未登录REM-422, a Small Molecule MYB mRNA Degrader, Demonstrates Anti-Leukemic Activity As Monotherapy and in Combination with Standards of Care in Preclinical Models of AMLREM-422，一种小分子MYB mRNA降解剂，在AML的临床前模型中显示出单药治疗以及与标准护理方案联合使用的抗白血病活性。
Levin-Furtney, Samantha; Thomas, Michael; Harney, Alycen M.; Shan, Mengge; Ivliev, Alexander; Stefek, Adam; Cameron, Michael; Prajapati, Sudeep; Seiler, Michael; Reynolds, Dominic; Buonamici, Silvia; Kung, Charles .png)
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收藏REM-422, a potent, selective, oral small moleculemRNA degrader of the MYB oncogene, induces regressions in mouse patient-derived xenograft models of adenoid cystic carcinomaCameron, M.; Levin-Furtney, S.; Harney, A.; Thomas, M.; Dunyak, B.; Shan, M.; Prajapati, S.; Siu, Y. A.; Nguyen, D.; Buonamici, S.; Seiler, M.; Vaillancourt, F.; Smith, P.; Reynolds, D.; Kung, C. 分享 收藏 Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS and AMLWheeler, Emily C.; Martin, Benjamin J. E.; Doyle, William C.; Neaher, Sofia; Conway, Caroline A.; Pitton, Caroline N.; Gorelov, Rebecca A.; Donahue, Melanie; Jann, Johann C.; Abdel-Wahab, Omar; Taylor, Justin; Seiler, Michael; Buonamici, Silvia; Pikman, Yana; Garcia, Jacqueline S.; Belizaire, Roger; Adelman, Karen; Tothova, Zuzana 分享 收藏 Development of MRT-2359, an orally bioavailable GSPT1 molecular glue degrader, for the treatment of lung cancers with MYC-induced translational addictionGavory, Gerald; Ghandi, Mahmoud; d'Alessandro, Anne-Cecile; Bonenfant, Debora; Cabanski, Maciej; Cantagallo, Lisa; Chicas, Agustin; Chen, Qian; Diesslin, Anna; King, Christopher; Massafra, Vittoria; Narayan, Rajiv; Osmont, Arnaud; Peck, Dave; Ortiz, Carolina Perdomo; Schillo, Martin; Singh, Ambika; Tiedt, Ralph; Tortoioli, Simone; Buonamici, Silvia; Janku, Filip; Wallace, Owen; Fasching, Bernhard 分享 收藏 Identification of GSPT1-directed molecular glue degrader (MGD) for the treatment of Myc-driven breast cancerGavory, Gerald; Fasching, Bernhard; Bonenfant, Debora; Sadok, Amine; Singh, Ambika; Schillo, Martin; Massafra, Vittoria; d'Alessandro, Anne-Cecile; Castle, John; Ghandi, Mahmoud; Chicas, Agustin; Delobel, Frederic; Flohr, Alexander; Ottaviani, Giorgio; Ryckmans, Thomas; Laine, Anne-Laure; Eidam, Oliv; Wang, Hannah; Bernett, Ilona; Chan, Laura; Gorrini, Chiara; Roumiliotis, Theo; Choudhary, Jyoti; LeBihan, Yann-Vai; Cabry, Marc; Stubbs, Mark; Burke, Rosemary; Van Montfort, Rob; Caldwell, John; Chopra, Rajesh; Collins, Ian; Buonamici, Silvia 分享 收藏 Intron retention is a hallmark and spliceosome represents a therapeutic vulnerability in aggressive prostate cancerZhang, Dingxiao; Hu, Qiang; Liu, Xiaozhuo; Ji, Yibing; Chao, Hsueh-Ping; Liu, Yan; Tracz, Amanda; Kirk, Jason; Buonamici, Silvia; Zhu, Ping; Wang, Jianmin; Liu, Song; Tang, Dean G. 分享 收藏 Sensitivity to splicing modulation of BCL2 family genes reveals cancer therapeutic strategies for splicing modulatorsAird, Daniel; Teng, Teng; Huang, Chia-Ling; Pazolli, Ermira; Banka, Deepti; Cheung-Ong, Kahlin; Eifert, Cheryl; Furman, Craig; Wu, Jeremy; Seiler, Michael; Buonamici, Silvia; Fekkes, Peter; Karr, Craig; Palacino, James; Park, Eunice; Smith, Peter; Yu, Lihua; Mizui, Yoshiharu; Warmuth, Markus; Chicas, Agustin; Corson, Laura; Zhu, Ping 分享 收藏 Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulatorsAird, Daniel; Teng, Teng; Huang, Chia-Ling; Pazolli, Ermira; Banka, Deepti; Cheung-Ong, Kahlin; Eifert, Cheryl; Furman, Craig; Wu, Zhenhua Jeremy; Seiler, Michael; Buonamici, Silvia; Fekkes, Peter; Karr, Craig; Palacino, James; Park, Eunice; Smith, Peter G.; Yu, Lihua; Mizui, Yoshiharu; Warmuth, Markus; Chicas, Agustin; Corson, Laura; Zhu, Ping 分享 收藏 Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesotheliomaSciarrillo, Rocco; Wojtuszkiewicz, Anna; El Hassouni, Btissame; Funel, Niccola; Gandellini, Paolo; Lagerweij, Tonny; Buonamici, Silvia; Blijlevens, Maxime; van der Laan, Eveline A. Zeeuw; Zaffaroni, Nadia; Deraco, Marcello; Kusamura, Shigeki; Wurdinger, Tom; Peters, Godefridus J.; Molthoff, Carla F. M.; Jansen, Gerrit; Kaspers, Gertjan J. L.; Cloos, Jacqueline; Giovannetti, Elisa 分享 收藏 SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4Tzelepis, Konstantinos; De Braekeleer, Etienne; Aspris, Demetrios; Barbieri, Isaia; Vijayabaskar, M. S.; Liu, Wen-Hsin; Gozdecka, Malgorzata; Metzakopian, Emmanouil; Toop, Hamish D.; Dudek, Monika; Robson, Samuel C.; Hermida-Prado, Francisco; Yang, Yu Hsuen; Babaei-Jadidi, Roya; Garyfallos, Dimitrios A.; Ponstingl, Hannes; Dias, Joao M. L.; Gallipoli, Paolo; Seiler, Michael; Buonamici, Silvia; Vick, Binje; Bannister, Andrew J.; Rad, Roland; Prinjha, Rab K.; Marioni, John C.; Huntly, Brian; Batson, Jennifer; Morris, Jonathan C.; Pina, Cristina; Bradley, Allan; Jeremias, Irmela; Bates, David O.; Yusa, Kosuke; Kouzarides, Tony; Vassiliou, George S. 分享 收藏 Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependenciesten Hacken, Elisa; Valentin, Rebecca; Regis, Fara Faye D.; Sun, Jing; Yin, Shanye; Werner, Lillian; Deng, Jing; Gruber, Michaela; Wong, Jessica; Zheng, Mei; Gill, Amy L.; Seiler, Michael; Smith, Peter; Thomas, Michael; Buonamici, Silvia; Ghia, Emanuela M.; Kim, Ekaterina; Rassenti, Laura Z.; Burger, Jan A.; Kipps, Thomas J.; Meyerson, Matthew L.; Bachireddy, Pavan; Wang, Lili; Reed, Robin; Neuberg, Donna; Carrasco, Ruben D.; Brooks, Angela N.; Letai, Anthony; Davids, Matthew S.; Wu, Catherine J. 分享 收藏 Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast CancerPuyang, Xiaoling; Furman, Craig; Zheng, Guo Zhu; Wu, Zhenhua J.; Banka, Deepti; Aithal, Kiran; Agoulnik, Sergei; Bolduc, David M.; Buonamici, Silvia; Caleb, Benjamin; Das, Subhasree; Eckley, Sean; Fekkes, Peter; Hao, Ming-Hong; Hart, Andrew; Houtman, Rene; Irwin, Sean; Joshi, Jaya J.; Karr, Craig; Kim, Amy; Kumar, Namita; Kumar, Pavan; Kuznetsov, Galina; Lai, Weidong G.; Larsen, Nicholas; Mackenzie, Crystal; Martin, Lesley-Ann; Melchers, Diana; Moriarty, Alyssa; Tuong-Vi Nguyen; Norris, John; O'Shea, Morgan; Pancholi, Sunil; Prajapati, Sudeep; Rajagopalan, Sujatha; Reynolds, Dominic J.; Rimkunas, Victoria; Rioux, Nathalie; Ribas, Ricardo; Siu, Amy; Sivakumar, Sasirekha; Subramanian, Vanitha; Thomas, Michael; Vaillancourt, Frederic H.; Wang, John; Wardell, Suzanne; Wick, Michael J.; Yao, Shihua; Yu, Lihua; Warmuth, Markus; Smith, Peter G.; Zhu, Ping; Korpal, Manav 分享 收藏 Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1Schoepfer, Joseph; Jahnke, Wolfgang; Berellini, Giuliano; Buonamici, Silvia; Cotesta, Simona; Cowan-Jacob, Sandra W.; Dodd, Stephanie; Drueckes, Peter; Fabbro, Doriano; Gabriel, Tobias; Groell, Jean-Marc; Grotzfeld, Robert M.; Hassan, A. Quamrul; Henry, Chrystele; Iyer, Varsha; Jones, Darryl; Lombardo, Franco; Loo, Alice; Manley, Paul W.; Pelle, Xavier; Rummel, Gabriele; Salem, Bahaa; Warmuth, Markus; Wylie, Andrew A.; Zoller, Thomas; Marzinzik, Andreas L.; Furet, Pascal 分享 收藏 分享 收藏 Structural Basis of Splicing Modulation by Antitumor Macrolide CompoundsCretu, Constantin; Agrawal, Anant A.; Cook, Andrew; Will, Cindy L.; Fekkes, Peter; Smith, Peter G.; Luehrmann, Reinhard; Larsen, Nicholas; Buonamici, Silvia; Pena, Vladimir 分享 收藏 分享 收藏 H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancersSeiler, Michael; Yoshimi, Akihide; Darman, Rachel; Chan, Betty; Keaney, Gregg; Thomas, Michael; Agrawal, Anant A.; Caleb, Benjamin; Csibi, Alfredo; Sean, Eckley; Fekkes, Peter; Karr, Craig; Klimek, Virginia; Lai, George; Lee, Linda; Kumar, Pavan; Lee, Stanley Chun-Wei; Liu, Xiang; Mackenzie, Crystal; Meeske, Carol; Mizui, Yoshiharu; Padron, Eric; Park, Eunice; Pazolli, Ermira; Peng, Shouyong; Prajapati, Sudeep; Taylor, Justin; Teng, Teng; Wang, John; Warmuth, Markus; Yao, Huilan; Yu, Lihua; Zhu, Ping; Abdel-Wahab, Omar; Smith, Peter G.; Buonamici, Silvia 分享 收藏 分享 收藏 H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular CarcinomaJoshi, Jaya Julie; Coffey, Heather; Corcoran, Erik; Tsai, Jennifer; Huang, Chia-Ling; Ichikawa, Kana; Prajapati, Sudeep; Hao, Ming-Hong; Bailey, Suzanna; Wu, Jeremy; Rimkunas, Victoria; Karr, Craig; Subramanian, Vanitha; Kumar, Pavan; MacKenzie, Crystal; Hurley, Raelene; Satoh, Takashi; Yu, Kun; Park, Eunice; Rioux, Nathalie; Kim, Amy; Lai, Weidong G.; Yu, Lihua; Zhu, Ping; Buonamici, Silvia; Larsen, Nicholas; Fekkes, Peter; Wang, John; Warmuth, Markus; Reynolds, Dominic J.; Smith, Peter G.; Selvaraj, Anand 分享 收藏 分享 收藏 
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