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Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension 饮食诱导的肥胖和肾素介导的高血压合并射血分数保留的心力衰竭两次打击小鼠模型 Berger, Justin H.; Shi, Yuji; Matsuura, Timothy R.; Batmanov, Kirill; Chen, Xian; Tam, Kelly; Marshall, Mackenzie; Kue, Richard; Patel, Jiten; Taing, Renee; Callaway, Russell; Griffin, Joanna; Kovacs, Attila; Hirenallur-Shanthappa, Dinesh; Miller, Russell; Zhang, Bei B.; Flach, Rachel J. Roth; Kelly, Daniel P. 分享 收藏
Metabolic Syndrome Nonalcoholic Steatohepatitis Male Mouse With Adeno-Associated Viral Renin as a Novel Model for Heart Failure With Preserved Ejection Fraction Shi, Yuji; Perez-Bonilla, Patricia; Chen, Xian; Tam, Kelly; Marshall, Mackenzie; Morin, Jeffrey; Laviolette, Brianna; Kue, Nouaying R.; Damilano, Federico; Miller, Russell A.; Zhang, Bei B.; Roth Flach, Rachel J.; Hirenallur-Shanthappa, Dinesh 分享 收藏
Regulated dynamic subcellular GLUT4 localization revealed by proximal proteome mapping in human muscle cells Ray, Anuttoma; Wen, Jennifer; Yammine, Lucie; Culver, Jeff; Parida, Isabella Supardi; Garren, Jeonifer; Xue, Liang; Hales, Katherine; Xiang, Qing; Birnbaum, Morris J.; Zhang, Bei B.; Monetti, Mara; Mcgraw, Timothy E. 分享 收藏
Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels Flach, Rachel J. Roth J.; Bollinger, Eliza; Reyes, Allan R. R.; Laforest, Brigitte; Kormos, Bethany L. L.; Liu, Shenping; Reese, Matthew R. R.; Alsina, Luis A. Martinez A.; Buzon, Leanne; Zhang, Yuan; Bechle, Bruce; Rosado, Amy; Sahasrabudhe, Parag V. V.; Knafels, John; Bhattacharya, Samit K. K.; Omoto, Kiyoyuki; Stansfield, John C. C.; Hurley, Liam D. D.; Song, LouJin; Luo, Lina; Breitkopf, Susanne B. B.; Monetti, Mara; Cunio, Teresa; Tierney, Brendan; Geoly, Frank J. J.; Delmore, Jake; Siddall, C. Parker; Xue, Liang; Yip, Ka N. N.; Kalgutkar, Amit S. S.; Miller, Russell A. A.; Zhang, Bei B. B.; Filipski, Kevin J. J. 分享 收藏
Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance Blair, Megan C.; Neinast, Michael D.; Jang, Cholsoon; Chu, Qingwei; Jung, Jae Woo; Axsom, Jessie; Bornstein, Marc R.; Thorsheim, Chelsea; Li, Kristina; Hoshino, Atsushi; Yang, Steven; Roth Flach, Rachel J.; Zhang, Bei B.; Rabinowitz, Joshua D.; Arany, Zoltan 分享 收藏
Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI 代谢失调和脂肪组织纤维化: 胶原VI的作用 Khan, Tayeba; Muise, Eric S.; Iyengar, Puneeth; Wang, Zhao V.; Chandalia, Manisha; Abate, Nicola; Zhang, Bei B.; Bonaldo, Paolo; Chua, Streamson; Scherer, Philipp E. 分享 收藏
GDF15 neutralization restores muscle function and physical performance in a mouse model of cancer cachexia Kim-Muller, Ja Young; Song, LouJin; Paulhus, Brianna LaCarubba; Pashos, Evanthia; Li, Xiangping; Rinaldi, Anthony; Joaquim, Stephanie; Stansfield, John C.; Zhang, Jiangwei; Robertson, Andrew; Pang, Jincheng; Opsahl, Alan; Boucher, Magalie; Breen, Danna; Hales, Katherine; Sheikh, Abdul; Wu, Zhidan; Zhang, Bei B. 分享 收藏
BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice Bollinger, Eliza; Peloquin, Matthew; Libera, Jenna; Albuquerque, Bina; Pashos, Evanthia; Shipstone, Arun; Hadjipanayis, Angela; Sun, Zhongyuan; Xing, Gang; Clasquin, Michelle; Stansfield, John C.; Tierney, Brendan; Gernhardt, Steven; Siddall, C. Parker; Greizer, Timothy; Geoly, Frank J.; Vargas, Sarah R.; Gao, Lily C.; Williams, George; Marshall, Mackenzie; Rosado, Amy; Steppan, Claire; Filipski, Kevin J.; Zhang, Bei B.; Miller, Russell A.; Flach, Rachel J. Roth 分享 收藏
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GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates GDF-15中和减轻了基于铂的化疗引起的小鼠和非人灵长类动物的呕吐，厌食和体重减轻 Breen, Danna M.; Kim, Hanna; Bennett, Donald; Calle, Roberto A.; Collins, Susie; Esquejo, Ryan M.; He, Tao; Joaquim, Stephanie; Joyce, Alison; Lambert, Matthew; Lin, Laura; Pettersen, Betty; Qiao, Shuxi; Rossulek, Michelle; Weber, Gregory; Wu, Zhidan; Zhang, Bei B.; Birnbaum, Morris J. 分享 收藏
Growth differentiation factor 15 (GDF-15) inhibition attenuates platinum-based chemotherapy-induced emesis, anorexia and weight loss and increases survival Breen, Danna M.; Beaumont, Kevin; Bennett, Donald; Brosnan, Julia; Calle, Roberto; Chabot, Jeffrey R.; Collins, Susie; Cunio, Teresa; Esquejo, Ryan M.; Joaquim, Stephanie; Joyce, Alison; Kim, Hanna; Lin, Laura; Pettersen, Betty; Qiao, Shuxi; Rossulek, Michelle; Tierney, Brendan; Walters, Karen M.; Weber, Gregory; Wu, Zhidan; Zhang, Bei B.; Birnbaum, Morris J. 分享 收藏
CK1 δ/ε Inhibitor PF-05006739 Ameliorates Hepatic Steatosis and Hyperinsulinemia in Dio Mice Peloquin, Matthew; Litchfield, John; Zhang, Bei B.; Chang, Cheng; Miller, Russell A.; Bernardo, Barbara; Luthra, Suman; Cortes, Christian; Li, Xiangping, II; Zou, Chang J. 分享 收藏
Branched-Chain Ketoacid Dehydrogenase Kinase Inhibition Acutely Improves Glycemia and Alters the Response to Feeding in Mice Bollinger, Eliza; Siddall, Charles Parker; Greizer, Timothy; Libera, Jenna L.; Hariri, Ghazal; Pashos, Evanthia E.; Shipstone, Arun; Hadjipanayis, Angela; Sun, Zhongyuan; Xing, Gang; Clasquin, Michelle F.; Zhang, Bei B.; Miller, Russell A.; Flach, Rachel Roth 分享 收藏
GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans GDF15提供小鼠和人类营养应激的内分泌信号 Patel, Satish; Alvarez-Guaita, Anna; Melvin, Audrey; Rimmington, Debra; Dattilo, Alessia; Miedzybrodzka, Emily L.; Cimino, Irene; Maurin, Anne-Catherine; Roberts, Geoffrey P.; Meek, Claire L.; Virtue, Samuel; Sparks, Lauren M.; Parsons, Stephanie A.; Redman, Leanne M.; Bray, George A.; Liou, Alice P.; Woods, Rachel M.; Parry, Sion A.; Jeppesen, Per B.; Kolnes, Anders J.; Harding, Heather P.; Ron, David; Vidal-Puig, Antonio; Reimann, Frank; Gribble, Fiona M.; Hulston, Carl J.; Farooqi, I. Sadaf; Fafournoux, Pierre; Smith, Steven R.; Jensen, Jorgen; Breen, Danna; Wu, Zhidan; Zhang, Bei B.; Coll, Anthony P.; Savage, David B.; O'Rahilly, Stephen 分享 收藏
Hepatic GALE Regulates Whole-Body Glucose Homeostasis by Modulating Tff3 Expression Zhu, Yi; Zhao, Shangang; Deng, Yingfeng; Gordillo, Ruth; Ghaben, Alexandra L.; Shao, Mengle; Zhang, Fang; Xu, Ping; Li, Yang; Cao, Huachuan; Zagnitko, Olga; Scott, David A.; Gupta, Rana K.; Xing, Chao; Zhang, Bei B.; Lin, Hua V.; Scherer, Philipp E. 分享 收藏
The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL Emmerson, Paul J.; Wang, Feng; Du, Yong; Liu, Qian; Pickard, Richard T.; Gonciarz, Malgorzata D.; Coskun, Tamer; Hamang, Matthew J.; Sindelar, Dana K.; Ballman, Kimberly K.; Foltz, Lisa A.; Muppidi, Avinash; Alsina-Fernandez, Jorge; Barnard, Gavin C.; Tang, Jason X.; Liu, Xilin; Mao, Xudong; Siegel, Robert; Sloan, John H.; Mitchell, Pamela J.; Zhang, Bei B.; Gimeno, Ruth E.; Shan, Bei; Wu, Xinle 分享 收藏
Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes Shah, Shrenik K.; He, Shuwen; Guo, Liangqin; Quang Truong; Qi, Hongbo; Du, Wu; Lai, Zhong; Liu, Jian; Jian, Tianying; Hong, Qingmei; Dobbelaar, Peter; Ye, Zhixiong; Sherer, Edward; Feng, Zhe; Yu, Yang; Wong, Frederick; Samuel, Koppara; Madiera, Maria; Karanam, Bindhu V.; Reddy, Vijay B.; Mitelman, Stan; Tong, Sharon X.; Chicchi, Gary G.; Tsao, Kwei-Lan; Trusca, Dorina; Feng, Yue; Wu, Margaret; Shao, Qing; Trujillo, Maria E.; Eiermann, George J.; Li, Cai; Pachanski, Michele; Fernandez, Guillermo; Nelson, Donald; Bunting, Patricia; Morissette, Pierre; Volksdorf, Sylvia; Kerr, Janet; Zhang, Bei B.; Howard, Andrew D.; Zhou, Yun-Ping; Pasternak, Alexander; Nargund, Ravi P.; Hagmann, William K. 分享 收藏
Diamine Derivatives as Novel Small-Molecule, Potent, and Subtype-Selective Somatostatin SST3 Receptor Agonists Li, Derun; Wu, Zhicai; Yu, Yang; Ball, Richard G.; Guo, Liangqin; Sherer, Edward; He, Shuwen; Hong, Qingmei; Lai, Zhong; Qi, Hongbo; Quang Truong; Yang, David X.; Chicchi, Gary G.; Tsao, Kwei-Lan; Trusca, Dorina; Trujillo, Maria; Pachanski, Michele; Eiermann, George J.; Howard, Andrew D.; Zhou, Yun-Ping; Zhang, Bei B.; Nargund, Ravi P.; Hagmann, William K. 分享 收藏
The Role of Voltage-Gated Potassium Channels Kv2.1 and Kv2.2 in the Regulation of Insulin and Somatostatin Release from Pancreatic Islets Li, Xiaoyan (Nina); Herrington, James; Petrov, Aleksandr; Ge, Lan; Eiermann, George; Xiong, Yusheng; Jensen, Mette V.; Hohmeier, Hans E.; Newgard, Christopher B.; Garcia, Maria L.; Wagner, Michael; Zhang, Bei B.; Thornberry, Nancy A.; Howard, Andrew D.; Kaczorowski, Gregory J.; Zhou, Yun-Ping 分享 收藏
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