未登录 Inhibition of Cardiac Fibrosis and Pro-Fibrotic Collagen Hormone Endotrophin by VS-041, a Novel Drug Candidate for Heart Failure with Preserved Ejection Fraction VS-041对心脏纤维化和促纤维化胶原蛋白激素Endotrophin的抑制作用，该药物是一种新型射血分数保留的心力衰竭候选药物 Plonowski, Artur; Berger, Joel; Pratt, Benjamin; Krupa, Magdalena; Vekich, John; Bochenek, Wieslaw; Larson, Christopher; Moreno, Ydalina; Genovese, Federica 分享 收藏
Endotrophin neutralization through targeted antibody treatment protects from renal fibrosis in a podocyte ablation model 在足细胞消融模型中，通过靶向抗体治疗中和内皮营养蛋白可防止肾脏纤维化 An, Yu A.; Xiong, Wei; Chen, Shiuhwei; Bu, Dawei; Rutkowski, Joseph M.; Berger, Joel P.; Kusminski, Christine M.; Zhang, Ningyan; An, Zhiqiang; Scherer, Philipp E. 分享 收藏
The association of enteric neuropathy with gut phenotypes in acute and progressive models of Parkinson's disease McQuade, Rachel M.; Singleton, Lewis M.; Wu, Hongyi; Lee, Sophie; Constable, Remy; Di Natale, Madeleine; Ringuet, Mitchell T.; Berger, Joel P.; Kauhausen, Jessica; Parish, Clare L.; Finkelstein, David, I; Furness, John B.; Diwakarla, Shanti 分享 收藏
Chronic isolation stress is associated with increased colonic and motor symptoms in the A53T mouse model of Parkinson's disease 慢性隔离应激与帕金森病A53T小鼠模型结肠和运动症状增加相关 Diwakarla, Shanti; Finkelstein, David I.; Constable, Remy; Artaiz, Olivia; Di Natale, Madeleine; McQuade, Rachel M.; Lei, Enie; Chai, Xin-yi; Ringuet, Mitchell T.; Fothergill, Linda J.; Lawson, Victoria A.; Ellett, Laura J.; Berger, Joel P.; Furness, John B. 分享 收藏
Endothelial Cell-Targeted Deletion of PPARγ Blocks Rosiglitazone-Induced Plasma Volume Expansion and Vascular Remodeling in Adipose Tissue Akiyama, Taro E.; Skelhorne-Gross, Graham E.; Lightbody, Elizabeth D.; Rubino, Rachel E.; Shi, Jia Yue; McNamara, Lesley A.; Sharma, Neelam; Zycband, Emanuel, I; Gonzalez, Frank J.; Liu, Haiying; Woods, John W.; Chang, C. H.; Berger, Joel P.; Nicol, Christopher J. B. 分享 收藏
Relaxin Family Member Insulin-Like Peptide 6 Ameliorates Cardiac Fibrosis and Prevents Cardiac Remodeling in Murine Heart Failure Models Maruyama, Sonomi; Wu, Chia-Ling; Yoshida, Sumiko; Zhang, Dongying; Li, Pei-Hsuan; Wu, Fangzhou; Duffen, Jennifer Parker; Yao, Rouan; Jardin, Blake; Adham, Ibrahim M.; Law, Ronald; Berger, Joel; Di Marchi, Richard; Walsh, Kenneth 分享 收藏
Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic Acid (MK-0533): A Novel Selective Peroxisonne Proliferator-Activated Receptor γ Modulator for the Treatment of Type 2 Diabetes Mellitus with a Reduced Potential to Increase Plasma and Extracellular Fluid Volume (vol 52, pg 3846, 2009) Acton, John J.; Akiyama, Taro E.; Chang, Ching H.; Colwell, Lawrence; Debenham, Sheryl; Doebber, Thomas; Einstein, Monica; Liu, Kun; McCann, Margaret E.; Moller, David E.; Muise, Eric S.; Tan, Yejun; Thompson, John R.; Wong, Kenny K.; Wu, Margaret; Xu, Libo; Meinke, Peter T.; Berger, Joel P.; Wood, Harold B. 分享 收藏
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Novel Transcriptome Profiling Analyses Demonstrate that Selective Peroxisome Proliferator-Activated Receptor γ (PPARγ) Modulators Display Attenuated and Selective Gene Regulatory Activity in Comparison with PPARγ Full Agonists Tan, Yejun; Muise, Eric S.; Dai, Hongyue; Raubertas, Richard; Wong, Kenny K.; Thompson, G. Marie; Wood, Harold B.; Meinke, Peter T.; Lum, Pek Yee; Thompson, John R.; Berger, Joel P. 分享 收藏
FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents Mu, James; Pinkstaff, Jason; Li, Zhihua; Skidmore, Lillian; Li, Nina; Myler, Heather; Dallas-Yang, Qing; Putnam, Anna-Maria; Yao, Jun; Bussell, Stuart; Wu, Margaret; Norman, Thea C.; Rodriguez, Carlos G.; Kimmel, Bruce; Metzger, Joseph M.; Manibusan, Anthony; Lee, Darin; Zaller, Dennis M.; Zhang, Bei B.; DiMarchi, Richard D.; Berger, Joel P.; Axelrod, Douglas W. 分享 收藏
Pharmacokinetic and Pharmacodynamic Properties of the Glucokinase Activator MK-0941 in Rodent Models of Type 2 Diabetes and Healthy Dogs Eiki, Jun-ichi; Nagata, Yasufumi; Futamura, Mayumi; Sasaki-Yamamoto, Kaori; Iino, Tomoharu; Nishimura, Teruyuki; Chiba, Masato; Ohyama, Sumika; Yoshida-Yoshimioto, Riki; Fujii, Kenji; Hosaka, Hideka; Goto-Shimazaki, Hiroko; Kadotani, Akito; Ohe, Tomoyuki; Lin, Songnian; Langdon, Ronald B.; Berger, Joel P. 分享 收藏
Benzimidazolones: A New Class of Selective Peroxisome Proliferator-Activated Receptor γ (PPARγ) Modulators Liu, Weiguo; Lau, Fiona; Liu, Kun; Wood, Harold B.; Zhou, Gaochao; Chen, Yuli; Li, Ying; Akiyama, Taro E.; Castriota, Gino; Einstein, Monica; Wang, Chualin; McCann, Margaret E.; Doebber, Thomas W.; Wu, Margaret; Chang, Ching H.; McNamara, Lesley; McKeever, Brian; Mosley, Ralph T.; Berger, Joel P.; Meinke, Peter T. 分享 收藏
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Suppression of PC-1/ENPP-1 expression improves insulin sensitivity in vitro and in vivo Zhou, Heather H.; Chin, Chen-Ni; Wu, Margaret; Ni, Weihua; Quan, Shuo; Liu, Franklin; Dallas-Yang, Qing; Ellsworth, Kenneth; Ho, Thu; Zhang, Aiwu; Natasha, Tajneen; Li, Jing; Chapman, Kevin; Strohl, William; Li, Cai; Wang, I-Ming; Berger, Joel; An, Zhiqiang; Zhang, Bei B.; Jiang, Guoqiang 分享 收藏
Discovery of a Highly Potent, Selective, and Bioavailable Soluble Epoxide Hydrolase Inhibitor with Excellent Ex Vivo Target Engagement Shen, Hong C.; Ding, Fa-Xiang; Wang, Siyi; Deng, Qiaolin; Zhang, Xiaoping; Chen, Yuli; Zhou, Gaochao; Xu, Suoyu; Chen, Hsuan-Shen; Tong, Xinchun; Tong, Vincent; Mitra, Kaushik; Kumar, Sanjeev; Tsai, Christine; Stevenson, Andra S.; Pai, Lee-Yuh; Alonso-Galicia, Magdalena; Chen, Xiaoli; Soisson, Stephen M.; Roy, Sophie; Zhang, Bei; Tata, James R.; Berger, Joel P.; Colletti, Steven L. 分享 收藏
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Discovery of a Peroxisome Proliferator Activated Receptor γ (PPARγ) Modulator with Balanced PPARα Activity for the Treatment of Type 2 Diabetes and Dyslipidemia Liu, Weiguo; Liu, Kun; Wood, Harold B.; McCann, Margaret E.; Doebber, Thomas W.; Chang, Ching H.; Akiyama, Taro E.; Einstein, Monica; Berger, Joel P.; Meinke, Peter T. 分享 收藏
Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic Acid (MK-0533): A Novel Selective Peroxisome Proliferator-Activated Receptor γ Modulator for the Treatment of Type 2 Diabetes Mellitus with a Reduced Potential to Increase Plasma and Extracellular Fluid Volume Acton, John J., III; Akiyama, Taro E.; Chang, Ching H.; Colwell, Lawrence; Debenham, Sheryl; Doebber, Thomas; Einstein, Monica; Liu, Kun; McCann, Margaret E.; Moller, David E.; Muise, Eric S.; Tan, Yugen; Thompson, John R.; Wong, Kenny K.; Wu, Margaret; Xu, Libo; Meinke, Peter T.; Berger, Joel P.; Wood, Harold B. 分享 收藏
Proangiogenic Contribution of Adiponectin toward Mammary Tumor Growth In vivo Landskroner-Eiger, Shira; Qian, Binzhi; Muise, Eric S.; Nawrocki, Andrea R.; Berger, Joel P.; Fine, Eugene J.; Koba, Wade; Deng, Yingfeng; Pollard, Jeffrey W.; Scherer, Philipp E. 分享 收藏
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