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RXC008, a first-in-class gastrointestinal restricted pan-ROCK inhibitor developed for treatment of intestinal fibrosis shows GI restriction and tolerability: Results from the phase 1 program in healthy participants. Rieder, F.; Marshall, A.; Houslay, K.; Kilgour, E.; Naveed, T.; Huettner, S.; Koch, A.; Khan, N.; Timmis, H. 分享 收藏
Meta-analysis informed machine learning: Supporting cytokine storm detection during CAR-T cell Therapy Meta分析知情机器学习: 支持car-t细胞治疗期间的细胞因子风暴检测 Bogatu, Alex; Wysocka, Magdalena; Wysocki, Oskar; Butterworth, Holly; Pillai, Manon; Allison, Jennifer; Landers, Donal; Kilgour, Elaine; Thistlethwaite, Fiona; Freitas, Andre 分享 收藏
A COX-2-based pro-tumourigenic inflammatory signature predicts poor outcome in early-stage non-small cell lung cancer Fife, Victoria; Roberts, Matthew; Bromley, Christian P.; Morgan, Derrick; Atkinson, Sophie; Zhou, Cong; Chaturvedi, Anshuman; Bagley, Steven; Ashton, Garry; Coussens, Lisa M.; Crosbie, Philip A.; Dive, Caroline; Kilgour, Elaine; Zelenay, Santiago 分享 收藏
Serial monitoring of genomic alterations in circulating tumor cells of ER-positive/HER2-negative advanced breast cancer: feasibility of precision oncology biomarker detection ER阳性/HER2-negative晚期乳腺癌循环肿瘤细胞基因组改变的系列监测: 精确肿瘤生物标志物检测的可行性 Cani, Andi K.; Dolce, Emily M.; Darga, Elizabeth P.; Hu, Kevin; Liu, Chia-Jen; Pierce, Jackie; Bradbury, Kieran; Kilgour, Elaine; Aung, Kimberly; Schiavon, Gaia; Carroll, Danielle; Carr, T. Hedley; Klinowska, Teresa; Lindemann, Justin; Marshall, Gayle; Rowlands, Vicky; Harrington, Elizabeth A.; Barrett, J. Carl; Sathiyayogan, Nitharsan; Morrow, Christopher; Sero, Valeria; Armstrong, Anne C.; Baird, Richard; Hamilton, Erika; Im, Seock-Ah; Jhaveri, Komal; Patel, Manish R.; Dive, Caroline; Tomlins, Scott A.; Udager, Aaron M.; Hayes, Daniel F.; Paoletti, Costanza 分享 收藏
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Early Adaptation of Colorectal Cancer Cells to the Peritoneal Cavity Is Associated with Activation of Sternness Programs and Local Inflammation 大肠癌细胞对腹膜腔的早期适应与干细胞程序和局部炎症的激活有关。 Barriuso, Jorge; Nagaraju, Raghavendar T.; Belgamwar, Shreya; Chakrabarty, Bipasha; Burghel, George J.; Schlecht, Helene; Foster, Lucy; Kilgour, Elaine; Wallace, Andrew J.; Braun, Michael; Dive, Caroline; Evans, D. Gareth; Bristow, Robert G.; Saunders, Mark P.; O'Dwyer, Sarah T.; Aziz, Omer 分享 收藏
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PD-L1 and immune infiltrates are differentially expressed in distinct subgroups of gastric cancer PD-L1和免疫浸润在胃癌的不同亚组中差异表达 Angell, H. K.; Lee, J.; Kim, K-M.; Kim, K.; Kim, S-T.; Park, S. H.; Kang, W. K.; Sharpe, A.; Ogden, J.; Davenport, A.; Hodgson, D. R.; Barrett, J. C.; Kilgour, E. 分享 收藏
TRIBE; Tyrosine kinase inhibitor therapy in renal-cell carcinoma: Immune biomarker evaluation Villa, S.; Pillai, M.; Graham, D.; Kilgour, E.; Overton, N.; Vasudev, N.; Hughes, A.; Walker, A.; Dransfield, S.; Thistlethwaite, F. 分享 收藏
SELECT-2: a phase II, double-blind, randomized, placebo-controlled study to assess the efficacy of selumetinib plus docetaxel as a second-line treatment of patients with advanced or metastatic non-small-cell lung cancer Soria, J. -C.; Fueloep, A.; Maciel, C.; Fischer, J. R.; Girotto, G.; Lago, S.; Smit, E.; Ostoros, G.; Eberhardt, W. E. E.; Lishkovska, P.; Lovick, S.; Mariani, G.; McKeown, A.; Kilgour, E.; Smith, P.; Bowen, K.; Kohlmann, A.; Carlile, D. J.; Jaenne, P. A. 分享 收藏
A Phase Ib Open-Label Multicenter Study of AZD4547 in Patients with Advanced Squamous Cell Lung Cancers Paik, Paul K.; Shen, Ronglai; Berger, Michael F.; Ferry, David; Soria, Jean-Charles; Mathewson, Alastair; Rooney, Claire; Smith, Neil R.; Cullberg, Marie; Kilgour, Elaine; Landers, Donal; Frewer, Paul; Brooks, Nigel; Andre, Fabrice 分享 收藏
Development of a pharmacodynamic biomarker assay for AZD4785, an antisense oligonucleotide targeting KRAS Rooney, Claire; Ross, Sarah; Staniszewska, Anna; Lennarz, Sabine; Kilgour, Elaine; Revenko, Alexey S.; Macleod, A. Robert; Pierce, Andrew; Lyne, Paul D.; Barrett, J. Carl; Harrington, Elizabeth A. 分享 收藏
A randomized, open-label study of the efficacy and safety of AZD4547 monotherapy versus paclitaxel for the treatment of advanced gastric adenocarcinoma with FGFR2 polysomy or gene amplification Van Cutsem, E.; Bang, Y. -J.; Mansoor, W.; Petty, R. D.; Chao, Y.; Cunningham, D.; Ferry, D. R.; Smith, N. R.; Frewer, P.; Ratnayake, J.; Stockman, P. K.; Kilgour, E.; Landers, D. 分享 收藏
Selumetinib Plus Docetaxel Compared With Docetaxel Alone and Progression-Free Survival in Patients With KRAS-Mutant Advanced Non-Small Cell Lung Cancer The SELECT-1 Randomized Clinical Trial Janne, Pasi A.; van den Heuvel, Michel M.; Barlesi, Fabrice; Cobo, Manuel; Mazieres, Julien; Crino, Lucio; Orlov, Sergey; Blackhall, Fiona; Wolf, Juergen; Garrido, Pilar; Poltoratskiy, Artem; Mariani, Gabriella; Ghiorghiu, Dana; Kilgour, Elaine; Smith, Paul; Kohlmann, Alexander; Carlile, David J.; Lawrence, David; Bowen, Karin; Vansteenkiste, Johan 分享 收藏
Identification of Pharmacodynamic Transcript Biomarkers in Response to FGFR Inhibition by AZD4547 Delpuech, Oona; Rooney, Claire; Mooney, Lorraine; Baker, Dawn; Shaw, Robert; Dymond, Michael; Wang, Dennis; Zhang, Pei; Cross, Sarah; Veldman-Jones, Margaret; Wilson, Joanne; Davies, Barry R.; Dry, Jonathan R.; Kilgour, Elaine; Smith, Paul D. 分享 收藏
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Selumetinib in combination with docetaxel as second-line treatment for patients with KRAS-mutant advanced NSCLC: Results from the phase III SELECT-1 trial Janne, P. A.; van den Heuvel, M.; Barlesi, F.; Cobo, M.; Mazieres, J.; Crino, L.; Orlov, S.; Blackhall, F.; Wolf, J.; Garrido, P.; Poltoratskiy, A.; Mariani, G.; Ghiorghiu, D.; Kilgour, E.; Smith, P.; Kohlmann, A.; Carlile, D.; Lawrence, D.; Bowen, K.; Vansteenkiste, J. F. 分享 收藏
Programmed death-ligand 1 (PD-L1) and immune infiltrates are prognostic for better outcome and enriched in the ATM (ataxia telangiectasia mutated)-low segment of gastric cancer (GC) Kilgour, E.; Angell, H.; Kim, K-M.; Ahn, S.; Kim, S. T.; Sharpe, A.; Ogden, J.; Davenport, A.; Barrett, J. C.; Hodgson, D.; Lee, J. 分享 收藏
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