Christopher H.S. McIntosh

University of British Columbia

55H指数

244论文数

9.9K被引数

收录论文 47

发表时间

Glucose-dependent insulinotropic polypeptide-mediated up-regulation of β-cell antiapoptotic Bcl-2 gene expression is coordinated by cyclic AMP (cAMP) response element binding protein (CREB) and cAMP-responsive CREB coactivator 2

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

118

OAAI

Kim, Su-Jin; Nian, Cuilan; Widenmaier, Scott; McIntosh, Christopher H. S.

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function (vol 18, pg 2388, 2009)

HUMAN MOLECULAR GENETICS

IF3.2

2015-03-08

OAAI

Shu, Luan; Matveyenko, Aleksey V.; Kerr-Conte, Julie; Cho, Jae-Hyoung; McIntosh, Christopher H. S.; Maedler, Kathrin

Incretin-stimulated interaction between β-cell Kv1.5 and Kvβ2 channel proteins involves acetylation/deacetylation by CBP/SirT1

BIOCHEMICAL JOURNAL

IF4.3

2013-03-28

PREAI

Kim, Su-Jin; Ao, Ziliang; Warnock, Garth; McIntosh, Christopher H. S.

Resistin Knockout Mice Exhibit Impaired Adipocyte Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR) Expression

DIABETES

IF7.5

2013-01-17

OAAI

Kim, Su-Jin; Nian, Cuilan; McIntosh, Christopher H. S.

Glucose-dependent insulinotropic polypeptide signaling in pancreatic β-cells and adipocytes 胰腺 β 细胞和脂肪细胞中葡萄糖依赖性促胰岛素多肽信号传导

JOURNAL OF DIABETES INVESTIGATION

IF3

2012-02-21

OAAI

McIntosh, Christopher H. S.; Widenmaier, Scott; Kim, Su-Jin

Pancreatic β-cell prosurvival effects of the incretin hormones involve post-translational modification of Kv2.1 delayed rectifier channels

CELL DEATH AND DIFFERENTIATION

IF15.4

2011-08-05

OAAI

Kim, S-J; Widenmaier, S. B.; Choi, W. S.; Nian, C.; Ao, Z.; Warnock, G.; McIntosh, C. H. S.

Adipocyte expression of the glucose-dependent insulinotropic polypeptide receptor involves gene regulation by PPARγ and histone acetylation 葡萄糖依赖性促胰岛素多肽受体的脂肪细胞表达涉及ppar γ 和组蛋白乙酰化的基因调控

JOURNAL OF LIPID RESEARCH

IF4.1

2011-04-01

OAAI

Kim, Su-Jin; Nian, Cuilan; McIntosh, Christopher H. S.

GIP increases human adipocyte LPL expression through CREB and TORC2-mediated trans-activation of the LPL gene

JOURNAL OF LIPID RESEARCH

IF4.1

2010-11-01

112

OAAI

Kim, Su-Jin; Nian, Cuilan; McIntosh, Christopher H. S.

Sitagliptin (MK0431) Inhibition of Dipeptidyl Peptidase IV Decreases Nonobese Diabetic Mouse CD4+ T-Cell Migration Through Incretin-Dependent and -Independent Pathways 西格列汀 (MK0431) 抑制二肽基肽酶IV通过肠促胰岛素依赖性和非依赖性途径降低非肥胖糖尿病小鼠CD4 T细胞迁移

DIABETES

IF7.5

2010-04-05

OAAI

Kim, Su-Jin; Nian, Cuilan; McIntosh, Christopher H. S.

Suppression of p38 MAPK and JNK via Akt-mediated Inhibition of Apoptosis Signal-regulating Kinase 1 Constitutes a Core Component of the β-Cell Pro-survival Effects of Glucose-dependent Insulinotropic Polypeptide

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2009-10-01

102

OAAI

Widenmaier, Scott B.; Ao, Ziliang; Kim, Su-Jin; Warnock, Garth; McIntosh, Christopher H. S.

Glucose-dependent Insulinotropic Polypeptide and Glucagon-like Peptide-1 Modulate β-Cell Chromatin Structure

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2009-05-01

OAAI

Kim, Su-Jin; Nian, Cuilan; McIntosh, Christopher H. S.

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

HUMAN MOLECULAR GENETICS

IF3.2

2009-04-21

255

OAAI

Shu, Luan; Matveyenko, Aleksey V.; Kerr-Conte, Julie; Cho, Jae-Hyoung; McIntosh, Christopher H. S.; Maedler, Kathrin

Noncanonical Activation of Akt/Protein Kinase B in β-Cells by the Incretin Hormone Glucose-dependent Insulinotropic Polypeptide

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2009-04-01

OAAI

Widenmaier, Scott B.; Sampaio, Arthur V.; Underhill, T. Michael; McIntosh, Christopher H. S.

Dipeptidyl Peptidase IV Inhibition With MK0431 Improves Islet Graft Survival in Diabetic NOD Mice Partially via T-Cell Modulation

DIABETES

IF7.5

2009-03-01

105

OAAI

Kim, Su-Jin; Nian, Cuilan; Doudet, Doris J.; McIntosh, Christopher H. S.

Inhibition of dipeptidyl peptidase IV with sitagliptin (MK0431) prolongs islet graft survival in streptozotocin-induced diabetic mice

DIABETES

IF7.5

2008-05-01

OAAI

Kim, Su-Jin; Nian, Cuilan; Doudet, Doris J.; McIntosh, Christopher H. S.

Resistin is a key mediator of glucose-dependent insulinotropic polypeptide (GIP) stimulation of lipoprotein lipase (LPL) activity in adipocytes

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2007-11-01

111

OAAI

Kim, Su-Jin; Nian, Cuilan; McIntosh, Christopher H. S.

Activation of lipoprotein lipase by glucose-dependent insulinotropic polypeptide in adipocytes - A role for a protein kinase B, LKB1, and AMP-activated protein kinase cascade

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2007-03-01

196

OAAI

Kim, Su-Jin; Nian, Cuilan; McIntosh, Christopher H. S.

Quantitative micro positron emission tomography (PET) imaging for the in vivo determination of pancreatic islet graft survival

NATURE MEDICINE

IF50

2006-12-03

PREAI

Kim, Su-Jin; Doudet, Doris J.; Studenov, Andrei R.; Nian, Cuilan; Ruth, Thomas J.; Gambhir, Sanjiv Sam; McIntosh, Christopher H. S.

Effects of dipeptidyl peptidase IV on the satiety actions of peptide YY

DIABETOLOGIA

IF10.2

2006-06-27

OAAI

Unniappan, S.; McIntosh, C. H. S.; Demuth, H. -U.; Heiser, U.; Wolf, R.; Kieffer, T. J.

Applications of dipeptidyl peptidase IV inhibitors in diabetes mellitus

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

IF2.8

2006-05-01

PREAI

McIntosh, CHS; Demuth, HU; Kim, S; Pospisilik, JA; Pederson, RA

研究方向