未登录Efficacy of Multivalent Adenovirus-Based Vaccine against Simian Immunodeficiency Virus Challenge
Casimiro, Danilo R.; Cox, Kara; Tang, Aimin; Sykes, Kara J.; Feng, Meizhen; Wang, Fubao; Bett, Andrew; Schleif, William A.; Liang, Xiaoping; Flynn, Jessica; Tobery, Timothy W.; Wilson, Keith; Finnefrock, Adam; Huang, Lingyi; Vitelli, Salvatore; Lin, Jing; Patel, Deepa; Davies, Mary-Ellen; Heidecker, Gwendolyn J.; Freed, Daniel C.; Dubey, Sheri; O'Connor, David H.; Watkins, David I.; Zhang, Zhi-Qiang; Shiver, John W. .png)
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收藏分享 收藏 Cytotoxic T-lymphocyte escape does not always explain the transient control of simian immunodeficiency virus SIVmac239 viremia in adenovirus-boosted and DNA-primed Mamu-A*01-positive rhesus macaquesMcDermott, AB; O'Connor, DH; Fuenger, S; Piaskowski, S; Martin, S; Lofredo, J; Reynolds, M; Reed, J; Furlott, J; Jacoby, T; Riek, C; Dodds, E; Krebs, K; Davies, ME; Schleif, WA; Casimiro, DR; Shiver, JW; Watkins, DI 分享 收藏 Attenuation of simian immunodeficiency virus SIVmac239 infection by prophylactic immunization with DNA and recombinant adenoviral vaccine vectors expressing GagCasimiro, DR; Wang, FB; Schleif, WA; Liang, XP; Zhang, ZQ; Tobery, TW; Davies, ME; McDermott, AB; O'Connor, DH; Fridman, A; Bagchi, A; Tussey, LG; Bett, AJ; Finnefrock, AC; Fu, TM; Tang, AM; Wilson, KA; Chen, MC; Perry, HC; Heidecker, GJ; Freed, DC; Carella, A; Punt, KS; Sykes, KJ; Huang, LY; Ausensi, VI; Bachinsky, M; Sadasivan-Nair, U; Watkins, DI; Emini, EA; Shiver, JW 分享 收藏 A human monoclonal antibody neutralizes diverse HIV-1 isolates by binding a critical gp41 epitopeMiller, MD; Geleziunas, R; Bianchi, E; Lennard, S; Hrin, R; Zhang, HC; Lu, MQ; An, ZQ; Ingallinella, P; Finotto, M; Mattu, M; Finnefrock, AC; Bramhill, D; Cook, J; Eckert, DM; Hampton, R; Patel, M; Jarantow, S; Joyce, J; Ciliberto, G; Cortese, R; Lu, P; Strohl, W; Schleif, W; McElhaugh, M; Lane, S; Lloyd, C; Lowe, D; Osbourn, J; Vaughan, T; Emini, E; Barbato, G; Kim, PS; Hazuda, DJ; Shiver, JW; Pessi, A 分享 收藏 Vectored Gag and Env but not Tat show efficacy against simian-human immunodeficiency virus 89.6p challenge in Mamu-A*01-negative rhesus monkeysLiang, XP; Casimiro, DR; Schleif, WA; Wang, FB; Davies, ME; Zhang, ZQ; Fu, TM; Finnefrock, AC; Handt, L; Citron, MP; Heidecker, G; Tang, AM; Chen, MC; Wilson, KA; Gabryelski, L; McElhaugh, M; Carella, A; Moyer, C; Huang, LY; Vitelli, S; Patel, D; Lin, J; Emini, EA; Shiver, JW 分享 收藏 Covalent stabilization of coiled coils of the HIV gp41 N region yields extremely potent and broad inhibitors of viral infectionBianchi, E; Finotto, M; Ingallinella, P; Hrin, R; Carella, AV; Hou, XS; Schleif, WA; Miller, MD; Geleziunas, R; Pessi, A 分享 收藏 分享 收藏 Characterization of gp120 and its single-chain derivatives, gp120-CD4D12 and gp120-M9:: Implications for targeting the CD4i epitope in human immunodeficiency virus vaccine designVaradarajan, R; Sharma, D; Chakraborty, K; Patel, M; Citron, M; Sinha, P; Yadav, R; Rashid, U; Kennedy, S; Eckert, D; Geleziunas, R; Bramhill, D; Schleif, W; Liang, XP; Shiver, J 分享 收藏 Synthesis and biological evaluation of 5R- and 5S-methyl substituted D- and L-configuration 1,3-dioxolane nucleoside analogsBera, S; Malik, L; Bhat, B; Carroll, SS; Hrin, R; MacCoss, M; McMasters, DR; Miller, MD; Moyer, G; Olsen, DB; Schleif, WA; Tomassini, JE; Eldrup, AB 分享 收藏 A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integraseHazuda, DJ; Anthony, NJ; Gomez, RP; Jolly, SM; Wai, JS; Zhuang, LH; Fisher, TE; Embrey, M; Guare, JP; Egbertson, MS; Vacca, JP; Huff, JR; Felock, PJ; Witmer, MV; Stillmock, KA; Danovich, R; Grobler, J; Miller, MD; Espeseth, AS; Jin, LX; Chen, IW; Lin, JH; Kassahun, K; Ellis, JD; Wong, BK; Xu, W; Pearson, PG; Schleif, WA; Cortese, R; Emini, E; Summa, V; Holloway, MK; Young, SD 分享 收藏 分享 收藏 Efficacy of indinavir-ritonavir-based regimens in HIV-1-infected patients with prior protease inhibitor failuresCampo, RE; Moreno, JN; Suarez, G; Miller, N; Kolber, MA; Holder, DJ; Shivaprakash, M; DeAngelis, DM; Wright, JL; Schleif, WA 分享 收藏 CCR5 antagonists: 3-(pyrrolidin-1-yl)propionic acid analogues with potent anti-HIV activityLynch, CL; Hale, JJ; Budhu, RJ; Gentry, AL; Finke, PE; Caldwell, CG; Mills, SG; MacCoss, M; Shen, DM; Chapman, KT; Malkowitz, L; Springer, MS; Gould, SL; DeMartino, JA; Siciliano, SJ; Cascieri, MA; Carella, A; Carver, G; Karen, H; Schleif, WA; Danzeisen, R; Hazuda, D; Kessler, J; Lineberger, J; Miller, M; Emini, E 分享 收藏 Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitorsSmith, AB; Cantin, LD; Pasternak, A; Guise-Zawacki, L; Yao, WQ; Charnley, AK; Barbosa, J; Sprengeler, PA; Hirschmann, R; Munshi, S; Olsen, DB; Schleif, WA; Kuo, LC 分享 收藏 Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cellsZhuang, LC; Wai, JS; Embrey, MW; Fisher, TE; Egbertson, MS; Payne, LS; Guare, JP; Vacca, JP; Hazuda, DJ; Felock, PJ; Wolfe, AL; Stillmock, KA; Witmer, MV; Moyer, G; Schleif, WA; Gabryelski, LJ; Leonard, YM; Lynch, JJ; Michelson, SR; Young, SD 分享 收藏 Mamu-A*01 allele-mediated attenuation of disease progression in simian-human immunodeficiency virus infectionZhang, ZQ; Fu, TM; Casimiro, DR; Davies, ME; Liang, XP; Schleif, WA; Handt, L; Tussey, L; Chen, MC; Tang, AM; Wilson, KA; Trigona, WL; Freed, DC; Tan, CY; Horton, M; Emini, EA; Shiver, JW 分享 收藏 L-735,524 - THE DESIGN OF A POTENT AND ORALLY BIOAVAILABLE HIV PROTEASE INHIBITORDORSEY, BD; LEVIN, RB; MCDANIEL, SL; VACCA, JP; GUARE, JP; DARKE, PL; ZUGAY, JA; EMINI, EA; SCHLEIF, WA; QUINTERO, JC; LIN, JH; CHEN, IW; HOLLOWAY, MK; FITZGERALD, PMD; AXEL, MG; OSTOVIC, D; ANDERSON, PS; HUFF, JR 分享 收藏 PYRROLINONE-BASED HIV PROTEASE INHIBITORS - DESIGN, SYNTHESIS, AND ANTIVIRAL ACTIVITY - EVIDENCE FOR IMPROVED TRANSPORTSMITH, AB; HIRSCHMANN, R; PASTERNAK, A; GUZMAN, MC; YOKOYAMA, A; SPRENGELER, PA; DARKE, PL; EMINI, EA; SCHLEIF, WA 分享 收藏 Residual human immunodeficiency virus (HIV) type 1 RNA and DNA in lymph nodes and HIV RNA in genital secretions and in cerebrospinal fluid after suppression of viremia for 2 yearsGünthard, HF; Havlir, DV; Fiscus, S; Zhang, ZQ; Eron, J; Mellors, J; Gulick, R; Frost, SDW; Brown, AJL; Schleif, W; Valentine, F; Jonas, L; Meibohm, A; Ignacio, CC; Isaacs, R; Gamagami, R; Emini, E; Haase, A; Richman, DD; Wong, JK 分享 收藏 
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