.; Nyborg, Andrew C.; Ettinger, Rachel; Herbst, Ronald; Kiener, Peter A.; Wu, Herren 分享 收藏
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Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway Higgs, Brandon W.; Liu, Zheng; White, Barbara; Zhu, Wei; White, Wendy I.; Morehouse, Chris; Brohawn, Philip; Kiener, Peter A.; Richman, Laura; Fiorentino, David; Greenberg, Steven A.; Jallal, Bahija; Yao, Yihong 分享 收藏
Relationship between disease activity and type 1 interferon-and other cytokine-inducible gene expression in blood in dermatomyositis and polymyositis Greenberg, S. A.; Higgs, B. W.; Morehouse, C.; Walsh, R. J.; Kong, S. Won; Brohawn, P.; Zhu, W.; Amato, A.; Salajegheh, M.; White, B.; Kiener, P. A.; Jallal, B.; Yao, Y. 分享 收藏
IL-9 Governs Allergen-induced Mast Cell Numbers in the Lung and Chronic Remodeling of the Airways Kearley, Jennifer; Erjefalt, Jonas S.; Andersson, Cecilia; Benjamin, Ebony; Jones, Carla P.; Robichaud, Annette; Pegorier, Sophie; Brewah, Yambasu; Burwell, Timothy J.; Bjermer, Leif; Kiener, Peter A.; Kolbec, Roland; Lloyd, Clare M.; Coyle, Anthony J.; Humbles, Alison A. 分享 收藏
B-Cell Depletion In Vitro and In Vivo with an Afucosylated Anti-CD19 Antibody Herbst, Ronald; Wang, Yue; Gallagher, Sandra; Mittereder, Nanette; Kuta, Ellen; Damschroder, Melissa; Woods, Rob; Rowe, Daniel C.; Cheng, Li; Cook, Kim; Evans, Krista; Sims, Gary P.; Pfarr, David S.; Bowen, Michael A.; Dall'Aqua, William; Shlomchik, Mark; Tedder, Thomas F.; Kiener, Peter; Jallal, Bahija; Wu, Herren; Coyle, Anthony J. 分享 收藏
Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor α antibody, in a phase I study of subjects with mild asthma Busse, William W.; Katial, Rohit; Gossage, David; Sari, Suha; Wang, Bing; Kolbeck, Roland; Coyle, Anthony J.; Koike, Masamichi; Spitalny, George L.; Kiener, Peter A.; Geba, Gregory P.; Molfino, Nestor A. 分享 收藏
MEDI-563, a humanized anti-IL-5 receptor α mAb with enhanced antibody-dependent cell-mediated cytotoxicity function MEDI-563，具有增强的抗体依赖性细胞介导的细胞毒性功能的人源化anti-IL-5受体 α mAb Kolbeck, Roland; Kozhich, Alexander; Koike, Masamichi; Peng, Li; Andersson, Cecilia K.; Damschroder, Melissa M.; Reed, Jennifer L.; Woods, Robert; Dall'Acqua, William W.; Stephens, Geoffrey L.; Erjefalt, Jonas S.; Bjermer, Leif; Humbles, Alison A.; Gossage, David; Wu, Herren; Kiener, Peter A.; Spitalny, George L.; Mackay, Charles R.; Molfino, Nestor A.; Coyle, Anthony J. 分享 收藏
Cell Type-Specific Recognition of Human Metapneumoviruses (HMPVs) by Retinoic Acid-Inducible Gene I (RIG-I) and TLR7 and Viral Interference of RIG-I Ligand Recognition by HMPV-B1 Phosphoprotein Goutagny, Nadege; Jiang, Zhaozhao; Tian, Jane; Parroche, Peggy; Schickli, Jeanne; Monks, Brian G.; Ulbrandt, Nancy; Ji, Hong; Kiener, Peter A.; Coyle, Anthony J.; Fitzgerald, Katherine A. 分享 收藏
A glycoengineered anti-CD19 antibody (MEDI-551) is effective as monotherapy or in combination treatment in mouse models of B-cell malignancies Ward, Beth K.; Mittereder, N.; Kuta, E.; Sims, G.; Damschroeder, M.; Dall'Acqua, W.; Bowen, M. A.; Wu, H.; Tedder, T. F.; Kiener, P. A.; Jallal, B.; Coyle, T.; Herbst, R. 分享 收藏
Antibody-Dependent Cell-Mediated Cytotoxicity Effector-Enhanced EphA2 Agonist Monoclonal Antibody Demonstrates Potent Activity against Human Tumors Bruckheimer, Elizabeth M.; Fazenbaker, Christine A.; Gallagher, Sandra; Mulgrew, Kathy; Fuhrmann, Stacy; Coffman, Karen T.; Walsh, William; Ready, Shannon; Cook, Kim; Damschroder, Melissa; Kinch, Michael; Kiener, Peter A.; Woods, Rob; Gao, Changshou; Dall'Acqua, William; Wu, Herren; Coats, Steven 分享 收藏
Potent Control of Tumor Growth by CEA/CD3-bispecific Single-chain Antibody Constructs That Are Not Competitively Inhibited by Soluble CEA Lutterbuese, Ralf; Raum, Tobias; Kischel, Roman; Lutterbuese, Petra; Schlereth, Bernd; Schaller, Evelyne; Mangold, Susanne; Rau, Doris; Meier, Petra; Kiener, Peter A.; Mulgrew, Kathy; Oberst, Michael D.; Hammond, Scott A.; Baeuerle, Patrick A.; Kufer, Peter 分享 收藏
Macrophage Impairment Underlies Airway Occlusion in Primary Respiratory Syncytial Virus Bronchiolitis Reed, Jennifer L.; Brewah, Yambasu A.; Delaney, Tracy; Welliver, Timothy; Burwell, Timothy; Benjamin, Ebony; Kuta, Ellen; Kozhich, Alexander; McKinney, LuAnn; Suzich, JoAnn; Kiener, Peter A.; Avendano, Luis; Velozo, Luis; Humbles, Alison; Welliver, Robert C., Sr.; Coyle, Anthony J. 分享 收藏
A Human Antibody-Drug Conjugate Targeting EphA2 Inhibits Tumor Growth In vivo Jackson, Dowdy; Gooya, John; Mao, Shenlan; Kinneer, Krista; Xu, Linda; Camara, Margarita; Fazenbaker, Christine; Fleming, Ryan; Swamynathan, Sudha; Meyer, Damon; Senter, Peter D.; Gao, Changshou; Wu, Herren; Kinch, Michael; Coats, Steven; Kiener, Peter A.; Tice, David A. 分享 收藏
YKL-40 is elevated in patients with chronic obstructive pulmonary disease and activates alveolar macrophages Letuve, Severine; Kozhich, Alexander; Arouche, Nassim; Grandsaigne, Martine; Reed, Jennifer; Dombret, Marie-Christine; Kiener, Peter A.; Aubier, Michel; Coyle, Anthony J.; Pretolani, Marina 分享 收藏
Mechanism of action of Sifnalimumab, a human IFN-α neutralizing monoclonal antibody Cibotti, R.; Oganesyan, V.; Liang, M.; Vainshtein, I.; Morris, C.; Riggs, J.; Dall'Acqua, W.; Roskos, L.; Kiener, P.; Coyle, A. J. 分享 收藏
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