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E

E Seböková

roche holding

H指数:32

被引数:4,255

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A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

合理设计的单体肽三激动剂可纠正啮齿动物的肥胖和糖尿病

NATURE MEDICINE

IF50

2014-12-08525

PREAI

Finan, Brian; Yang, Bin; Ottaway, Nickki; Smiley, David L.; Ma, Tao; Clemmensen, Christoffer; Chabenne, Joe; Zhang, Lianshan; Habegger, Kirk M.; Fischer, Katrin; Campbell, Jonathan E.; Sandoval, Dar Leen; Seeley, Randy J.; Bleicher, Konrad; Uhles, Sabine; Riboulet, William; Funk, Jurgen; Hertel, Cornelia; Belli, Sara; Sebokova, Elena; Conde-Knape, Karin; Konkar, Anish; Drucker, Daniel J.; Gelfanov, Vasily; Pfluger, Paul T.; Muller, Timo D.; Perez-Tilve, Diego; DiMarchi, Richard D.; Tschop, Matthias H.

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2013-10-30542

PREAI

Finan, Brian; Ma, Tao; Ottaway, Nickki; Mueller, Timo D.; Habegger, Kirk M.; Heppner, Kristy M.; Kirchner, Henriette; Holland, Jenna; Hembree, Jazzminn; Raver, Christine; Lockie, Sarah H.; Smiley, David L.; Gelfanov, Vasily; Yang, Bin; Hofmann, Susanna; Bruemmer, Dennis; Drucker, Daniel J.; Pfluger, Paul T.; Perez-Tilve, Diego; Gidda, Jaswant; Vignati, Louis; Zhang, Lianshan; Hauptman, Jonathan B.; Lau, Michele; Brecheisen, Mathieu; Uhles, Sabine; Riboulet, William; Hainaut, Emmanuelle; Sebokova, Elena; Conde-Knape, Karin; Konkar, Anish; DiMarchi, Richard D.; Tschoep, Matthias H.

Effects of the dual PPAR-α/γ agonist aleglitazar on glycaemic control and organ protection in the Zucker diabetic fatty rat

DIABETES OBESITY & METABOLISM

IF5.7

2012-10-0317

PRE

Combined activation of PPAR-gamma and PPAR-alpha reduces the negative effects of PPAR-gamma agonism on bone and may attenuate PPAR-gamma-mediated loss of bone strength

IF3.6

2012-05-011

PREAI

Combination treatment with pioglitazone and fenofibrate attenuates pioglitazone-mediated acceleration of bone loss in ovariectomized rats

JOURNAL OF ENDOCRINOLOGY

IF3.9

2011-11-0717

OAAI

Rhesus Macaques Develop Metabolic Syndrome With Reversible Vascular Dysfunction Responsive to Pioglitazone

IF38.6

2011-07-0551

OAAI

Taspoglutide, a novel human once-weekly GLP-1 analogue, protects pancreatic β-cells in vitro and preserves islet structure and function in the Zucker diabetic fatty rat in vivo

DIABETES OBESITY & METABOLISM

IF5.7

2011-02-237

PREAI

Effects of aleglitazar, a balanced dual peroxisome proliferator-activated receptor α/γ agonist on glycemic and lipid parameters in a primate model of the metabolic syndrome

CARDIOVASCULAR DIABETOLOGY

IF10.6

2011-01-0140

OAAI

Taspoglutide, a novel human once-weekly analogue of glucagon-like peptide-1, improves glucose homeostasis and body weight in the Zucker diabetic fatty rat

DIABETES OBESITY & METABOLISM

IF5.7

2010-06-2412

PREAI

Taspoglutide, an Analog of Human Glucagon-Like Peptide-1 with Enhanced Stability and in Vivo Potency

IF3.3

2010-04-0955

OAAI

High prevalence of prediabetes and diabetes in a population exposed to high levels of an organochlorine cocktail

IF10.2

2010-02-2589

PREAI

Reduced plaque formation induced by rosiglitazone in an STZ-diabetes mouse model of atherosclerosis is associated with downregulation of adhesion molecules

ATHEROSCLEROSIS

IF5.7

2008-07-0140

PREAI

Possible effects of environmental nitrates and toxic organochlorines on human thyroid in highly polluted areas in Slovakia

IF6.7

2008-03-0142

PREAI

High lipid levels in Slovak rural population - Consequence of thyroid dysfunction or nutritional status?

LIPIDS AND SYNDROMES OF INSULIN RESISTANCE: FROM MOLECULAR BIOLOGY TO CLINICAL MEDICINE

IF0

2006-12-170

PREAI

Diet-induced insulin resistance is associated with decreased activity of type I iodothyronine 5'-deiodinase in rat liver

LIPIDS AND SYNDROMES OF INSULIN RESISTANCE: FROM MOLECULAR BIOLOGY TO CLINICAL MEDICINE

IF0

2006-12-171

PREAI

Nuclear all-trans retinoic acid receptors in liver of rats with diet-induced insulin resistance

LIPIDS AND SYNDROMES OF INSULIN RESISTANCE: FROM MOLECULAR BIOLOGY TO CLINICAL MEDICINE

IF0

2006-12-173

PREAI

Fatty acid composition in fractions of structural and storage lipids in liver and skeletal muscle of hereditary hypertriglyceridemic rats

LIPIDS AND SYNDROMES OF INSULIN RESISTANCE: FROM MOLECULAR BIOLOGY TO CLINICAL MEDICINE

IF0

2006-12-1710

PREAI

Phenotype and genotype comparison of hereditary hypertriglyceridemic (hHTG) and Brown-Norway (BN) rats - Identification of quantitative trait loci (QTLs) for the Insulin Resistance Syndrome

LIPIDS AND SYNDROMES OF INSULIN RESISTANCE: FROM MOLECULAR BIOLOGY TO CLINICAL MEDICINE

IF0

2006-12-171

PREAI

Hyperinsulinemia and sympathoadrenal system activity in the rat

LIPIDS AND SYNDROMES OF INSULIN RESISTANCE: FROM MOLECULAR BIOLOGY TO CLINICAL MEDICINE

IF0

2006-12-179

PREAI

Glucose transport and insulin signaling in rat muscle and adipose tissue - Effect of lipid availability

LIPIDS AND SYNDROMES OF INSULIN RESISTANCE: FROM MOLECULAR BIOLOGY TO CLINICAL MEDICINE

IF0

2006-12-177

PREAI