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Compartment-specific Metabolic Alterations to Insulin Reflect Adiposity-driven Variation and Predict Type 2 Diabetes 对胰岛素的隔室特异性代谢改变反映肥胖驱动的变化并预测2型糖尿病 Sevilla-Gonzalez, Magdalena; Hanson, Paul A.; Islam, Jesse; Hsu, Sarah; Tsoukas, Michael A.; Marliss, Errol B.; Reiner, Alexander P.; Gravel, Michel; Kooperberg, Charles; Clish, Clary B.; Manning, Alisa K.; Sladek, Rob; Meigs, James B.; Burgos, Sergio A. 分享 收藏
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EndoPRS: Incorporating endophenotype information to improve polygenic risk scores for clinical endpoints-A study in asthma EndoPRS：将内表型信息纳入多基因风险评分以改善临床终点的应用——一项哮喘研究 Kharitonova, EV; Sun, Q; Ockerman, F; Chen, B; Zhou, LY; Hysong, MR; Tuftin, B; Cao, HY; Mathias, RA; Auer, PL; Ober, C; Raffield, LM; Reiner, AP; Cox, NJ; Kelada, SNP; Tao, R; Li, Y 分享 收藏
Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood 血液中嵌合体Y染色体缺失的基因组与表型相关性 Jakubek, YA; Ma, XL; Stilp, AM; Yu, FL; Bacon, J; Wong, JW; Aguet, F; Ardlie, K; Arnett, DK; Barnes, K; Bis, JC; Blackwell, T; Becker, LC; Boerwinkle, E; Bowler, RP; Budoff, MJ; Carson, AP; Chen, JW; Cho, MH; Coresh, J; Cox, NJ; Vries, PSD; Demeo, DL; Fardo, DW; Fornage, M; Guo, XQ; Hall, ME; Heard-Costa, N; Hidalgo, B; Irvin, MR; Johnson, AD; Jorgenson, E; Kenny, EE; Kessler, MD; Levy, D; Li, Y; Lima, JAC; Liu, YM; Locke, AE; Loos, RJF; Machiela, MJ; Mathias, RA; Mitchell, BD; Murabito, JM; Mychaleckyj, JC; North, KE; Orchard, P; Parker, SCJ; Pershad, Y; Peyser, PA; Pratte, KA; Psaty, BM; Raffield, LM; Redline, S; Rich, SS; Rotter, JI; Shah, SJ; Smith, JA; Smith, AP; Smith, A; Taub, MA; Tiwari, HK; Tracy, R; Tuftin, B; Bick, AG; Sankaran, VG; Reiner, AP; Scheet, P; Auer, PL 分享 收藏
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Cardiovascular Risk Factors and Genetic Risk in Transthyretin V142I Carriers 心血管风险因素和遗传风险在转甲状腺素蛋白V142I携带者中 Shetty, Naman S.; Gaonkar, Mokshad; Pampana, Akhil; Patel, Nirav; Morrison, Alanna C.; Reiner, Alexander P.; Carson, April P.; Yu, Bing; Psaty, Bruce M.; Kooperberg, Charles; Fatkin, Diane; Boerwinkle, Eric; Rotter, Jerome I.; Taylor, Kent D.; Irvin, Marguerite R.; Hall, Michael E.; Maurer, Mathew; Fornage, Myriam; Armstrong, Nicole D.; Bart, Nicole; Goyal, Parag; Rich, Stephen S.; Vasan, Ramachandran S.; Arora, Garima; Arora, Pankaj 分享 收藏
Integrative proteomic analyses across common cardiac diseases yield mechanistic insights and enhanced prediction 跨常见心脏疾病的综合蛋白质组学分析可产生机制见解和增强的预测 Schuermans, Art; Pournamdari, Ashley B.; Lee, Jiwoo; Bhukar, Rohan; Ganesh, Shriienidhie; Darosa, Nicholas; Small, Aeron M.; Yu, Zhi; Hornsby, Whitney; Koyama, Satoshi; Kooperberg, Charles; Reiner, Alexander P.; Januzzi, James L.; Honigberg, Michael C.; Natarajan, Pradeep 分享 收藏
Identification of proteins associated with type 2 diabetes risk in diverse racial and ethnic populations 在不同种族和民族人群中鉴定与2型糖尿病风险相关的蛋白质 Liu, Shuai; Zhu, Jingjing; Zhong, Hua; Wu, Chong; Xue, Haoran; Darst, Burcu F.; Guo, Xiuqing; Durda, Peter; Tracy, Russell P.; Liu, Yongmei; Johnson, W. Craig; Taylor, Kent D.; Manichaikul, Ani W.; Goodarzi, Mark O.; Gerszten, Robert E.; Clish, Clary B.; Chen, Yii-Der Ida; Highland, Heather; Haiman, Christopher A.; Gignoux, Christopher R.; Lange, Leslie; Conti, David V.; Raffield, Laura M.; Wilkens, Lynne; Le Marchand, Loic; North, Kari E.; Young, Kristin L.; Loos, Ruth J.; Buyske, Steve; Matise, Tara; Peters, Ulrike; Kooperberg, Charles; Reiner, Alexander P.; Yu, Bing; Boerwinkle, Eric; Sun, Quan; Rooney, Mary R.; Echouffo-Tcheugui, Justin B.; Daviglus, Martha L.; Qi, Qibin; Mancuso, Nicholas; Li, Changwei; Deng, Youping; Manning, Alisa; Meigs, James B.; Rich, Stephen S.; Rotter, Jerome I.; Wu, Lang 分享 收藏
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Gene expression and splicing QTL analysis of blood cells in African American participants from the Jackson Heart Study 杰克逊心脏研究非裔美国人参与者血细胞的基因表达和剪接QTL分析 Wen, Jia; Sun, Quan; Huang, Le; Zhou, Lingbo; Doyle, Margaret F.; Ekunwe, Lynette; Durda, Peter; Olson, Nels C.; Reiner, Alexander P.; Li, Yun; Raffield, Laura M. 分享 收藏
Multi-ancestry polygenic risk scores for venous thromboembolism 静脉血栓栓塞的多祖先多基因风险评分 Jee, Yon Ho; Thibord, Florian; Dominguez, Alicia; Sept, Corriene; Boulier, Kristin; Venkateswaran, Vidhya; Ding, Yi; Cherlin, Tess; Verma, Shefali Setia; Lo Faro, Valeria; Bartz, Traci M.; Boland, Anne; Brody, Jennifer A.; Deleuze, Jean-Francois; Emmerich, Joseph; Germain, Marine; Johnson, Andrew D.; Kooperberg, Charles; Morange, Pierre-Emmanuel; Pankratz, Nathan; Psaty, Bruce M.; Reiner, Alexander P.; Smadja, David M.; Sitlani, Colleen M.; Suchon, Pierre; Tang, Weihong; Tregouet, David-Alexandre; Zollner, Sebastian; Pasaniuc, Bogdan; Damrauer, Scott M.; Sanna, Serena; Snieder, Harold; Kabrhel, Christopher; Smith, Nicholas L.; Kraft, Peter 分享 收藏
Epigenetic and proteomic signatures associate with clonal hematopoiesis expansion rate 表观遗传和蛋白质组学特征与克隆造血扩增率相关 Mack, Taralynn M.; Raddatz, Michael A.; Pershad, Yash; Nachun, Daniel C.; Taylor, Kent D.; Guo, Xiuqing; Shuldiner, Alan R.; O'Connell, Jeffrey R.; Kenny, Eimear E.; Loos, Ruth J. F.; Redline, Susan; Cade, Brian E.; Psaty, Bruce M.; Bis, Joshua C.; Brody, Jennifer A.; Silverman, Edwin K.; Yun, Jeong H.; Cho, Michael H.; DeMeo, Dawn L.; Levy, Daniel; Johnson, Andrew D.; Mathias, Rasika A.; Yanek, Lisa R.; Heckbert, Susan R.; Smith, Nicholas L.; Wiggins, Kerri L.; Raffield, Laura M.; Carson, April P.; Rotter, Jerome I.; Rich, Stephen S.; Manichaikul, Ani W.; Gu, C. Charles; Chen, Yii-Der Ida; Lee, Wen-Jane; Shoemaker, M. Benjamin; Roden, Dan M.; Kooperberg, Charles; Auer, Paul L.; Desai, Pinkal; Blackwell, Thomas W.; Smith, Albert V.; Reiner, Alexander P.; Jaiswal, Siddhartha; Weinstock, Joshua S.; Bick, Alexander G. 分享 收藏
Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes Keener, Rebecca; Chhetri, Surya B.; Connelly, Carla J.; Taub, Margaret A.; Conomos, Matthew P.; Weinstock, Joshua; Ni, Bohan; Strober, Benjamin; Aslibekyan, Stella; Auer, Paul L.; Barwick, Lucas; Becker, Lewis C.; Blangero, John; Bleecker, Eugene R.; Brody, Jennifer A.; Cade, Brian E.; Celedon, Juan C.; Chang, Yi-Cheng; Cupples, L. Adrienne; Custer, Brian; Freedman, Barry I.; Gladwin, Mark T.; Heckbert, Susan R.; Hou, Lifang; Irvin, Marguerite R.; Isasi, Carmen R.; Johnsen, Jill M.; Kenny, Eimear E.; Kooperberg, Charles; Minster, Ryan L.; Naseri, Take; Viali, Satupa'itea; Nekhai, Sergei; Pankratz, Nathan; Peyser, Patricia A.; Taylor, Kent D.; Telen, Marilyn J.; Wu, Baojun; Yanek, Lisa R.; Yang, Ivana V.; Albert, Christine; Arnett, Donna K.; Ashley-Koch, Allison E.; Barnes, Kathleen C.; Bis, Joshua C.; Blackwell, Thomas W.; Boerwinkle, Eric; Burchard, Esteban G.; Carson, April P.; Chen, Zhanghua; Chen, Yii-Der Ida; Darbar, Dawood; de Andrade, Mariza; Ellinor, Patrick T.; Fornage, Myriam; Gelb, Bruce D.; Gilliland, Frank D.; He, Jiang; Islam, Talat; Kaab, Stefan; Kardia, Sharon L. R.; Kelly, Shannon; Konkle, Barbara A.; Kumar, Rajesh; Loos, Ruth J. F.; Martinez, Fernando D.; McGarvey, Stephen T.; Meyers, Deborah A.; Mitchell, Braxton D.; Montgomery, Courtney G.; North, Kari E.; Palmer, Nicholette D.; Peralta, Juan M.; Raby, Benjamin A.; Redline, Susan; Rich, Stephen S.; Roden, Dan; Rotter, Jerome I.; Ruczinski, Ingo; Schwartz, David; Sciurba, Frank; Shoemaker, M. Benjamin; Silverman, Edwin K.; Sinner, Moritz F.; Smith, Nicholas L.; Smith, Albert V.; Tiwari, Hemant K.; Vasan, Ramachandran S.; Weiss, Scott T.; Williams, L. Keoki; Zhang, Yingze; Ziv, Elad; Raffield, Laura M.; Reiner, Alexander P.; Arvanitis, Marios; Greider, Carol W.; Mathias, Rasika A.; Battle, Alexis 分享 收藏
Whole genome sequencing based analysis of inflammation biomarkers in the Trans-Omics for Precision Medicine (TOPMed) consortium Jiang, Min-Zhi; Gaynor, Sheila M.; Li, Xihao; Van Buren, Eric; Stilp, Adrienne; Buth, Erin; Wang, Fei Fei; Manansala, Regina; Gogarten, Stephanie M.; Li, Zilin; Polfus, Linda M.; Salimi, Shabnam; Bis, Joshua C.; Pankratz, Nathan; Yanek, Lisa R.; Durda, Peter; Tracy, Russell P.; Rich, Stephen S.; Rotter, Jerome, I; Mitchell, Braxton D.; Lewis, Joshua P.; Psaty, Bruce M.; Pratte, Katherine A.; Silverman, Edwin K.; Kaplan, Robert C.; Avery, Christy; North, Kari E.; Mathias, Rasika A.; Faraday, Nauder; Lin, Honghuang; Wang, Biqi; Carson, April P.; Norwood, Arnita F.; Gibbs, Richard A.; Kooperberg, Charles; Lundin, Jessica; Peters, Ulrike; Dupuis, Josee; Hou, Lifang; Fornage, Myriam; Benjamin, Emelia J.; Reiner, Alexander P.; Bowler, Russell P.; Lin, Xihong; Auer, Paul L.; Raffield, Laura M. 分享 收藏
MagicalRsq-X: A cross-cohort transferable genotype imputation quality metric Magicalrsq-x: 一种跨队列可转移基因型归约质量指标 Sun, Quan; Yang, Yingxi; Rosen, Jonathan D.; Chen, Jiawen; Li, Xihao; Guan, Wyliena; Jiang, Min-Zhi; Wen, Jia; Pace, Rhonda G.; Blackman, Scott M.; Bamshad, Michael J.; Gibson, Ronald L.; Cutting, Garry R.; O'Neal, Wanda K.; Knowles, Michael R.; Kooperberg, Charles; Reiner, Alexander P.; Raffield, Laura M.; Carson, April P.; Rich, Stephen S.; Rotter, Jerome I.; Loos, Ruth J. F.; Kenny, Eimear; Jaeger, Byron C.; Min, Yuan -, I; Fuchsberger, Christian; Li, Yun 分享 收藏
Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes 2型糖尿病患者发生心血管疾病的时间-事件全基因组关联研究 Kwak, Soo Heon; Hernandez-Cancela, Ryan B.; DiCorpo, Daniel A.; Condon, David E.; Merino, Jordi; Wu, Peitao; Brody, Jennifer A.; Yao, Jie; Guo, Xiuqing; Ahmadizar, Fariba; Meyer, Mariah; Sincan, Murat; Mercader, Josep M.; Lee, Sujin; Haessler, Jeffrey; Vy, Ha My T.; Lin, Zhaotong; Armstrong, Nicole D.; Gu, Shaopeng; Tsao, Noah L.; Lange, Leslie A.; Wang, Ningyuan; Wiggins, Kerri L.; Trompet, Stella; Liu, Simin; Loos, Ruth J. F.; Judy, Renae; Schroeder, Philip H.; Hasbani, Natalie R.; Bos, Maxime M.; Morrison, Alanna C.; Jackson, Rebecca D.; Reiner, Alexander P.; Manson, JoAnn E.; Chaudhary, Ninad S.; Carmichael, Lynn K.; Chen, Yii-Der Ida; Taylor, Kent D.; Ghanbari, Mohsen; van Meurs, Joyce; Pitsillides, Achilleas N.; Psaty, Bruce M.; Noordam, Raymond; Do, Ron; Park, Kyong Soo; Jukema, J. Wouter; Kavousi, Maryam; Correa, Adolfo; Rich, Stephen S.; Damrauer, Scott M.; Hajek, Catherine; Cho, Nam H.; Irvin, Marguerite R.; Pankow, James S.; Nadkarni, Girish N.; Sladek, Robert; Goodarzi, Mark O.; Florez, Jose C.; Chasman, Daniel I.; Heckbert, Susan R.; Kooperberg, Charles; Dupuis, Josee; Malhotra, Rajeev; de Vries, Paul S.; Liu, Ching-Ti; Rotter, Jerome I.; Meigs, James B. 分享 收藏
Radon Exposure and Incident Stroke Risk in the Women's Health Initiative Buchheit, Sophie F.; Collins, Jason M.; Anthony, Kurtis M.; Love, Shelly-Ann M.; Stewart, James D.; Gondalia, Rahul; Huang, David Y.; Manson, JoAnn E.; Reiner, Alexander P.; Schwartz, Gary G.; Vitolins, Mara Z.; Schumann, R. Randall; Smith, Richard L.; Whitsel, Eric A. 分享 收藏
Improving polygenic risk prediction in admixed populations by explicitly modeling ancestral-differential effects via GAUDI 通过高迪明确建模祖先差异效应，改善混合人群的多基因风险预测 Sun, Quan; Rowland, Bryce T.; Chen, Jiawen; Mikhaylova, Anna V.; Avery, Christy; Peters, Ulrike; Lundin, Jessica; Matise, Tara; Buyske, Steve; Tao, Ran; Mathias, Rasika A.; Reiner, Alexander P.; Auer, Paul L.; Cox, Nancy J.; Kooperberg, Charles; Thornton, Timothy A.; Raffield, Laura M.; Li, Yun 分享 收藏
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