未登录 An IL-12 partial agonist sustains intratumoral lymphocyte activation and detoxifies systemic IL-12 therapy Koliesnik, Ievgen; Totagrande, Michael; Jayaraman, Bhargavi; Burgess, Ryan; Tran, Kim Quyen; Bauer, Michele; Balasubrahmanyam, Priyanka; Ali, Mohammed; Rosas, Henry; Emmerich, Jan; Chaturvedi, Deepti; Rokkam, Deepti; Singh, Somya; Chang, Woei; Buffone, Cindy; Mehta-Damani, Anita; Malefyt, Rene de Waal; Greb, Heiko; Ratti, Navneet; Rosen, David B.; Zuniga, Luis; Kastelein, Robert A.; Aspuria, Paul-Joseph; Vivona, Sandro; Oft, Martin; Lupardus, PatrickJ. 分享 收藏
Novel IL-12 Partial Agonist For Cancer Immunotherapy Avoids NK-cell Mediated Toxicity Koliesnik, Ievgen; Emmerich, Jan; Tran, Kim Q.; Bauer, Michele; Totagrande, Michael; Jayaraman, Bhargavi; Buffone, Cindy; Balasubrahmanyam, Priyanka; Rokkam, Deepti; Malefyt, Rene de Waal; Zuniga, Luis; Greb, Heiko; Ratti, Navneet; Vivona, Sandro; Oft, Martin; Lupardus, Patrick J.; Kastelein, Robert A. 分享 收藏
Biophysical and Immunological Characterization and In Vivo Pharmacokinetics and Toxicology in Nonhuman Primates of the Anti-PD-1 Antibody Pembrolizumab Hutchins, Beth; Starling, Gary C.; McCoy, Mark A.; Herzyk, Danuta; Poulet, Frederique M.; Dulos, John; Liu, Liming; Kang, Soonmo Peter; Fayadat-Dilman, Laurence; Hsieh, Mark; Andrews, Christine L.; Ayanoglu, Gulesi; Cullen, Constance; Malefyt, Rene de Waal; Kastelein, Robert A.; Le Saux, Sabine; Lee, Julie; Li, Sophie; Malashock, Dan; Sadekova, Svetlana; Soder, George; van Eenennaam, Hans; Willingham, Aarron; Yu, Ying; Streuli, Michel; Carven, Gregory J.; van Elsas, Andrea 分享 收藏
IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells Sherlock, Jonathan P.; Joyce-Shaikh, Barbara; Turner, Scott P.; Chao, Cheng-Chi; Sathe, Manjiri; Grein, Jeff; Gorman, Daniel M.; Bowman, Edward P.; McClanahan, Terrill K.; Yearley, Jennifer H.; Eberl, Gerard; Buckley, Christopher D.; Kastelein, Robert A.; Pierce, Robert H.; LaFace, Drake M.; Cua, Daniel J. 分享 收藏
Biomarkers of Therapeutic Response in the IL-23 Pathway in Inflammatory Bowel Disease Cayatte, Corinne; Joyce-Shaikh, Barbara; Vega, Felix; Boniface, Katia; Grein, Jeffrey; Murphy, Erin; Blumenschein, Wendy M.; Chen, Smiley; Malinao, Maria-Christina; Basham, Beth; Pierce, Robert H.; Bowman, Edward P.; McKenzie, Brent S.; Elson, Charles O.; Faubion, William A.; Malefyt, Rene de Waal; Kastelein, Robert A.; Cua, Daniel; McClanahan, Terrill K.; Beaumont, Maribel 分享 收藏
IL-27 Blocks RORc Expression to Inhibit Lineage Commitment of Th17 Cells Diveu, Caroline; McGeachy, Mandy J.; Boniface, Katia; Stumhofer, Jason S.; Sathe, Manjiri; Joyce-Shaikh, Barbara; Chen, Yi; Tato, Cristina M.; McClanahan, Terrill K.; Malefyt, Rene de Waal; Hunter, Christopher A.; Cua, Daniel J.; Kastelein, Robert A. 分享 收藏
Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling Boniface, Katia; Bak-Jensen, Kristian S.; Li, Ying; Blumenschein, Wendy M.; McGeachy, Mandy J.; McClanahan, Terrill K.; McKenzie, Brent S.; Kastelein, Robert A.; Cua, Daniel J.; Malefyt, Rene de Waal 分享 收藏
Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation Kleinschek, Melanie A.; Boniface, Katia; Sadekova, Svetlana; Grein, Jeff; Murphy, Erin E.; Turner, Scott P.; Raskin, Lisa; Desai, Bela; Faubion, William A.; Malefyt, Rene de Waal; Pierce, Robert H.; McClanahan, Terrill; Kastelein, Robert A. 分享 收藏
The Essential Role of Single Ig IL-1 Molecule/Toll IL-1R8 in Regulation Immune Response Bulek, Katarzyna; Swaidani, Shadi; Qin, Jinzhong; Lu, Yi; Gulen, Muhammet F.; Herjan, Tomasz; Min, Booki; Kastelein, Robert A.; Aronica, Mark; Kosz-Vnenchak, Magdalena; Li, Xiaoxia 分享 收藏
Protective Immunity to Systemic Infection with Attenuated Salmonella enterica serovar Enteritidis in the Absence of IL-12 Is Associated with IL-23-Dependent IL-22, but Not IL-17 在没有IL-12的情况下，对减毒沙门氏菌血清型肠炎全身感染的保护性免疫与IL-23-Dependent IL-22有关，但与IL-17无关。 Schulz, Silke M.; Koehler, Gabriele; Schuetze, Nicole; Knauer, Jens; Straubinger, Reinhard K.; Chackerian, Alissa A.; Witte, Ellen; Wolk, Kerstin; Sabat, Robert; Iwakura, Yoichiro; Holscher, Christoph; Mueller, Uwe; Kastelein, Robert A.; Alber, Gottfried 分享 收藏
Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine Zaph, Colby; Du, Yurong; Saenz, Steven A.; Nair, Meera G.; Perrigoue, Jacqueline G.; Taylor, Betsy C.; Troy, Amy E.; Kobuley, Dmytro E.; Kastelein, Robert A.; Cua, Daniel J.; Yu, Yimin; Artis, David 分享 收藏
Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells 人树突状细胞中白细胞介素12和白细胞介素23产生的差异调节 Gerosa, Franca; Baldani-Guerra, Barbara; Lyakh, Lyudmila A.; Batoni, Giovanna; Esin, Semih; Winkler-Pickett, Robin T.; Consolaro, Maria Rita; De Marchi, Mario; Giachino, Daniela; Robbiano, Angela; Astegiano, Marco; Sambataro, Angela; Kastelein, Robert A.; Carra, Giuseppe; Trinchieri, Giorgio 分享 收藏
Development, cytokine profile and function of human interleukin 17-producing helper T cells Wilson, Nicholas J.; Boniface, Katia; Chan, Jason R.; McKenzie, Brent S.; Blumenschein, Wendy M.; Mattson, Jeanine D.; Basham, Beth; Smith, Kathleen; Chen, Taiying; Morel, Franck; Lecron, Jean-Claude; Kastelein, Robert A.; Cua, Daniel J.; McClanahan, Terrill K.; Bowman, Edward P.; Malefyt, Rene de Waal 分享 收藏
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IL-25 regulates Th17 function in autoimmune inflammation Kleinschek, Melanie A.; Owyang, Alexander M.; Joyce-Shaikh, Barbara; Langrish, Claire L.; Chen, Yi; Gorman, Daniel M.; Blumenschein, Wendy M.; McClanahan, Terrill; Brombacher, Frank; Hurst, Stephen D.; Kastelein, Robert A.; Cua, Daniel J. 分享 收藏
IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis IL-23通过TNF和IL-20R2-dependent机制刺激表皮增生，对牛皮癣的发病机理有影响 Chan, Jason R.; Blumenschein, Wendy; Murphy, Erin; Diveu, Caroline; Wiekowski, Maria; Abbondanzo, Susan; Lucian, Linda; Geissler, Richard; Brodie, Scott; Kimball, Alexa B.; Gorman, Daniel M.; Smith, Kathleen; Malefyt, Rene de Waal; Kastelein, Robert A.; McClanahan, Terrill K.; Bowman, Edward P. 分享 收藏
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